5-Aza-2′-deoxycytidine induces retinoic acid receptor- β2 demethylation and growth inhibition in esophageal squamous carcinoma cells

Cancer Letters

Volumn 230, Issue 2, 2005, Pages 271-283

  Liu, Zhongmin ^a   Zhang, Liyong ^a,b   Ding, Fang ^a   Li, Jie ^a   Guo, Mingzhou ^c   Li, Wendong ^a   Wang, Yunhai ^d   Yu, Zaicheng ^d   Zhan, Qimin ^a   Wu, Min ^a   Liu, Zhihua ^a  

^a CANCER HOSPITAL   (China)

^b TSINGHUA UNIVERSITY   (China)

^c JOHNS HOPKINS UNIVERSITY   (United States)

^d ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

5 aza dc; Esophageal squamous cell carcinoma; Growth inhibition; Hypermethylation; RAR 2

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; BISULFITE; MESSENGER RNA; RETINOIC ACID RECEPTOR BETA; RETINOIC ACID RECEPTOR BETA 2; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER GRADING; CANCER INHIBITION; CANCER STAGING; CARCINOGENESIS; CARCINOMA CELL; CONTROLLED STUDY; CORRELATION ANALYSIS; DEMETHYLATION; DNA METHYLATION; DOWN REGULATION; DRUG MECHANISM; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; ESOPHAGUS MUCOSA; FEMALE; GENE IDENTIFICATION; GENE INACTIVATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MOLECULAR DYNAMICS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RECEPTOR GENE; SEQUENCE ANALYSIS; SOLID TUMOR; STATISTICAL SIGNIFICANCE; TRANSCRIPTION TERMINATION; TUMOR SUPPRESSOR GENE;

ADULT; AGED; AGED, 80 AND OVER; ANTIMETABOLITES, ANTINEOPLASTIC; AZACITIDINE; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DNA METHYLATION; DNA MODIFICATION METHYLASES; ESOPHAGEAL NEOPLASMS; ESOPHAGUS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; RECEPTORS, RETINOIC ACID; RNA, MESSENGER;

EID: 27744545241     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2005.01.012     Document Type: Article

References (43)

