Epidermal growth factor receptor and its inhibition in radiotherapy: In vivo findings

International Journal of Radiation Biology

Volumn 79, Issue 7, 2003, Pages 539-545

  Milas, L ^a   Mason, K A ^b   Ang, K K ^b  

^a UNIVERSITY OF TEXAS   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR ANTIBODY; ERLOTINIB; GEFITINIB; MONOCLONAL ANTIBODY;

CANCER RADIOTHERAPY; CARCINOMA; CONFERENCE PAPER; CORRELATION ANALYSIS; CYTOTOXICITY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; GENE TRANSFER; HEAD AND NECK CARCINOMA; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RADIATION DOSE; RADIATION RESPONSE; RADIOSENSITIVITY; SIGNAL TRANSDUCTION; TISSUE REGENERATION; TUMOR CELL; TUMOR XENOGRAFT;

ANIMALS; HUMANS; NEOPLASMS; PROLIFERATING CELL NUCLEAR ANTIGEN; RADIATION TOLERANCE; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION;

MURINAE;

EID: 0142216254     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/0955300031000114747     Document Type: Conference Paper

References (36)

1. AKIMOTO, T., HUNTER, N. R., BUCHMILLER, L., MASON, K., ANG, K. K. and MILAS, L., 1999, Inverse relationship between epidermal growth factor receptor expression and radiocurability of murine carcinomas. Clinical Cancer Research, 5, 2884-2890.
2. ANG, K. K., BERKEY, B. A., TU, X., ZHANG, H. Z., KATZ, R., HAMMOND, E. H., FU, K. K. and MILAS, L., 2002, Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma. Cancer Research, 62, 7350-7356.
3. BALABAN, N., MONI, J., SHANNON, M., DANG, L., MURPHY, K. E. and GOLDKORN, T., 1996, The effect of ionizing radiation on signal transduction: antibodies to EGF receptor sensitize A431 cells to radiation. Biochimica et Biophysica Acta, 1314, 147-156.
4. BANDYOPADHYAY, D., MANDAL, M., ADAM, L., MENDELSOHN, J. and KUMAR, R., 1998, Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells. Journal of Biological Chemistry, 273, 1568-1573.
5. BIANCO, C., BIANCO, R., TORTORA, G., DAMIANO, V., GUERRIERI, P., MONTEMAGGI, P., MENDELSOHN, J., DE PLACIDO, S., BIANCO, A. R. and CIARDIELLO, F., 2000, Antitumor activity of combined treatment of human cancer cells with ionizing radiation and anti-epidermal growth factor receptor monoclonal antibody C225 plus type I protein kinase A antisense oligonucleotide. Clinical Cancer Research, 6, 4343-4350.
6. DICKSTEIN, B. N., WOSIKOWSKI, K. and BATES, S., 1995, Increased resistance to cytotoxic agents in ZR75B human breast cancer cells transfected with epidermal growth factor receptor. Molecular and Cellular Endocrinology, 110, 205-211.
7. GILLE, J., SWERLICK, R. A. and CAUGHMAN, S. W., 1997, Transforming growth factor-alpha-induced transcriptional activation of the vascular permeability factor (VPF/ VEGF) gene requires AP-2 dependent DNA binding and transactivation. EMBO Journal, 16, 750-759.
8. GOLDKORN, T., BALABAN, N., SHANNON, M. and MATSUKUMA, K., 1997, EGF receptor phosphorylation is affected by ionizing radiation. Cancer Research, 59, 3374-3378.
9. GORSKI, D. H., BECKETT, M. A., JASKOWIAK, N. T., CALVIN, D. P., MAUCERI, H. J., SALLOUM, R. M., SEETHARAM, S., KOONS, A., HARI, D. M., KUFE, D. W. and WEISCHSELBAUM, R. R., 1999, Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation. Cancer Research, 59, 3374-3378.
10. GORSKI, D. H., MAUCERI, H. J., SALLOUM, R. M., GATELY, S., HELLMAN, S., BECKETT, M. A., SUKHATME, V. P., SOFF, G. A., KUFE, D. W. and WEICHSELBAUM, R. R., 1998, Potentiation of the antitumor effect of ionizing radiation by brief concomitant exposures to angiostatin. Cancer Research, 58, 5686-5689.
11. HUANG, S.-M., BOCK, J. M. and HARARI, P. M., 1999, Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Research, 59, 1935-1940.
12. HUANG, S. M. and HARARI, P. M., 2000, Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics, and tumor angiogenesis. Clinical Cancer Research, 6, 2166-2174.
13. KATAYOSE, Y., KIM, M., RAKKAR, A. N. S., LI, Z. W., COWAN, K. H. and SETH, P., 1997, Promoting apoptosis: a novel activity associated with the cycle-dependent kinase inhibitor p27. Cancer Research, 57, 5441-5445.
14. KELMAN, Z., 1997, PCNA: structure, functions and interactions. Oncogene, 4, 629-640.
15. LIANG, K., ANG, K. K., MILAS, L., HUNTER, N. and FAN, Z., in press, Increased radioresistance of OCA-I mouse ovarian carcinoma cells expressing human epidermal growth factor receptor. International Journal of Radiation, Oncology, Biology and Physics.
