메뉴 건너뛰기




Volumn 101, Issue 8, 2003, Pages 3294-3301

Discrimination of polycythemias and thrombocytoses by novel, simple, accurate clonality assays and comparison with PRV-1 expression and BFU-E response to erythropoietin

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ERYTHROPOIETIN; MESSENGER RNA; PROTEIN TYROSINE KINASE; AGAMMAGLOBULINAEMIA TYROSINE KINASE; ALLOANTIGEN; CD177 PROTEIN, HUMAN; CELL SURFACE RECEPTOR; HOMEODOMAIN PROTEIN; MEMBRANE PROTEIN;

EID: 0038281343     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-07-2287     Document Type: Article
Times cited : (134)

References (55)
  • 4
    • 0019818299 scopus 로고
    • Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell
    • Fialkow PJ, Faguet GB, Jacobson RJ, Vaidya K, Murphy S. Evidence that essential thrombocythemia is a clonal disorder with origin in a multipotent stem cell. Blood. 1981;58:916-919.
    • (1981) Blood , vol.58 , pp. 916-919
    • Fialkow, P.J.1    Faguet, G.B.2    Jacobson, R.J.3    Vaidya, K.4    Murphy, S.5
  • 5
    • 0026091590 scopus 로고
    • Clonal granulocytes and bone marrow cells in the cellular phase of agnogenic myeloid metaplasia
    • Kreipe H, Jaquet K, Feigner J, Radzun HJ, Parwaresch MR. Clonal granulocytes and bone marrow cells in the cellular phase of agnogenic myeloid metaplasia. Blood. 1991;78:1814-1817.
    • (1991) Blood , vol.78 , pp. 1814-1817
    • Kreipe, H.1    Jaquet, K.2    Feigner, J.3    Radzun, H.J.4    Parwaresch, M.R.5
  • 6
    • 7144223296 scopus 로고
    • Gene action in the X chromosome of the mouse
    • Lyon MF. Gene action in the X chromosome of the mouse. Nature. 1961;190:372-373.
    • (1961) Nature , vol.190 , pp. 372-373
    • Lyon, M.F.1
  • 7
    • 0002826398 scopus 로고
    • The normal human female as a mosaic of X-chromosome activity: Studies using the gene for G6PD deficiency as a marker
    • Beutler E, Yeh M, Fairbanks VF. The normal human female as a mosaic of X-chromosome activity: studies using the gene for G6PD deficiency as a marker. Proc Natl Acad Sci U S A. 1962;48:9-16.
    • (1962) Proc Natl Acad Sci U S A , vol.48 , pp. 9-16
    • Beutler, E.1    Yeh, M.2    Fairbanks, V.F.3
  • 8
    • 0014208048 scopus 로고
    • Value of genetic variants of glucose-6-phosphate dehydrogenase in tracing the origin of malignant tumors
    • Beutler E, Collins Z, Irwin LE. Value of genetic variants of glucose-6-phosphate dehydrogenase in tracing the origin of malignant tumors. N Engl J Med. 1967;276:389-391.
    • (1967) N Engl J Med , vol.276 , pp. 389-391
    • Beutler, E.1    Collins, Z.2    Irwin, L.E.3
  • 9
    • 0022820116 scopus 로고
    • Active X chromosome DNA is unmethylated at eight CCGG sites clustered in a guanine-plus-cytosine-rich island at the 5′ end of the gene for phosphoglycerate kinase
    • Keith DH, Singer-Sam J, Riggs AD. Active X chromosome DNA is unmethylated at eight CCGG sites clustered in a guanine-plus-cytosine-rich island at the 5′ end of the gene for phosphoglycerate kinase. Mol Cell Biol. 1986;6:4122-4125.
    • (1986) Mol Cell Biol , vol.6 , pp. 4122-4125
    • Keith, D.H.1    Singer-Sam, J.2    Riggs, A.D.3
  • 10
    • 0021992165 scopus 로고
    • Use of restriction fragment length polymorphisms to determine the clonal origin of human tumors
    • Vogelstein B, Fearon ER, Hamilton SR, Feinberg AP. Use of restriction fragment length polymorphisms to determine the clonal origin of human tumors. Science. 1985;227:642-645.
