Maturation of human monocyte-derived dendritic cells (MoDCs) in the presence of prostaglandin E2 optimizes CD4 and CD8 T cell-mediated responses to protein antigens: Role of PGE2 in chemokine and cytokine expression by MoDCs

International Immunology

Volumn 17, Issue 12, 2005, Pages 1561-1572

  Rubio, Marie T ^a   Means, Terry K ^a   Chakraverty, Ronjon ^a   Shaffer, Juanita ^a   Fudaba, Yasuhiro ^a   Chittenden, Meredith ^a   Luster, Andrew D ^a   Sykes, Megan ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Dendritic cells; Human; Prostaglandin E2; T helper 1; T helper 2

Indexed keywords

CD4 ANTIGEN; CD40 LIGAND; CD8 ANTIGEN; CHEMOKINE; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 6; MESSENGER RNA; PROSTAGLANDIN E2; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TUMOR NECROSIS FACTOR;

ADULT; ANTIGEN PRESENTING CELL; ARTICLE; CELL MATURATION; CELL MIGRATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MALE; MIXED LYMPHOCYTE REACTION; MONOCYTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STEADY STATE; T LYMPHOCYTE; TH1 CELL; UPREGULATION;

ANTIGEN PRESENTATION; ANTIGENS; CANCER VACCINES; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELLS, CULTURED; CHEMOKINES; DENDRITIC CELLS; DINOPROSTONE; GENE EXPRESSION REGULATION; HUMANS; MONOCYTES; T-LYMPHOCYTES, REGULATORY; TH1 CELLS;

EID: 28744456881     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxh335     Document Type: Article

References (60)

