메뉴 건너뛰기




Volumn 77, Issue 1, 1997, Pages 405-420

Computer simulation of the responses of human motoneurons to composite 1A EPSPS: Effects of background firing rate

Author keywords

[No Author keywords available]

Indexed keywords

POTASSIUM CHANNEL; SODIUM CHANNEL;

EID: 0031037161     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1997.77.1.405     Document Type: Article
Times cited : (46)

References (51)
  • 1
    • 0019975130 scopus 로고
    • Characteristics of postsynaptic potentials produced in single human motoneurons by homonymous group I volleys
    • ASHBY, P. AND ZILM, D. Characteristics of postsynaptic potentials produced in single human motoneurons by homonymous group I volleys. Exp. Brain Res. 47: 41-48, 1982.
    • (1982) Exp. Brain Res. , vol.47 , pp. 41-48
    • Ashby, P.1    Zilm, D.2
  • 2
    • 0016270293 scopus 로고
    • Firing behaviour of a neurone model based on the afterhyperpolarization conductance time course. First inter- Val firing
    • BALDISSERA, F. AND GUSTAFSSON, B. Firing behaviour of a neurone model based on the afterhyperpolarization conductance time course. First inter- val firing. Acta Physiol. Scand. 91: 528-544, 1974a.
    • (1974) Acta Physiol. Scand. , vol.91 , pp. 528-544
    • Baldissera, F.1    Gustafsson, B.2
  • 3
    • 0016263627 scopus 로고
    • Firing behaviour of a neuron model based on the afterhyperpolarization conductance time course and algebraic summation. Adaptation and steady state firing
    • BALDISSERA, F. AND GUSTAFSSON, B. Firing behaviour of a neuron model based on the afterhyperpolarization conductance time course and algebraic summation. Adaptation and steady state firing. Acta Physiol. Scand. 92: 27-47, 1974b
    • (1974) Acta Physiol. Scand. , vol.92 , pp. 27-47
    • Baldissera, F.1    Gustafsson, B.2
  • 4
    • 0018911160 scopus 로고
    • Voltage-sensitive outward currents in cat motoneurones
    • BARRETT, E. F., BARRETT, J. N., AND CRILL, W. E. Voltage-sensitive outward currents in cat motoneurones. J. Physiol. Lond, 304: 251-276, 1980.
    • (1980) J. Physiol. Lond , vol.304 , pp. 251-276
    • Barrett, E.F.1    Barrett, J.N.2    Crill, W.E.3
  • 5
    • 0018911159 scopus 로고
    • Voltage clamp of cat motoneurone soma: Properties of the fast inward current
    • BARRETT, J. N. AND CRILL, W. E. Voltage clamp of cat motoneurone soma: properties of the fast inward current. J. Physiol. Lond. 304: 231-249, 1980.
    • (1980) J. Physiol. Lond. , vol.304 , pp. 231-249
    • Barrett, J.N.1    Crill, W.E.2
  • 6
    • 0027524918 scopus 로고
    • Recruitment of motor units in response to transcranial magnetic stimulation in man
    • BAWA, P. AND LEMON, R. N. Recruitment of motor units in response to transcranial magnetic stimulation in man. J. Physiol. Lond. 471: 445-464, 1993.
    • (1993) J. Physiol. Lond. , vol.471 , pp. 445-464
    • Bawa, P.1    Lemon, R.N.2
  • 7
    • 0024504350 scopus 로고
    • Excitability of corticospiral neurons during tonic muscle contractions in man
    • BROUWER, B., ASHBY, P., AND MIDRONI, G. Excitability of corticospiral neurons during tonic muscle contractions in man. Exp. Brain Res. 74: 649-652, 1989.
    • (1989) Exp. Brain Res. , vol.74 , pp. 649-652
    • Brouwer, B.1    Ashby, P.2    Midroni, G.3
  • 8
    • 1842377460 scopus 로고
    • Analysis by Intracellular Recording
    • Seattle, WA: University of Washington
    • CALVIN, W. H. Motoneuron Input-Output Mechanisms: Analysis by Intracellular Recording (PhD thesis). Seattle, WA: University of Washington, 1966.
