Therapeutic approaches to organ preservation injury

Expert Opinion on Therapeutic Patents

Volumn 15, Issue 11, 2005, Pages 1489-1496

  Laight, David W ^a  

^a UNIVERSITY OF PORTSMOUTH   (United Kingdom)

Author keywords

Cold injury; Ischaemia; Organ preservation; Reperfusion; Transplantation

Indexed keywords

4 HYDROXYBUTYRIC ACID; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENOSINE DEAMINASE INHIBITOR; ANTIOXIDANT; APOPTOSIS INHIBITOR; BACTENECIN; BRADYKININ; CALCIUM CHANNEL BLOCKING AGENT; CELSIOR; COLLINS SOLUTION; DEFEROXAMINE; ENDOTHELIN RECEPTOR ANTAGONIST; EURO COLLINS SOLUTION; FLUOROCARBON; GLYCERYL TRINITRATE; GLYCINE; HTK SOLUTION; LAZAROID; LINSIDOMINE; MACROGOL; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NITRIC OXIDE DONOR; OPIATE; PRESERVATION SOLUTION; S NITROSOGLUTATHIONE; SELENOPROTEIN P; ST THOMAS HOSPITAL SOLUTION; TIRILAZAD; UNINDEXED DRUG; UNIVERSITY OF WISCONSIN SOLUTION;

ALLOGRAFT; ANGIOPLASTY; CELL METABOLISM; COLD INJURY; CORONARY ARTERY BYPASS GRAFT; CRYOPRESERVATION; DRUG MECHANISM; EXPLANT; HUMAN; HYPOTHERMIA; ISCHEMIA; MICROCIRCULATION; NERVE CELL LESION; NONHUMAN; ORGAN DONOR; ORGAN INJURY; ORGAN PRESERVATION; ORGAN TRANSPLANTATION; OXIDATIVE STRESS; PHENOTYPE; PROTECTION; REPERFUSION INJURY; REVIEW; STENT; SURGICAL TECHNIQUE;

EID: 27944474821     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543776.15.11.1489     Document Type: Review

References (108)

