Construction and analysis of new vector systems with improved interleukin-18 secretion in a xenogeneic human tumor model

Journal of Immunotherapy

Volumn 25, Issue SUPPL. 1, 2002, Pages

  Goto, Hiroyuku ^a   Osaki, Tadashi ^a   Nishino, Kazumi ^a   Tachibana, Isao ^a   Takeda, Yoshito ^a   Yoneda, Tsutomu ^a   Funakoshi, Toshiki ^a   Kimura, Hiromi ^a   Hayashi, Seiji ^a   Tahara, Hideaki ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Cancer therapy; Gene therapy; Interleukin 18; Peritoneal exuding cell; Viral vector

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 18; VIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; CANCER IMMUNOTHERAPY; CONFERENCE PAPER; GENE THERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TREATMENT OUTCOME; XENOGRAFT;

ADENOVIRIDAE; ANIMALS; COLONIC NEOPLASMS; DISEASE MODELS, ANIMAL; GENE THERAPY; GENETIC VECTORS; HUMANS; IMMUNITY, CELLULAR; INTERFERON TYPE II; INTERLEUKIN-18; KILLER CELLS, NATURAL; MICE; NEOPLASM TRANSPLANTATION; SENSITIVITY AND SPECIFICITY; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 18344372733     PISSN: 10538550     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002371-200203001-00006     Document Type: Conference Paper

References (22)

1. Cloning of a new cytokine that induces IFN-γ production by T cells
2. IFN-γ-inducing factor/IL-18 administration mediates IFN-γ and IL-12 independent anti-tumor effects
3. In vivo antitumor effects of murine interferon-γ-inducing factor/interleukin-18 in mice bearing syngeneic Meth A sarcoma malignant ascites
4. Potent antitumor effects mediated by local expression of the mature form of the interferon-γ-inducing factor, IL-18
5. Differential antitumor effects of administration of rIL-18 or rIL-12 are mediated primarily by Fas-FasL and perforin induced tumor apoptosis respectively
6. Caspase-1 processes IFN-γ-inducing factor and regulates LPS-induced IFN-γ production
7. Activation of interferon-γ inducing factor mediated by interleukin-1β converting enzyme
8. Human interleukin 1β fused to human growth hormone signal peptide is N-glycosylated and secreted by Chinese hamster ovary cells
9. Fusion of a signal sequence to the interleukin-1β gene directs the protein from cytoplastic accumulation to extracellular release
10. Constitutive intra-articular expression of human IL-1β after gene transfer to rabbit synovium produces all major pathologies of human rheumatoid arthritis
11. Production of high-titer helper-free retroviruses by transient transfection
12. Effective eradication of established murine tumors with IL-12 gene therapy using a polycistronic retroviral vector
13. Efficient generation of recombinant adenoviruses using adenovirus DNA- terminal protein complex and a cosmid bearing the full-length virus genome
14. A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock
15. Gene therapy for carcinoembryonic antigen-producing human lung cancer cells by cell type-specific expression of herpes simplex virus thymidine kinase gene
16. A mechanism underlying synergy between IL-12 and IFN-g-inducing factor in enhanced production of IFN-γ
17. Molecular cloning of the interleukin 1β converting enzyme
18. A novel heterodimetric cysteine protease is required for interleukin 1β processing in monocytes
19. Eradication of murine bladder carcinoma by intratumor injection of a bicistronic adenoviral vector carrying cDNAs for the IL-12 heterodimer and its inhibition by the IL-12 p40 subunit homodimer
20. A newly defined interleukin-1?
21. Interleukin-12 (IL-12) and IL-18 synergistically induce the fungicidal activity of murine peritoneal exudate cells against Cryptococcus neoformans through production of gamma interferon by natural killer cells
22. Interleukin-18: A novel cytokine that augments both innate and acquired immunity