Increased erythropoiesis in polycythemia vera is associated with increased erythroid progenitor proliferation and increased phosphorylation of Akt/PKB

Experimental Hematology

Volumn 33, Issue 2, 2005, Pages 152-158

  Dai, Chunhua ^a   Chung, Ik Joo ^a   Krantz, Sanford B ^a,b,c,d  

^a Hematology/Oncology Division   (United States)

^b VANDERBILT INGRAM CANCER CENTER   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d VANDERBILT UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; ERYTHROPOIETIN; GLYCOGEN SYNTHASE KINASE 3; KI 67 ANTIGEN; PROTEIN KINASE B; STEM CELL FACTOR;

ADULT; APOPTOSIS; ARTICLE; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ASSAY; ENZYME PHOSPHORYLATION; ERYTHROID PRECURSOR CELL; ERYTHROPOIESIS; FEMALE; HUMAN; HUMAN CELL; INCUBATION TIME; MALE; MOLECULAR DYNAMICS; NICK END LABELING; PATHOGENESIS; POLYCYTHEMIA VERA; PRIORITY JOURNAL; WESTERN BLOTTING;

ADULT; ANTIGENS, CD34; APOPTOSIS; CELL CYCLE; CELL DIVISION; COLONY-FORMING UNITS ASSAY; ERYTHROPOIESIS; FEMALE; GLYCOGEN SYNTHASE KINASE 3; HEMATOPOIETIC STEM CELLS; HUMANS; KI-67 ANTIGEN; MALE; MIDDLE AGED; PHOSPHORYLATION; POLYCYTHEMIA VERA; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; REFERENCE VALUES;

EID: 12844271547     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exphem.2004.10.017     Document Type: Article

References (51)