    • (1966) Motoneuron Input-Output Mechanisms
    • Calvin, W.H.1
  • 9
    • 0015944935 scopus 로고
    • Three modes of repetitive firing and the role of threshold time course between spikes
    • CALVIN, W. H. Three modes of repetitive firing and the role of threshold time course between spikes. Brain Res. 69: 341-346, 1974.
    • (1974) Brain Res , vol.69 , pp. 341-346
    • Calvin, W.H.1
  • 10
    • 0014307547 scopus 로고
    • Synaptic noise and other sources of randomness in motoneuron interspike intervals
    • CALVIN, W. H. AND STEVENS, C. F. Synaptic noise and other sources of randomness in motoneuron interspike intervals. J. Neurophysiol. 31: 574-587, 1968.
    • (1968) J. Neurophysiol. , vol.31 , pp. 574-587
    • Calvin, W.H.1    Stevens, C.F.2
  • 11
    • 0014591232 scopus 로고
    • Statistical analysis of motor unit firing patterns in a human skeletal muscle
    • CLAMANN, H. P. Statistical analysis of motor unit firing patterns in a human skeletal muscle. Biophys. J. 9: 1233-1251, 1969.
    • (1969) Biophys. J. , vol.9 , pp. 1233-1251
    • Clamann, H.P.1
  • 12
    • 0024552702 scopus 로고
    • Cable properties of cat spinal motoneurones measured by combining voltage clamp, current clamp and intracellular staining
    • CLEMENTS, J. D. AND REDMAN, S. J. Cable properties of cat spinal motoneurones measured by combining voltage clamp, current clamp and intracellular staining. J. Physiol. Lond. 409: 63-87, 1989.
    • (1989) J. Physiol. Lond. , vol.409 , pp. 63-87
    • Clements, J.D.1    Redman, S.J.2
  • 13
    • 0023253109 scopus 로고
    • Cross-correlation assessment of synaptic strength of single fiber connections with triceps surae motoneurones in cats
    • COPE, T. C., FETZ, E. E., AND MATSUMURA, M. Cross-correlation assessment of synaptic strength of single fiber connections with triceps surae motoneurones in cats. J. Physiol. Lond. 390: 161-188, 1987.
    • (1987) J. Physiol. Lond. , vol.390 , pp. 161-188
    • Cope, T.C.1    Fetz, E.E.2    Matsumura, M.3
  • 14
    • 0023200815 scopus 로고
    • Membrane area and dendritic structure in type-identified triceps surae alpha motoneurons
    • CULLHEIM, S., FLESHMAN, J. W., GLENN, L. L., AND BURKE, R. E. Membrane area and dendritic structure in type-identified triceps surae alpha motoneurons. J. Comp. Neurol. 255: 68-81, 1987.
    • (1987) J. Comp. Neurol. , vol.255 , pp. 68-81
    • Cullheim, S.1    Fleshman, J.W.2    Glenn, L.L.3    Burke, R.E.4
  • 15
    • 0024601114 scopus 로고
    • Computer software for development and simulation of compartmental models of neurons
    • DE SCHUTTER, E. Computer software for development and simulation of compartmental models of neurons. Comput. Biol. Med. 19: 71-81, 1989.
    • (1989) Comput. Biol. Med. , vol.19 , pp. 71-81
    • De Schutter, E.1
  • 16
    • 0015794804 scopus 로고
    • Action potential of the motorneuron
    • DODGE, F. A., JR. AND COOLEY, J. W. Action potential of the motorneuron. IBM J. Res. Dev. 17: 219-229, 1973.