1. Steinman, R. M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271.
2. Banchereau, J. and Steinman, R. M. 1998. Dendritic cells and the control of immunity. Nature 392:245.
3. Sallusto, F. and Lanzavecchia, A. 2000. Understanding dendritic cell and T-lymphocyte traffic through the analysis of chemokine receptor expression. Immunol. Rev. 177:134.
4. Avigan, D. 1999. Dendritic cells: Development, function and potential use for cancer immunotherapy. Blood Rev. 13:51.
5. Luft, T., Pang, K. C., Thomas, E. et al. 1998. A serum-free culture model for studying the differentiation of human dendritic cells from adult CD34+ progenitor cells. Exp. Hematol. 26:489.
6. Romani, N., Reider, D., Heuer, M. et al. 1996. Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability. J. Immunol. Methods 196:137.
7. Sallusto, F. and Lanzavecchia, A. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 179:1109.
8. Verhasselt, V., Buelens, C., Willems, F., De Groote, D., Haeffner-Cavaillon, N. and Goldman, M. 1997. Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells: Evidence for a soluble CD14-dependent pathway. J. Immunol. 158:2919.
9. Jefford, M., Schnurr, M., Toy, T. et al. 2003. Functional comparison of DCs generated in vivo with Flt3 ligand or in vitro from blood monocytes: differential regulation of function by specific classes of physiologic stimuli. Blood 102:1753.
10. Liu, Y. J., Kanzler, H., Soumelis, V. and Gilliet, M. 2001. Dendritic cell lineage, plasticity and cross-regulation. Nat. Immunol. 2:585.
11. Needleman, P., Turk, J., Jakschik, B. A., Morrison, A. R. and Lefkowith, J. B. 1986. Arachidonic acid metabolism. Annu. Rev. Biochem. 55:69.
12. Harris, S. G., Padilla, J., Koumas, L., Ray, D. and Phipps, R. P. 2002. Prostaglandins as modulators of immunity. Trends Immunol. 23:144.
13. Katamura, K., Shintaku, N., Yamauchi, Y. et al. 1995. Prostaglandin E2 at priming of naive CD4+ T cells inhibits acquisition of ability to produce IFN-gamma and IL-2, but not IL-4 and IL-5. J. Immunol. 155:4604.
14. Jonuleit, H., Kuhn, U., Muller, G. et al. 1997. Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur. J. Immunol. 27:3135.
15. Kalinski, P., Schuitemaker, J. H., Hilkens, C. M. and Kapsenberg, M. L. 1998. Prostaglandin E2 induces the final maturation of IL-12-deficient CD1a+CD83+ dendritic cells: The levels of IL-12 are determined during the final dendritic cell maturation and are resistant to further modulation. J. Immunol. 161:2804.
16. Rieser, C., Bock, G., Klocker, H., Bartsch, G. and Thurnher, M. 1997. Prostaglandin E2 and tumor necrosis factor alpha cooperate to activate human dendritic cells: Synergistic activation of interleukin 12 production. J. Exp. Med. 186:1603.
17. Scandella, E., Men, Y., Gillessen, S., Forster, R. and Groettrup, M. 2002. Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells. Blood 100:1354.
18. Lee, A. W., Truong, T., Bickham, K. et al. 2002. A clinical grade cocktail of cytokines and PGE2 results in uniform maturation of human monocyte-derived dendritic cells: Implications for immunotherapy. Vaccine 20(Suppl. 4):A8.
19. Hilkens, C. M., Kalinski, P., de Boer, M. and Kapsenberg, M. L. 1997. Human dendritic cells require exogenous interleukin-12-inducing factors to direct the development of naive T-helper cells toward the Th1 phenotype. Blood 90:1920.
20. Gately, M. K., Renzetti, L. M., Magram, J. et al. 1998. The interleukin-12/interleukin-12-receptor system: Role in normal and pathologic immune responses. Annu. Rev. Immunol. 16:495.
21. Gately, M. K., Carvajal, D. M., Connaughton, S. E. et al. 1996. Interleukin-12 antagonist activity of mouse interleukin-12 p40 homodimer in vitro and in vivo. Ann. NY Acad. Sci. 795:1.
22. Gillessen, S., Carvajal, D., Ling, P. et al. 1995. Mouse interleukin-12 (IL-12) p40 homodimer: A potent IL-12 antagonist. Eur. J. Immunol. 25:200.
23. Strassmann, G., Patil-Koota, V., Finkelman, F., Fong, M. and Kambayashi, T. 1994. Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2. J. Exp. Med. 180:2365.
24. van der Pouw Kraan, T. C., Boeije, L. C., Smeenk, R. J., Wijdenes, J. and Aarden, L. A. 1995. Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production. J. Exp. Med. 181:775.
25. Lee, J. J., Takei, M., Hori, S. et al. 2002. The role of PGE(2) in the differentiation of dendritic cells: How do dendritic cells influence T-cell polarization and chemokine receptor expression? Stem Cells 20:448.
26. Luft, T., Jefford, M., Luetjens, P. et al. 2002. Functionally distinct dendritic cell (DC) populations induced by physiologic stimuli: prostaglandin E(2) regulates the migratory capacity of specific DC subsets. Blood 100:1362.
27. Rieser, C., Papesh, C., Herold, M. et al. 1998. Differential deactivation of human dendritic cells by endotoxin desensitization: Role of tumor necrosis factor-alpha and prostaglandin E2. Blood 91:3112.
28. Dieu, M. C., Vanbervliet, B., Vicari, A. et al. 1998. Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites. J. Exp. Med. 188:373.
29. Sallusto, F., Palermo, B., Lenig, D. et al. 1999. Distinct patterns and kinetics of chemokine production regulate dendritic cell function. Eur. J. Immunol. 29:1617.
30. Adorini, L., Penna, G., Giarratana, N. and Uskokovic, M. 2003. Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting allograft rejection and autoimmune diseases. J. Cell Biochem. 88:227.
