Differential induction of colitis and gastritis in HLA-B27 transgenic rats selectively colonized with Bacteroides vulgatus or Escherichia coli

Infection and Immunity

Volumn 67, Issue 6, 1999, Pages 2969-2974

  Rath, Heiko C ^a,c   Wilson, Kenneth H ^b   Sartor, R Balfour ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b DUKE UNIVERSITY   (United States)

^c UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HLA B27 ANTIGEN; MYELOPEROXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; BACTEROIDES; BACTEROIDES VULGATUS; CELL INFILTRATION; COLITIS; CONTROLLED STUDY; DIGESTIVE SYSTEM INFLAMMATION; DISEASE SEVERITY; ENZYME ACTIVITY; ESCHERICHIA COLI; GASTRITIS; HISTOPATHOLOGY; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSGENIC ANIMAL;

EID: 0032984363     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.6.2969-2974.1999     Document Type: Article

References (37)

1. Aranda, R., B. C. Sydora, P. L. McAllister, S. W. Binder, H. Y. Yang, S. R. Targan, and M. Kronenberg. 1997. Analysis of intestinal lymphocytes in mouse colitis mediated by transfer of CD4+, CD45RBhigh T cells to SCID recipients. J. Immunol. 158:3464-3473.
2. Auer, I. O., A. Roder, F. Wensinck, J. P. van de Merwe, and H. Schmidt. 1983. Selected bacterial antibodies in Crohn's disease and ulcerative colitis. Scand. J. Gastroenterol. 18:217-223.
3. Brandwein, S. L., R. P. McCabe, Y. Cong, K. B. Waites, B. U. Ridwan, P. A. Dean, E. H. Birkenmeier, J. P. Sundberg, and C. O. Elson. 1997. Spontaneously colitic C3H/HeJ Bir mice demonstrate selective antibody reactivity to antigens of the enteric bacterial flora. J. Immunol. 159:44-52.
4. Breban, M., R. E. Hammer, J. A. Richardson, and J. D. Taurog. 1993. Transfer of the inflammatory disease of HLA-B27 transgenic rats by bone marrow engraftment. J. Exp. Med. 178:1607-1616.
5. Breban, M., J. L. Fernandez-Sueiro, J. A. Richardson, R. R. Hadavand, S. D. Maika, R. E. Hammer, and J. D. Taurog. 1996. T cells, but not thymic exposure to HLA-B27, are required for the inflammatory disease of the HLA-B27 transgenic rats. J. Immunol. 156:794-803.
6. Brown, R. G., J. P. O'Leary, and E. R. Woodward. 1974. Hepatic effects of jejunoileal bypass for morbid obesity. Am. J. Surg. 127:53-58.
7. Cong, Y., S. L. Brandwein, R. P. McCabe, A. Lazenby, E. H. Birkenmeier, J. P. Sundberg, and C. O. Elson. 1998. CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease. J. Exp. Med. 187:855-864.
8. Contractor, N. V., H. Bassiri, T. Reya, A. Y. Park, D. C. Baumgart, M. A. Wasik, S. G. Emerson, and S. R. Carding. 1998. Lymphoid hyperplasia, autoimmunity, and compromised intestinal intraepithelial lymphocyte development in colitis-free gnotobiotic IL-2-deficient mice. J. Immunol. 160:385-394.
9. Dianda, L., A. M. Hanby, N. A. Wright, A. Sebesteny, A. C. Hayday, and M. J. Owen. 1997. T cell receptor-alpha beta-deficient mice fail to develop colitis in the absence of a microbial environment. Am. J. Pathol. 150:91-97.
10. Drenick, E. J., J. Fisler, and D. Johnson. 1982. Hepatic steatosis after intestinal bypass - prevention and reversal by metronidazole, irrespective of protein-calorie malnutrition. Gastroenterology 82:535-548.
11. Grisham, M. B., J. N. Benoit, and D. N. Granger. 1990. Assessment of leukocyte involvement during ischemia and reperfusion of intestine. Methods Enzymol. 186:729-742.
12. Hammer, R. E., S. D. Maika, J. A. Richardson, J. P/ Tang, and J. D. Taurog. 1990. Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2m: an animal model of HLA-B27-associated human disorders. Cell 63:1099-1112.
13. Krook, A., B. Lindstrom, J. Kjellander, G. Jamerot, and L. Bodin. 1981. Relation between concentrations of metronidazole and Bacteroides spp in faeces of patients with Crohn's disease and healthy individuals. J. Clin. Pathol. 34:645-650.
14. Lichtman, S. N., J. Keku, J. H. Schwab, and R. B. Sartor. 1991. Hepatic injury associated with small bowel bacterial overgrowth in rats is prevented by metronidazole and tetracycline. Gastroenterology 100:513-519.
15. Lichtman, S. N., R. B. Sartor, J. Keku, and J. H. Schwab. 1990. Hepatic inflammation in rats with experimental small intestinal bacterial overgrowth. Gastroenterology 98:414-423.
16. Lichtman, S. N., J. Wang, R. B. Sartor, C. Zhang, D. E. Bender, F. G. Dalldorf, and J. H. Schwab. 1995. Reactivation of arthritis induced by small bowel bacterial overgrowth in rats: role of cytokines, luminal bacteria and bacterial polymers. Infect. Immun. 63:2295-2301.
