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Volumn 108, Issue 3, 2005, Pages 353-361

Peptide therapy for allergic diseases: Basic mechanisms and new clinical approaches

Author keywords

Asthma; Epitope; Immunological tolerance; Immunology; Major histocompatibility complex

Indexed keywords

ALLERGEN; API M 1 PEPTIDE; CD4 ANTIGEN; CYTOKINE; EPITOPE; FEL D 1 PEPTIDE; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

EID: 28044448543     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2005.05.004     Document Type: Review
Times cited : (27)

References (69)
  • 1
    • 0034846513 scopus 로고    scopus 로고
    • Role of IL-10 in allergen-specific immunotherapy and normal response to allergens
    • C.A. Akdis, and K. Blaser Role of IL-10 in allergen-specific immunotherapy and normal response to allergens Microbes Infect 3 2001 891 898
    • (2001) Microbes Infect , vol.3 , pp. 891-898
    • Akdis, C.A.1    Blaser, K.2
  • 2
    • 0029820287 scopus 로고    scopus 로고
    • Epitope-specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro
    • C.A. Akdis, M. Akdis, T. Blesken, D. Wymann, S.S. Alkan, and U. Muller Epitope-specific T cell tolerance to phospholipase A2 in bee venom immunotherapy and recovery by IL-2 and IL-15 in vitro J Clin Invest 98 1996 1676 1683
    • (1996) J Clin Invest , vol.98 , pp. 1676-1683
    • Akdis, C.A.1    Akdis, M.2    Blesken, T.3    Wymann, D.4    Alkan, S.S.5    Muller, U.6
  • 3
    • 2942685507 scopus 로고    scopus 로고
    • Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells
    • M. Akdis, J. Verhagen, A. Taylor, F. Karamloo, C. Karagiannidis, and R. Crameri Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells J Exp Med 199 2004 1567 1575
    • (2004) J Exp Med , vol.199 , pp. 1567-1575
    • Akdis, M.1    Verhagen, J.2    Taylor, A.3    Karamloo, F.4    Karagiannidis, C.5    Crameri, R.6
  • 4
    • 0001118822 scopus 로고    scopus 로고
    • A dosing protocol of allergen-derived T cell peptide epitopes for the treatment of allergic disease
    • C. Alexander, W.L. Oldfield, K. Shirley, M. Larche, and A.B. Kay A dosing protocol of allergen-derived T cell peptide epitopes for the treatment of allergic disease J Allergy Clin Immunol 107 2001 176
    • (2001) J Allergy Clin Immunol , vol.107 , pp. 176
    • Alexander, C.1    Oldfield, W.L.2    Shirley, K.3    Larche, M.4    Kay, A.B.5
  • 5
    • 13244291456 scopus 로고    scopus 로고
    • Fel d 1-derived T cell peptide therapy induces recruitment of CD4CD25; CD4 interferon-gamma T helper type 1 cells to sites of allergen-induced late-phase skin reactions in cat-allergic subjects
    • C. Alexander, S. Ying, B. Kay, and M. Larche Fel d 1-derived T cell peptide therapy induces recruitment of CD4CD25; CD4 interferon-gamma T helper type 1 cells to sites of allergen-induced late-phase skin reactions in cat-allergic subjects Clin Exp Allergy 35 1 2005 52 58
    • (2005) Clin Exp Allergy , vol.35 , Issue.1 , pp. 52-58
    • Alexander, C.1    Ying, S.2    Kay, B.3    Larche, M.4
  • 6
  • 7
    • 0028900289 scopus 로고
    • Activation of T cells recognizing self 60-kD heat shock protein can protect against experimental arthritis
    • S.M. Anderton, Z.R. van Der, B. Prakken, A. Noordzij, and W. van Eden Activation of T cells recognizing self 60-kD heat shock protein can protect against experimental arthritis J Exp Med 181 1995 943 952
    • (1995) J Exp Med , vol.181 , pp. 943-952
    • Anderton, S.M.1    Van Der, Z.R.2    Prakken, B.3    Noordzij, A.4    Van Eden, W.5
  • 8
    • 0031615666 scopus 로고    scopus 로고
    • Antigen-specific tolerance induction and the immunotherapy of experimental autoimmune disease
    • S.M. Anderton, C. Burkhart, G.Y. Liu, B. Metzler, and D.C. Wraith Antigen-specific tolerance induction and the immunotherapy of experimental autoimmune disease Novartis Found Symp 215 1998 120 131
