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Volumn 7, Issue 6, 2005, Pages 843-863

Evaluation of solution and solid-phase approaches to the synthesis of libraries of α,α-disubstituted-α-acylaminoketones

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EID: 28244452920     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc0500396     Document Type: Article
Times cited : (11)

References (97)
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    • Pre-formed ketone or protected ketone loaded onto resin; see: (a) Bernard, E.; Vanderesse, R. Tetrahedron Lett. 2004, 45, 8603-8606.
    • (2004) Tetrahedron Lett. , vol.45 , pp. 8603-8606
    • Bernard, E.1    Vanderesse, R.2
  • 43
    • 0034678033 scopus 로고    scopus 로고
    • (a) Schreiber, S. L. Science 2000, 287, 1964-1969.
    • (2000) Science , vol.287 , pp. 1964-1969
    • Schreiber, S.L.1
  • 47
    • 0004015433 scopus 로고    scopus 로고
    • Oxford University Press: New York
    • Terrett, N. K. Combinatorial Chemistry; Oxford University Press: New York, 1998; pp 15-19.
    • (1998) Combinatorial Chemistry , pp. 15-19
    • Terrett, N.K.1
  • 58
    • 28244441909 scopus 로고    scopus 로고
    • note
    • -1). Comparison of the normalized integrals of the carbamate and amide carbonyl stretches in samples of 12{9} allowed the conversion percentage to be estimated. These values were confirmed in certain cases by measuring the UV absorbance of the piperidine-dibenzofluvene adduct released when the Fmoc group was removed from 12{9}.
  • 93
    • 85102091675 scopus 로고    scopus 로고
    • 2 is a product of Argonaut Technologies, Inc., Redwood City, CA (http://www.argotech.com).
  • 96
    • 28244463908 scopus 로고    scopus 로고
    • note
    • 2 for 24 h. Ligand stock solutions were prepared (10 mM in DMSO) and diluted 100-fold in media; then, 50 μL of diluted ligand solution was added to each well. The final concentration of DMSO was maintained at 0.03% in both controls and treatments. β-Galactosidase reporter gene expression was measured 48 h after treatment of the cells using Gal Screen bioluminescent reporter gene assay system from Tropix (GSY1000). Luminescence was detected at room temperature using a Dynex MLX microtiter plate luminometer. Fold inductions were calculated by dividing relative light units (RLU) in ligand-treated cells with RLU in DMSO-treated cells.
  • 97


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.