Activation of the mitogen-activated protein kinase pathway is involved in and sufficient for megakaryocytic differentiation of CMK cells

Blood

Volumn 90, Issue 9, 1997, Pages 3462-3470

  Melemed, Allen S ^b   Ryder, John W ^b   Vik, Terry A ^a  

^a RILEY HOSPITAL FOR CHILDREN   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; FIBRINOGEN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE INHIBITOR; STEM CELL FACTOR;

ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MEGAKARYOBLAST; MEGAKARYOCYTE; PRIORITY JOURNAL;

EID: 0030737420     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v90.9.3462     Document Type: Article

References (35)

1. Schlessinger J, Ullrich A: Growth factor signaling by receptor tyrosine kinases. Neuron 9:383, 1992
2. Blenis J: Signal transduction via the MAP kinases: Proceed at your own RSK. Proc Natl Acad Sci USA 90:5889, 1993
3. Crews CM, Erikson RL: Extracellular signals and reversible protein phosphorylation: What to Mek of it all. Cell 74:215, 1993
4. Marshall CJ: Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179, 1995
5. Matsuda S, Kosako H, Takenaka K, Moriyama K, Sakai H, Akiyama T, Gotoh Y, Nishida E: Xenopus MAP kinase activator: Identification and function as a key intermediate in the phosphorylation cascade. EMBO J 11:973, 1992
6. Gomez N, Traverse S, Cohen P: Identification of a MAP kinase kinase in phaeochromocytoma (PC12) cells. FEBS Lett 314:461, 1992
7. Crews CM, Erikson RL: Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: Relationship to the fission yeast byrl gene product. Proc Natl Acad Sci USA 89:8205, 1992
8. Dent P, Haser W, Haystead T, Vincent LA, Roberts TM, Sturgill TW: Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro. Science 257:1404, 1992
9. Howe LR, Leevers SJ, Gómez N, Nakielny S, Cohen P, Marshall CJ: Activation of the MAP kinase pathway by the protein kinase raf. Cell 71:335, 1992
10. Kyriakis JM, App H, Zhang X, Banerjee P, Brautigan DL, Rapp UR, Avruch J: Raf-1 activates MAP kinase-kinase. Nature 358:417, 1992
11. Marais MB, Wynne J, Treisman R: The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 73:381, 1993
12. Whitmarsh AJ. Shore P, Sharrocks AD, Davis RJ: Integration of MAP kinase signal transduction pathways at the serum response element. Science 269:403, 1995
13. Cowley S, Paterson H, Kemp P, Marshall C: Activation of MAP kinase kinase is necessary and sufficient for PC 12 differentiation and for transformation of NIH 3T3 cells. Cell 77:841, 1994
14. Mansour SJ, Matten WT, Hermann AS, Candia JM, Rong S, Fukasawa K, Woude GFV, Ahn NG: Transformation of mammalian cells by constitutively active MAP kinase kinase. Science 265:966, 1994
15. Huang W, Erikson RL: Constitutive activation of MEK1 by mutation of serine phosphorylation sites. Proc Natl Acad Sci USA 91:8960, 1994
16. Brunner D, Oellers N, Szahad J, Biggs III WH, Zipursky SL, Hafen E: A gain of function mutation in drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways. Cell 76:875, 1994
17. Umbhauer M, Marshall CJ, Mason CS. Old RW, Smith JC: Mesoderm induction in Xenopus caused by activation of MAP kinase. Nature 376:58, 1995
18. Chabot B, Stephenson DA, Chapman VM, Besmer P, Bernstein A: The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature 335:88, 1988
19. Geissler EN, Ryan MA. Housman DE: The dominant-white spotting (W) locus of the mouse encodes the c-kit protooncogene. Cell 55:185, 1988
20. Yarden Y, Kuang W-J. Yang-Feng T, Coussens E, Munemitsu S, Dull TJ, Chen E, Schlessinger J, Francke U, Ullrich A: Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J 6:3341, 1987
21. Okuda K, Sanghera JS, Pelech SL, Kanakura Y, Hallek M, Griffin JD, Druker BJ: Granulocyte-macrophage colony-stimulating factor, interleukin-3, and steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase. Blood 79:2880, 1992
22. Miyazawa K, Hendrie PC, Mantel C, Wood K, Ashman LK, Broxmeyer HE: Comparative analysis of signaling pathways between mast cell growth factor (c-kit ligand) and granulocyte-macrophage colony-stimulating factor in a human factor-dependent myeloid cell line involves phosphorylation of Raf-I, GTPase-activating protein and mitogen-activated protein kinase. Exp Hematol 19:1110, 1991
23. Bashey A, Healy L, Marshall CJ: Proliferative but not nonpro-liferative response to granulocyte colony-stimulating factor are associated with rapid activation of the p21ras/MAP kinase signaling pathway. Blood 83:949, 1994
24. Alberola-Ila J, Forbush KA, Seger R, Krebs EG, Perlmutter RM: Selective requirement for MAP kinase activation in thymocyte differentiation. Nature 373:620, 1995
25. Crompton T, Gilmour KC, Owen MJ: The MAP kinase pathway controls differentiation from double-negative to double-positive thymocyte. Cell 86:243, 1996
26. Sato T, Fuse A, Eguchi M, Hayashi Y, Ryo R, Adachi M, Kishimoto Y, Teramura M, Mizoguchi H, Shima Y, Komori I, Sunami S, Okimoto Y, Nakajima H: Establishment of a human leukae- mic cell line (CMK) with megakaryocytic characteristics from a Down's syndrome patient with acute megakaryoblastic leukaemia. Br J Haematol 72:184, 1989
27. Hu ZB, Ma W, Uphoff CC, Quentmeier H, Drexler HG: c-kit expression in human megakaryoblastic leukemia cell lines. Blood 83:2133, 1994
28. Alessandrini A, Crews CM, Erikson RL: Phorbol ester stimulates a protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product. Proc Natl Acad Sci USA 89:8200, 1992
29. Calvo V, Crews CM, Vik TA, Bierer BE: Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin. Proc Natl Acad Sci USA 89:7571, 1992
30. Kozak M: Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell 44:283, 1986
31. Abdel-Malek Abdel-Hafiz H, Heasley LE, Kyriakis JM, Avruch J, Kroll DJ, Johnson GL, Hoeffler JP: Activating transcription factor-2 DNA-binding activity is stimulated by phosphorylation catalyzed by p42 and p54 microtubule-associated protein kinases. Mol Endocrinol 6:2079, 1992
32. Yamada M, Komatsu N, Okada K, Kato T, Hiroshi M, Miura Y: Thrombopoietin induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in a human thrombopoietin-dependent cell line. Biochem Biophys Res Comm 217:230, 1995
33. Yang Y, Yin T: Interleukin (IL)-11-mediated signal transduction. Ann N Y Acad Sci 762:31, 1995
34. Nagata Y, Todokoro K: Thrombopoietin induces activation of at least two distinct signaling pathways. FEBS Lett 377:497, 1995
35. Pang L, Sawada T, Decker SJ, Saltiel AR: Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. J Biol Chem 270:13585, 1995