    • (1998) Novartis Found Symp , vol.215 , pp. 120-131
    • Anderton, S.M.1    Burkhart, C.2    Liu, G.Y.3    Metzler, B.4    Wraith, D.C.5
  • 9
    • 0034665515 scopus 로고    scopus 로고
    • Inducing tolerance by intranasal administration of long peptides in naive and primed CBA/J mice
    • M. Astori, C. von Garnier, A. Kettner, N. Dufour, G. Corradin, and F. Spertini Inducing tolerance by intranasal administration of long peptides in naive and primed CBA/J mice J Immunol 165 2000 3497 3505
    • (2000) J Immunol , vol.165 , pp. 3497-3505
    • Astori, M.1    Von Garnier, C.2    Kettner, A.3    Dufour, N.4    Corradin, G.5    Spertini, F.6
  • 10
    • 0031054483 scopus 로고    scopus 로고
    • Modulation of the allergic immune response in BALB/c mice by subcutaneous injection of high doses of the dominant T cell epitope from the major birch pollen allergen Bet v 1
    • L. Bauer, B. Bohle, B. Jahn-Schmid, U. Wiedermann, A. Daser, and H. Renz Modulation of the allergic immune response in BALB/c mice by subcutaneous injection of high doses of the dominant T cell epitope from the major birch pollen allergen Bet v 1 Clin Exp Immunol 107 1997 536 541
    • (1997) Clin Exp Immunol , vol.107 , pp. 536-541
    • Bauer, L.1    Bohle, B.2    Jahn-Schmid, B.3    Wiedermann, U.4    Daser, A.5    Renz, H.6
  • 11
    • 0033786776 scopus 로고    scopus 로고
    • Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
    • B. Bielekova, B. Goodwin, N. Richert, I. Cortese, T. Kondo, and G. Afshar Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand Nat Med 6 2000 1167 1175
    • (2000) Nat Med , vol.6 , pp. 1167-1175
    • Bielekova, B.1    Goodwin, B.2    Richert, N.3    Cortese, I.4    Kondo, T.5    Afshar, G.6
  • 12
    • 0027323846 scopus 로고
    • Peripheral T-cell tolerance induced in naive and primed mice by subcutaneous injection of peptides from the major cat allergen Fel d I
    • T.J. Briner, M.C. Kuo, K.M. Keating, B.L. Rogers, and J.L. Greenstein Peripheral T-cell tolerance induced in naive and primed mice by subcutaneous injection of peptides from the major cat allergen Fel d I Proc Natl Acad Sci U S A 90 1993 7608 7612
    • (1993) Proc Natl Acad Sci U S a , vol.90 , pp. 7608-7612
    • Briner, T.J.1    Kuo, M.C.2    Keating, K.M.3    Rogers, B.L.4    Greenstein, J.L.5
  • 13
    • 0032821774 scopus 로고    scopus 로고
    • Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: A role for IL-10
    • C. Burkhart, G.Y. Liu, S.M. Anderton, B. Metzler, and D.C. Wraith Peptide-induced T cell regulation of experimental autoimmune encephalomyelitis: a role for IL-10 Int Immunol 11 1999 1625 1634
    • (1999) Int Immunol , vol.11 , pp. 1625-1634
    • Burkhart, C.1    Liu, G.Y.2    Anderton, S.M.3    Metzler, B.4    Wraith, D.C.5
  • 14
    • 0024592929 scopus 로고
    • Peptide-specific prevention of experimental allergic encephalomyelitis. Neonatal tolerance induced to the dominant T cell determinant of myelin basic protein
    • J.P. Clayton, G.M. Gammon, D.G. Ando, D.H. Kono, L. Hood, and E.E. Sercarz Peptide-specific prevention of experimental allergic encephalomyelitis. Neonatal tolerance induced to the dominant T cell determinant of myelin basic protein J Exp Med 169 1989 1681 1691
    • (1989) J Exp Med , vol.169 , pp. 1681-1691
    • Clayton, J.P.1    Gammon, G.M.2    Ando, D.G.3    Kono, D.H.4    Hood, L.5    Sercarz, E.E.6
  • 15
    • 0000836828 scopus 로고    scopus 로고
    • Immunostimulatory oligonucleotides conjugated to Amb a 1: Safety, skin test reactivity and basophil histamine release
    • P.S. Creticos, J.J. Eiden, S. Balcer, G. Van Nest, A. Kagey-Sobotka, and S. Tuck Immunostimulatory oligonucleotides conjugated to Amb a 1: safety, skin test reactivity and basophil histamine release J Allergy Clin Immunol 105 1 2000, January S70 (Abstract)
    • (2000) J Allergy Clin Immunol , vol.105 , Issue.1 , pp. 70