1. COLLINS BH: Organ transplantation. Ann. Surg. (2003) 238:S72-S89.
2. MCLAREN AJ, FRIEND PJ: Trends in organ preservation. Transpl. Int. (2003) 16:701-708.
3. STOREY KB: Cold ischemic organ preservation: lessons from natural systems. J. Invest. Med. (2004) 52:315-322.
4. SOUTHARD JH, BELZER FO: Organ preservation. Annu. Rev. Med. (1995) 46:235-247.
5. MÜHLBACHER F, LANGER F, MITTERMAYER C: Preservation solutions for transplantation. Transpl. Proc. (1999) 31:2069-2070.
6. 'T HART NA, LEUVENINK HG, PLOEG RJ: New solutions in organ preservation. Transpl. Rev. (2002) 16:131-141.
7. NYDEGGER UE, CARREL T, LAUMONIER T et al.: New concepts in organ preservation. Transpl. Immunol. (2002) 9:215-225.
8. CHEN FS, NAKAMURA T, WADA H: Development of new organ preservation solutions in Kyoto University. Yonsei Med. J. (2004) 45:1107-1114.
9. SALAHUDEEN AK: Cold ischemic injury of transplanted kidneys: new insights from experimental studies. Am. J. Physiol. Renal Physiol. (2004) 287:F181-F187.
10. REDDY S, GREENWOOD J, MANIAKIN SB et al.: Non-heart-beating donor porcine livers: the adverse effect of cooling. Liver Transpl. (2005) 11:35-38.
11. RAUEN U, DE GROOT H: Mammalian cell injury induced by hypothermia - the emerging role for reactive oxygen species. Biol. Chem. (2002) 383:477-488.
12. RIVARD AL, GALLEGOS RP, BIANCO R et al.: The basic science aspect of donor heart preservation: a review. J. Am. Soc. Extra Corp. Tech. (2004) 36:269-274.
13. AL-QATTAN MM: Ischaemia-reperfusion injury. J. Hand Surg. (1998) 23B:570-573.
14. WILHELM MJ, PRATSCHKE J, LASKOWSKI I et al.: Ischemia and reperfusion injury. Transpl. Rev. (2003) 17:140-157.
15. LAND WG: The role of postischemic reperfusion injury and other nonantigen-dependent inflammatory pathways in transplantation. Transplantation (2005) 79:505-514.
16. CUZZOCREA S, RILEY DP, CAPUTI AP et al.: Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischaemia/reperfusion injury. Pharmacol. Rev. (2001) 53:135-159.
17. BHAUMIK G, SRIVASTAVA KK, SELVAMURTHY W et al.: The role of free radicals in cold injuries. Int. J. Biometeorol. (1995) 38:171-175.
18. IRIE H, KATO T, IKEBE K et al.: Antioxidant effect of MCI-186, a new free radical scavenger, on ischemia-reperfusion injury in a rat hindlimb amputation model. J. Surg. Res. (2003) 120:312-319.
19. ABE T, UNNO M, TAKEUCHI H et al.: A new free radical scavenger, edaravone, ameliorates oxidative liver damage due to ischemia-reperfusion in vitro and in vivo. J. Gastrointest. Surg. (2004) 8:604-615.
20. ITO K, OZASA H, HORIKAWA S: Edaravone protects against lung injury induced by intestinal ischaemia/reperfusion in rat. Free Rad. Biol. Med. (2004) 38:369-374.
21. GHISLENI G, PORCIÚNCULA LO, CIMAROSTI H et al.: Diphenyl diselenide protects rat hippocampal slices submitted to oxygen-glucose deprivation and diminishes inducible nitric oxide synthase immunocontent. Brain Res. (2003) 986:196-199.
22. TEŠKA V, KUNTSCHER V, HASMAN D et al.: Importance of selenium for the influence of ischemia-reperfusion syndrome after kidney transplantation from a non-heart beating donor in a pig model. Transpl. Proc. (2002) 34:3057-3059.
23. TEŠKA V, KUNTSCHER, V MOLÁEK J et al.: Can ischemia-reperfusion syndrome in transplanted kidneys procured from non-heart beating donors be influenced by adding selenium into the reperfusion solution? An experimental study. Transpl. Proceed. (2003) 35:3125-3127.
24. HORWITZ LD: Bucillamine: a potent thiol donor with multiple clinical applications. Cardiovasc. Drug Rev. (2003) 21:77-90.