    • (1985) Science , vol.227 , pp. 642-645
    • Vogelstein, B.1    Fearon, E.R.2    Hamilton, S.R.3    Feinberg, A.P.4
  • 11
    • 0023626415 scopus 로고
    • Clonal analysis using recombinant DNA probes from the X-chromosome
    • Vogelstein B, Fearon ER, Hamilton SR, et al. Clonal analysis using recombinant DNA probes from the X-chromosome. Cancer Res. 1987;47:4806-4813.
    • (1987) Cancer Res , vol.47 , pp. 4806-4813
    • Vogelstein, B.1    Fearon, E.R.2    Hamilton, S.R.3
  • 12
    • 0025324635 scopus 로고
    • Methylation patterns at the hypervariable X-chromosome locus DXS255 (M27 beta): Correlation with X-inactivation status
    • Boyd Y, Fraser NJ. Methylation patterns at the hypervariable X-chromosome locus DXS255 (M27 beta): correlation with X-inactivation status. Genomics. 1990;7:182-187.
    • (1990) Genomics , vol.7 , pp. 182-187
    • Boyd, Y.1    Fraser, N.J.2
  • 13
    • 0026678490 scopus 로고
    • Methylation of Hpall and Hhal sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation
    • Allen RC, Zoghbi HY, Moseley AB, Rosenblatt HM, Belmont JW. Methylation of Hpall and Hhal sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation. Am J Hum Genet. 1992;51:1229-1239.
    • (1992) Am J Hum Genet , vol.51 , pp. 1229-1239
    • Allen, R.C.1    Zoghbi, H.Y.2    Moseley, A.B.3    Rosenblatt, H.M.4    Belmont, J.W.5
  • 14
    • 0027958082 scopus 로고
    • Clonality and X-inactivation patterns in hematopoietic cell populations detected by the highly informative M27 beta DNA probe
    • Fey MF, Liechti-Gallati S, von Rohr A, et al. Clonality and X-inactivation patterns in hematopoietic cell populations detected by the highly informative M27 beta DNA probe. Blood. 1994;83:931-938.
    • (1994) Blood , vol.83 , pp. 931-938
    • Fey, M.F.1    Liechti-Gallati, S.2    Von Rohr, A.3
  • 15
    • 0027174362 scopus 로고
    • A novel clonality assay based on transcriptional analysis of the active X chromosome
    • Prchal JT, Guan YL. A novel clonality assay based on transcriptional analysis of the active X chromosome. Stem Cells. 1993;11(suppl 1):62-65.
    • (1993) Stem Cells , vol.11 , Issue.SUPPL. 1 , pp. 62-65
    • Prchal, J.T.1    Guan, Y.L.2
  • 16
    • 0027454606 scopus 로고
    • Transcriptional analysis of the active X-chromosome in normal and clonal hematopoiesis
    • Prchal JT, Guan YL, Prchal JF, Barany F. Transcriptional analysis of the active X-chromosome in normal and clonal hematopoiesis. Blood. 1993;81:269-271.
    • (1993) Blood , vol.81 , pp. 269-271
    • Prchal, J.T.1    Guan, Y.L.2    Prchal, J.F.3    Barany, F.4
  • 18
    • 0030909351 scopus 로고    scopus 로고
    • Rapid determination of clonality by detection of two closely-linked X chromosome exonic polymorphisms using allele-specific PCR
    • Liu Y, Phelan J, Go RC, Prchal JF, Prchal JT. Rapid determination of clonality by detection of two closely-linked X chromosome exonic polymorphisms using allele-specific PCR. J Clin Invest. 1997;99:1984-1990.
    • (1997) J Clin Invest , vol.99 , pp. 1984-1990
    • Liu, Y.1    Phelan, J.2    Go, R.C.3    Prchal, J.F.4    Prchal, J.T.5
  • 19
    • 0034019735 scopus 로고    scopus 로고
    • A polymorphism of the X-linked gene IDS increases the number of females informative for transcriptional clonality assays
    • Gregg XT, Kralovics R, Prchal JT. A polymorphism of the X-linked gene IDS increases the number of females informative for transcriptional clonality assays. Am J Hematol. 2000;63:184-191.