1. A.R. Green Pathogenesis of polycythemia vera Lancet 347 1996 844 845
2. J.W. Adamson, J.W. Singer, and P. Catalano Polycythemia vera; Further in vitro studies of hematopoietic regulation J Clin Invest 66 1980 1363 1368
3. S. Hinshelwood, A.J. Bench, and A.R. Green Pathogenesis of polycythemia vera Blood Rev 11 1997 224 232
4. J.F. Prchal, and A.A. Axelrad Bone marrow responses in polycythemia vera N Engl J Med 290 1974 1382
5. M.J. Fisher, J.F. Prchal, J.T. Prchal, and A.D. D'Andrea Anti-erythropoietin (EPO) receptor monoclonal antibodies distinguish EPO-dependent and EPO-independent erythroid progenitors in polycythemia vera Blood 84 1994 1982 1991
6. C.J. Eaves, and A.C. Eaves Erythropoietin dose-response curves for three classes of erythroid progenitors in normal human marrow and in patients with polycythemia vera Blood 52 1978 1196 1210
7. P.N. Correa, D. Eskinazi, and A.A. Axelrad Circulating erythroid progenitors in polycythemia vera are hypersensitive to insulin-like growth factor-1 in vitro: studies in an improved serum-free medium Blood 83 1994 99 112
8. E.D. Zanjani, J.D. Lutton, R. Hoffman, and L.R. Wasserman Erythroid colony formation by polycythemia vera bone marrow in vitro J Clin Invest 59 1977 841 848
9. N. Casedevall, W. Vainchenker, and C. Lacombe Erythroid progenitors in polycythemia vera: Demonstration of their hypersensitivity to erythropoietin using serum-free cultures Blood 59 1982 447 451
10. C.H. Dai, S.B. Krantz, R.T. Means, W.T. Horn, and H.S. Gilbert Polycythemia vera blood burst-forming units-erythroid are hypersensitive to interleukin-3 J Clin Invest 87 1991 391 396
11. C.H. Dai, S.B. Krantz, E.N. Dessypris, R.T. Means Jr., S.T. Horn, and H.S. Gilbert Polycythemia vera: II. Hypersensitivity of bone marrow erythroid, granulocyte-macrophage, and megakaryocyte progenitor cells to interleukin-3 and granulocyte-macrophage colony-stimulating factor Blood 80 1992 891 899
12. C.H. Dai, S.B. Krantz, W.F. Green, and H.S. Gilbert Polycythemia vera. III. Burst-forming units-erythroid (BFU-E) response to stem cell factor and c-kit receptor expression Br J Haematol 86 1994 12 21
13. A.M. Mirza, P.N. Correa, and A.A. Axelrad Increased basal and induced tyrosine phosphorylation of the insulin-like growth factor I receptor β subunit in circulating mononuclear cells of patients with polycythemia vera Blood 86 1995 877 882
14. R.T. Means Jr., S.B. Krantz, S.T. Sawyer, and H.S. Gilbert Erythropoietin receptors in polycythemia vera J Clin Invest 84 1989 1340 1344
15. A.M. Mirza, S. Ezzat, and A.A. Axelrad Insulin-like growth factor binding protein-1 is elevated in patients with polycythemia vera and stimulates erythroid burst formation in vitro Blood 89 1997 1862 1869
16. C.-H. Dai, S.B. Krantz, S.T. Koury, and K. Kollar Polycythemia vera IV. Specific binding of stem cell factor to normal and polycythemia vera highly purified erythroid progenitor cells Br J Haematol 88 1994 497 505
17. M. Silva, C. Richard, A. Benito, C. Sanz, I. Olalla, and J. Fernandez-Luna Expression of bcl-x in erythroid precursors from patients with polycythemia vera N Engl J Med 338 1998 564 571
18. A.R. Moliterno, and J.L. Spivak Posttranslational processing of the thrombopoietin receptor is impaired in polycythemia vera Blood 94 1999 2555 2561
19. S. Temerinac, S. Klippel, and E. Strunck Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera Blood 95 2000 2569 2576
20. C.H. Dai, S.B. Krantz, and S.T. Saywer Polycythemia vera V. Enhanced proliferation and phosphorylation due to vanadate are diminished in polycythemia vera erythroid progenitor cells: a possible defect of phosphatase activity in polycythemia vera Blood 89 1997 3574 3581
21. X. Sui, S.B. Krantz, and Z. Zhao Identification of increased protein tyrosine phosphatase activity in polycythemia vera erythroid progenitor cells Blood 90 1997 651 657
22. M. Xu, X. Sui, R. Zhao, C.H. Dai, S.B. Krantz, and Z.Z. Zhao PTP-MEG2 is activated in polycythemia vera erythroid progenitor cells and is required for growth and expansion of erythroid cells Blood 102 2003 4354 4360
23. F.A. Asimakopoulos, S. Hinshelwood, and J.G.R. Gilbert The gene encoding hematopoietic cell phosphatase (SHP-1) is structurally and transcriptionally intact in polycythemia vera Oncogene 14 1997 1215 1222
