A functional role of mitogen-activated protein kinases, Erk1 and Erk2, in the differentiation of a human leukemia cell line, UT-7/GM: A possible key factor for cell fate determination toward erythroid and megakaryocytic lineages

International Journal of Hematology

Volumn 73, Issue 1, 2001, Pages 78-83

  Uchida, Mie ^a   Kirito, Keita ^a   Shimizu, Ritsuko ^a   Miura, Yasusada ^a   Ozawa, Keiya ^a   Komatsu, Norio ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Erythropoiesis; Erythropoietin; Megakaryopoiesis; Signal transduction; Thrombopoietin

Indexed keywords

ENZYME INHIBITOR; ERYTHROPOIETIN; MAP2K1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; PROTEIN SERINE THREONINE KINASE; THROMBOPOIETIN;

ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL LINEAGE; CYTOLOGY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ERYTHROID PRECURSOR CELL; HUMAN; LEUKEMIA; MEGAKARYOCYTE; PATHOLOGY; PHYSIOLOGY;

CELL DIFFERENTIATION; CELL LINEAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; ERYTHROID PROGENITOR CELLS; ERYTHROPOIETIN; HUMANS; LEUKEMIA; MAP KINASE KINASE 1; MEGAKARYOCYTES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; THROMBOPOIETIN; TUMOR CELLS, CULTURED;

EID: 0035228939     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02981906     Document Type: Article

References (2)

1. Nishida Y, Gotoh Y. The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem Sci. 1993;18:128-131.
2. Bittorf T, Jaster R, Brock J. Rapid activation of the MAP kinase pathway in hematopoietic cells by erythropoietin, granulocytemacrophage colony-stimulating factor and interleukin-3. Cell Signal. 1994;6:305-311.