    • (2000) Am J Hematol , vol.63 , pp. 184-191
    • Gregg, X.T.1    Kralovics, R.2    Prchal, J.T.3
  • 20
    • 0036362911 scopus 로고    scopus 로고
    • Clonality studies in cancer based on X chromosome inactivation phenomenon
    • Phelan JT II, Prchal JT. Clonality studies in cancer based on X chromosome inactivation phenomenon. Methods Mol Med. 2002;68:251-270.
    • (2002) Methods Mol Med , vol.68 , pp. 251-270
    • Phelan J.T. II1    Prchal, J.T.2
  • 21
    • 0031972966 scopus 로고    scopus 로고
    • X-chromosome inactivation in healthy females: Incidence of excessive lyonization with age and comparison of assays involving DNA methylation and transcript polymorphisms
    • El-Kassar N, Hetet G, Briere J, Grandchamp B. X-chromosome inactivation in healthy females: incidence of excessive lyonization with age and comparison of assays involving DNA methylation and transcript polymorphisms. Clin Chem. 1998;44:61-67.
    • (1998) Clin Chem , vol.44 , pp. 61-67
    • El-Kassar, N.1    Hetet, G.2    Briere, J.3    Grandchamp, B.4
  • 23
    • 0031019581 scopus 로고    scopus 로고
    • Clonality analysis of hematopoiesis in essential thrombocythemia: Advantages of studying T lymphocytes and platelets
    • El-Kassar N, Hetet G, Briere J, Grandchamp B. Clonality analysis of hematopoiesis in essential thrombocythemia: advantages of studying T lymphocytes and platelets. Blood. 1997;89:128-134.
    • (1997) Blood , vol.89 , pp. 128-134
    • El-Kassar, N.1    Hetet, G.2    Briere, J.3    Grandchamp, B.4
  • 24
    • 0027374141 scopus 로고
    • Iduronate-2-sulfatase gene mutations in 16 patients with mucopolysaccharidosis type II (Hunter syndrome)
    • Bunge S, Steglich C, Zuther C, et al. Iduronate-2-sulfatase gene mutations in 16 patients with mucopolysaccharidosis type II (Hunter syndrome). Hum Mol Genet. 1993;2:1871-1875.
    • (1993) Hum Mol Genet , vol.2 , pp. 1871-1875
    • Bunge, S.1    Steglich, C.2    Zuther, C.3
  • 25
    • 0016391236 scopus 로고
    • Bone-marrow responses in polycythemia vera
    • Prchal JF, Axelrad AA. Bone-marrow responses in polycythemia vera [letter]. N Engl J Med. 1974;290:1382.
    • (1974) N Engl J Med , vol.290 , pp. 1382
    • Prchal, J.F.1    Axelrad, A.A.2
  • 26
    • 0018163444 scopus 로고
    • Erythropoietin (Ep) dose-response curves for three classes of erythroid progenitors in normal human marrow and in patients with polycythemia vera
    • Eaves CJ, Eaves AC. Erythropoietin (Ep) dose-response curves for three classes of erythroid progenitors in normal human marrow and in patients with polycythemia vera. Blood. 1978;52:1196-1210.
    • (1978) Blood , vol.52 , pp. 1196-1210
    • Eaves, C.J.1    Eaves, A.C.2
  • 27
    • 0034656066 scopus 로고    scopus 로고
    • Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera
    • Temednac S, Klippel S, Strunck E, et al. Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera. Blood. 2000;95:2569-2576.
    • (2000) Blood , vol.95 , pp. 2569-2576
    • Temednac, S.1    Klippel, S.2    Strunck, E.3
  • 28
    • 79960971629 scopus 로고    scopus 로고
    • Quantification of PRV-1 expression, a molecular marker for the diagnosis of polycythemia vera
    • Klippel S, Strunck E, Temerinac S, et al. Quantification of PRV-1 expression, a molecular marker for the diagnosis of polycythemia vera [abstract]. Blood. 2001;98:470a.
    • (2001) Blood , vol.98
    • Klippel, S.1    Strunck, E.2    Temerinac, S.3
  • 29
    • 79960971482 scopus 로고    scopus 로고
    • Development of a new quantitative PCR-based assay for the polycythemia rubra vera-1 (PRV-1) gene: Diagnostic and therapeutic implications
    • Fruehauf S, Topaly J, Villalobos M, et al. Development of a new quantitative PCR-based assay for the polycythemia rubra vera-1 (PRV-1) gene: diagnostic and therapeutic implications [abstract]. Blood. 2001;98:629a.
