-
1
-
-
0037283601
-
The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes
-
S.E. Kahn The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes Diabetologia 46 2003 3 19
-
(2003)
Diabetologia
, vol.46
, pp. 3-19
-
-
Kahn, S.E.1
-
2
-
-
0036092239
-
Banting lecture 2001, dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
-
J.D. McGarry Banting lecture 2001, dysregulation of fatty acid metabolism in the etiology of type 2 diabetes Diabetes 51 2002 7 18
-
(2002)
Diabetes
, vol.51
, pp. 7-18
-
-
McGarry, J.D.1
-
3
-
-
0023117178
-
Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity
-
S. Fujioka, Y. Matsuzawa, K. Tokunaga, and S. Tarui Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity Metabolism 36 1987 54 59
-
(1987)
Metabolism
, vol.36
, pp. 54-59
-
-
Fujioka, S.1
Matsuzawa, Y.2
Tokunaga, K.3
Tarui, S.4
-
4
-
-
0021813187
-
Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man
-
D.R. Matthews, J.P. Hosker, A.S. Rudenski, B.A. Naylor, D.F. Treacher, and R.C. Turner Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man Diabetologia 28 1985 412 419
-
(1985)
Diabetologia
, vol.28
, pp. 412-419
-
-
Matthews, D.R.1
Hosker, J.P.2
Rudenski, A.S.3
Naylor, B.A.4
Treacher, D.F.5
Turner, R.C.6
-
5
-
-
0025066328
-
Insulin release and peripheral sensitivity at the oral glucose tolerance test
-
J. Cederholm, and L. Wibell Insulin release and peripheral sensitivity at the oral glucose tolerance test Diabetes Res. Clin. Pract. 10 1990 167 175
-
(1990)
Diabetes Res. Clin. Pract.
, vol.10
, pp. 167-175
-
-
Cederholm, J.1
Wibell, L.2
-
7
-
-
0032764784
-
13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents
-
13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents Diabetes 48 1999 1600 1606
-
(1999)
Diabetes
, vol.48
, pp. 1600-1606
-
-
Perseghin, G.1
Scifo, P.2
De Cobelli, F.3
Pagliato, E.4
Battezzati, A.5
Arcelloni, C.6
Vanzulli, A.7
Testolin, G.8
Pozza, G.9
Del Maschio, A.10
Luzi, L.11
-
8
-
-
0032934826
-
1H NMR spectroscopy study
-
1H NMR spectroscopy study Diabetologia 42 1999 113 116
-
(1999)
Diabetologia
, vol.42
, pp. 113-116
-
-
Krssak, M.1
Falk Petersen, K.2
Dresner, A.3
Dipietro, L.4
Vogel, S.M.5
Rothman, D.L.6
Roden, M.7
Shulman, G.I.8
-
9
-
-
0032960890
-
Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects
-
S. Jacob, J. Machann, K. Rett, K. Brechtel, A. Volk, W. Renn, E. Maerker, S. Matthaei, F. Schick, C.D. Claussen, and H.U. Haring Association of increased intramyocellular lipid content with insulin resistance in lean nondiabetic offspring of type 2 diabetic subjects Diabetes 48 1999 1113 1119
-
(1999)
Diabetes
, vol.48
, pp. 1113-1119
-
-
Jacob, S.1
MacHann, J.2
Rett, K.3
Brechtel, K.4
Volk, A.5
Renn, W.6
Maerker, E.7
Matthaei, S.8
Schick, F.9
Claussen, C.D.10
Haring, H.U.11
-
10
-
-
0035487317
-
Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle
-
A. Virkamaki, E. Korsheninnikova, A. Seppala-Lindroos, S. Vehkavaara, T. Goto, J. Halavaara, A.M. Hakkinen, and H. Yki-Jarvinen Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle Diabetes 50 2001 2337 2343
-
(2001)
Diabetes
, vol.50
, pp. 2337-2343
-
-
Virkamaki, A.1
Korsheninnikova, E.2
Seppala-Lindroos, A.3
Vehkavaara, S.4
Goto, T.5
Halavaara, J.6
Hakkinen, A.M.7
Yki-Jarvinen, H.8
-
11
-
-
0029583826
-
Liver fat, serum triglycerides and visceral adipose tissue in insulin-sensitive and insulin-resistant black men with NIDDM
-
M.A. Banerji, M.C. Buckley, R.L. Chaiken, D. Gordon, H.E. Lebovitz, and J.G. Kral Liver fat, serum triglycerides and visceral adipose tissue in insulin-sensitive and insulin-resistant black men with NIDDM Int. J. Obes. Relat. Metab. Disord. 19 1995 839 840
-
(1995)
Int. J. Obes. Relat. Metab. Disord.