17. Mizoguchi, A., E. Mizoguchi, C. Chiba, and A. K. Bhan. 1996. Role of appendix in the development of inflammatory bowel disease in TCR-alpha mutant mice. J. Exp. Med. 184:707-715.
18. Mourelle, M., A. Salas, F. Guarner, E. Crespo, A. Garcia-Lafuente, and J. R. Malagelada. 1998. Stimulation of transforming growth factor beta 1 by enteric bacteria in the pathogenesis of rat intestinal fibrosis. Gastroenterology 114:519-526.
19. Onderdonk, A. B., and J. G. Bartlett. 1979. Bacteriological studies of experimental ulcerative colitis. Am. J. Clin. Nutr. 32:258-265.
20. Onderdonk, A. B., M. L. Franklin, and R. L. Cisneros. 1981. Production of experimental ulcerative colitis in gnotobiotic guinea pigs with simplified microflora. Infect. Immun. 32:225-231.
21. Onderdonk, A. B., J. A. Richardson, R. E. Hammer, and J. D. Taurog. 1998. A correlation of cecal microflora of HLA-B27 transgenic rats with inflammatory bowel disease. Infect. Immun. 66:6022-6023.
22. Rath, H. C., H. H. Herfarth, J. S. Ikeda, W. B. Grenther, T. E. Hamm, Jr., E. Balish, J. D. Taurog, R. E. Hammer, K. H. Wilson, and R. B. Sartor. 1996. Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats. J. Clin. Investig. 98:945-953.
23. Rath, H. C., J. S. Ikeda, H.-J. Linde, J. Schölmerich, K. H. Wilson, and R. B. Sartor. 1999. Varying cecal bacterial loads influences colitis and gastritis in HLA-B27 transgenic rats. Gastroenterology 116:310-319.
24. Rath, H. C., M. Schultz, L. A. Dieleman, F. Li, H. Kölbl, W. Falk, J. Schölmerich, and R. B. Sartor. 1998. Selective vs. broad spectrum antibiotics in the prevention and treatment of experimental colitis in two rodent models. Gastroenterology 114:A1067. (Abstract.)
25. 24a.Rath, H. C., and R. B. Sartor. Unpublished results.
26. Sartor, R. B. 1997. The influence of normal microbial flora on the development of chronic mucosal inflammation. Res. Immunol. 148:567-576.
27. Sartor, R. B. Microbial factors in the pathogenesis of Crohn's disease, ulcerative colitis and experimental intestinal inflammation. In J. B. Kirsner (ed.). Inflammatory bowel disease, in press. The Williams & Wilkins Co., Baltimore, Md.
28. Sartor, R. B., H. C. Rath, and R. K. Sellon. 1996. Microbial factors in chronic intestinal inflammation. Curr. Opin. Gastroenterol. 12:327-333.
29. Sellon, R. K., S. L. Tonkonogy, M. Schultz, W. B. Grenter, E. Balish, D. M. Rennick, and R. B. Sartor. 1998. Normal enteric flora are necessary for the development of spontaneous colitis and immune system activation in IL-10-deficient mice. Infect. Immun. 66:5224-5231.
30. Severijnen, A. J., R. van Kleef, M. P. Hazenberg, and J. P. van de Merwe. 1989. Cell wall fragments from major residents of the human intestinal flora induce chronic arthritis in rats. J. Rheumatol. 16:1061-1068.
31. Stimpson, S. A., R. R. Brown, S. K. Anderle, D. G. Klapper, R. L. Clark, W. J. Cromartie, and J. H. Schwab. 1986. Arthropathic properties of cell wall polymers from normal flora bacteria. Infect. Immun. 51:240-249.
32. Sutherland, L., J. Singleton, J. Sessions, S. Hanauer, E. Krawitt, G. Rankin, R. Summers, H. Mekhjian, N. Greenberger, M. Kelly, J. Levine, A. Thomson, E. Alpert, and E. Prokipchuk. 1991. Double blind, placebo controlled trial of metronidazole in Crohn's disease. Gut 32:1071-1075.
33. Taurog, J. D., J. A. Richardson, J. T. Croft, W. A. Simmons, M. Zhou, J. L. Fernandez-Sueiro, E. Balish, and R. E. Hammer. 1994. The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J. Exp. Med. 180:2359-2364.
34. van de Merwe, J. P., A. M. Schroder, F. Wensinck, and M. P. Hazenberg. 1988. The obligate anaerobic faecal flora of patients with Crohn's disease and their first-degree relatives. Scand. J. Gastroenterol. 23:1125-1131.
35. 26 mice after bone marrow transplantation or T cell transfer. Gastroenterology 116:A838. (Abstract.)
36. Wells, C. L., E. M. van de Westerlo, R. P. Jechorek, B. A. Feltis, T. D. Wilkins, and S. L. Erlandsen. 1996. Bacteroides fragilis enterotoxin modulates epithelial permeability and bacterial internalization by HT-29 enterocytes. Gastroenterology 110:1429-1437.
37. Yamada, T., E. Deitch, R. D. Specian, M. A. Perry, R. B. Sartor, and M. B. Grisham. 1993. Mechanisms of acute and chronic intestinal inflammation induced by indomethacin. Inflammation 17:641-662.