Effect of diabetes on the mechanisms of intrathecal antinociception of sildenafil in rats

European Journal of Pharmacology

Volumn 527, Issue 1-3, 2005, Pages 60-70

  Araiza Saldaña, Claudia Ivonne ^a   Reyes García, Gerardo ^b   Bermúdez Ocaña, Deysi Yadira ^a   Pérez Severiano, Francisca ^c   Granados Soto, Vinicio ^a  

^a DEPARTAMENTO DE FÍSICA   (Mexico)

^b INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

^c NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY   (Mexico)

Author keywords

Cyclic GMP; K+ channel; Protein kinase G; Sildenafil; Spinal processing

Indexed keywords

APAMIN; CHARYBDOTOXIN; CYCLIC GMP DEPENDENT PROTEIN KINASE INHIBITOR; FORMALDEHYDE; GLIBENCLAMIDE; KT 5823; N(G) NITRO DEXTRO ARGININE METHYL ESTER; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR; PHOSPHODIESTERASE INHIBITOR; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; QUINOXALINE DERIVATIVE; SILDENAFIL; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DOSE RESPONSE; DRUG MECHANISM; FEMALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANALGESIA; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; CARBAZOLES; CYCLIC GMP-DEPENDENT PROTEIN KINASES; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; FORMALDEHYDE; GUANYLATE CYCLASE; INDOLES; INJECTIONS, SPINAL; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; OXADIAZOLES; PAIN; PAIN MEASUREMENT; PHOSPHODIESTERASE INHIBITORS; PIPERAZINES; POTASSIUM CHANNEL BLOCKERS; QUINOXALINES; RATS; RATS, WISTAR; STREPTOZOCIN; TIME FACTORS;

EID: 28544437499     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2005.10.016     Document Type: Article

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