25. NAKAO A, NETO JS, KANNO S et al.: Protection against ischemia/reperfusion injury in cardiac and renal transplantation with carbon monoxide, biliverdin and both. Am. J. Transpl. (2005) 5:282-291.
26. KATORI M, BUSUTTIL RW, KUPIEC-WEGLINSKI JW: Heme oxygenase-1 system in organ transplantation. Transpl. (2002) 74:905-912.
27. OTTERBEIN LE: Carbon monoxide: innovative anti-inflammatory properties of an age-old gas molecule. Antioxid. Redox Signal. (2002) 4:309-319.
28. TSUCHIHASHI S, FONDEVILA C, KUPIEC-WEGLINSKI JW: Heme oxygenase system in ischemia and reperfusion injury. Ann. Transpl. (2004) 9:84-87.
29. VILLA RF, GORNI A: Pharmacology of lazaroids and brain energy metabolism: a review. Pharmacol. Rev. (1997) 49:99-136.
30. KAVANAGH RJ, KAM PC: Lazaroids: efficacy and metabolism of action of the 21-aminosteroids in neuroprotection. Br. J. Anaesthesia (2001) 86:110-119.
31. GARVIN PJ, NIEHOFF ML, ROBINSON SM et al.: Renoprotective effects of the 21-aminosteroid U74389G in ischemia-reperfusion injury and cold storage preservation. Transplantation (1997) 63:194-201.
32. DUGUAY P, CHEN H, DALOZE P et al.: Cardioprotective effects of the lazaroid U74389G following cold preservation and transplantation of rat hearts. Transplantation (1996) 61:1023-1028.
33. SHERMAN IA, SAIBIL FG, JANOSSY TI: γ-Hydroxybutyrate mediated protection of liver function after long-term hypothermic storage. Transplantation (1994) 57:8-11.
34. YAMASAKI N, OKA T, YAMAMOTO S et al.: Twenty-four hour preservation in γ-hydroxybutyrate improves lung function in a canine single-lung allotransplantation. Transplantation (1999) 67:529-533.
35. BOYD AJ, SHERMAN LA, SAIBIL FG et al.: The protective effect of γ-hydroxybutyrate in regional intestinal ischaemia in the hamster. Gastroenterology (1990) 99:860-862.
36. ZHONG Z, WHEELER WD, LI X et al.: L-glycine: a novel anti-inflammatory, immunomodulatory, and cytoprotective agent. Curr. Opin. Clin. Nutr. Metab. Care (2003) 6:229-240.
37. THURMAN RG, SCHEMMER P, ZHONG Z et al.: Kupffer cell-dependent reperfusion injury in liver transplantation: new clinically relevant use of glycine. Langenbecks Arch. Chir. Suppl. Kongressbd (1998) 115:185-190.
38. WEINBERG JM, DAVIS JA, ABARZUA M et al.: Cytoprotective effects of glycine and glutathione against hypoxic injury to renal tubes. J. Clin. Invest. (1987) 80:1446-1454.
39. MANGINO MJ, MURPHY MK, GRABAU GG et al.: Protective effects of glycine during hypothermic renal ischemia-reperfusion injury. Am. J. Physiol. (1991) 261:F841-F848.
40. LEE, W-C, JENG, L-B, LIN PJ et al.: Nitric oxide donor improved endothelium-dependent relaxation of canine hepatic artery after preservation with UW solution. Transpl. Proceed. (2000) 32:2306-2307.
41. BAXTER K, HOWDEN B, SAUNDER A et al.: Improved cardiac preservation by the addition of nitroglycerine to colloid-free University of Wisconsin solution (MUW). J. Heart Lung Transpl. (1999) 18:769-774.
42. QUINTANA AB, LENZI HL, ALMAD LL et al.: Effect of S-nitrosoglutathione (GSNO) added to the University of Wisconsin solution (UW): functional response to cold preservation/reperfusion of rat liver. Ann. Hepatol. (2002) 1:183-191.
43. MCANULTY JF, FOLEY JD, REID TW et al.: Suppression of cold ischemic injury in stored kidneys by the antimicrobial peptide bactenecin. Cryobiology (2004) 49:230-240.
44. HAUET T, GOUJON JM, BAUMERT H et al.: Polyethylene glycol reduces the inflammatory injury to cold ischemia/reperfusion in autotransplanted pig kidneys. Kid. Int. (2002) 62:654-667.