1. D.M. Parkin, P. Pisani, and J. Ferlay Estimates of the worldwide incidence of eighteen major cancers in 1985 Int. J. Cancer 54 4 1993 594 606
2. R. Montesano, M. Hollstein, and P. Hainaut Genetic alterations in esophageal cancer and their relevance to etiology and pathogenesis: a review Int. J. Cancer 69 1996 225 235
3. M. Oka, K. Yamamoto, M. Takahashi, M. Hakozaki, T. Abe, and N. Iizuka Relationship between serum levels of interleukin 6, various disease parameters and malnutrition in patients with esophageal squamous cell carcinoma Cancer Res. 56 1996 2776 2780
4. M. Wu, N. Hu, and X.Q. Wang H.T. Lynch T. Hirayama Genetic factor in the etiology of esophageal cancer and the strategy of its prevention in high-incidence areas of North China Genetic Epidemiology for Cancer 270 1995 CRC Press Inc Boca Raton, FL 17702 17711
5. N. Hu, S.M. Dawsey, M. Wu, and P.R. Taylor Family history of oesophageal cancer in Shanxi Province China Eur. J. Cancer 27 1991 1336
6. N. Hu, S.M. Dawsey, M. Wu, G.E. Bonney, L.J. He, X.Y. Han, M. Fu, and P.R. Taylor Familial aggregation of esophageal cancer in Yangcheng County,Shanxi Province, China Int. J. Epidemiol. 21 1992 877 882
7. W. Zhang, J.E. Bailey-Wilson, W. Li, X. Wang, C. Zhang, and X. Mao Segregation analysis of esophageal cancer in a moderately high-incidence area of northern China Am. J. Hum. Genet. 67 1 2000 110 119
8. G. Li, N. Hu, A.M. Goldstein, Z.Z. Tang, M.J. Roth, and Q.H. Wang Allelic loss on chromosome bands 13q11-q13 in esophageal squamous cell carcinoma Genes Chromosomes Cancer (Phila). 31 2001 390 397
9. T.R.J. Evans, and S.B. Kaye Retinoids: present role and future potential Br. J. Cancer 80 1999 1 8
10. P. Chambon A decade of molecular biology of retinoic acid receptors Fed. Am. Soc. Exp. Biol. J. 10 1996 940 954
11. S.J. Collins, K.A. Robertson, and L. Muller Retinoic acid-induced granulocytic differentiation of HL-60 myeloid leukemia cells is mediated directly through the retinoic acid receptor (RARα) Mol. Cell Biol. 10 1990 2154 2163
12. X.C. Xu, and R. Lotan Aberrant expression and function of retinoic acid receptors in cancer H. Nau W.S. Blaner Handbook of Experimental Pharmacology: Retinoids 1999 Springerverlag Berlin 323 324
13. H. Qiu, W. Zhang, A.K. El-Naggar, S.M. Lippman, P. Lin, R. Lotan, and X.C. Xu Loss of retinoic acid receptor-beta expression is an early event during esophageal carcinogenesis Am. J. Pathol. 155 1999 1519 1523
14. X.C. Xu, N. Sneige, X. Liu, R. Nandagiri, J.J. Lee, and F. Lukmanji Progressive decrease in nuclear retinoic acid receptor beta messenger RNA level during breast carcinogenesis Cancer Res. 57 1997 4992 4996
15. Q. Yang, I. Mori, L. Shan, M. Nakamura, Y. Nakamura, and H. Utsunomiya Biallelic inactivation of retinoic acid receptor beta2 gene by epigenetic change in breast cancer Am. J. Pathol. 158 2001 299 303
16. H. Qiu, R. Lotan, S.M. Lippman, and X.C. Xu Lack of correlation between expression of retinoic acid receptor-beta and loss of heterozygosity on chromosome band 3p24 in esophageal cancer Genes Chromosomes Cancer 28 2000 196 202
17. H. Tanaka, Y. Shimada, M. Imamura, I. Shibagaki, and K. Ishizaki Multiple types of aberrations in the p16 (INK4a) and the p15(INK4b) genes in 30 esophageal squamous-cell-carcinoma cell lines Int. J. Cancer 70 1997 437 442
18. Y. Shimada, M. Imamura, T. Wagata, N. Yamaguchi, and T. Tobe Characterization of 21 newly established esophageal cancer cell lines Cancer 69 2 1992 277 284
19. Y. Shimada, and M. Imamura Prognostic significance of cell culture in carcinoma of the oesophagus Br. J. Surg. 80 5 1993 605 607
20. Y. Kanda, Y. Nishiyama, Y. Shimada, M. Imamura, H. Nomura, H. Hiai, and M. Fukumoto Analysis of gene amplification and overexpression in human esophageal-carcinoma cell lines Int. J. Cancer 58 2 1994 291 297
21. H. Tanaka, I. Shibagaki, Y. Shimada, T. Wagata, M. Imamura, and K. Ishizaki Characterization of p53 gene mutations in esophageal squamous cell carcinoma cell lines: increased frequency and different spectrum of mutations from primary tumors Int. J. Cancer 65 3 1996 372 376
22. Y.L. Han, F. Wei, X. Xu, Y. Cai, B. Cheng, and J. Wang Establishment and comparative genomic hybridization analysis of human esophageal carcinoma cell line EC9706 Chin. J. Med. Genet. 19 2002 455 457
23. J. Sambrook, E.F. Fritsch, and T. Maniatis Molecular cloning: a laboratory manual 1989 Cold Spring Harbor Laboratory Press Cold Spring Harbor, NY
