Genetic engineering of recombinant hypoallergenic oligomers of the major birch pollen allergen, Bet v 1: Candidates for specific immunotherapy

International Archives of Allergy and Immunology

Volumn 118, Issue 2-4, 1999, Pages 218-219

  Vrtala, Susanne ^d   Hirtenlehner, Kora ^d   Susani, Markus ^b   Hufnagl, Peter ^d   Binder, Bernd R ^d   Vangelista, Luca ^a   Pastore, Annalisa ^a   Sperr, Wolfgang R ^d   Valent, Peter ^d   Ebner, Christof ^d   Kraft, Dietrich ^d   Valenta, Rudolf ^c  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b Institute of Molecular Biology Salzburg   (Austria)

^c UNIVERSITY OF VIENNA   (Austria)

^d NONE

Author keywords

Bet v 1; Birch pollen allergens; Hypoallergenic allergens; Immunotherapy; Recombinant; Skin testing; Type I allergy

Indexed keywords

ALLERGEN; OLIGOMER; POLLEN ANTIGEN; VACCINE;

CONFERENCE PAPER; GENETIC ENGINEERING; HUMAN; IMMUNOTHERAPY; POLLEN ALLERGY; PRIORITY JOURNAL; SKIN TEST;

EID: 0032963493     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000024075     Document Type: Conference Paper

References (8)

1. Jarolim E, Rumpold H, Endler AT, Ebner H, Breitenbach M, Scheiner O, Kraft D: IgE and IgG antibodies of patients with allergy to birch as tools to define the allergen profile of Betula verrucosa. Allergy 1989;44:385-395.
2. Breiteneder H, Pettenburger K, Bito A, Valenta R, Kraft D, Rumpold H, Scheiner O, Breitenbach M: The gene coding for the major birch pollen allergen Bet v 1, is highly homologous to a pea disease resistance response gene. EMBO J 1989;8:1935-1938.
3. Valenta R, Duchêne M, Vrtala S, Birkner T, Ebner C, Hirschwehr R, Breitenbach M, Rumpold H, Scheiner O, Kraft D: Recombinant allergens for immunoblot diagnosis of tree pollen allergy. J Allergy Clin Immunol 1991;88:889-894.
4. Niederberger V, Pauli G, Grönlund H, Fröschl R, Rumpold H, Kraft D, Valenta R, Spitzauer S: Recombinant birch pollen allergens (rBet v 1, rBet v 2) contain most of the IgE epitopes present in birch, alder, hornbeam, hazel and oak pollen: A quantitative IgE inhibition study using sera from different populations. J Allergy Clin Immunol 1998;102:579-591.
5. Ebner C, Hirschwehr R, Bauer L, Breiteneder H, Valenta R, Ebner H, Kraft D, Scheiner O: Identification of allergens in fruits and vegetables: IgE crossreactivities with the important birch pollen allergens Bet v 1 and Bet v 2 (birch profilin). J Allergy Clin Immunol 1995;95:962-969.
6. Vrtala S, Hirtenlehner K, Vangelista L, Pastore A, Eichler H-G, Sperr WR, Valent P, Ebner C, Kraft D. Valenta R: Conversion of the major birch pollen allergen, Bet v 1, into two nonanaphylactic T cell epitope-containing fragments. Candidates for a novel form of specific immunotherapy. J Clin Invest 1997;99:1673-1681.
7. Pauli G, Purohit A, Oster JP, Vrtala S, Niederberger V, Kraft D, Valenta R: Clinical evaluation of genetically engineered hypoallergenic rBet v 1 derivatives. Int Arch Allergy Immunol 1999;in press.
8. Valenta R, Almo S, Ball T, Dolecek C, Steinberger P, Laffer S, Eibensteiner P, Flicker S, Vrtala S, Spitzauer S, Valent P, Denepoux S, Kraft D, Banchereau J, Lebecque S: The immunoglobulin E-allergen interaction: A target for therapy of type I allergic diseases. Int Arch Allergy Immunol 1998;116:167-176.