    • (1973) IBM J. Res. Dev. , vol.17 , pp. 219-229
    • Dodge Jr., F.A.1    Cooley, J.W.2
  • 17
    • 0020642933 scopus 로고
    • Relation between shapes of post-synaptic potentials and changes in firing probability of cat moloneurons
    • FETZ, E. E. AND GUSTAFSSON, B. Relation between shapes of post-synaptic potentials and changes in firing probability of cat moloneurons. J. Physiol. Lond. 341: 387-410, 1983.
    • (1983) J. Physiol. Lond. , vol.341 , pp. 387-410
    • Fetz, E.E.1    Gustafsson, B.2
  • 18
    • 0020644138 scopus 로고
    • The synaptic current evoked in cat spinal motoneurones by impulses in single group la axons
    • FINKEL, A. S. AND REDMAN, S. J. The synaptic current evoked in cat spinal motoneurones by impulses in single group la axons. J. Physiol. Lond. 342: 615-632, 1983.
    • (1983) J. Physiol. Lond. , vol.342 , pp. 615-632
    • Finkel, A.S.1    Redman, S.J.2
  • 19
    • 0023733789 scopus 로고
    • Electrotonic architecture of type-identified α-motoneurons in the cat spinal cord
    • FLESHMAN, J. W., SEGEV, I., AND BURKE, R. E. Electrotonic architecture of type-identified α-motoneurons in the cat spinal cord. J. Neurophysiol. 60: 60-85, 1988.
    • (1988) J. Neurophysiol. , vol.60 , pp. 60-85
    • Fleshman, J.W.1    Segev, I.2    Burke, R.E.3
  • 20
    • 0021286976 scopus 로고
    • Influence of stretch-evoked synaptic potentials on firing probability of cat spinal motoneurones
    • GUSTAFSSON, B. AND MCCREA, D. Influence of stretch-evoked synaptic potentials on firing probability of cat spinal motoneurones. J. Physiol. Lond. 347: 431-451, 1984.
    • (1984) J. Physiol. Lond. , vol.347 , pp. 431-451
    • Gustafsson, B.1    Mccrea, D.2
  • 21
    • 35649001607 scopus 로고
    • A quantitative description of membrane current and its application to conduction and excitation in nerve
    • HODGKIN, A. L. AND HUXLEY, A. F. A quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. Lond. 117: 500-544, 1952.
    • (1952) J. Physiol. Lond. , vol.117 , pp. 500-544
    • Hodgkin, A.L.1    Huxley, A.F.2
  • 23
    • 0029621195 scopus 로고
    • Responses of human motoneurons to la inputs: Effects of background firing rate
    • JONES, K. E. AND BAWA, P. Responses of human motoneurons to la inputs: effects of background firing rate. Can. J. Physiol Pharmacol 73: 1224-1234, 1995.
    • (1995) Can. J. Physiol Pharmacol , vol.73 , pp. 1224-1234
    • Jones, K.E.1    Bawa, P.2
  • 24
    • 0013568561 scopus 로고    scopus 로고
    • Active membrane models of type-identified cat spinal motoneurons
    • JONES, K. E. AND BAWA, P. Active membrane models of type-identified cat spinal motoneurons. Can. J. Physiol. Pharmacol. 74: Axvi, 1996a.
    • (1996) Can. J. Physiol. Pharmacol. , vol.74
    • Jones, K.E.1    Bawa, P.2
  • 25
    • 0013567982 scopus 로고    scopus 로고
    • Simulating human data with a motoneuron model
    • JONES, K. E. AND BAWA, P. Simulating human data with a motoneuron model. Can. J. Physiol. Pharmacol. 74: Axvii, 1996b.
    • (1996) Can. J. Physiol. Pharmacol. , vol.74
    • Jones, K.E.1    Bawa, P.2
  • 26
    • 0000938182 scopus 로고
    • Time course of excitability changes of human α-motoneurones following single spikes and doublets
    • edited by A. Taylor, M. Gladden, and R. Durbaba. New York: Plenum
    • JONES K. E., CALANOT, B., HALL, A., AND BAWA, P. Time course of excitability changes of human α-motoneurones following single spikes and doublets. In: Alpha and Gamma Motor Sytems, edited by A. Taylor, M. Gladden, and R. Durbaba. New York: Plenum, 1995, p. 103-105.