    • Creticos, P.S.1    Eiden, J.J.2    Balcer, S.3    Van Nest, G.4    Kagey-Sobotka, A.5    Tuck, S.6
  • 16
    • 0030003889 scopus 로고    scopus 로고
    • Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-gamma
    • S.R. Durham, S. Ying, V.A. Varney, M.R. Jacobson, R.M. Sudderick, and I.S. Mackay Grass pollen immunotherapy inhibits allergen-induced infiltration of CD4+ T lymphocytes and eosinophils in the nasal mucosa and increases the number of cells expressing messenger RNA for interferon-gamma J Allergy Clin Immunol 97 1996 1356 1365
    • (1996) J Allergy Clin Immunol , vol.97 , pp. 1356-1365
    • Durham, S.R.1    Ying, S.2    Varney, V.A.3    Jacobson, M.R.4    Sudderick, R.M.5    MacKay, I.S.6
  • 18
    • 13344287034 scopus 로고    scopus 로고
    • Dissection of immunoglobulin e and T lymphocyte reactivity of isoforms of the major birch pollen allergen Bet v 1: Potential use of hypoallergenic isoforms for immunotherapy
    • F. Ferreira, K. Hirtenlehner, A. Jilek, J. Godnik-Cvar, H. Breiteneder, and R. Grimm Dissection of immunoglobulin E and T lymphocyte reactivity of isoforms of the major birch pollen allergen Bet v 1: potential use of hypoallergenic isoforms for immunotherapy J Exp Med 183 1996 599 609
    • (1996) J Exp Med , vol.183 , pp. 599-609
    • Ferreira, F.1    Hirtenlehner, K.2    Jilek, A.3    Godnik-Cvar, J.4    Breiteneder, H.5    Grimm, R.6
  • 19
    • 0027056539 scopus 로고
    • Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy
    • A. Gaur, B. Wiers, A. Liu, J. Rothbard, and C.G. Fathman Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy Science 258 1992 1491 1494
    • (1992) Science , vol.258 , pp. 1491-1494
    • Gaur, A.1    Wiers, B.2    Liu, A.3    Rothbard, J.4    Fathman, C.G.5
  • 20
    • 0030058433 scopus 로고    scopus 로고
    • Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells
    • H. Groux, M. Bigler, J.E. de Vries, and M.G. Roncarolo Interleukin-10 induces a long-term antigen-specific anergic state in human CD4+ T cells J Exp Med 184 1996 19 29
    • (1996) J Exp Med , vol.184 , pp. 19-29
    • Groux, H.1    Bigler, M.2    De Vries, J.E.3    Roncarolo, M.G.4
  • 21
    • 0032739068 scopus 로고    scopus 로고
    • Skin test evaluation of genetically engineered hypoallergenic derivatives of the major birch pollen allergen, Bet v 1: Results obtained with a mix of two recombinant Bet v 1 fragments and recombinant Bet v 1 trimer in a Swedish population before the birch pollen season
    • M. Hage-Hamsten, M. Kronqvist, O. Zetterstrom, E. Johansson, V. Niederberger, and S. Vrtala Skin test evaluation of genetically engineered hypoallergenic derivatives of the major birch pollen allergen, Bet v 1: results obtained with a mix of two recombinant Bet v 1 fragments and recombinant Bet v 1 trimer in a Swedish population before the birch pollen season J Allergy Clin Immunol 104 1999 969 977
    • (1999) J Allergy Clin Immunol , vol.104 , pp. 969-977
    • Hage-Hamsten, M.1    Kronqvist, M.2    Zetterstrom, O.3    Johansson, E.4    Niederberger, V.5    Vrtala, S.6
  • 22
    • 0031041686 scopus 로고    scopus 로고
    • Increases in IL-12 messenger RNA+ cells accompany inhibition of allergen-induced late skin responses after successful grass pollen immunotherapy
    • Q.A. Hamid, E. Schotman, M.R. Jacobson, S.M. Walker, and S.R. Durham Increases in IL-12 messenger RNA+ cells accompany inhibition of allergen-induced late skin responses after successful grass pollen immunotherapy J Allergy Clin Immunol 99 1997 254 260
    • (1997) J Allergy Clin Immunol , vol.99 , pp. 254-260
    • Hamid, Q.A.1    Schotman, E.2    Jacobson, M.R.3    Walker, S.M.4    Durham, S.R.5
  • 23
    • 0033591638 scopus 로고    scopus 로고
    • Immunoglobulin E-independent major histocompatibility complex-restricted T cell peptide epitope-induced late asthmatic reactions