, vol.19
, pp. 839-840
-
-
Banerji, M.A.1
Buckley, M.C.2
Chaiken, R.L.3
Gordon, D.4
Lebovitz, H.E.5
Kral, J.G.6
-
12
-
-
0029558305
-
The influence of fatty liver on insulin clearance and insulin resistance in non-diabetic Japanese subjects
-
T. Goto, T. Onuma, K. Takabe, and J.G. Kral The influence of fatty liver on insulin clearance and insulin resistance in non-diabetic Japanese subjects Int. J. Obes. Relat. Metab. Disord. 19 1995 841 845
-
(1995)
Int. J. Obes. Relat. Metab. Disord.
, vol.19
, pp. 841-845
-
-
Goto, T.1
Onuma, T.2
Takabe, K.3
Kral, J.G.4
-
13
-
-
0342314436
-
Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients
-
L. Ryysy, A.M. Hakkinen, T. Goto, S. Vehkavaara, J. Westerbacka, J. Halavaara, and H. Yki-Jarvinen Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients Diabetes 49 2000 749 758
-
(2000)
Diabetes
, vol.49
, pp. 749-758
-
-
Ryysy, L.1
Hakkinen, A.M.2
Goto, T.3
Vehkavaara, S.4
Westerbacka, J.5
Halavaara, J.6
Yki-Jarvinen, H.7
-
14
-
-
0036312905
-
Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men
-
A. Seppala-Lindroos, S. Vehkavaara, A.M. Hakkinen, T. Goto, J. Westerbacka, A. Sovijarvi, J. Halavaara, and H. Yki-Jarvinen Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men J. Clin. Endocrinol. Metab. 87 2002 3023 3028
-
(2002)
J. Clin. Endocrinol. Metab.
, vol.87
, pp. 3023-3028
-
-
Seppala-Lindroos, A.1
Vehkavaara, S.2
Hakkinen, A.M.3
Goto, T.4
Westerbacka, J.5
Sovijarvi, A.6
Halavaara, J.7
Yki-Jarvinen, H.8
-
15
-
-
0035431018
-
Nonalcoholic fatty liver disease. a feature of metabolic syndrome
-
G. Marchesini, M. Brizi, G. Bianchi, S. Tomassetti, E. Bugianesi, M. Lenzi, A.J. McCullough, S. Natale, G. Forlani, and N. Melchionda Nonalcoholic fatty liver disease. A feature of metabolic syndrome Diabetes 50 2001 1844 1850
-
(2001)
Diabetes
, vol.50
, pp. 1844-1850
-
-
Marchesini, G.1
Brizi, M.2
Bianchi, G.3
Tomassetti, S.4
Bugianesi, E.5
Lenzi, M.6
McCullough, A.J.7
Natale, S.8
Forlani, G.9
Melchionda, N.10
-
16
-
-
0034745183
-
Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 gene is associated with increased antilipolytic insulin sensitivity
-
M. Stumvoll, H.G. Wahl, K. Loblein, R. Becker, F. Machicao, S. Jacob, and H. Haring Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma2 gene is associated with increased antilipolytic insulin sensitivity Diabetes 50 2001 876 881
-
(2001)
Diabetes
, vol.50
, pp. 876-881
-
-
Stumvoll, M.1
Wahl, H.G.2
Loblein, K.3
Becker, R.4
MacHicao, F.5
Jacob, S.6
Haring, H.7
-
17
-
-
0036091918
-
Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: Interaction with family history of type 2 diabetes
-
M. Stumvoll, O. Tschritter, A. Fritsche, H. Staiger, W. Renn, M. Weisser, F. Machicao, and H. Haring Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes Diabetes 51 2002 37 41
-
(2002)
Diabetes
, vol.51
, pp. 37-41
-
-
Stumvoll, M.1
Tschritter, O.2
Fritsche, A.3
Staiger, H.4
Renn, W.5
Weisser, M.6
MacHicao, F.7
Haring, H.8
-
18
-