24. C.H. Dai, and S.B. Krantz Increased expression of the INK4a/ARF locus in polycythemia vera Blood 97 2001 3424 3432
25. J.L. Spivak Polycythemia vera: myths, mechanisms, and management Blood 100 2002 4272 4290
26. K. Sawada, S.B. Krantz, and J.S. Kans Purification of human erythroid colony-forming units and demonstration of specific binding of erythropoietin J Clin Invest 80 1987 357 366
27. J.J. Michiels, and E. Juvonen Proposal for revised diagnostic criteria of essential thrombocythemia and polycythemia vera by the Thrombocythemia Vera Study Group Semin Thromb Hemost 23 1997 339 347
28. J.J. Michiels, T. Barbui, and G. Finnazi Diagnosis and treatment of polycythemia vera and possible future study designs of the PVSG Leuk Lymphoma 36 2000 239 258
29. C.H. Dai, J.O. Price, T. Brunner, and S.B. Krantz Fas Ligand is present in human erythroid colony-forming cells and interacts with Fas induced by interferon γ to produce erythroid cell apoptosis Blood 91 1998 1235 1242
30. U. Dissanayake, N.W. Johnson, and K.A.A.S. Warnakulasuriya Comparison of cell proliferation in the center and advancing fronts of oral squamous cell carcinomas using Ki-67 index Cell Prolif 36 2003 255 264
31. G.D. Vita, M.T. Berlingieri, and R. Visconti Akt/protein kinase B promotes survival and hormone-independent proliferation of thyroid cells in the absence of dedifferentiating and transforming effects Cancer Res 60 2000 3916 3920
32. + progenitor cells from polycythemia vera patients: Evidence for delayed determination Int J Oncol 23 2003 437 443
33. V. Ugo, C. Marzac, and I. Teyssandier Multiple signaling pathways are involved in erythropoietin-independent differentiation of erythroid progenitors in polycythemia vera Exp Hematol 32 2004 179 187
34. D.P. Brazil, and B.A. Hemmings Ten years of protein kinase B signaling: a hard Akt to follow Trends Biochem Sci 26 2001 657 664
35. T.F. Franke, C.P. Hornik, and L. Segev PI3K/Akt and apoptosis: size matters Oncogene 22 2003 8983 8998
36. W.S. EI-Deiry Akt takes center stage in cell-cycle deregulation Nat Cell Biol 3 2001 E1 E3
37. P. Sen, S. Mukherjee, and D. Ray Involvement of the Akt/PKB signaling pathway with disease processes Mol Cell Biochem 253 2003 241 246
38. B. Li, S.A. Desai, and R.A. MacCorke-Chosnek A novel conditional Akt 'survival switch' reversibly protects cells from apoptosis Gene Ther 9 2002 233 244
39. J.R. Testa, and A. Bellacosa Akt plays a central role in tumorigenesis Proc Natl Acad Sci U S A 25 2001 10983 10985
40. C. Segrelles, S. Ruiz, and P. Perez Functional roles of Akt signaling in mouse skin tumorigenesis Oncogene 21 2002 53 64
41. J. Hsu, Y. Shi, L. Hu, M. Fisher, T.F. Franke, and A. Lichtenstein Role of the AKT kinase in expression of multiple myeloma clones: effects on cytokine-dependent proliferative and survival responses Oncogene 21 2002 1391 1400
42. H. Eldar-Finkelman Glycogen synthase kinase 3: an emerging therapeutic target Trends Mol Med 8 2002 126 132
43. R.S. Jope, and G.V.W. Johnson The glamour and gloom of glycogen synthase kinase-3 Trends Biochem Sci 29 2004 95 102
44. S.E. Hardt, and J. Sadoshima Glycogen synthase kinase-3β. A novel regulator of cardiac hypertrophy and development Circ Res 90 2002 1055 1063
45. E. Smith, G.A. Coetzee, and B. Frenkel Glucocorticoids inhibit cell cycle progression in differentiating osteoblasts via glycogen synthase kinase-3β J Biol Chem 277 2002 18191 18197
46. W. Elyaman, F. Terro, N.S. Wong, and J. Hugon In vivo activation and nuclear translocation of phosphorylated glycogen synthase kinase-3β in neuronal apoptosis: links to tau phosphorylation Eur J Neurosci 15 2002 651 660
47. K.-W. Park, H.-M. Yang, and S.-W. Youn Constitutively active glycogen synthase kinase-3β gene transfer sustains apoptosis, inhibits proliferation of vascular smooth muscle cells, and reduces neointima formation after balloon injury in rats Arterioscler Thromb Vasc Biol 23 2003 1364 1369
48. A. Toker, and A.C. Newton Cellular signaling: pivoting around PDK-1 Cell 103 2000 185 188
49. M.A. Lawlor, A. Mora, and P.R. Ashby Essential role of PDK1 in regulating cell size and development in mice EMBO J 21 2002 3728 3738
50. N.R. Leslie, and C.P. Downes PTEN: The down side of PI 3-kinase signaling Cell Signal 14 2002 285 295
51. C. Eng PTEN: One gene, many syndromes Hum Mutat 22 2003 183 198