Transplant graft vasculopathy: An emerging target for prevention and treatment of renal allograft dysfunction

Yonsei Medical Journal

Volumn 45, Issue 6, 2004, Pages 1053-1058

  Kang, Duk Hee ^a   Kang, Shin Wook ^b   Jeong, Hyeon Joo ^b   Kim, Yu Seun ^b   Yang, Chul Woo ^c   Johnson, Richard J ^d  

^a Ewha Womans University School of Medicine   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c The Catholic University of Korea   (South Korea)

^d UNIVERSITY OF FLORIDA   (United States)

Author keywords

Circulating endothelial cell; Endothelium; Graft vasculopathy; Hypoxia

Indexed keywords

ANGIOGENIC FACTOR; ANGIOPOIETIN; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; BASIC FIBROBLAST GROWTH FACTOR; CALCINEURIN INHIBITOR; CYCLOSPORIN A; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; FINGOLIMOD; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GROWTH FACTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMMUNOSUPPRESSIVE AGENT; RAPAMYCIN; RECOMBINANT ERYTHROPOIETIN; SURVIVIN; VASCULOTROPIN;

ACUTE GRAFT REJECTION; ARTERY DISEASE; CELL DAMAGE; CELL FUNCTION; CHRONIC ALLOGRAFT NEPHROPATHY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DISEASE MARKER; ENDOTHELIUM CELL; GRAFT FAILURE; HOMEOSTASIS; HUMAN; MICROVASCULATURE; PREDICTION; RENAL GRAFT DYSFUNCTION; RENOVASCULAR DISEASE; REVIEW; THROMBOTIC THROMBOCYTOPENIC PURPURA; VASCULAR ENDOTHELIUM;

EID: 12344301206     PISSN: 05135796     EISSN: None     Source Type: Journal    
DOI: 10.3349/ymj.2004.45.6.1053     Document Type: Review

References (50)