    • B.M. Haselden, A.B. Kay, and M. Larche Immunoglobulin E-independent major histocompatibility complex-restricted T cell peptide epitope-induced late asthmatic reactions J Exp Med 189 1999 1885 1894
    • (1999) J Exp Med , vol.189 , pp. 1885-1894
    • Haselden, B.M.1    Kay, A.B.2    Larche, M.3
  • 24
    • 0034827454 scopus 로고    scopus 로고
    • Proliferation and release of IL-5 and IFN-gamma by peripheral blood mononuclear cells from cat-allergic asthmatics and rhinitics, non-cat-allergic asthmatics, and normal controls to peptides derived from Fel d 1 chain 1
    • B.M. Haselden, E. Syrigou, M. Jones, D. Huston, K. Ichikawa, and M.D. Chapman Proliferation and release of IL-5 and IFN-gamma by peripheral blood mononuclear cells from cat-allergic asthmatics and rhinitics, non-cat-allergic asthmatics, and normal controls to peptides derived from Fel d 1 chain 1 J Allergy Clin Immunol 108 2001 349 356
    • (2001) J Allergy Clin Immunol , vol.108 , pp. 349-356
    • Haselden, B.M.1    Syrigou, E.2    Jones, M.3    Huston, D.4    Ichikawa, K.5    Chapman, M.D.6
  • 25
    • 0027451437 scopus 로고
    • Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice
    • G.F. Hoyne, R.E. O'Hehir, D.C. Wraith, W.R. Thomas, and J.R. Lamb Inhibition of T cell and antibody responses to house dust mite allergen by inhalation of the dominant T cell epitope in naive and sensitized mice J Exp Med 178 1993 1783 1788
    • (1993) J Exp Med , vol.178 , pp. 1783-1788
    • Hoyne, G.F.1    O'Hehir, R.E.2    Wraith, D.C.3    Thomas, W.R.4    Lamb, J.R.5
  • 26
    • 0030068998 scopus 로고    scopus 로고
    • Regulation of house dust mite responses by intranasally administered peptide: Transient activation of CD4+ T cells precedes the development of tolerance in vivo
    • G.F. Hoyne, B.A. Askonas, C. Hetzel, W.R. Thomas, and J.R. Lamb Regulation of house dust mite responses by intranasally administered peptide: transient activation of CD4+ T cells precedes the development of tolerance in vivo Int Immunol 8 1996 335 342
    • (1996) Int Immunol , vol.8 , pp. 335-342
    • Hoyne, G.F.1    Askonas, B.A.2    Hetzel, C.3    Thomas, W.R.4    Lamb, J.R.5
  • 27
  • 28
    • 0038363534 scopus 로고    scopus 로고
    • IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy
    • M. Jutel, M. Akdis, F. Budak, C. Aebischer-Casaulta, M. Wrzyszcz, and K. Blaser IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy Eur J Immunol 33 2003 1205 1214
    • (2003) Eur J Immunol , vol.33 , pp. 1205-1214
    • Jutel, M.1    Akdis, M.2    Budak, F.3    Aebischer-Casaulta, C.4    Wrzyszcz, M.5    Blaser, K.6
  • 29
    • 0033791462 scopus 로고    scopus 로고
    • Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. the Altered Peptide Ligand in relapsing MS Study Group
    • L. Kappos, G. Comi, H. Panitch, J. Oger, J. Antel, and P. Conlon Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial. The Altered Peptide Ligand in relapsing MS Study Group Nat Med 6 2000 1176 1182
    • (2000) Nat Med , vol.6 , pp. 1176-1182
    • Kappos, L.1    Comi, G.2    Panitch, H.3    Oger, J.4    Antel, J.5    Conlon, P.6
  • 30
    • 0027394526 scopus 로고
    • Prevention of experimental autoimmune arthritis with a peptide fragment of type II collagen
    • G. Ku, M. Kronenberg, D.J. Peacock, P. Tempst, M.L. Banquerigo, and B.S. Braun Prevention of experimental autoimmune arthritis with a peptide fragment of type II collagen Eur J Immunol 23 1993 591 599
    • (1993) Eur J Immunol , vol.23 , pp. 591-599
    • Ku, G.1    Kronenberg, M.2    Peacock, D.J.3    Tempst, P.4    Banquerigo, M.L.5    Braun, B.S.6
  • 31
    • 0020569052 scopus 로고
    • Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin
    • J.R. Lamb, B.J. Skidmore, N. Green, J.M. Chiller, and M. Feldmann Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin J Exp Med 157 1983 1434 1447
