Current issues in the utility of 19F nuclear magnetic resonance methodologies for the assessment of tumour hypoxia

Philosophical Transactions of the Royal Society B: Biological Sciences

Volumn 359, Issue 1446, 2004, Pages 987-996

  Robinson, Simon P ^a   Griffiths, John R ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

2 nitroimidazole; 19F NMR; Hypoxia; Perfluorocarbon

Indexed keywords

HYPOXIA; TUMOR;

EID: 2942704056     PISSN: 09628436     EISSN: None     Source Type: Journal    
DOI: 10.1098/rstb.2003.1376     Document Type: Review

References (59)

1. Aboagye, E. O., Maxwell, R. J., Kelson, A. B., Tracy, M., Lewis, A. D., Graham, M. A., Horsman, M. R., Griffiths, J. R. & Workman, P. 1997 Preclinical evaluation of the fluorinated 2-nitroimidazole N-(2-hydroxy-3,3,3- trifluropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR-4554) as a probe for the measurement of tumor hypoxia. Cancer Res. 57, 3314-3318.
2. Aboagye, E. O., Maxwell, R. J., Horsman, M. R., Lewis, A. D., Workman, P., Tracy, M. & Griffiths, J. R. 1998 The relationship between tumour oxygenation determined by oxygen electrode measurements and magnetic resonance spectroscopy of the fluorinated 2-nitroimidazole SR-4554. Br. J. Cancer 77, 65-70.
3. Adam, M. F., Dorie, M. J. & Brown, J. M. 1999 Oxygen tension measurements of tumours growing in mice. Int. J. Rad. Oncol. Biol. Phys. 45, 171-180.
4. 31P magnetic resonance spectroscopy. Magn. Reson. Imag. 14, 541-551.
5. Brizel, D. M., Rosner, G. L., Harrelson, J., Prosnitz, L. R. & Dewhirst, M. W. 1994 Pretreatment oxygenation profiles of human soft tissue sarcomas. Int. J. Rad. Oncol. Biol. Phys. 30, 635-642.
6. Brizel, D. M., Scully, S. P., Harrelson, J., Layfield, L. J., Bean, J. M., Prosnitz, L. R. & Dewhirst, M. W. 1996 Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res. 56, 941-943.
7. Brizel, D. M., Sibley, G. S., Prosnitz, L. R., Scher, R. L. & Dewhirst, M. W. 1997 Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck. Int. J. Rad. Oncol. Biol. Phys. 38, 285-289.
8. Chaplin, D. J., Horsman, M. R. & Aoki, D. S. 1991 Nicotinamide, fluosol DA and carbogen: a strategy to reoxygenate acutely and chronically hypoxic cells in vivo. Br. J. Cancer 63, 109-113.
9. 19F inversion-recovery echo-planar imaging of perfluoro-15-crown-5-ether. Magn. Reson. Med. 32, 88-97.
10. Evans, S. M., Bergeron, M., Ferriero, D. M., Sharp, F. R., Hermeking, H., Kitsis, R. N., Geenen, D. L., Bialik, S., Lord, E. M. & Koch, C. J. 1997 Imaging hypoxia in diseased states. Adv. Exp. Med. Biol. 428, 595-603.
11. Fan, X., River, J. N., Zamora, M., Al-Hallaq, H. A. & Karczmar, G. S. 2002 Effect of carbogen on tumor oxygenation: combined fluorine-19 and proton MRI measurements. Int. J. Rad. Oncol. Biol. Phys. 54, 1202-1209.
12. Fyles, A. W. (and 10 others) 1998 Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiother. Oncol. 48, 149-156.
13. Hall, E. J. 1994 Radiobiology for the radiologist, 4th edn. Philadelphia, PA: Lippincott.
14. Harris, A. L. 2002 Hypoxia - a key regulatory factor in tumour growth. Nature Rev. Cancer 2, 38-47.
15. 19F NMR relaxometry of a perfluorocarbon emulsion. Magn. Reson. Med. 29, 303-310.
16. 2 tension measurements. Cancer Res. 51, 6098-6102.
17. Hockel, M., Schlenger, K., Aral, B., Mitze, M., Schaffer, U. & Vaupel, P. 1996 Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 56, 4509-4515.
18. Horsman, M. R. 1998 Measurement of tumor oxygenation. Int. J. Rad. Oncol. Biol. Phys. 42, 701-704.
19. 19F NMR spectroscopy of hexafluorobenzene. Int. J. Rad. Oncol. Biol. Phys. 41, 161-171.