1. Cines DB, Pollak E, Buck CA, Loscalzo J, Zimmerman GA, McEver RP, et al. Endothelial cell in physiology and in the pathophysiology of vascular disorders. Blood 1998;91:3527-61.
2. Bell D, Johns TE, Lopez LM. Endothelial dysfunction: implications for therapy of cardiovascular diseases. Ann Pharmacother 1998;32:459-70.
3. Dzau VJ, Gibbons GH, Mann M, Braun-Dullaeus R. Future horizons in cardiovascular molecular therapies. Am J Cardiol 1997;80:33-9.
4. Kang D-H, Kanellis J, Hugo C, Truong L, Anderson S, Kerjaschki D, et al. Role of the microvascular endothelium in progressive renal disease. J Am Soc Nephrol 2002;13:806-16.
5. Epstein FH, Agmon Y, Brezis M. Physiology of renal hypoxia. Ann NY Acad Sci 1994;718:72-81.
6. Zhong Z, Arteel GE, Connor HD, Yin M, Frankenberg MV, Stachlewitz RF, et al. Cyclosporin A increases hypoxia and free radical production in rat kidneys: prevention by dietary glycine. Am J Physiol 1998;275: F595-604.
7. Suga SI, Phillips MI, Ray PE, Raleigh JA, Vio CP, Kim YG, et al. Hypokalemia induces renal injury and alterations in vasoactive mediators that favor salt sensitivity. Am J Physiol Renal Physiol 2001;281:F620-9.
8. Fine LG, Orphanides C, Norman JT. Progressive renal disease: the chronic hypoxia hypothesis. Kidney Int 1998;65:S74-8.
9. Norman JT, Clark IM, Garcia PL. Hypoxia promotes fibrogenesis in human renal fibroblasts. Kdney Int 2000; 58:2351-66.
10. Olivetti G, Anversa P, Rigamonti W, Vitali-Mazza L, Loud A. Morphometry of the renal corpuscle during normal postnatal growth and compensatory hypertrophy; a light microscope study. Cell Biol 1977;75:573-85.
11. Marcussen N, Nyengaard J, Christensen S. Compensatory growth of glomeruli is accomplished by an increased number of glomerular capillaries. Lab Invest 1994;70:868-74.
12. Kang DH, Anderson S, Kim YG, Mazzalli M, Suga S, Jefferson JA, et al. Impaired angiogenesis in the aging kidney: potential role of VEGF and TSP-1 in renal disease. Am J Kidney Dis 2001;37:601-11.
13. Kang DH, Joly AH, Oh SW, Hugo C, Kerjaschki D, Gordon KL, et al. Impaired angiogenesis in the remnant kidney model (I): Potential role of vascular endothelial growth factor and thrombospondin-1. J Am Soc Nephrol 2001;12:1434-47.
14. Bohle A, Mackensen-Haen S, Wehrmann M. Significance of post-glomerular capillaries in the pathogenesis of chronic renal failure. Kidney Blood Press Res 1996;19:191-5.
15. Pascual M, Theruvath T, Kawai T, Tolkoff-Rubin N, Cosimi AB. Strategies to improve long-term outcomes after renal transplantation. N Engl J Med 2002;346: 580-90.
16. Kooijmans-Coutinho MF, Hermans J, Schrama E, Daha MR, Bruijn JA, van der Woude FJ. Interstitial rejection, vascular rejection, and diffuse thrombosis of renal allografts: Predisposing factors, histology, immunohistochemistry, and relation to outcome. Transplantation 1996;61:1338-44.
17. Sijpkens YW, Doxiadis II, van Kemenade FJ, Zwinderman AH, de Fijter JW, Claas FH, et al. Chronic rejection with or without transplant vasculopathy. Clin Transplant 2003;17:163-70.
18. Sudhir K, MacGregor JS, DeMarco T, De Groot CJ, Taylor RN, Chou TM, et al. Cyclosporine impairs release of endothelium-derived relaxing factors in epicardial and resistance coronary arteries. Circulation 1994;90:3018-23.
19. Diederich D, Skopec J, Diederich A, Dai FX. Cyclosporine produces endothelial dysfunction by increased production of superoxide. Hypertension 1994;23:957-61.
20. Moore LC, Mason J, Feld L, Van Liew JB, Kaskel FJ. Effect of cyclosporine on endothelial albumin leakage in rats. J Am Soc Nephrol 1992;3:51-7.
21. Kochi S, Takanaga H, Matsuo H, Ohtani H, Naito M, Tsuruo T, et al. Induction of apoptosis in mouse brain capillary endothelial cells by cyclosporin A and tacrolimus. Life Sci 2000;66:2255-60.
22. Collins P, Wilkie M, Razak K, Abbot S, Harley S, Bax C, et al. Cyclosporine and cremaphor modulate von Willebrand factor release from cultured human endothelial cells. Transplantation 1993;56:1218-23.
23. Grieff M, Loertscher R, Shohaib SA, Stewart DJ. Cyclosporine-induced elevation in circulating endothelin-1 in patients with solid-organ transplants. Transplantation 1993;56:880-4.
24. Seron D, Moreso F. Transplant vasculopathy in early protocol renal allograft biopsies. Transplant Proc 1999; 31:2219-20.
25. Mauiyyedi S, Pelle PD, Saidman S, Collins AB, Pascual M, Tolkoff-Rubin NE, et al. Chronic humoral rejection: Identification of antibody-mediated chronic renal allograft rejection by C4d deposits in peritubular capillaries. J Am Soc Nephrol 2001;12:574-82.