    • (2001) Blood , vol.98
    • Fruehauf, S.1    Topaly, J.2    Villalobos, M.3
  • 30
    • 0003415792 scopus 로고    scopus 로고
    • Polycythemia vera
    • Hoffman R, Benz EJJ, Shattil SJ, et al, eds. New York, NY: Churchill Livingstone
    • Hoffman R. Polycythemia vera. In: Hoffman R, Benz EJJ, Shattil SJ, et al, eds. Hematology: Basic Principles and Practice. 3rd ed. New York, NY: Churchill Livingstone; 2000;1130-1151.
    • (2000) Hematology: Basic Principles and Practice. 3rd Ed. , pp. 1130-1151
    • Hoffman, R.1
  • 31
    • 0030882659 scopus 로고    scopus 로고
    • Detection of rifampin resistance by single-strand conformation polymorphism analysis of cerebrospinal fluid of patients with tuberculosis of the central nervous system
    • Scarpellini P, Braglia S, Brambilla AM, et al. Detection of rifampin resistance by single-strand conformation polymorphism analysis of cerebrospinal fluid of patients with tuberculosis of the central nervous system. J Clin Microbiol. 1997;35:2802-2806.
    • (1997) J Clin Microbiol , vol.35 , pp. 2802-2806
    • Scarpellini, P.1    Braglia, S.2    Brambilla, A.M.3
  • 32
    • 0032128336 scopus 로고    scopus 로고
    • Absence of polycythemia in a child with a unique erythropoietin receptor mutation in a family with autosomal dominant primary polycythemia
    • Kralovics R, Sokol L, Prchal JT. Absence of polycythemia in a child with a unique erythropoietin receptor mutation in a family with autosomal dominant primary polycythemia. J Clin Invest. 1998;102:124-129.
    • (1998) J Clin Invest , vol.102 , pp. 124-129
    • Kralovics, R.1    Sokol, L.2    Prchal, J.T.3
  • 33
    • 0028237666 scopus 로고
    • Isolation of cosmid and cDNA clones in the region surrounding the BTK gene at Xq21.3-q22
    • Vorechovsky I, Vetrie D, Holland J, et al. Isolation of cosmid and cDNA clones in the region surrounding the BTK gene at Xq21.3-q22. Genomics. 1994;21:517-524.
    • (1994) Genomics , vol.21 , pp. 517-524
    • Vorechovsky, I.1    Vetrie, D.2    Holland, J.3
  • 34
    • 0032541324 scopus 로고    scopus 로고
    • Chromosomal mapping, tissue distribution and cDNA sequence of four-and-a-half LIM domain protein 1 (FHL1)
    • Lee SM, Tsui SK, Chan KK, et al. Chromosomal mapping, tissue distribution and cDNA sequence of four-and-a-half LIM domain protein 1 (FHL1). Gene. 1998;216:163-170.
    • (1998) Gene , vol.216 , pp. 163-170
    • Lee, S.M.1    Tsui, S.K.2    Chan, K.K.3
  • 35
    • 0020034279 scopus 로고
    • Primary thrombocythemia: Clonal origin of platelets, erythrocytes, and granulocytes in a GdB/Gd Mediterranean subject
    • Gaetani GF, Ferraris AM, Galiano S, Giuntini P, Canepa L, d'Urso M. Primary thrombocythemia: clonal origin of platelets, erythrocytes, and granulocytes in a GdB/Gd Mediterranean subject. Blood. 1982;59:76-79.
    • (1982) Blood , vol.59 , pp. 76-79
    • Gaetani, G.F.1    Ferraris, A.M.2    Galiano, S.3    Giuntini, P.4    Canepa, L.5    D'Urso, M.6
  • 36
    • 0028362575 scopus 로고
    • Clonality in chronic myeloproliferative disorders defined by X-chromosome linked probes: Demonstration of heterogeneity in lineage involvement
    • Tsukamoto N, Morita K, Maehara T, et al. Clonality in chronic myeloproliferative disorders defined by X-chromosome linked probes: demonstration of heterogeneity in lineage involvement. Br J Haematol. 1994;86:253-258.