20. Hunjan, S., Zhao, D., Constantinescu, A., Hahn, E. W., Antich, P. P. & Mason, R. P. 2001 Tumor oximetry: demonstration of an enhanced dynamic mapping procedure using fluorine-19 echo planar magnetic resonance imaging in the Dunning prostate R3327-AT1 rat tumor. Int. J. Rad. Oncol. Biol. Phys. 49, 1097-1108.
21. 19F magnetic resonance spectroscopy. Int. J. Rad. Biol. 58, 1025-1034.
22. Joseph, J., Jaiswal, A. K., Stobbe, C. C. & Chapman, J. D. 1994 The role of specific reductases in the intracellular activation and binding of 2-nitroimidazoles. Int. J. Rad. Oncol. Biol. Phys. 29, 351-355.
23. Kaanders, J. H. A. M., Pop, L. A. M., Marres, H. A. M., Bruaset, I., van den Hoogen, F. J. A., Merkx, M. A. W. & van der Kogel, A. J. 2002a ARCON: experience in 215 patients with advanced head-and-neck cancer. Int. J. Rad. Oncol. Biol. Phys. 52, 769-778.
24. Kaanders, J. H. A. M., Wijffels, K. I. E. M., Marres, H. A. M., Ljungkvist, A. S. E., Pop, L. A. M., van den Hoogen, F. J. A., de Wilde, P. C. M., Bussink, J., Raleigh, J. A. & van der Kogel, A. J. 2002b Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer. Cancer Res. 62, 7066-7074.
25. 19F magnetic resonance spectroscopy and immunohistochemistry. Rad. Res. 129, 71-79.
26. 19F PBSR EPI of hexafluorobenzene. Magn. Reson. Imag. 15, 971-981.
27. 19F] magnetic resonance spectroscopy. Cancer Commun. 3, 133-139.
28. Lord, E. M., Harwell, L. & Koch, C. J. 1993 Detection of hypoxic cells by monoclonal antibody recognising 2-nitroimidazole adducts. Cancer Res. 53, 5721-5726.
29. 19F MRI of neat PFC droplets. Adv. Exp. Med. Biol. 428, 569-572.
30. 19F MRI of perfluorocarbons. Curr. Sci. 76, 753-762.
31. Mason, R. P., Antich, P. P., Babcock, E. E., Constantinescu, A., Peschke, P. & Hahn, E. W. 1994 Non-invasive determination of tumor oxygen tension and local variation with growth. Int. J. Rad. Oncol. Biol. Phys. 29, 95-103.
32. 19F NMR indicator of tumor oxygenation. NMR Biomed. 9, 125-134.
33. Mason, R. P., Hunjan, S., Le, D., Constantinescu, A., Barker, B. R., Wong, P. S., Peschke, P., Hahn, E. W. & Antich, P. P. 1998 Regional tumor oxygen tension: fluorine echo planar imaging of hexafluorobenzene reveals heterogeneity of dynamics. Int. J. Rad. Oncol. Biol. Phys. 42, 747-750.
34. Mason, R. P., Constantinescu, A., Hunjan, S., Le, D., Hahn, E. W., Antich, P. P., Blum, C. & Peschke, P. 1999 Regional tumor oxygenation and measurement of dynamic changes. Rad. Res. 152, 239-249.
35. 19F magnetic resonance spectroscopy in vivo. Int. J. Rad. Oncol. Biol. Phys. 16, 925-929.
36. Nordsmark, M., Overgaard, M. & Overgaard, J. 1996 Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother. Oncol. 41, 31-39.
37. Nordsmark, M. (and 10 others) 2001 Invasive oxygen measurements and pimonidazole labeling in human cervix carcinoma. Int. J. Rad. Oncol. Biol. Phys. 49, 581-586.
38. 2 during growth and in response to carbogen breathing using 15C5-loaded alginate capsules as oxygen sensors. Proc. Int. Soc. Magn. Reson. Med. Abstract 635.
39. Parhami, P. & Fung, P. M. 1983 Fluorine-19 relaxation study of perfluoro chemicals as oxygen carriers. J. Phys. Chem. 87, 1928-1931.
40. Raleigh, J. A., Franko, A. J., Treiber, E. O., Lunt, J. A. & Allen, P. S. 1986 Covalent binding of a fluorinated 2-nitroimidazole to EMT-6 tumours in BALB/c mice: detection by F-19 nuclear magnetic resonance at 2.35T. Int. J. Rad. Oncol. Biol. Phys. 12, 1243-1245.
41. 19F magnetic resonance method for measuring oxygen deficiency in tumors. Magn. Reson. Med. 22, 451-466.