-
0034745057
-
A polymorphism in the 5′ untranslated region and a Met229 → Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to type II diabetes mellitus
-
H. Mori, H. Okazawa, K. Iwamoto, E. Maeda, M. Hashiramoto, and M. Kasuga A polymorphism in the 5′ untranslated region and a Met229 → Leu variant in exon 5 of the human UCP1 gene are associated with susceptibility to type II diabetes mellitus Diabetologia 44 2001 373 376
-
(2001)
Diabetologia
, vol.44
, pp. 373-376
-
-
Mori, H.1
Okazawa, H.2
Iwamoto, K.3
Maeda, E.4
Hashiramoto, M.5
Kasuga, M.6
-
19
-
-
0028136536
-
DNA polymorphism in the uncoupling protein (UCP) gene and human body fat
-
J.M. Oppert, M.C. Vohl, M. Chagnon, F.T. Dionne, A.M. Cassard-Doulcier, D. Ricquier, L. Perusse, and C. Bouchard DNA polymorphism in the uncoupling protein (UCP) gene and human body fat Int. J. Obes. Relat. Metab. Disord. 18 1994 526 531
-
(1994)
Int. J. Obes. Relat. Metab. Disord.
, vol.18
, pp. 526-531
-
-
Oppert, J.M.1
Vohl, M.C.2
Chagnon, M.3
Dionne, F.T.4
Cassard-Doulcier, A.M.5
Ricquier, D.6
Perusse, L.7
Bouchard, C.8
-
20
-
-
0029843407
-
Additive effect of a → G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesity
-
K. Clement, J. Ruiz, A.M. Cassard-Doulcier, F. Bouillaud, D. Ricquier, A. Basdevant, B. Guy-Grand, and P. Froguel Additive effect of A → G (-3826) variant of the uncoupling protein gene and the Trp64Arg mutation of the beta 3-adrenergic receptor gene on weight gain in morbid obesity Int. J. Obes. Relat. Metab. Disord. 20 1996 1062 1066
-
(1996)
Int. J. Obes. Relat. Metab. Disord.
, vol.20
, pp. 1062-1066
-
-
Clement, K.1
Ruiz, J.2
Cassard-Doulcier, A.M.3
Bouillaud, F.4
Ricquier, D.5
Basdevant, A.6
Guy-Grand, B.7
Froguel, P.8
-
21
-
-
0033999008
-
Association of -3826 G variant in uncoupling protein-1 with increased BMI in overweight Australian women
-
L.K. Heilbronn, K.L. Kind, E. Pancewicz, A.M. Morris, M. Noakes, and P.M. Clifton Association of -3826 G variant in uncoupling protein-1 with increased BMI in overweight Australian women Diabetologia 43 2000 242 244
-
(2000)
Diabetologia
, vol.43
, pp. 242-244
-
-
Heilbronn, L.K.1
Kind, K.L.2
Pancewicz, E.3
Morris, A.M.4
Noakes, M.5
Clifton, P.M.6
-
22
-
-
19444366098
-
Inverse correlation between serum adiponectin concentration and hepatic lipid content in Japanese with type 2 diabetes
-
K. Maeda, K. Ishihara, K. Miyake, Y. Kaji, H. Kawamitsu, M. Fujii, K. Sugimura, and T. Ohara Inverse correlation between serum adiponectin concentration and hepatic lipid content in Japanese with type 2 diabetes Metabolism 54 2005 775 780
-
(2005)
Metabolism
, vol.54
, pp. 775-780
-
-
Maeda, K.1
Ishihara, K.2
Miyake, K.3
Kaji, Y.4
Kawamitsu, H.5
Fujii, M.6
Sugimura, K.7
Ohara, T.8
-
23
-
-
0029130796
-
Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population
-
L. Excoffier, and M. Slatkin Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population Mol. Biol. Evol. 12 1995 921 927
-
(1995)
Mol. Biol. Evol.
