Down-regulation of protein kinase c inhibits insulin-like growth factor i-induced vascular smooth muscle cell proliferation, migration, and gene expression

Endocrinology

Volumn 140, Issue 10, 1999, Pages 4622-4632

  Yano, K ^a   Bauchat, J R ^a   Liimatta, M B ^a   Clemmons, D R ^a   Duan, C ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; DNA; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; SOMATOMEDIN C;

ANIMAL CELL; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; DNA SYNTHESIS; DOWN REGULATION; ENZYME ANALYSIS; ENZYME REGULATION; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SWINE; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

EID: 0033304873     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.10.7035     Document Type: Article

References (47)

1. Insulin-like growth factor I and its binding proteins in the cardiovascular system
2. Growth factors and atherosclerosis
3. Inhibition of vascular smooth muscle cell growth through antisense transcription of a rat insulin-like growth factor i receptor cDNA
4. Regulation of vascular smooth muscle cell insulin-like growth factor i receptors by phosphorothioate oligonucleotides. Effects on cell growth and evidence that sense targeting at the ATG site increases receptor expression
5. Characterization of induction of protooncogene c-myc and cellular growth in human vascular smooth muscle cells by insulin and IGF-I
6. Platelet-derived growth factor isoforms decrease insulin-like growth factor i gene expression in rat vascular smooth muscle cells and selectively stimulate the biosynthesis of insulin-like growth factor binding protein 4
7. Vascular smooth muscle cells synthesize two forms of insulin-like growth factor binding proteins which are regulated differently by the insulin-like growth factors
8. Regulation of insulin-like growth factor (IGF) binding protein-2 synthesis and degradation by plateletderived growth factor and the IGFs is enhanced by serum deprivation in vascular smooth muscle cells
9. Fibroblast growth factor regulates insulin-like growth factor-binding protein production by vascular smooth muscle cells
10. Expression and insulin-like growth factor-dependent proteolysis of insulin-like growth factor-binding protein-4 are regulated by cell confluence in vascular smooth muscle cells
11. Insulin-like growth factor-I (IGF-I) regulates IGF-binding protein-5 synthesis through transcriptional activation of the gene in aortic smooth muscle cells
12. Insulin-like growth factor binding protein production by bovine and human vascular smooth muscle cells: Production of insulin-like growth factor binding protein-6 by human smooth muscle
13. Differential expression and biological effects of insulin-like growth factor-binding protein-4 and -5 in vascular smooth muscle cells
14. Molecular and cellular aspects of the insulin-like growth factor i receptor
15. Intracellular signaling in arterial smooth muscle migration versus proliferation
16. Platelet-derived growth factor stimulates protein kinase A through a mitogen-activated protein kinase-dependent pathway in human arterial smooth muscle cells
17. The fumagillin analogue TNP-470 inhibits DNA synthesis of vascular smooth muscle cells stimulated by platelet-derived growth factor and insulin-like growth factor-I: Possible involvement of cyclin-dependent kinase 2
18. IGF-I-regulated IGFBP-5 gene expression requires P13 kinase but not MAP kinase activation
19. Protein kinase C regulates chondrogenesis of mesenchymes via mitogen-activated protein kinase signaling
20. Requirement for phosphatidylinositol 3'-kinase to protect hemopoietic progeultors against apoptosis depends upon the extracellular survival factor
21. Vascular smooth muscle cells exhibit increased growth in response to elevated glucose
22. A synthetic peptide substrate for selective assay of protein kinase C
23. Transcription factor AP-2 regulates human insulin-like growth factor binding protein-5 gene expression
24. Binding of vitronectin to an aVB3 integrin is necessary for smooth muscle cells to migrate in response to IGF-I
25. Protein kinase C: Structure, function, and regulation
26. Protein kinase C delta inhibits the proliferation of vascular smooth muscle cells by suppressing G1 cyclin expression
27. PKC epsilon functions as an oncogene by enhancing activation of the Raf kinase
28. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C
29. Selective inhibition of protein kinase C isozyrnes by the indolocarbazole Go 6976
30. Protein kinase C-ζ mediates angiotensin II activation of ERK1/2 in vascular smooth muscle cells
31. The synergistic effect of PDGF-AA and IGF-1 on VSMC proliferation might be explained by the differential activation of their intracellular signaling pathways
32. Nuclear diacylglycerol produced by phosphoinositlde-specific phospholipase C is responsible for nuclear translocation of protein kinase C-α
33. Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation
34. Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate
35. Platelet-derived growth factor activates protein kinase C ε through redundant and independent signaling pathways involving phospholipase C γ or phosphatidylinositol 3-kinase
36. Lipid second messengers
37. Activation of protein kinase C-ζ and phosphatidylinositol 3'-kinase and promotion of macrophage differentiation by insulin-like growth factor-I
38. Differentiatiated phenotype of smooth muscle cells depend on signaling pathways through insulin-like growth factors and phosphatidylinositol 3-kinase
39. Insulin like growth factor-I, protein kinase-C, calcium and cyclic AMP: Partners in the regulation of chondrocyte mitogenesis and metabolism
40. 3H]2-deoxyglucose uptake, diacylglycerol generation and protein kinase C activation in BC3H-1 myocytes
41. Temporal changes in intracellular distribution of protein kinase C in Swiss 3T3 cells during mltogenic stimulation with insulin-like growth factor I and bombesin: Translocation to the nucleus follows rapid changes in nuclear polyphosphoinositides
42. Involvement of protein kinase-C in the mitogenic effect of insulin-like growth factor-I on rat astrocytes
43. Platelet-derived growth factor-BB, insulin-like growth factor-I, and phorbol ester activate different signaling pathways for stimulation of vascular smooth muscle cell migration
44. Insulin-like growth factor I and protein kinase C activation stimulate pulmonary artery smooth muscle cell proliferation through separate but synergistic pathways
45. Fate of immunoprecipitable protein kinase C in GH3 cells treated with phorbol 12-myristate 13-acetate
46. Mitogenic signaling of insulin-like growth factor I in MCF-7 human breast cancer cells requires phosphatidylinositol 3-kinase and is independent of mitogen-activated protein kinase
47. Requirement of Ras-GTP-Raf complexes for activation of Raf-1 by protein kinase C