31. Jonuleit, H., Adema, G. and Schmitt, E. 2003. Immune regulation by regulatory T cells: Implications for transplantation. Transpl. Immunol. 11:267.
32. Kuwana, M. 2002. Induction of anergic and regulatory T cells by plasmacytoid dendritic cells and other dendritic cell subsets. Hum. Immunol. 63:1156.
33. Mahnke, K., Qian, Y., Knop, J. and Enk, A. H. 2003. Induction of CD4+/ CD25+ regulatory T cells by targeting of antigens to immature dendritic cells. Blood 101:4862.
34. Manavalan, J. S., Rossi, P. C., Vlad, G. et al. 2003. High expression of ILT3 and ILT4 is a general feature of tolerogenic dendritic cells. Transpl. Immunol. 11:245.
35. Pasare, C. and Medzhitov, R. 2003. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 299:1033.
36. Hayashi, F., Means, T. K. and Luster, A. D. 2003. Toll-like receptors stimulate human neutrophil function. Blood 102:2660.
37. Lyons, A. B. 2000. Analysing cell division in vivo and in vitro using flow cytometric measurement of USE dye dilution. J. Immunol. Methods 243:147.
38. Jefford, M., Maraskovsky, E., Cebon, J. and Davis, I. D. 2001. The use of dendritic cells in cancer therapy. Lancet Oncol. 2:343.
39. Steinman, R. M. and Dhodapkar, M. 2001. Active immunization against cancer with dendritic cells: The near future. Int. J. Cancer 94:459.
40. Jonuleit, H., Giesecke-Tuettenberg, A., Tuting, T. et al. 2001. A comparison of two types of dendritic cell as adjuvants for the induction of melanoma-specific T-cell responses in humans following intranodal injection. Int. J. Cancer 93:243.
41. Mosmann, T. R. and Sad, S. 1996. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 17:138.
42. Rissoan, M. C., Soumelis, V., Kadowaki, N. et al. 1999. Reciprocal control of T helper cell and dendritic cell differentiation. Science 283:1183.
43. Soumelis, V., Reche, P. A., Kanzler, H. et al. 2002. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat. Immunol. 3:673.
44. Vieira, P. L., de Jong, E. C., Wierenga, E. A., Kapsenberg, M. L. and Kalinski, P. 2000. Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction. J. Immunol. 164:4507.
45. Tanaka, H., Demeure, C. E., Rubio, M., Delespesse, G. and Sarfati, M. 2000. Human monocyte-derived dendritic cells induce naive T cell differentiation into T helper cell type 2 (Th2) or Th1/Th2 effectors. Role of stimulator/responder ratio. J. Exp. Med. 192:405.
46. Jonuleit, H., Schmitt, E., Schuler, G., Knop, J. and Enk, A. H. 2000. Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J. Exp. Med. 192:1213.
47. Kalinski, P., Hilkens, C. M., Snijders, A., Snijdewint, F. G. and Kapsenberg, M. L. 1997. IL-12-deficient dendritic cells, generated in the presence of prostaglandin E2, promote type 2 cytokine production in maturing human naive T helper cells. J. Immunol. 159:28.
48. Kalinski, P., Schuitemaker, J. H., Hilkens, C. M., Wierenga, E. A. and Kapsenberg, M. L. 1999. Final maturation of dendritic cells is associated with impaired responsiveness to IFN-gamma and to bacterial IL-12 inducers: Decreased ability of mature dendritic cells to produce IL-12 during the interaction with Th cells. J. Immunol. 162:3231.
49. Means, T. K., Hayashi, F., Smith, K. D., Aderem, A. and Luster, A. D. 2003. The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells. J. Immunol. 170:5165.
50. Rossi, D. and Zlotnik, A. 2000. The biology of chemokines and their receptors. Annu. Rev. Immunol. 18:217.
51. Vestergaard, C., Bang, K., Gesser, B., Yoneyama, H., Matsushima, K. and Larsen, C. G. 2000. A Th2 chemokine, TARC, produced by keratinocytes may recruit CLA+CCR4+ lymphocytes into lesional atopic dermatitis skin. J. Investig. Dermatol. 115:640.
52. Caux, C., Massacrier, C., Vanbervliet, B., Barthelemy, C., Liu, Y. J. and Banchereau, J. 1994. Interleukin 10 inhibits T cell alloreaction induced by human dendritic cells. Int. Immunol. 6:1177.
53. Corinti, S., Albanesi, C., la Sala, A., Pastore, S. and Girolomoni, G. 2001. Regulatory activity of autocrine IL-10 on dendritic cell functions. J. Immunol. 166:4312.
54. Cella, M., Scheidegger, D., Palmer-Lehmann, K., Lane, P., Lanzavecchia, A. and Alber, G. 1996. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184:747.
55. Snijders, A., Kalinski, P., Hilkens, C. M. and Kapsenberg, M. L. 1998. High-level IL-12 production by human dendritic cells requires two signals. Int. Immunol. 10:1593.
56. Kalinski, P., Vieira, P. L., Schuitemaker, J. H., de Jong, E. C. and Kapsenberg, M. L. 2001. Prostaglandin E(2) is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer. Blood 97:3466.
57. Mailliard, R. B., Egawa, S., Cai, Q. et al. 2002. Complementary dendritic cell-activating function of CD8+ and CD4+ T cells: Helper role of CD8+ T cells in the development of T helper type 1 responses. J. Exp. Med. 195:473.
58. Oppmann, B., Lesley, R., Blom, B. et al. 2000. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 13:715.
59. Schnurr, M., Toy, T., Shin, A., Wagner, M., Cebon, J. and Maraskovsky, E. 2005. Extracellular nucleotide signaling by P2 receptors inhibits IL-12 and enhances IL-23 expression in human dendritic cells: A novel role for the cAMP pathway. Blood 105:1582.
60. Lutz, M. B. and Schuler, G. 2002. Immature, semi-mature and fully mature dendritic cells: Which signals induce tolerance or immunity? Trends Immunol. 23:445.