    • (1983) J Exp Med , vol.157 , pp. 1434-1447
    • Lamb, J.R.1    Skidmore, B.J.2    Green, N.3    Chiller, J.M.4    Feldmann, M.5
  • 32
    • 17644401678 scopus 로고    scopus 로고
    • Peptide-based therapeutic vaccines for allergic and autoimmune diseases
    • M. Larche, and D.C. Wraith Peptide-based therapeutic vaccines for allergic and autoimmune diseases Nat Med 11 2005 S69 S76
    • (2005) Nat Med , vol.11
    • Larche, M.1    Wraith, D.C.2
  • 33
    • 1342308180 scopus 로고    scopus 로고
    • Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease
    • E.M. Ling, T. Smith, X.D. Nguyen, C. Pridgeon, M. Dallman, and J. Arbery Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease Lancet 363 2004 608 615
    • (2004) Lancet , vol.363 , pp. 608-615
    • Ling, E.M.1    Smith, T.2    Nguyen, X.D.3    Pridgeon, C.4    Dallman, M.5    Arbery, J.6
  • 36
    • 0014988001 scopus 로고
    • Preparation and properties of allergoids, derived from native pollen allergens by mild formalin treatment
    • D.G. Marsh Preparation and properties of allergoids, derived from native pollen allergens by mild formalin treatment Int Arch Allergy Appl Immunol 41 1971 199 215
    • (1971) Int Arch Allergy Appl Immunol , vol.41 , pp. 199-215
    • Marsh, D.G.1
  • 37
    • 0014786859 scopus 로고
    • Studies on "allergoids" prepared from naturally occurring allergens: I. Assay of allergenicity and antigenicity of formalinized rye group I component
    • D.G. Marsh, L.M. Lichtenstein, and D.H. Campbell Studies on "allergoids" prepared from naturally occurring allergens: I. Assay of allergenicity and antigenicity of formalinized rye group I component Immunology 18 1970 705 722
    • (1970) Immunology , vol.18 , pp. 705-722
    • Marsh, D.G.1    Lichtenstein, L.M.2    Campbell, D.H.3
  • 38
    • 43949151501 scopus 로고
    • Immunotherapy of autoimmune disease with synthetic peptides
    • B. Metzler, and D.C. Wraith Immunotherapy of autoimmune disease with synthetic peptides Immunol Today 15 1994 91
    • (1994) Immunol Today , vol.15 , pp. 91
    • Metzler, B.1    Wraith, D.C.2
  • 39
    • 1042278947 scopus 로고    scopus 로고
    • Peptide-based immunotherapy of systemic lupus erythematosus
    • F. Monneaux, and S. Muller Peptide-based immunotherapy of systemic lupus erythematosus Autoimmun Rev 3 2004 16 24
    • (2004) Autoimmun Rev , vol.3 , pp. 16-24
    • Monneaux, F.1    Muller, S.2
  • 40
    • 0345701527 scopus 로고    scopus 로고
    • T cell recognition and therapeutic effect of a phosphorylated synthetic peptide of the 70K snRNP protein administered in MR/lpr mice
    • F. Monneaux, J.M. Lozano, M.E. Patarroyo, J.P. Briand, and S. Muller T cell recognition and therapeutic effect of a phosphorylated synthetic peptide of the 70K snRNP protein administered in MR/lpr mice Eur J Immunol 33 2003 287 296
    • (2003) Eur J Immunol , vol.33 , pp. 287-296
    • Monneaux, F.1    Lozano, J.M.2    Patarroyo, M.E.3    Briand, J.P.4    Muller, S.5
  • 41
    • 0031866059 scopus 로고    scopus 로고
    • Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom
    • U. Muller, C.A. Akdis, M. Fricker, M. Akdis, T. Blesken, and F. Bettens Successful immunotherapy with T-cell epitope peptides of bee venom phospholipase A2 induces specific T-cell anergy in patients allergic to bee venom J Allergy Clin Immunol 101 1998 747 754
    • (1998) J Allergy Clin Immunol , vol.101 , pp. 747-754
    • Muller, U.1    Akdis, C.A.2    Fricker, M.3    Akdis, M.4    Blesken, T.5    Bettens, F.6
  • 42
    • 50249230114 scopus 로고
    • Prophylactic innoculation against hay fever
    • L. Noon Prophylactic innoculation against hay fever Lancet i 1911 1572 1573
    • (1911) Lancet , vol.1 , pp. 1572-1573
    • Noon, L.1
  • 44
    • 10744232817 scopus 로고    scopus 로고
    • Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity
