Adenovirus-mediated interleukin-18 mutant in vivo gene transfer inhibits tumor growth through the induction of T cell immunity and activation of natural killer cell cytotoxicity

Cancer Gene Therapy

Volumn 11, Issue 6, 2004, Pages 397-407

  Hwang, Kyung Sun ^a   Cho, Won Kyung ^a   Yoo, Jinsang ^a   Seong, Young Rim ^b   Kim, Bum Kyeng ^c   Kim, Samyong ^d   Im, Dong Soo ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Samyang Corporation   (South Korea)

^c Konyang University   (South Korea)

^d Chungnam National University   (South Korea)

Author keywords

Adenovirus vector; IL 18 mutant; Liver cancer; Renal cancer

Indexed keywords

ADENOVIRUS VECTOR; CASPASE 3; CD4 ANTIGEN; CD8 ANTIGEN; COMPLEMENTARY DNA; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 18; INTERLEUKIN 1BETA CONVERTING ENZYME; TRYPSIN;

5' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL ACTIVATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DELETION MUTANT; DRUG POTENCY; FEMALE; GENE TRANSFER; HUMAN; HUMAN CELL; IMMUNOHISTOLOGY; IN VIVO STUDY; KIDNEY CARCINOMA; LYMPHOCYTE FUNCTION; LYMPHOCYTIC INFILTRATION; MOUSE; NATURAL KILLER CELL MEDIATED CYTOTOXICITY; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; T LYMPHOCYTE; TH1 CELL; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; VIRUS RECOMBINANT; WILD TYPE;

ADENOVIRIDAE; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CELL LINE; CELL LINE, TUMOR; CLONING, MOLECULAR; CULTURE MEDIA; DNA, COMPLEMENTARY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE TRANSFER TECHNIQUES; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; GREEN FLUORESCENT PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INTERFERON TYPE II; INTERLEUKIN-18; INTERLEUKIN-2; KIDNEY NEOPLASMS; KILLER CELLS, NATURAL; LIVER NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; MODELS, GENETIC; MUTATION; T-LYMPHOCYTES; TIME FACTORS; TRANSFECTION;

ADENOVIRIDAE; ANIMALIA; MURINAE; MUS MUSCULUS;

EID: 2942590859     PISSN: 09291903     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cgt.7700711     Document Type: Article

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