24. Q. Yang, I. Mori, L. Shan, M. Nakamura, Y. Nakamura, and H. Utsunomiya Biallelic inactivation of retinoic acid receptor beta2 gene by epigenetic change in breast cancer Am. J. Pathol. 158 2001 299 303
25. J.G. Herman, J.R. Graff, S. Myohanen, B.D. Nelkin, and S.B. Baylin Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands Proc. Natl Acad. Sci. USA 93 1996 9821 9826
26. M. Widschwendter, J. Berger, M. Hermann, H.M. Muller, A. Amberger, and M. Zeschnigk Methylation and silencing of the retinoic acid receptor-beta2 gene in breast cancer J. Natl Cancer. Inst. 92 2000 826 832
27. T. Ivanova, A. Petrenko, T. Gritsko, S. Vinokourova, E. Eshilev, and V. Kobzeva Methylation and silencing of the retinoic acid receptor-beta 2 gene in cervical cancer BMC Cancer 2 2002 4
28. X.C. Xu, X. Liu, E. Tahara, S.M. Lippman, and R. Lotan Expression and up-regulation of retinoic acid receptor-beta is associated with retinoid sensitivity and colony formation in esophageal cancer cell lines Cancer Res. 59 1999 2477 2483
29. G. Liu, M. Wu, G. Levi, and N. Ferrari Inhibition of cancer cell growth by all-trans retinoic acid and its analog N-(4-hydroxyphenyl) retinamide: a possible mechanism of action via regulation of retinoid receptors expression Int. J. Cancer 78 1998 248 254
30. T. Kuroki, F. Trapasso, S. Yendamuri, A. Matsuyama, H. Alder, M. Mori, and C.M. Croce Allele loss and promoter hypermethylation of VHL, RAR-beta, RASSF1A, and FHIT tumor suppressor genes on chromosome 3p in esophageal squamous cell carcinoma Cancer Res. 63 2003 3724 3728
31. D. Bartsch, B. Boye, C. Baust, H. zur Hausen, and E. Schwarz Retinoic acid-mediated repression of human papillomavirus 18 transcription and different ligand regulation of the retinoic acid receptor beta gene in non-tumorigenic and tumorigenic HeLa hybrid cells EMBO J. 11 1992 2283 2291
32. L. Hu, D.L. Crowe, J.G. Rheinwald, P. Chambon, and L.J. Gudas Abnormal expression of retinoic acid receptors and keratin 19 by human oral and epidermal squamous cell carcinoma cell lines Cancer Res. 51 1991 3972 3981
33. A. Arapshian, Y.S. Kuppumbatti, and R. Mira-y-Lopez Methylation of conserved CpG sites neighboring the beta retinoic acid response element may mediate retinoic acid receptor beta gene silencing in MCF-7 breast cancer cells Oncogene 19 2000 4066 4070
34. S. Cote, D. Sinnett, and R.L. Momparler Demethylation by 5-aza-2′-deoxycytidine of specific 5-methylcytosine sites in the promoter region of the retinoic acid receptor beta gene in human colon carcinoma cells Anticancer Drugs 9 1998 743 750
35. T. Nakayama, M. Watanabe, M. Yamanaka, Y. Hirokawa, H. Suzuki, and H. Ito The role of epigenetic modifications in retinoic acid receptor beta2 gene expression in human prostate cancers Lab Invest. 81 2001 1049 1057
36. S. Ogasawara, C. Maesawa, G. Tamura, and R. Satodate Frequent microsatellite alterations on chromosome 3p in esophageal squamous cell carcinoma Cancer Res. 55 1995 891 894
37. M.O. Lee, and H.J. Kang Role of coactivators and corepressors in the induction of the RARβ gene in human colon cancer cells Biol. Pham. Bull. 25 2002 1298 1302
38. B. Lin, G.Q. Chen, D. Xiao, S.K. Kolluri, X. Cao, H. Su, and X.K. Zhang Orphan receptor COUP-TF is required for induction of retinoic acid receptor beta, growth inhibition, and apoptosis by retinoic acid in cancer cells, Mol Cell Biol. 20 2000 957 970
39. R.L. Momparler, D.Y. Bouffard, L.F. Momparler, J. Dionne, K. Belanger, and J. Ayoub Pilot: phase I-II study on 5-aza-2′-deoxycytidine (Decitabine) in patients with metastatic lung cancer Anticancer Drugs 8 1997 358
40. G.E. Rivard, R.L. Momparler, J. Demers, P. Beniot, R. Raymond, K.T. Lin, and L.F. Momparler phase I study on 5-aza-2′-deoxycytidine in children with acute leukemia Leuk. Res. 5 1981 453
41. S.Y. Sun, H. Wan, P. Yue, W.K. Hong, and R. Lotan Evidence that retinoic acid receptor beta induction by retinoids is important for tumor cell growth inhibition J. Biol. Chem. 275 2000 17149 17153
42. S. Lehmann, C. Paul, and H. Torma Retinoid receptor expression and its correlation to retinoid sensitivity in non-M3 acute myeloid leukemia blast cells Clin. Cancer Res. 7 2001 367 373
43. Q. Yang, L. Shan, G. Yoshimura, M. Nakamura, Y. Nakamura, and T. Suzuma 5-aza-2′-deoxycytidine induces retinoic acid receptor beta2 gene demethylation, cell cycle arrest and growth inhibition in breast carcinoma cells Cancer Anticancer Drugs 22 2002 2753 2756