Expression in blood cells may contribute to biochemical and pathological improvements after neonatal intravenous gene therapy for mucopolysaccharidosis VII in dogs

Molecular Genetics and Metabolism

Volumn 87, Issue 1, 2006, Pages 8-21

  Wang, Bin ^a   O'Malley, Thomas M ^b   Xu, Lingfei ^a   Vite, Charles ^b   Wang, Ping ^b   O'Donnell, Patricia A ^b   Ellinwood, N Matthew ^b   Haskins, Mark E ^b   Ponder, Katherine Parker ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Gene therapy; Glycosaminoglycan; Lysosomal storage disease; Mucopolysaccharidosis; Retroviral vector

Indexed keywords

BETA GLUCURONIDASE; GLYCOSAMINOGLYCAN; LIVER PROTEIN; RETROVIRUS VECTOR; RNA; VIRUS DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CELL; BRAIN NERVE CELL; CELL MIGRATION; CELL TYPE; CONTROLLED STUDY; DOG; DRUG UPTAKE; ENZYME ACTIVITY; ENZYME RELEASE; GENE THERAPY; KIDNEY TUBULE; LIVER; LIVER CELL; LUNG; LYSOSOME STORAGE DISEASE; MOLECULAR GENETICS; MUCOPOLYSACCHARIDOSIS TYPE 7; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SMALL INTESTINE; SPLEEN; THYMUS;

ANIMALS; ANIMALS, NEWBORN; BETA-N-ACETYLHEXOSAMINIDASE; DNA, VIRAL; DOGS; GENE THERAPY; GENETIC VECTORS; GLUCURONIDASE; GLYCOSAMINOGLYCANS; INJECTIONS, INTRAVENOUS; LEUKOCYTES; LIVER; MUCOPOLYSACCHARIDOSIS VII; RETROVIRIDAE; RNA, VIRAL; SPLEEN; TISSUE DISTRIBUTION; TRANSDUCTION, GENETIC;

ANIMALIA; CANIS FAMILIARIS;

EID: 29344470027     PISSN: 10967192     EISSN: 10967206     Source Type: Journal    
DOI: 10.1016/j.ymgme.2005.08.014     Document Type: Article

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