    • (1994) Br J Haematol , vol.86 , pp. 253-258
    • Tsukamoto, N.1    Morita, K.2    Maehara, T.3
  • 37
    • 0028295482 scopus 로고
    • Expression of Bruton's agammaglobulinemia tyrosine kinase gene, BTK, is selectively downregulated in T lymphocytes and plasma cells
    • Smith CI, Baskin B, Humire-Greiff P, et al. Expression of Bruton's agammaglobulinemia tyrosine kinase gene, BTK, is selectively downregulated in T lymphocytes and plasma cells. J Immunol. 1994;152:557-565.
    • (1994) J Immunol , vol.152 , pp. 557-565
    • Smith, C.I.1    Baskin, B.2    Humire-Greiff, P.3
  • 38
    • 0024756969 scopus 로고
    • Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction
    • Orita M, Suzuki Y, Sekiya T, Hayashi K. Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. Genomics. 1989;5:874-879.
    • (1989) Genomics , vol.5 , pp. 874-879
    • Orita, M.1    Suzuki, Y.2    Sekiya, T.3    Hayashi, K.4
  • 39
    • 0024595101 scopus 로고
    • Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms
    • Orita M, Iwahana H, Kanazawa H, Hayashi K, Sekiya T. Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms. Proc Natl Acad Sci U S A. 1989;86:2766-2770.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 2766-2770
    • Orita, M.1    Iwahana, H.2    Kanazawa, H.3    Hayashi, K.4    Sekiya, T.5
  • 40
    • 0026207465 scopus 로고
    • PCR-SSCP: A simple and sensitive method for detection of mutations in the genomic DNA
    • Hayashi K. PCR-SSCP: a simple and sensitive method for detection of mutations in the genomic DNA. PCR Methods Appl. 1991;1:34-38.
    • (1991) PCR Methods Appl , vol.1 , pp. 34-38
    • Hayashi, K.1
  • 42
    • 0023109203 scopus 로고
    • Carrier detection in X-linked agammaglobulinemia by analysis of X-chromosome inactivation
    • Fearon ER, Winkelstein JA, Civin CI, Pardoll DM, Vogelstein B. Carrier detection in X-linked agammaglobulinemia by analysis of X-chromosome inactivation. N Engl J Med. 1987;316:427-431.
    • (1987) N Engl J Med , vol.316 , pp. 427-431
    • Fearon, E.R.1    Winkelstein, J.A.2    Civin, C.I.3    Pardoll, D.M.4    Vogelstein, B.5
  • 43
    • 0035106628 scopus 로고    scopus 로고
    • Pathogenetic mechanisms of polycythemia vera and congenital polycythemic disorders
    • Prchal JT. Pathogenetic mechanisms of polycythemia vera and congenital polycythemic disorders. Semin Hematol. 2001;38:10-20.
    • (2001) Semin Hematol , vol.38 , pp. 10-20
    • Prchal, J.T.1
  • 44
    • 0030021624 scopus 로고    scopus 로고
    • Clonal stability of blood cell lineages indicated by X-chromosomal transcriptional polymorphism
    • Prchal JT, Prchal JF, Belickova M, et al. Clonal stability of blood cell lineages indicated by X-chromosomal transcriptional polymorphism. J Exp Med. 1996;183:561-567.
    • (1996) J Exp Med , vol.183 , pp. 561-567
    • Prchal, J.T.1    Prchal, J.F.2    Belickova, M.3
  • 45
    • 0032576744 scopus 로고    scopus 로고
    • X inactivation in females with X-linked disease
    • Puck JM, Willard HF. X inactivation in females with X-linked disease. N Engl J Med. 1998;338:325-328.
    • (1998) N Engl J Med , vol.338 , pp. 325-328
    • Puck, J.M.1    Willard, H.F.2
  • 46
    • 0019212580 scopus 로고
    • Wiskott-Aldrich syndrome: Cellular impairments and their implication for carrier detection
    • Prchal JT, Carroll AJ, Prchal JF, et al. Wiskott-Aldrich syndrome: cellular impairments and their implication for carrier detection. Blood. 1980;56:1048-1054.
    • (1980) Blood , vol.56 , pp. 1048-1054
    • Prchal, J.T.1    Carroll, A.J.2    Prchal, J.F.3
  • 47
    • 0037441601 scopus 로고    scopus 로고
    • Mutations in the VHL gene in sporadic apparently congenital polycythemia
    • Pastore YD, Jelinek J, Ang S, et al. Mutations in the VHL gene in sporadic apparently congenital polycythemia. Blood. 2003;101:1591-1595.