    • K.T. Nouri-Aria, P.A. Wachholz, J.N. Francis, M.R. Jacobson, S.M. Walker, and L.K. Wilcock Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity J Immunol 172 2004 3252 3259
    • (2004) J Immunol , vol.172 , pp. 3252-3259
    • Nouri-Aria, K.T.1    Wachholz, P.A.2    Francis, J.N.3    Jacobson, M.R.4    Walker, S.M.5    Wilcock, L.K.6
  • 45
    • 0035878077 scopus 로고    scopus 로고
    • Engagement of Fc epsilon RI on human monocytes induces the production of IL-10 and prevents their differentiation in dendritic cells
    • N. Novak, T. Bieber, and N. Katoh Engagement of Fc epsilon RI on human monocytes induces the production of IL-10 and prevents their differentiation in dendritic cells J Immunol 167 2001 797 804
    • (2001) J Immunol , vol.167 , pp. 797-804
    • Novak, N.1    Bieber, T.2    Katoh, N.3
  • 46
    • 0032424257 scopus 로고    scopus 로고
    • Engineering of hypoallergenic mutants of the Brassica pollen allergen, Bra r 1, for immunotherapy
    • T. Okada, I. Swoboda, P.L. Bhalla, K. Toriyama, and M.B. Singh Engineering of hypoallergenic mutants of the Brassica pollen allergen, Bra r 1, for immunotherapy FEBS Lett 434 1998 255 260
    • (1998) FEBS Lett , vol.434 , pp. 255-260
    • Okada, T.1    Swoboda, I.2    Bhalla, P.L.3    Toriyama, K.4    Singh, M.B.5
  • 47
    • 0035423535 scopus 로고    scopus 로고
    • Allergen-derived T cell peptide-induced late asthmatic reactions precede the induction of antigen-specific hyporesponsiveness in atopic allergic asthmatic subjects
    • W.L. Oldfield, A.B. Kay, and M. Larche Allergen-derived T cell peptide-induced late asthmatic reactions precede the induction of antigen-specific hyporesponsiveness in atopic allergic asthmatic subjects J Immunol 167 2001 1734 1739
    • (2001) J Immunol , vol.167 , pp. 1734-1739
    • Oldfield, W.L.1    Kay, A.B.2    Larche, M.3
  • 48
    • 0037031090 scopus 로고    scopus 로고
    • Effect of T-cell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: A randomised controlled trial
    • W.L. Oldfield, M. Larche, and A.B. Kay Effect of T-cell peptides derived from Fel d 1 on allergic reactions and cytokine production in patients sensitive to cats: a randomised controlled trial Lancet 360 2002 47 53
    • (2002) Lancet , vol.360 , pp. 47-53
    • Oldfield, W.L.1    Larche, M.2    Kay, A.B.3
  • 49
    • 0013687727 scopus 로고    scopus 로고
    • Comparison of genetically engineered hypoallergenic rBet v 1 derivatives with rBet v 1 wild-type by skin prick and intradermal testing: Results obtained in a French population
    • G. Pauli, A. Purohit, J.P. Oster, F. de Blay, S. Vrtala, and V. Niederberger Comparison of genetically engineered hypoallergenic rBet v 1 derivatives with rBet v 1 wild-type by skin prick and intradermal testing: results obtained in a French population Clin Exp Allergy 30 2000 1076 1084
    • (2000) Clin Exp Allergy , vol.30 , pp. 1076-1084
    • Pauli, G.1    Purohit, A.2    Oster, J.P.3    De Blay, F.4    Vrtala, S.5    Niederberger, V.6
  • 50
    • 0031793244 scopus 로고    scopus 로고
    • Immunotherapy with Fel d 1 peptides decreases IL-4 release by peripheral blood T cells of patients allergic to cats
    • J. Pene, A. Desroches, L. Paradis, B. Lebel, M. Farce, and C.F. Nicodemus Immunotherapy with Fel d 1 peptides decreases IL-4 release by peripheral blood T cells of patients allergic to cats J Allergy Clin Immunol 102 1998 571 578
    • (1998) J Allergy Clin Immunol , vol.102 , pp. 571-578
    • Pene, J.1    Desroches, A.2    Paradis, L.3    Lebel, B.4    Farce, M.5    Nicodemus, C.F.6
  • 51
    • 0030953059 scopus 로고    scopus 로고
    • Peptide-induced nasal tolerance for a mycobacterial heat shock protein 60 T cell epitope in rats suppresses both adjuvant arthritis and nonmicrobially induced experimental arthritis