16. MAUCERI, H. J., HANNA, N. N., BECKETT, M. A., GORSKI, D. H., STABA, M. J., STELLATO, K. A., BIGELOW, K., HEIMANN, R., GATELY, S., DHANABAL, M., SOFF, G. A., SUKHATME, V. P., KUFE, D. W. and WEICHSELBAUM, R. R., 1998, Combined effects of angiostatin and ionizing radiation in antitumor therapy. Nature, 394, 287-291.
17. MENDELSOHN, J., 2000, Blockade of receptors for growth factors: an anticancer therapy. The Fourth Annual Joseph H. Burchenal American Association for Cancer Research Clinical Research Award Lecture. Clinical Cancer Research, 6, 747-753.
18. MENDELSOHN, J. and FAN, Z., 1997, Epidermal growth factor receptor family and chemosensitization. Journal of National Cancer Institute, 89, 341-343.
19. MILAS, L., AKIMOTO, T., HUNTER, N. R., GUTTENBERGER, R. and THAMES, H. D., 2002, Relationship between cyclin D1 expression and poor radioresponse of murine carcinomas. International Journal of Radiation, Oncology, Biology, and Physics, 52, 514-421.
20. MILAS, L., FAN, Z., MASON, K. A. and ANG, K. K., 2003, Role of epidermal growth factor receptor (EGFR) and its inhibition in radiotherapy. In C. Nieder, L. Milas and K. K. Ang (eds), Modification of Radiation Response (Heidelberg: Springer), pp. 189-204.
21. MILAS, L., MASON, K., HUNTER, N., PETERSEN, S., YAMAKAW, M., ANG, K. K., MENDELSOHN, J. and FAN, Z., 2000, In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody. Clinical Cancer Research, 6, 701-708.
22. MILAS, L., YAMADA, S., HUNTER, N., YAMADA, S., HUNTER, N., GUTTENBERGER, R. and THAMES, H. D., 1991, Changes in TCD50 as a measure of clonogen doubling time in irradiated and unirradiated tumors. International Journal of Radiation, Oncology, Biology, and Physics, 21, 1195-1202.
23. NASU, S., ANG, K. K., FAN, Z. and MILAS, L., 2001, C225 antiepidermal growth factor receptor antibody enhances tumor radiocurability. International Radiation, Oncology, Biology, and Physics, 51, 474-477.
24. PEROTTE, P., MATSUMOTO, T., INOUE, K., KUNIYASU, H., EVE, B. Y., HICKLIN, D. J., RADINSKY, R. and DINNEY, C. P., 1999, Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. Clinical Cancer Research, 5, 257-265.
25. RUIFROK, A. and MCBRIDE, W., 1999, Growth factors: biological and clinical aspects. International Journal of Radiation, Oncology, Biology and Physics, 43, 877-881.
26. SCHMIDT-ULLRICH, R. K., DENT, P., GRANT, S., MIKKELSEN, R. B. and VALERIE, K., 2000, Signal transduction and cellular radiation responses. Radiation Research, 153, 245-257.
27. SCHMIDT-ULLRICH, R. K., MIKKELSEN, R. B., DENT, P., TODD, D. G., VALERIE, K., KAVANAGH, B. D., CONTESSA, J. N., RORRER, W. K. and CHEN, R. B., 1997, Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation. Oncogene, 15, 1191-1197.
28. SCHMIDT-ULLRICH, R. K., VALERIE, K., FOGLEMAN, P. B. and WALTERS, J., 1996, Radiation-induced autophosphorylation of epidermal growth factor receptor in human malignant mammary and squamous epithelial cells. Radiation Research, 145, 81-85.
29. KIP1 in inducting cell cycle arrest, apoptosis and inhibition of tumorigenicity. Oncogene, 18, 1663-1676.
30. SCHRIEBER, A. B., WINKLER, M. E. and DERYNCK, R., 1986, Transforming growth factor-α: a more potent angiogenic mediator than epidermal growth factor. Science (Washington, DC), 223, 1250-1253.
31. TEICHER, B. A., HOLDEN, S. A., DUPUIS, N. P., KAKEJI, Y., IKEBE, M., EMI, Y. and GOFF, D., 1995, Potentiation of cytotoxic therapies by TNP-470 and minocycline in mice bearing EMT-6 mammary carcinoma. Breast Cancer Research Treatment, 36, 227-236.
32. THAMES, H., JR., RUIFROK, A. C. C., MILAS, L., HUNTER, N., MASON, K. A., TERRY, N. H. A. and WHITE, R. A., 1996, Accelerated repopulation during fractionated irradiation of a murine ovarian carcinoma: downregulation of apoptosis as a possible mechanism. International Journal of Radiation Oncology, Biology, and Physics, 35, 951-962.
33. ULLRICH, A. and SCHLESSINGER, J., 1990, Signal transduction by receptors with tyrosine kinase activity. Cell, 61, 203-212.
34. Kip1 overexpression causes apoptotic death of mammalian cells. Oncogene, 15, 2991-2997.
35. WOLLMAN, R., YAHALOM, J., MAXY, R., PINTO, J. and FUKS, Z., 1994, Effect of epidermal growth factor on the growth and radiation sensitivity of human breast cancer cells in vitro. International Journal of Radiation, Oncology, Biology and Physics, 30, 91-98.
36. WOODBURN, J. R., 1999, The epidermal growth factor receptor and its inhibition in cancer treatment. Pharmacology Tlierapeutics, 82, 241-250.