    • (1995) Alpha and Gamma Motor Sytems , pp. 103-105
    • Jones, K.E.1    Calanot, B.2    Hall, A.3    Bawa, P.4
  • 27
    • 84979126209 scopus 로고
    • High-frequency repetitive firing of cat lumbosacral motoneurones stimulated by long-lasting injected curents
    • KERNELL, D. High-frequency repetitive firing of cat lumbosacral motoneurones stimulated by long-lasting injected curents. Acta Physiol. Scand. 65: 74-86, 1965a.
    • (1965) Acta Physiol. Scand. , vol.65 , pp. 74-86
    • Kernell, D.1
  • 28
    • 84979101010 scopus 로고
    • The limits of firing frequency in cat lumbosacral motoneaurones possessing different time course of afterhyperpolarization
    • KERNELL, D. The limits of firing frequency in cat lumbosacral motoneaurones possessing different time course of afterhyperpolarization. Acta Physiol. Scand. 65: 87-100, 1965b.
    • (1965) Acta Physiol. Scand. , vol.65 , pp. 87-100
    • Kernell, D.1
  • 29
    • 0015453710 scopus 로고
    • Motoneurone models based on voltage clamp equations for peripheral nerve
    • KERNELL, D. AND SJÖHOLM, H. Motoneurone models based on voltage clamp equations for peripheral nerve. Acta Physiol. Scand. 86: 546-562, 1972.
    • (1972) Acta Physiol. Scand. , vol.86 , pp. 546-562
    • Kernell, D.1    Sjöholm, H.2
  • 30
    • 0017904446 scopus 로고
    • EGTA and motoneuronal after potentials
    • KRNJEVIC, K., PUIL, E., AND WERMAN, R. EGTA and motoneuronal after potentials. J. Physiol. Lond. 275: 199-223, 1978.
    • (1978) J. Physiol. Lond. , vol.275 , pp. 199-223
    • Krnjevic, K.1    Puil, E.2    Werman, R.3
  • 31
    • 0029917628 scopus 로고    scopus 로고
    • Relationship of firing intervals of human motor units to the trajectory of post-spike afterhyperpolarization
    • MATTHEWS, P. B. C. Relationship of firing intervals of human motor units to the trajectory of post-spike afterhyperpolarization. J. Physiol. Lond. 492: 597-628, 1996.
    • (1996) J. Physiol. Lond. , vol.492 , pp. 597-628
    • Matthews, P.B.C.1
  • 32
    • 0024342454 scopus 로고
    • Ia reflexes and EPSPs in human soleus motor neurons
    • MILES, T. S., TURKER, K. S., AND LE, T. H. Ia reflexes and EPSPs in human soleus motor neurons. Exp. Brain Res. 77: 628-636, 1989.
    • (1989) Exp. Brain Res. , vol.77 , pp. 628-636
    • Miles, T.S.1    Turker, K.S.2    Le, T.H.3
  • 33
    • 0016189650 scopus 로고
    • On numerical integration of the Hodgkin and Huxley equations for a membrane action potential
    • MOORE, J. W., AND RAMON, F. On numerical integration of the Hodgkin and Huxley equations for a membrane action potential. J. Theor. Biol. 45: 249-273, 1974.
    • (1974) J. Theor. Biol. , vol.45 , pp. 249-273
    • Moore, J.W.1    Ramon, F.2
  • 34
    • 0014046501 scopus 로고
    • Delayed depolarization in cat spinal motoneurons
    • NELSON, P. G. AND BURKE, R. E. Delayed depolarization in cat spinal motoneurons. Exp. Neurol. 17: 16-26, 1967.