    • B.J. Prakken, Z.R. van Der, S.M. Anderton, P.J. van Kooten, W. Kuis, and W. van Eden Peptide-induced nasal tolerance for a mycobacterial heat shock protein 60 T cell epitope in rats suppresses both adjuvant arthritis and nonmicrobially induced experimental arthritis Proc Natl Acad Sci U S A 94 1997 3284 3289
    • (1997) Proc Natl Acad Sci U S a , vol.94 , pp. 3284-3289
    • Prakken, B.J.1    Van Der, Z.R.2    Anderton, S.M.3    Van Kooten, P.J.4    Kuis, W.5    Van Eden, W.6
  • 52
    • 0036065042 scopus 로고    scopus 로고
    • Inhibition of adjuvant-induced arthritis by interleukin-10-driven regulatory cells induced via nasal administration of a peptide analog of an arthritis-related heat-shock protein 60 T cell epitope
    • B.J. Prakken, S. Roord, P.J. van Kooten, J.P. Wagenaar, W. van Eden, and S. Albani Inhibition of adjuvant-induced arthritis by interleukin-10-driven regulatory cells induced via nasal administration of a peptide analog of an arthritis-related heat-shock protein 60 T cell epitope Arthritis Rheum 46 2002 1937 1946
    • (2002) Arthritis Rheum , vol.46 , pp. 1937-1946
    • Prakken, B.J.1    Roord, S.2    Van Kooten, P.J.3    Wagenaar, J.P.4    Van Eden, W.5    Albani, S.6
  • 53
    • 12144289938 scopus 로고    scopus 로고
    • Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis
    • B.J. Prakken, R. Samodal, T.D. Le, F. Giannoni, G.P. Yung, and J. Scavulli Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis Proc Natl Acad Sci U S A 101 2004 4228 4233
    • (2004) Proc Natl Acad Sci U S a , vol.101 , pp. 4228-4233
    • Prakken, B.J.1    Samodal, R.2    Le, T.D.3    Giannoni, F.4    Yung, G.P.5    Scavulli, J.6
  • 57
    • 0027443372 scopus 로고
    • Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals
    • H. Secrist, C.J. Chelen, Y. Wen, J.D. Marshall, and D.T. Umetsu Allergen immunotherapy decreases interleukin 4 production in CD4+ T cells from allergic individuals J Exp Med 178 1993 2123 2130
    • (1993) J Exp Med , vol.178 , pp. 2123-2130
    • Secrist, H.1    Chelen, C.J.2    Wen, Y.3    Marshall, J.D.4    Umetsu, D.T.5
  • 58
    • 0030444839 scopus 로고    scopus 로고
    • Fel d 1 peptides: Effect on skin tests and cytokine synthesis in cat-allergic human subjects
    • F.E. Simons, M. Imada, Y. Li, W.T. Watson, and K.T. HayGlass Fel d 1 peptides: effect on skin tests and cytokine synthesis in cat-allergic human subjects Int Immunol 8 1996 1937 1945
    • (1996) Int Immunol , vol.8 , pp. 1937-1945
    • Simons, F.E.1    Imada, M.2    Li, Y.3    Watson, W.T.4    Hayglass, K.T.5
  • 59
    • 0029962104 scopus 로고    scopus 로고
    • Mucosal tolerance and suppression of collagen-induced arthritis (CIA) induced by nasal inhalation of synthetic peptide 184-198 of bovine type II collagen (CII) expressing a dominant T cell epitope
    • N.A. Staines, N. Harper, F.J. Ward, V. Malmstrom, R. Holmdahl, and S. Bansal Mucosal tolerance and suppression of collagen-induced arthritis (CIA) induced by nasal inhalation of synthetic peptide 184-198 of bovine type II collagen (CII) expressing a dominant T cell epitope Clin Exp Immunol 103 1996 368 375
    • (1996) Clin Exp Immunol , vol.103 , pp. 368-375
    • Staines, N.A.1    Harper, N.2    Ward, F.J.3    Malmstrom, V.4    Holmdahl, R.5    Bansal, S.6
  • 60
    • 0035923541 scopus 로고    scopus 로고
    • Vaccination, prevention, and treatment of experimental autoimmune neuritis (EAN) by an oligomerized T cell epitope
    • M. Stienekemeier, K. Falk, O. Rotzschke, A. Weishaupt, C. Schneider, and K.V. Toyka Vaccination, prevention, and treatment of experimental autoimmune neuritis (EAN) by an oligomerized T cell epitope Proc Natl Acad Sci U S A 98 2001 13872 13877
    • (2001) Proc Natl Acad Sci U S a , vol.98 , pp. 13872-13877
    • Stienekemeier, M.1    Falk, K.2    Rotzschke, O.3    Weishaupt, A.4    Schneider, C.5    Toyka, K.V.6
  • 61
  • 62
    • 34247623962 scopus 로고    scopus 로고