45. MATSUMOTO S: Clinical application of perfluorocarbons for organ preservation. Artif. Cells Blood Substit. Immobil. Biotechnol. (2005) 33:75-82.
46. HANSEN TN, DAWSON PE, BROCKBANK KG: Effects of hypothermia upon endothelial cells: mechanisms and clinical importance. Cryobiology (1994) 31:101-106.
47. KEVELAITIS E, NYBORG NC, MENASCHÉ P: Coronary endothelial dysfunction of isolated hearts subjected to prolonged cold storage: patterns and contributing factors. Ann. Thorac. Surg. (1997) 63:20-27.
48. LAUDE K, BEAUCHAMP P, THUILLEZ C et al.: Endothelial protective effects of preconditioning. Cardiovasc. Res. (2002) 55:466-473.
49. STOICA SC, GODDARD M, LARGE SR: The endothelium in clinical cardiac transplantation. Ann. Thorac. Surg. (2002) 73:1002-1008.
50. PAROLARI A, RUBINI P, CANNATA A et al.: Endothelial damage during myocardial preservation and storage. Ann. Thorac. Surg. (2002) 73:682-690.
51. KANG DH, KANG SW, JEONG HJ et al.: Transplant graft vasculopathy: an emerging target for prevention and treatment of renal allograft dysfunction. Yonsei Med. J. (2004) 45:1053-1058.
52. RUEL M, KHAN TA, VOISINE P et al.: Vasomotor dysfunction after cardiac surgery. Eur. J. Cardiothoracic Surg. (2004) 26:1002-1014.
53. REDONDO J, MANSO AM, PACHECO ME et al.: Hypothermic storage of coronary endothelial cells reduces nitric oxide synthase activity and expression. Cryobiolagy (2000) 41:292-300.
54. ZOU W, YANG Q, YIM AP et al.: Impaired endothelium-derived hyperpolarising factor-mediated relaxation in porcine pulmonary microarteries after cold storage with Euro-Collins and University of Wisconsin solutions. Cardiothorac. Transpl. (2003) 126:208-215.
55. YANG Q, ZHANG R-Z, YIM AP et al.: Histidine-tryptophan-ketoglutarate solution maximally preserves endothelium-derived hyperpolarizing factor-mediated function during heart preservation: comparison with University of Wisconsin solution. J. Heart Lung. Transpl. (2004) 23:352-359.
56. WILSON CH, STANSBY G, HASWELL M et al.: Evaluation of eight preservation solutions for endothelial in situ preservation. Transplantation (2004) 78:1008-1013.
57. CHU Y, WU YC, CHOU YC et al.: Endothelium-dependent relaxation of canine pulmonary artery after prolonged lung graft preservation in University of Wisconsin solution: role of L-arginine supplementation. J. Heart Lung Transpl. (2004) 23:592-598.
58. MOHARA J, OSHIMA K, TSUTSUMI H et al.: FK409 ameliorates ischemia-reperfusion injury following 12-hour cold preservation. J. Heart Lung. Transpl. (2000) 19:694-700.
59. ATP channel. Ann. Rev. Physiol. (2000) 62:79-109.
60. KOSIERADZKI M: Mechanisms of ischemic preconditioning and its application in transplantation. Ann. Transpl. (2002) 7: 12-20.
61. MURRY CE, JENNINGS RB, REIMER KA et al.: Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation (1986) 74:1124-1136.
62. CLAVIEN PA, SELZNER M, RUDIGER HA et al.: A prospective randomized study in 100 consecutive patients undergoing major liver resection with versus without ischemic preconditioning. Ann. Surg. (2003) 238:843-850.
63. COMPAGNON P, LINDELL S, AMETANI MS et al.: Ischemic preconditioning and liver tolerance to warm or cold ischemia: experimental studies in large animals. Transplantation (2005). 79:1393-1400.
64. DE JONG JW, DE JONGE R, KEIJZER E et al.: The role of adenosine in preconditioning. Pharmacol. Therap. (2000) 87:141-149.
65. OBATA T. Adenosine production and its interaction with protection of ischemic and reperfusion injury of the myocardium. Life Sci. (2002) 71:2083-2103.