42. Raleigh, J. A., Chou, S.-C., Tables, L., Suchindran, S., Varia, M. A. & Horsman, M. R. 1998 Relationship of hypoxia to metallothionein expression in murine tumors. Int. J. Rad. Oncol. Biol. Phys. 42, 727-730.
43. Raleigh, J. A., Chou, S.-C., Arteel, G. E. & Horsman, M. R. 1999 Comparisons among pimonidazole binding, oxygen electrode measurements, and radiation response in C3H mouse tumors. Rad. Res. 151, 580-589.
44. Robinson, S. P., Howe, F. A., Rodrigues, L. M., Stubbs, M. & Griffiths, J. R. 1998 Magnetic resonance imaging techniques for monitoring changes in tumor oxygenation and blood flow. Semin. Rad. Oncol. 8, 197-207.
45. Robinson, S. P., Collingridge, D. R., Rodrigues, L. M., Howe, F. A., Chaplin, D. J. & Griffiths, J. R. 1999 Tumour response to hypercapnia and hyperoxia monitored by FLOOD magnetic resonance imaging. NMR Biomed. 12, 98-106.
46. Robinson, S. P., Kostourou, V., Troy, H., Whitley, G. St J. & Griffiths, J. R. 2002 An in vivo assessment of the relationship of tumour hypoxia and angiogenesis. Proc. Int. Soc. Magn. Reson. Med. Abstract 2182.
47. Rojas, A. 1991 Radiosensitisation with normobaric oxygen and carbogen. Radiother. Oncol. 20, 65-70.
48. Secomb, T. W., Hsu, R., Ong, E. T., Gross, J. F. & Dewhirst, M. W. 1995 Analysis of the effects of oxygen supply and demand on hypoxic fraction in tumors. Acta Oncol. 34, 313-316.
49. Seddon, B. M., Maxwell, R. J., Honess, D. J., Grimshaw, R., Raynaud, F., Tozer, G. M. & Workman, P. 2002 Validation of the fluorinated 2-nitroimidazole SR-4554 as a non-invasive hypoxia marker detected by magnetic resonance spectroscopy. Clin. Cancer Res. 8, 2323-2335.
50. Seddon, B. M., Payne, G. S., Simmons, L., Ruddle, R., Grimshaw, R., Tan, S., Turner, A. S., Raynaud, F., Halbert, G., Leach, M. O., Judson, I. & Workman, P. 2003 A phase I study of SR-4554 via intravenous administration for non-invasive investigation of tumor hypoxia by magnetic resonance spectroscopy in patients with malignancy. Clin. Cancer Res. 9, 5101-5112.
51. Snyder, S. A., Lanzen, J. L., Braun, R. D., Rosner, G., Secomb, T. W., Biaglow, J., Brizel, D. M. & Dewhirst, M. W. 2001 Simultaneous administration of glucose and hyperoxic gas achieves greater improvement in tumor oxygenation than hyperoxic gas alone. Int. J. Rad. Oncol. Biol. Phys. 51, 494-506.
52. Song, Y., Constantinescu, A. & Mason, R. P. 2002 Dynamic breast tumor oximetry: the development of prognostic radiology. Technol. Cancer Res. Treat. 1, 471-478.
53. 19F-MR relaxometry. Int. J. Rad. Oncol. Biol. Phys. 44, 649-658.
54. Wang, Z., Su, M. Y. & Nalcioglu, O. 2002 Applications of dynamic contrast enhanced MRI in oncology: measurement of tumor oxygen tension. Technol. Cancer Res. Treat. 1, 29-38.
55. 19F MRI of hexafluorobenzene. In SPIE Conf. Optical Tomography and Spectroscopy of Tissue III, San Jose, CA, pp. 601-610.
56. Workman, P. 1992 Bioreductive mechanisms. Int. J. Rad. Oncol. Biol. Phys. 22, 631-637.
57. Workman, P., Maxwell, R. J. & Griffiths, J. R. 1992 Non-invasive MRS in new anticancer drug development. NMR Biomed. 5, 270-272.
58. Yen, K. A., Biade, S., Lanciano, R. M., Brown, D. Q., Fenning, M. C., Babb, J. S., Hanks, G. E. & Chapman, J. D. 1995 Polarographic needle electrode measurements of oxygen in rat prostate carcinomas: accuracy and reproducibility. Int. J. Rad. Oncol. Biol. Phys. 33, 111-118.
59. Zhao, D., Constantinescu, A., Hahn, E. W. & Mason, R. P. 2002 Differential oxygen dynamics in two diverse Dunning prostate R3327 rat tumor sublines (Mat-Lu and HI) with respect to growth and respiratory challenge. Int. J. Rad. Oncol. Biol. Phys. 53, 744-756.