    • Successful immunotherapy with matrix metalloproteinase-derived peptides in adjuvant arthritis depends on the timing of peptide administration
    • J.H. van Bilsen, J.P. Wagenaar-Hilbers, M.J. van der Cammen, M.E. van Dijk, W. van Eden, and M.H. Wauben Successful immunotherapy with matrix metalloproteinase-derived peptides in adjuvant arthritis depends on the timing of peptide administration Arthritis Res 4 2002 R2
    • (2002) Arthritis Res , vol.4 , pp. 2
    • Van Bilsen, J.H.1    Wagenaar-Hilbers, J.P.2    Van Der Cammen, M.J.3    Van Dijk, M.E.4    Van Eden, W.5    Wauben, M.H.6
  • 63
    • 0025979907 scopus 로고
    • Usefulness of immunotherapy in patients with severe summer hay fever uncontrolled by antiallergic drugs
    • V.A. Varney, M. Gaga, A.J. Frew, V.R. Aber, A.B. Kay, and S.R. Durham Usefulness of immunotherapy in patients with severe summer hay fever uncontrolled by antiallergic drugs BMJ 302 1991 265 269
    • (1991) BMJ , vol.302 , pp. 265-269
    • Varney, V.A.1    Gaga, M.2    Frew, A.J.3    Aber, V.R.4    Kay, A.B.5    Durham, S.R.6
  • 64
    • 0027222095 scopus 로고
    • Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses
    • V.A. Varney, Q.A. Hamid, M. Gaga, S. Ying, M. Jacobson, and A.J. Frew Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen-induced late-phase cutaneous responses J Clin Invest 92 1993 644 651
    • (1993) J Clin Invest , vol.92 , pp. 644-651
    • Varney, V.A.1    Hamid, Q.A.2    Gaga, M.3    Ying, S.4    Jacobson, M.5    Frew, A.J.6
  • 65
    • 18244391173 scopus 로고    scopus 로고
    • T cell epitope immunotherapy induces a CD4(+) T cell population with regulatory activity
    • A. Verhoef, C. Alexander, A.B. Kay, and M. Larche T cell epitope immunotherapy induces a CD4(+) T cell population with regulatory activity PLoS Med 2 2005 e78
    • (2005) PLoS Med , vol.2 , pp. 78
    • Verhoef, A.1    Alexander, C.2    Kay, A.B.3    Larche, M.4
  • 66
    • 0028229166 scopus 로고
    • Specific T-cell tolerance may be preceded by a primary response
    • L. Vidard, L.J. Colarusso, and B. Benacerraf Specific T-cell tolerance may be preceded by a primary response Proc Natl Acad Sci U S A 91 1994 5627 5631
    • (1994) Proc Natl Acad Sci U S a , vol.91 , pp. 5627-5631
    • Vidard, L.1    Colarusso, L.J.2    Benacerraf, B.3
  • 67
    • 0032963493 scopus 로고    scopus 로고
    • Genetic engineering of recombinant hypoallergenic oligomers of the major birch pollen allergen, Bet v 1: Candidates for specific immunotherapy
    • S. Vrtala, K. Hirtenlehner, M. Susani, P. Hufnagl, B.R. Binder, and L. Vangelista Genetic engineering of recombinant hypoallergenic oligomers of the major birch pollen allergen, Bet v 1: candidates for specific immunotherapy Int Arch Allergy Immunol 118 1999 218 219
    • (1999) Int Arch Allergy Immunol , vol.118 , pp. 218-219
    • Vrtala, S.1    Hirtenlehner, K.2    Susani, M.3    Hufnagl, P.4    Binder, B.R.5    Vangelista, L.6
  • 68
    • 0030856261 scopus 로고    scopus 로고
    • Tolerance induction to myelin basic protein by intravenous synthetic peptides containing epitope P85 VVHFFKNIVTP96 in chronic progressive multiple sclerosis
    • K.G. Warren, I. Catz, and K.W. Wucherpfennig Tolerance induction to myelin basic protein by intravenous synthetic peptides containing epitope P85 VVHFFKNIVTP96 in chronic progressive multiple sclerosis J Neurol Sci 152 1997 31 38
    • (1997) J Neurol Sci , vol.152 , pp. 31-38
    • Warren, K.G.1    Catz, I.2    Wucherpfennig, K.W.3
  • 69
    • 0025602793 scopus 로고
    • Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity
    • S. Webb, C. Morris, and J. Sprent Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity Cell 63 1990 1249 1256
    • (1990) Cell , vol.63 , pp. 1249-1256
    • Webb, S.1    Morris, C.2    Sprent, J.3


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