    • (1967) Exp. Neurol. , vol.17 , pp. 16-26
    • Nelson, P.G.1    Burke, R.E.2
  • 35
    • 0029035199 scopus 로고
    • Responses to transcramal magnetic stimulation of human motoneurons at different firing rates
    • OLIVIER, E., BAWA, P., AND LEMON, R. N. Responses to transcramal magnetic stimulation of human motoneurons at different firing rates. J. Physiol. Lond. 485: 257-269, 1995.
    • (1995) J. Physiol. Lond. , vol.485 , pp. 257-269
    • Olivier, E.1    Bawa, P.2    Lemon, R.N.3
  • 36
    • 0026563215 scopus 로고
    • Corticospinal projections to upper limb motoneurones in humans
    • PALMER, E. AND ASHBY, P. Corticospinal projections to upper limb motoneurones in humans. J. Physiol. Lond. 448: 397-412, 1992.
    • (1992) J. Physiol. Lond. , vol.448 , pp. 397-412
    • Palmer, E.1    Ashby, P.2
  • 37
    • 0015333468 scopus 로고
    • Discharge frequency and discharge pattern of human motor units during voluntary contraction of muscle
    • PERSON, R. S. AND KUDINA, L. P. Discharge frequency and discharge pattern of human motor units during voluntary contraction of muscle. EEC Clin. Neurophysiol. 32: 471-483, 1972.
    • (1972) EEC Clin. Neurophysiol. , vol.32 , pp. 471-483
    • Person, R.S.1    Kudina, L.P.2
  • 38
    • 0027185242 scopus 로고
    • A variable-threshold motoneuron model that incorporates time-and voltage-dependant potassium and calcium conductances
    • POWERS, R. K. A variable-threshold motoneuron model that incorporates time-and voltage-dependant potassium and calcium conductances. J. Neurophysiol. 70: 246-262, 1993.
    • (1993) J. Neurophysiol. , vol.70 , pp. 246-262
    • Powers, R.K.1
  • 39
    • 0027217559 scopus 로고
    • Two modes of interspace interval shortening by brief transient depolarizations in cat neocortical neurons
    • REYES, A. D. AND FETZ, E. E. Two modes of interspace interval shortening by brief transient depolarizations in cat neocortical neurons. J. Neurophysiol 69: 1661-1672, 1993.
    • (1993) J. Neurophysiol , vol.69 , pp. 1661-1672
    • Reyes, A.D.1    Fetz, E.E.2
  • 40
    • 0029670122 scopus 로고    scopus 로고
    • + currents in neurones: Types, physiological roles and modualtion
    • + currents in neurones: types, physiological roles and modualtion. Trends Neurosci. 19: 150-154, 1996.
    • (1996) Trends Neurosci , vol.19 , pp. 150-154
    • Sah, P.1
  • 41
    • 0015337411 scopus 로고
    • Membrane-potential trajectories between spikes underlying motoneuron firing rates
    • SCHWINDT, P. C. AND CALVIN, W. H. Membrane-potential trajectories between spikes underlying motoneuron firing rates. J. Neurophysiol. 35: 311-325, 1972.
    • (1972) J. Neurophysiol. , vol.35 , pp. 311-325
    • Schwindt, P.C.1    Calvin, W.H.2
  • 42
    • 0015755791 scopus 로고
    • Nature of conductances underlying the rhythmic firing in cat spinal motoneurons
    • SCHWINDT P. C. AND CALVIN, W. H. Nature of conductances underlying the rhythmic firing in cat spinal motoneurons. J. Neurophysiol. 36: 955-973, 1973.
    • (1973) J. Neurophysiol. , vol.36 , pp. 955-973
    • Schwindt, P.C.1    Calvin, W.H.2
  • 43
    • 0026671249 scopus 로고
    • Single neuron models: Oversimple, complex and reduced
    • SEGEV, I. Single neuron models: oversimple, complex and reduced. Trends Neurosci. 15: 414-421, 1992.