, vol.12
, pp. 921-927
-
-
Excoffier, L.1
Slatkin, M.2
-
24
-
-
0021322138
-
Thermogenic mechanisms in brown fat
-
D.G. Nicholls, and R.M. Locke Thermogenic mechanisms in brown fat Physiol. Rev. 64 1984 1 64
-
(1984)
Physiol. Rev.
, vol.64
, pp. 1-64
-
-
Nicholls, D.G.1
Locke, R.M.2
-
25
-
-
0027731309
-
Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
-
B.B. Lowell, V. Susulic, A. Hamann, J.A. Lawitts, J. Himms-hagen, B.B. Boyer, L.P. Kozak, and J.S. Flier Development of obesity in transgenic mice after genetic ablation of brown adipose tissue Nature 366 1993 740 742
-
(1993)
Nature
, vol.366
, pp. 740-742
-
-
Lowell, B.B.1
Susulic, V.2
Hamann, A.3
Lawitts, J.A.4
Himms-Hagen, J.5
Boyer, B.B.6
Kozak, L.P.7
Flier, J.S.8
-
26
-
-
0030717887
-
Uncoupling protein gene: Quantification of expression levels in adipose tissues of obese and non-obese humans
-
H. Oberkofler, G. Dallinger, Y.M. Liu, E. Hell, F. Krempler, and W. Patsch Uncoupling protein gene: quantification of expression levels in adipose tissues of obese and non-obese humans J. Lipid Res. 38 1997 2125 2133
-
(1997)
J. Lipid Res.
, vol.38
, pp. 2125-2133
-
-
Oberkofler, H.1
Dallinger, G.2
Liu, Y.M.3
Hell, E.4
Krempler, F.5
Patsch, W.6
-
27
-
-
3843083938
-
Peroxisome proliferator-activated receptor gamma agonism increases the capacity for sympathetically mediated thermogenesis in lean and ob/ob mice
-
H. Sell, J.P. Berger, P. Samson, G. Castriota, J. Lalonde, Y. Deshaies, and D. Richard Peroxisome proliferator-activated receptor gamma agonism increases the capacity for sympathetically mediated thermogenesis in lean and ob/ob mice Endocrinology 145 2004 3925 3934
-
(2004)
Endocrinology
, vol.145
, pp. 3925-3934
-
-
Sell, H.1
Berger, J.P.2
Samson, P.3
Castriota, G.4
Lalonde, J.5
Deshaies, Y.6
Richard, D.7
-
28
-
-
0034085884
-
A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice
-
Y. Fukui, S. Masui, S. Osada, K. Umesono, and K. Motojima A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice Diabetes 49 2000 759 767
-
(2000)
Diabetes
, vol.49
, pp. 759-767
-
-
Fukui, Y.1
Masui, S.2
Osada, S.3
Umesono, K.4
Motojima, K.5
-
29
-
-
0029887455
-
Expression of uncoupling protein in skeletal muscle and white fat of obese mice treated with thermogenic beta 3-adrenergic agonist
-
I. Nagase, T. Yoshida, K. Kumamoto, T. Umekawa, N. Sakane, H. Nikami, T. Kawada, and M. Saito Expression of uncoupling protein in skeletal muscle and white fat of obese mice treated with thermogenic beta 3-adrenergic agonist J. Clin. Invest. 97 1996 2898 2904
-
(1996)
J. Clin. Invest.
, vol.97
, pp. 2898-2904
-
-
Nagase, I.1
Yoshida, T.2
Kumamoto, K.3
Umekawa, T.4
Sakane, N.5
Nikami, H.6
Kawada, T.7
Saito, M.8
-
30
-
-
0031985802
-
Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes
-
J.E. Digby, C.T. Montague, C.P. Sewter, L. Sanders, W.O. Wilkison, S. O'Rahilly, and J.B. Prins Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes Diabetes 47 1998 138 141
-
(1998)
Diabetes
, vol.47
, pp. 138-141
-
-
Digby, J.E.1
Montague, C.T.2
Sewter, C.P.3
Sanders, L.4
Wilkison, W.O.5
O'Rahilly, S.6
Prins, J.B.7
-
31
-
-
0033787068
-
Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice
-
B. Li, L.A. Nolte, J.S. Ju, D.H. Han, T. Coleman, J.O. Holloszy, and C.F. Semenkovich Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice Nat. Med. 6 2000 115 1120
-
(2000)
Nat. Med.