66. TUNE JD, GORMAN MW, FEIGL EO: Matching coronary blood flow to myocardial oxygen consumption. J. Appl. Physiol. (2004) 97:404-415.
67. MUBAGWA K, FLAMENG W: Adenosine, adenosine receptors and myocardial protection: an updated overview. Cardiovasc. Res. (2001) 52:25-39.
68. MENTZER RM, RAHKO PS, MOLINA-VIAMONTE V et al.: Safety, tolerance, and efficacy of adenosine as an additive to blood cardioplegia in humans during coronary artery bypass surgery. Am. J. Cardiol. (1997) 79:38-43.
69. SILVA PH, DILLON D, VAN WYLEN DG: Adenosine deaminase inhibition augments interstitial adenosine but does not attenuate myocardial infarction. Cardiovasc. Res. (1995) 29:616-623.
70. GALLAGHER KP, MCCLANAHAN TB, MARTIN BJ et al.: Does adenosine deaminase inhibition protect ischemic myocardium? Adv. Exp. Med. Biol. (1994) 370:291-294.
71. MCCLANAHAN TB, IGNASIAK DP, MARTIN BJ et al.: Effect of adenosine deaminase inhibition with pentostatin on myocardial stunning in dogs. Basic Res. Cardiol. (1995) 90:176-183.
72. ELFATTAH-ABD AS, JESSEN ME, LEKVEN J et al.: Differential cardioprotection with selective inhibitors of adenosine metabolism and transport: role of purine release in ischemic and reperfusion injury. Mol. Cell Biochem. (1998) 180:179-191.
73. GRUBER HE: Acedesine: a preclinical overview. Adv. Exp. Med. Biol. (1994) 370:423-426.
74. GALINANES M, ZHAI X, BULLOUGH D et al.: Protection against injury during ischemia and reperfusion by acadesine derivatives GP-1-468 and GP-1-668. Studies in the transplanted rat heart. J. Thorac. Cardiovasc. Surg. (1995) 110:752-761.
75. PASUPATHY S, HOMER-VANNIASINKAM S: Ischaemic preconditioning protects against ischaemia/reperfusion injury: Emerging concepts. Eur. J. Vasc. Endovasc. Surg. (2005) 29:106-115.
76. GALLAGHER KP, MCCLANAHAN TB, MARTIN BJ et al.: Does adenosine deaminase inhibition protect ischemic myocardium? Adv. Exp. Med. Biol. (1994) 370:291-294.
77. BAXTER GF: Role of adenosine in delayed preconditioning of myocardium. Cardiovasc. Res. (2002) 55:483-494.
78. CAO B, LI N, WANG Y et al.: Protective effect of L-arginine preconditioning on ischemia and reperfusion injury associated with rat small bowel transplantation. World J. Gastroenterol. (2005) 11:2994-2997.
79. KLONER RA, REZKALLA SH: Cardiac protection during acute myocardial infarction: Where do we stand in 2004? J. Am. Coll. Cardiol. (2004) 44:276-286.
80. SOUTHARD JH, VAN GULIK TM, AMETANI MS et al.: Important components of the UW solution. Transplantation (1990) 49:251-257.
81. OPIE LH, SACK MN: Metabolic plasticity and the promotion of cardiac protection in ischemia and ischemic preconditioning. J. Mol. Cell. Cardiol. (2002) 34:1077-1089.
82. NICOLINI F, BEGHI C, MUSCARI C et al.: Myocardial protection in adult cardiac surgery: current opinions and future challenges. Eur. J. Cardiothoracic Surgery (2003) 24:986-993.
83. VIRÁG L, SZABÓ C: The therapeutic potential of poly(ADP-ribose)polymerase inhibitors. Pharmacol. Rev. (2002) 54:375-429.
84. MOUKARBEL GV, AYOUB CM, ABCHEE AB: Pharmacological therapy for myocardial reperfusion injury. Curr. Opin. Cardiol. (2003) 4:147-153.
85. SCARABELLI TM, GOTTLIEB RA: Functional and clinical repercussions of myocyte apoptosis in the multifaceted damage by ischemia/reperfusion injury: old and new concepts after 10 years of contributions. Cell Death Differ. (2004) 11:S144-152.
86. FISCHER S: Inhibition of angiotensin-converting enzyme by captopril: a novel approach to reduce ischemia-reperfusion injury after lung transplantation. Cardiovasc. Surg. (2000) 120:573-580.
