Increased lysosomal uptake of methotrexate-polyglutamates in two methotrexate-resistant cell lines with distinct mechanisms of resistance

Biochemical Pharmacology

Volumn 71, Issue 1-2, 2005, Pages 203-213

  Marshall, Lisa A ^a   Rhee, Myung S ^a   Hofmann, Lars ^b   Khodjakov, Alexey ^a,b   Schneider, Erasmus ^a,b  

^a WADSWORTH CENTER   (United States)

^b STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Drug resistance; Drug transport; Lysosomes; Methotrexate

Indexed keywords

METHOTREXATE; METHOTREXATE POLYGLUTAMATE;

ARTICLE; BINDING AFFINITY; CELL LINE; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOSOL; DRUG ACCUMULATION; DRUG RESISTANCE; DRUG UPTAKE; HUMAN; HUMAN CELL; HYDROLYSIS; LYSOSOME; PRIORITY JOURNAL; VELOCITY;

BETA-N-ACETYLHEXOSAMINIDASE; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; HUMANS; HYDROLYSIS; LYSOSOMES; METHOTREXATE; MICROSCOPY, FLUORESCENCE; OSMOSIS; POLYGLUTAMIC ACID;

EID: 28244484744     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2005.10.008     Document Type: Article

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