26. Herzenberg A, Gill J, Djurdiev O, Magil A. C4d deposition in acute rejection: An independent long-term prognostic factor. J Am Soc Nephrol 2001;13:234-41.
27. Ovuworie CA, Fox ER, Chow CM, Pascual M, Shih VE, Picard MH, et al. Vascular endothelial function in cyclosporine and tacrolimus treated renal transplant recipients. Transplantation 2001;72:1385-8.
28. Shimizu A, Colvin R, Yamanaka N. Rejection of peritubular capillaries in renal allo-and xenograft. Clin Transplant 2000;14:S6-S14.
29. Risau W. Differentiation of endothelium. FASEB J 1995; :926-33.
30. Avihingsanon Y, Ma N, Csizmadia E, Wang C, Pavlakis M, Giraldo M, et al. Expression of protective genes in human renal allografts: A regulatory response to injury associated with graft rejection. Transplantation 2002; 73:1079-85.
31. Dignat-George F, Sampol J. Circulating endothelial cells in vascular disorders: New insights into an old concept. Eur J Haematol 2000;65:215-20.
32. Woywodt A, Schroeder M, Gwinner W, Mengel M, Jaeger M, Schwarz A, et al. Elevated numbers of circulating endothelial cells in renal transplant recipients. Transplantation 2003;76:1-4.
33. Lagaaij E, Cramer-Knijnenburg G, van Kemenade F, van Es LA, Bruijn JA, van Krieken JH. Endothelial cell chimerism after renal transplantation and vascular rejection. Lancet 2001;357:33-7.
34. Gao Z, McAllister V, Williams G. Repopulation of liver endothelium by bone marrow derived cells. Lancet 2001;357:932-3.
35. Rookmaaker M, Tolboom H, Goldschmeding R, Zwaginga J, Rabelink T, Verhaar M. Bone marrow-derived cells contribute to endothelial repair after thrombotic microangiopathy. Blood 2002;99:1095.
36. Asahara. T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, et al. Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997;275:964-7.
37. Shintani S, Murohara T, Ikeda H, Ueno T, Honma T, Katoh A, et al. Mobilization of endothelial progenitor cells in patients with acute myocardial infarction. Circulation 2001;103:2776-9.
38. Quaini F, Urbanek K, Beltrami AP, Finato N, Beltrami CA, Nadal-Ginard B, et al. Chimerism of the transplanted heart. N Engl J Med 2002;346:5-15.
39. Kang DH, Hughes J, Mazzali M, Schreiner GF, Johnson RJ. Impaired angiogenesis in the remnant kidney model (II): VEGF administration reduces renal fibrosis and stabilizes renal function. J Am Soc Nephrol 2001;12: 1448-57.
40. Chavakis E, Dimmeler S. Regulation of endothelial cell survival and apoptosis during angiogenesis. Arterioscler Thromb Vasc Biol 2002;22:887-93.
41. Mesri M, Morales-Ruiz M, Ackermann E, Bennett CF, Pober JS, Sessa WC, et al. Suppression of vascular endothelial growth factor-mediated endothelial cell protection by survivin targeting. Am J Pathol 2001;158: 1757-65.
42. Guba M, von Breitenbuch P, Steinbauer M, Koehl G, Flegel S, Hornung M, et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor. Nat Med 2002;8:128-35.
43. Mandala S, Hajdu R, Bergstrom J, Quackenbush E, Xie J, Milligan J, et al. Alteration in lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science 2002;296:346-9.
44. Becker B, Becker Y, Leverson G, Heisey D. Erythropoietin therapy may retard progression in chronic renal transplant dysfunction. Nephrol Dial Transplant 2002; 17:1667-73.
45. Ribatti D, Vacca A, Roccaro AM, Crivellato E, Presta M. Erythropoietin as an angiogenic factor. Eur J Clin Invest 2003;33:891-6.
46. Dimmeler S, Aicher A, Vasa M, Mildner-Rihm C, Adler K, Tiemann M, et al. HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI3-kinase/Akt pathway. J Clin Invest 2001;108:391-7.
47. Zaltzman JS, Nash M, Chiu R, Prasad GV. ACE in renal transplant Renin-angiotensin system blockade in biopsy-proven allograft nephropathy. Transplant Proc 2003;35:2415-7.
48. Millan MT, Shizuru JA, Hoffmann P, Dejbakhsh-Jones S, Scandling JD, Grumet FC, et al. Mixed chimerism and immunosuppressive drug withdrawal after HLA-mismatched kidney and hematopoietic progenitor transplantation. Transplantation 2002;73:1386-91.
49. Abdi R, Huong T, Zee R, Brenner B, Milford E. Angiotensin gene polymorphism as a determinant of post-transplantation renal dysfunction and hypertension. Transplantation 2001;72:726-9.
50. Shenker NS, Haldar NA, Reilly JJ, Bunce M, Welsh KI, Marshall SE. The impact of endothelial nitric oxide synthase polymorphisms on long-term renal allograft outcome. Transpl Int 2003;16:391-5.