87. GÖTTMAN U, VAN DER WOUDE FJ, BRAUN C: Endothelin receptor antagonists: a new therapeutic option for improving the outcome after solid organ transplantation? Curr. Vasc. Pharmacol. (2003) 1:281-299.
88. RITTER T, KUPIEC-WEGLINSKI JW: Gene therapy for the prevention of ischaemia/reperfusion injury in organ transplantation. Curr. Gene Therap. (2005) 5:101-109.
89. KIM Y-S, DORÉ S: Catalytically inactive heme oxygenase-2 mutant is cytoprotective. Free Rad. Biol. Med. (2005) 39:558-564.
90. + cardioplegia. Cardiovasc. Surg. (2000) 8:466-473.
91. SIGG DC, COLES JA, OELTGEN PR et al.: Role of δ-opioid receptor agonists on infarct size reduction in swine. Am. J. Physiol. Heart Circ. Physiol. (2002) 282:H1953-H1960.
92. SINDRAM D, RÜDIGER HA, UPADHYA AG et al.: Ischemic preconditioning protects against cold ischemic injury through an oxidative stress dependent mechanism. J Hepatol. (2002) 36:78-84.
93. PERALTA C, SERAFN A, FERNÁNDEZ-ZABALEGUI L et al.: Liver ischemic preconditioning: a new strategy for the prevention of ischemia-reperfusion injury. Transpl. Proceed. (2003) 35:1800-1802.
94. ERSPAMER V, MELCHIORRI P, FALCONIERI-ERSPAMER G: Deltorphins: a family of naturally occurring peptides with high affinity and selectivity for δ opioid binding sites. Proc. Natl. Acad. Sci. USA (1989) 86:5188-5192:
95. OTTANI A, VERGONI AV, SALTINI S et al.: Effect of late treatment with γ-hydroxybutyrate on the histological and behavioural consequences of transient brain ischemia in the rat. Eur. J. Pharmacol. (2004) 485:183-191.
96. WEI ZZ, XIA SS: γ-Hydroxybutyrate protects the liver from warm ischemia-reperfusion injury in the rat. Hepatobiliary Pancreat. Dis. Int. (2004) 3:245-249.
97. TEOH LK, GRANT R, HULF JA et al.: A comparison between ischaemic preconditioning, intermittent cross-clamp fibrillation and cold crystalloid cardioplegia for myocardial protection during coronary artery bypass graft surgery. Cardiovasc. Surg. (2002) 10:251-255.
98. DOBSON GP: Organ arrest, protection and preservation: natural hibernation to cardiac surgery. Comp. Biochem. Physiol. (2004) 139:469-485.
99. DE HERT SG, TURANI F, MATHUR S et al.: Cardioprotection with volatile anesthetics: mechanisms and clinical implications. Anesth. Analg. (2005) 100:1584-1593.
100. LINDELL SL, KLAHN SL, PIAZZA TM et al.: Natural resistance to liver cold ischemia-reperfusion injury associated with the hibernation phenotype. Am. J. Physiol. Gastrointest Liver Physiol. (2005) 288:G473-G480.
101. KRENZ M, COHEN MV, DOWNEY JM: The protective and anti-protective effects of ethanol in a myocardial infarct model. Ann. NY Acad. Sci. (2002) 957:103-114.
102. LUCAS DL, BROWN RA, WASSEF M et al.: Alcohol and the cardiovascular system. J. Am. Coll. Cardiol. (2005) 45:1916-1924.
103. FRANCIS TJ, GOLDEN F ST C: Non-freezing cold injury: the pathogenesis. J. Roy. Nav. Med. Serv. (1985) 71:3-8.
104. THOMAS JR, SHURTLEFF D, SCHROT J et al.: Cold-induced perturbation of cutaneous blood flow in the rat model of non-freezing cold injury. Microvasc. Res. (194) 47:166-176.
105. IRWIN MS: Nature and mechanism of peripheral nerve damage in an experimental model of non-freezing cold injury. Ann. R. Coll. Surg. Engl. (1996) 78:372-379.
106. IRWIN MS: Neuropathy in non-freezing cold injury (trench foot). J. R. Soc. Med. (1997) 90:433-438.
107. LONG WB III, EDLICH RF, WINTERS KL et al.: Cold injuries. J. Long Term Eff. Med. Implants (2004) 15:67-78.
108. ENDRICH B, HAMMERSEN F, MEBMER K: Microvascular ultrastructure in non-freezing cold injuries. Res. Exp. Med. (1990) 190:365-379.