    • (2003) Blood , vol.101 , pp. 1591-1595
    • Pastore, Y.D.1    Jelinek, J.2    Ang, S.3
  • 48
    • 0033954268 scopus 로고    scopus 로고
    • Diagnosis and treatment of polycythemia vera and possible future study designs of the PVSG
    • Michiels JJ, Barbui T, Finazzi G, et al. Diagnosis and treatment of polycythemia vera and possible future study designs of the PVSG. Leuk Lymphoma. 2000;36:239-253.
    • (2000) Leuk Lymphoma , vol.36 , pp. 239-253
    • Michiels, J.J.1    Barbui, T.2    Finazzi, G.3
  • 49
    • 0033555392 scopus 로고    scopus 로고
    • A large proportion of patients with a diagnosis of essential thrombocythemia do not have a clonal disorder and may be at lower risk of thrombotic complications
    • Harrison CN, Gale RE, Machin SJ, Linch DC. A large proportion of patients with a diagnosis of essential thrombocythemia do not have a clonal disorder and may be at lower risk of thrombotic complications. Blood. 1999;93:417-424.
    • (1999) Blood , vol.93 , pp. 417-424
    • Harrison, C.N.1    Gale, R.E.2    Machin, S.J.3    Linch, D.C.4
  • 50
    • 0034669997 scopus 로고    scopus 로고
    • Hypersensitivity of circulating progenitor cells to megakaryocyte growth and development factor (PEG-rHu MGDF) in essential thrombocythemia
    • Axelrad AA, Eskinazi D, Correa PN, Amato D. Hypersensitivity of circulating progenitor cells to megakaryocyte growth and development factor (PEG-rHu MGDF) in essential thrombocythemia. Blood. 2000;96:3310-3321.
    • (2000) Blood , vol.96 , pp. 3310-3321
    • Axelrad, A.A.1    Eskinazi, D.2    Correa, P.N.3    Amato, D.4
  • 51
    • 0028055045 scopus 로고
    • Identification of masked polycythemia vera from patients with idiopathic marked thrombocytosis by endogenous erythroid colony assay
    • Shih LY, Lee CT. Identification of masked polycythemia vera from patients with idiopathic marked thrombocytosis by endogenous erythroid colony assay. Blood. 1994;83:744-748.
    • (1994) Blood , vol.83 , pp. 744-748
    • Shih, L.Y.1    Lee, C.T.2
  • 53
    • 0033575003 scopus 로고    scopus 로고
    • Direct comparison of GAPDH, beta-actin, cyclophilin, and 28S rRNA as internal standards for quantifying RNA levels under hypoxia
    • Zhong H, Simons JW. Direct comparison of GAPDH, beta-actin, cyclophilin, and 28S rRNA as internal standards for quantifying RNA levels under hypoxia. Biochem Biophys Res Commun. 1999;259:523-526.
    • (1999) Biochem Biophys Res Commun , vol.259 , pp. 523-526
    • Zhong, H.1    Simons, J.W.2
  • 54
    • 18744373593 scopus 로고    scopus 로고
    • Congenital Chuvash polycythemia: Altered oxygen homeostasis due to homozygosity for a hypomorphic VHL allele
    • Ang SO, Chen H, Hirota K, et al. Congenital Chuvash polycythemia: altered oxygen homeostasis due to homozygosity for a hypomorphic VHL allele. Nat Genet. 2002;32:614-621.
    • (2002) Nat Genet , vol.32 , pp. 614-621
    • Ang, S.O.1    Chen, H.2    Hirota, K.3
  • 55
    • 0036265158 scopus 로고    scopus 로고
    • Quantitative assessment of gene expression in highly purified hematopoietic cells using real-time reverse transcriptase polymerase chain reaction
    • Raaijmakers MH, van Emst L, de Witte T, Mensink E, Raymakers RA. Quantitative assessment of gene expression in highly purified hematopoietic cells using real-time reverse transcriptase polymerase chain reaction. Exp Hematol. 2002;30:481-487.
    • (2002) Exp Hematol , vol.30 , pp. 481-487
    • Raaijmakers, M.H.1    Van Emst, L.2    De Witte, T.3    Mensink, E.4    Raymakers, R.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.