    • (1992) Trends Neurosci. , vol.15 , pp. 414-421
    • Segev, I.1
  • 44
    • 0002257305 scopus 로고
    • Compartmental models of complex neurons
    • edited by C. Koch and I. Segev. Cambridge, MA: MIT Press
    • SEGEV, I. FLESHMAN, J. W., AND BURKE, R. E. Compartmental models of complex neurons. In: Methods in Neuronal Modeling, edited by C. Koch and I. Segev. Cambridge, MA: MIT Press, 1989, p. 63-96.
    • (1989) Methods in Neuronal Modeling , pp. 63-96
    • Segev, I.1    Fleshman, J.W.2    Burke, R.E.3
  • 45
    • 0025085615 scopus 로고
    • Computer simulation of group la EPSPs using morphologically realistic models of cat α-motoneurons
    • SEGEV, I., FLESHMAN, J. W., AND BURKE, R. E. Computer simulation of group la EPSPs using morphologically realistic models of cat α-motoneurons. J. Neurophysiol. 64: 648-660, 1990.
    • (1990) J. Neurophysiol. , vol.64 , pp. 648-660
    • Segev, I.1    Fleshman, J.W.2    Burke, R.E.3
  • 46
    • 0022387704 scopus 로고
    • Modeling the electrical behavior of anatomically complex neurons using a network analysis program: Passive membrane
    • SEGEV, I., FLESHMAN, J. W., MILLER, J. P., AND BUNOW, B. Modeling the electrical behavior of anatomically complex neurons using a network analysis program: passive membrane. Biol. Cybern. 53: 27-40, 1985.
    • (1985) Biol. Cybern. , vol.53 , pp. 27-40
    • Segev, I.1    Fleshman, J.W.2    Miller, J.P.3    Bunow, B.4
  • 47
    • 0017345549 scopus 로고
    • Motoneurons of different geometry and the size principle
    • TRAUB, R. D. Motoneurons of different geometry and the size principle. Biol Cybern. 25: 163-176, 1977.
    • (1977) Biol Cybern. , vol.25 , pp. 163-176
    • Traub, R.D.1
  • 48
    • 0001138509 scopus 로고
    • The spatial distribution of ionic conductances in normal and axotomized motorneurons
    • TRAUB, R. D. AND LLINÁS, R. The spatial distribution of ionic conductances in normal and axotomized motorneurons. Neuroscience 2: 829-849, 1977.
    • (1977) Neuroscience , vol.2 , pp. 829-849
    • Traub, R.D.1    Llinás, R.2
  • 49
    • 0024517399 scopus 로고
    • Effects of spatial and temporal dispersion of synaptic inputs on the time course of synaptic potentials
    • WALMSLEY, B. AND STUKLIS, R. Effects of spatial and temporal dispersion of synaptic inputs on the time course of synaptic potentials. J. Neurophysiol. 61: 681-687, 1989.
    • (1989) J. Neurophysiol. , vol.61 , pp. 681-687
    • Walmsley, B.1    Stuklis, R.2
  • 50
    • 0023089192 scopus 로고
    • Apamin depresses selectively the afterhyperpolarization of cat spinal motoneurones
    • ZHANG, L. AND KRNJEVIC, K. Apamin depresses selectively the afterhyperpolarization of cat spinal motoneurones. Neurosci. Lett. 74: 58-62, 1987.
    • (1987) Neurosci. Lett. , vol.74 , pp. 58-62
    • Zhang, L.1    Krnjevic, K.2
  • 51
    • 0021816236 scopus 로고
    • Membrane electrical properties and prediction of motor-unit type of medial gastrocnemius motoneurons in the cat
    • ZENGEL, J. E., REID, S. A., SYPERT, G. W., AND MUNSON, J. B. Membrane electrical properties and prediction of motor-unit type of medial gastrocnemius motoneurons in the cat. J. Neurophysiol. 53: 1323-1344, 1985.
    • (1985) J. Neurophysiol. , vol.53 , pp. 1323-1344
    • Zengel, J.E.1    Reid, S.A.2    Sypert, G.W.3    Munson, J.B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.