, vol.6
, pp. 115-1120
-
-
Li, B.1
Nolte, L.A.2
Ju, J.S.3
Han, D.H.4
Coleman, T.5
Holloszy, J.O.6
Semenkovich, C.F.7
-
32
-
-
19944432614
-
Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity
-
Y. Ishigaki, H. Katagiri, T. Yamada, T. Ogihara, J. Imai, K. Uno, Y. Hasegawa, J. Gao, H. Ishihara, T. Shimosegawa, H. Sakoda, T. Asano, and Y. Oka Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity Diabetes 54 2005 322 332
-
(2005)
Diabetes
, vol.54
, pp. 322-332
-
-
Ishigaki, Y.1
Katagiri, H.2
Yamada, T.3
Ogihara, T.4
Imai, J.5
Uno, K.6
Hasegawa, Y.7
Gao, J.8
Ishihara, H.9
Shimosegawa, T.10
Sakoda, H.11
Asano, T.12
Oka, Y.13
-
33
-
-
0033192479
-
Frequency and significance of the a → G (-3826) polymorphism in the promoter of the gene for uncoupling protein-1 with regard to metabolic parameters and adipocyte transcription factor binding in a large population-based Caucasian cohort
-
A. Schaffler, K.D. Palitzsch, E. Watzlawek, W. Drobnik, H. Schwer, J. Scholmerich, and G. Schmitz Frequency and significance of the A → G (-3826) polymorphism in the promoter of the gene for uncoupling protein-1 with regard to metabolic parameters and adipocyte transcription factor binding in a large population-based Caucasian cohort Eur. J. Clin. Invest. 29 1999 770 779
-
(1999)
Eur. J. Clin. Invest.
, vol.29
, pp. 770-779
-
-
Schaffler, A.1
Palitzsch, K.D.2
Watzlawek, E.3
Drobnik, W.4
Schwer, H.5
Scholmerich, J.6
Schmitz, G.7
-
34
-
-
85047697137
-
Genetic factors as predictors of weight gain in young adult Dutch men and women
-
C.T. van Rossum, B. Hoebee, J.C. Seidell, C. Bouchard, M.A. van Baak, C.P. de Groot, M. Chagnon, C. de Graaf, and W.H. Saris Genetic factors as predictors of weight gain in young adult Dutch men and women Int. J. Obes. Relat. Metab. Disord. 26 2002 517 528
-
(2002)
Int. J. Obes. Relat. Metab. Disord.
, vol.26
, pp. 517-528
-
-
Van Rossum, C.T.1
Hoebee, B.2
Seidell, J.C.3
Bouchard, C.4
Van Baak, M.A.5
De Groot, C.P.6
Chagnon, M.7
De Graaf, C.8
Saris, W.H.9
-
35
-
-
0038458975
-
Uncoupling protein 1 and 3 polymorphisms are associated with waist-to-hip ratio
-
S.M. Herrmann, J.G. Wang, J.A. Staessen, E. Kertmen, K. Schmidt-Petersen, W. Zidek, M. Paul, and E. Brand Uncoupling protein 1 and 3 polymorphisms are associated with waist-to-hip ratio J. Mol. Med. 81 2003 327 332
-
(2003)
J. Mol. Med.
, vol.81
, pp. 327-332
-
-
Herrmann, S.M.1
Wang, J.G.2
Staessen, J.A.3
Kertmen, E.4
Schmidt-Petersen, K.5
Zidek, W.6
Paul, M.7
Brand, E.8
|