Protein kinase C-ζ phosphorylates serine/threonine residues at the C-terminal binding motif of the tyrosine phosphatase SHP-2 of insulin receptor substrate 1

Signal Transduction

Volumn 2, Issue 1-2, 2002, Pages 40-45

  Lehmann, Rainer ^a   Beck, Alexander ^a   Moeschel, Klaus ^a   Schmidt, Eckhart K ^b   Deeg, Martin ^b   Rapp, Erdmann ^c   Sun, Xiao J ^d   Kellerer, Monika ^a   Voelter, Wolfgang ^a   Schleicher, Erwin D ^a   Häring, Hans U ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^c OTTO VON GUERICKE UNIVERSITY   (Germany)

^d UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

Insulin receptor substrate 1; Insulin resistance; PKC zeta; Protein kinase C; SHIP 2 tyrosine phosphatase

Indexed keywords

INSULIN RECEPTOR SUBSTRATE 1; PHOSPHORUS 32; PROTEIN KINASE C ZETA; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP 2; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; DEPHOSPHORYLATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HYPERINSULINEMIA; INSULIN RESISTANCE; NEGATIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION;

EID: 0036910760     PISSN: 16154053     EISSN: None     Source Type: Journal    
DOI: 10.1002/1615-4061(200205)2:1/2<40::AID-SITA40>3.0.CO;2-K     Document Type: Article

References (11)

1. Kellerer, M., Lammers, R., Häring, H.-U. (1999) Insulin signal transduction: Possible mechanisms for insulin resistance. Exp Clin Endocrinol Diabetes 107: 97-106.
2. Kellerer, M., Mushack, J., Seffer, E., Mischak, H., Ullrich, A., Häring, H.U. (1998) Protein kinase C isoforms alpha, delta and theta require insulin receptor substrate-1 to inhibit the tyrosine kinase activity of the insulin receptor in human kidney embryonic cells (HEK 293 cells). Diabetologia 41: 833-838.
3. Ravichandran, L. V., Esposito, D. L., Chen, J., Quon, M. J. (2001) PKC-zeta phosphorylates IRS-1 and impairs its ability to activate PI 3-kinase in response to insulin. J Biol Chem 276: 3543-3549.
4. Liu, Y. F., Paz, K., Hershkowitz, A. et al. (2001) Insulin stimulates PKC-zeta-mediated phosphorylation of insulin receptor substrate-1 (IRS-1): A self-attenuated mechanism to negatively regulate IRS proteins function. J Biol Chem 276: 14459-14465.
5. Qiao, L. Y., Goldberg, J. L., Russell, J. C., Sun, X. J. (1999) Identification of enhanced serine kinase activity in insulin resistance. J Biol Chem 274: 10625-10632.
6. Yates, J. R., Eng, J. K., McCormack, A. L., Schieltz, D. (1995) Method to correlate tandem mass spectra of modified peptides to amino acid sequences in the protein database. Anal Chem 67: 1426-1436.
7. 2 and θ Diabetologia 43: 443-449.
8. Pluskey, S., Wandless, T. J., Walsh, C. T., Shoelson, S. E. (1995) Potent stimulation of SH-PTP2 phosphatase activity by simultaneous occupancy of both SH2 domains. J Biol Chem 270: 2897-2900.
9. Myers, M. G. J., Mendez, R., Shi, P., Pierce, J. H., Rhoads, R., White, M. F. (1998) The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling. J Biol Chem 273: 26908-26914.
10. Goldstein, B. J., Bittner-Kowalczyk, A., White, M. F., Harbeck, M. (2000) Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the grb2 adaptor protein. J Biol Chem 275: 4283-4289.
11. Hof, P., Pluskey, S., Dhe, P. S., Eck, M. J., Shoelson, S. E. (1998) Crystal structure of the tyrosine phosphatase SHP-2. Cell 92: 441-450.