Solution-phase combinatorial synthesis of nonpeptide bradykinin antagonists

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 13, 2004, Pages 3543-3552

  Kam, Yoo Lim ^a   Rhee, Soo Jin ^a   Choo, Hea Young P ^a  

^a Ewha Womans University   (South Korea)

Author keywords

Antagonists; Nonpeptide bradykinin; Solution phase combinatorial synthesis

Indexed keywords

BRADYKININ ANTAGONIST; CARBONYL DERIVATIVE; N [(TERT BUTYLOXY)CARBONYL] N' (3,4,5 TRIMETHOXYBENZYL) N'' 1 (4 CHLOROBENZHYDRYL)PIPERAZINE IMINODIACETIC ACID DIAMIDE; N [(TERT BUTYLOXY)CARBONYL] N' (3,4,5 TRIMETHOXYBENZYL)IMINODIACETIC ACID MONOAMIDE; N [(TERT BUTYLOXY)CARBONYL] N' (4 METHOXYBENZYL) N'' 1 (4 CHLOROBENZHYDRYL)PIPERAZINE IMINODIACETIC ACID DIAMIDE; N [(TERT BUTYLOXY)CARBONYL] N' (4 METHOXYBENZYL)IMINODIACETIC ACID MONOAMIDE; N [(TERT BUTYLOXY)CARBONYL] N' (4 METHYLBENZYL) N'' 1 (4 CHLOROBENZHYDRYL)PIPERAZINE IMINODIACETIC ACID DIAMIDE; N [(TERT BUTYLOXY)CARBONYL] N' (4 METHYLBENZYL)IMINODIACETIC ACID MONOAMIDE; N [(TERT BUTYLOXY)CARBONYL] N' [1 (METHYL) 3 (PHENYL)PROPYL] N'' 1 (4 CHLOROBENZHYDRYL)PIPERAZINE IMINODIACETIC ACID DIAMIDE; N [(TERT BUTYLOXY)CARBONYL] N' [1 (METHYL) 3 (PHENYL)PROPYL]IMINODIACETIC ACID MONOAMIDE; N [(TERT BUTYLOXY)CARBONYL] N' [2 [4 (4 BROMOPHENYL)THIAZOLE]] N'' 1 (4 CHLOROBENZHYDRYL)PIPERAZINE IMINODIACETIC ACID DIAMIDE; N [(TERT BUTYLOXY)CARBONYL] N' [2 [4 (4 BROMOPHENYL)THIAZOLE]]IMINODIACETIC ACID MONOAMIDE; N [(TERT BUTYLOXY)CARBONYL] N' [2 [4 (4 CHLOROPHENYL)THIAZOLE]] N'' 1 (4 CHLOROBENZHYDRYL)PIPERAZINE IMINODIACETIC ACID DIAMIDE; N [(TERT BUTYLOXY)CARBONYL] N' [2 [4 (4 CHLOROPHENYL)THIAZOLE]]IMINODIACETIC ACID MONOAMIDE; N [(TERT BUTYLOXY)CARBONYL] N' [3 (5 TERT BUTYLISOXAZOLE)] N'' 1 (4 CHLOROBENZHYDRYL)PIPERAZINE IMINODIACETIC ACID DIAMIDE; N [(TERT BUTYLOXY)CARBONYL] N' [3 (5 TERT BUTYLISOXAZOLE)]IMINODIACETIC ACID MONOAMIDE; N [(TERT BUTYLOXY)CARBONYL] N' BENZYL N'' 1 (4 CHLOROBENZHYDRYL)PIPERAZINE IMINODIACETIC ACID DIAMIDE; N [(TERT BUTYLOXY)CARBONYL] N' BENZYLIMINODIACETIC ACID MONOAMIDE; N [(TERT BUTYLOXY)CARBONYL] N' CYCLOHEXYL N'' 1 (4 CHLOROBENZHYDRYL)PIPERAZINE IMINODIACETIC ACID DIAMIDE; N [(TERT BUTYLOXY)CARBONYL] N' CYCLOHEXYLIMINODIACETIC ACID MONOAMIDE; N [(TERT BUTYLOXY)CARBONYL] N' ISOPROPYL N'' 1 (4 CHLOROBENZHYDRYL)PIPERAZINE IMINODIACETIC ACID DIAMIDE; N [(TERT BUTYLOXY)CARBONYL] N' ISOPROPYLIMINODIACETIC ACID MONOAMIDE; N ACETYL N' (3,4,5 TRIMETHOXYBENZYL) N'' 1 (4 CHLOROBENZHYDRYL)PIPERAZINE IMINODIACETIC ACID TRIAMIDE; N ACETYL N' (4 METHOXYBENZYL) N'' 1 (4 CHLOROBENZHYDRYL)PIPERAZINE IMINODIACETIC ACID TRIAMIDE; N ACETYL N' (4 METHYLBENZYL) N'' 1 (4 CHLOROBENZHYDRYL)PIPERAZINE IMINODIACETIC ACID TRIAMIDE; N ACETYL N' [1 (METHYL) 3 (PHENYL)PROPYL] N'' 1 (4 CHLOROBENZHYDRYL)PIPERAZINE IMINODIACETIC ACID TRIAMIDE; N ACETYL N' BENZYL N'' 1 (4 CHLOROBENZHYDRYL)PIPERAZINE IMINODIACETIC ACID TRIAMIDE; PEPTIDE DERIVATIVE; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL TISSUE; ARTICLE; COMBINATORIAL CHEMISTRY; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG SYNTHESIS; GUINEA PIG; ILEUM; INTESTINE MUSCLE; NONHUMAN; SMOOTH MUSCLE;

AMINATION; ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; GUINEA PIGS; ILEUM; IMINO ACIDS; MALE; MOLECULAR STRUCTURE; MUSCLE, SMOOTH; QUINOLINES; RECEPTORS, BRADYKININ; SOLUTIONS;

CAVIA PORCELLUS; SUS SCROFA;

EID: 2942601911     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.04.031     Document Type: Article

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