Multiple types of aberrations in the p16 (INK4a) and the p15 (INK4b) genes in 30 esophageal squamous-cell-carcinoma cell lines

International Journal of Cancer

Volumn 70, Issue 4, 1997, Pages 437-442

  Tanaka, Hisashi ^a,b   Shimada, Yutaka ^b   Imamura, Masayuki ^b   Shibagaki, Ichio ^b   Ishizaki, Kanji ^a  

^a AICHI CANCER CENTER HOSPITAL   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P15; PROTEIN P16; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME ABERRATION; CONTROLLED STUDY; ESOPHAGUS CARCINOMA; HUMAN; HUMAN CELL; POINT MUTATION; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA;

CARCINOMA, SQUAMOUS CELL; CARRIER PROTEINS; CELL CYCLE PROTEINS; CHROMOSOME ABERRATIONS; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P16; ESOPHAGEAL NEOPLASMS; HUMANS; POINT MUTATION; POLYMERASE CHAIN REACTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0031035027     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19970207)70:4<437::AID-IJC11>3.0.CO;2-C     Document Type: Article

References (26)

1. DURO, D., BERNARD, O., VALLE, V.D., BERGER, R. and LARSEN, C.H., A new type of P16INK4/MTS1 gene transcript expressed in B-cell malignancies. Oncogene, 11, 21-29 (1995).
2. ESTÈVE, A., MARTEL-PLANCHE, G., SYLLA, B.S., HOLLSTEIN, M., HAINAUT, P. and MONTESANO, R., Low frequency of p16/CDKN2 mutations in esophageal carcinomas. Int. J. Cancer, 66, 301-304 (1996).
3. GONZALEZ-ZULUETA, M., BENDER, C.M., YANG, A.S., NGUYEN, T., BEART, R.W., VAN TURNOUT, J.M. and JONES, P.A., Methylation of the 5′CpG island of the p16/CDKN2 tumor-suppressor gene in normal and transformed human tissue correlates with gene silencing. Cancer Res., 55, 4531-4535 (1995).
4. INK4B is a potential effector of TGF-βinduced cell-cycle arrest. Nature (Land.), 371, 257-261 (1994).
5. HERMANN, J.G., MERLO, A., MAO, L., LAPIDUS, R.G., ISSA, J.P.J., DAVIDSON, N.E., SIDRANSKY, D. and BAYLIN, S.B., Inactivation of the CDKN2/P16/ MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res., 55, 4525-4530 (1995).
6. HIRAMA, T. and KOEFFLER, H.P., Role of cyclin-dependent kinase inhibitors in the development of cancer. Blood, 86, 841-854 (1995).
7. IGAKI, H., SASAKI, H., KISHI, T., SAKAMOTO, H., TACHLMORI, Y., KATO, H., WATANABE, H., SUGIMURA, T. and TERADA, M., Highly frequent homozygous deletion of the p16 gene in esophaseal-cancer cell lines. Biochem. biophys. Res. Commun., 203, 1090-1095 (1994).
8. IGAKI, H., SASAKK H., TACHIMORI, Y., KATO, H., WATANABE, H., KIMURA, T., HARADA, Y., SUGIMURA, T. and TERADA, M. Mutation frequency of the p16/CDKN2 gene in primary cancers in the upper digestive tract. Cancer Res., 55, 3421-3423 (1995).
9. KAMB, A., GRUIS, N.A., WEAVER-FELDHAUS, J., LIU, Q., HARSHMAN, K., TAVTIGIAN, S.V., STOCKERT, E., DAY, R.S., JOHNSON, B.E. and SKOLNICK, M.H., A cell-cycle regulator potentially involved in genesis of many tumor types. Science, 264, 436-440 (1994).
10. Liu, Q., YAN, Y.X., McCLURE, M., NAKAGAWA, H., FUJIWARA, F. and RUSTIGI, A.K., MTS1(CDKN2) tumor-suppressor gene deletions are frequent events in esophagus squamous-cell cancer and pancreatic-adenocarcinoma cell lines. Oncogene. 10, 619-622 (1995).
11. MAO, L., MERLO, A., BEDI, G., SHAPIRO, G.I., EDWARDS, C.D., ROLLINS, B.J. and SIDRANSKY, D., A novel p16(INK4a) transcript. Cancer Res., 55, 2995-2997 (1995).
12. MERLO, A., HERMAN, J.G., MAO, L. LEE, D.J., GABRIELSON, E., BURGER, P.C., BAYLIN, S.B. and SIDRANSKY, D., 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/ CDKN2/MTS1 in human cancers. Nature Med., 1, 686-692 (1995).
13. MORI, T., MIURA, K., AOKI, T., NISHIHIRA, T., MORI, S. and NAKAMURA, Y., Frequent somatic mutation of the MTS1/CDK41 (multiple tumor-suppressor/ cyclin-dependent kinase-4 inhibitor) gene in esophageal squamous-cell carcinoma. Cancer Res., 54, 3396-3397 (1994).
14. NOBORI, T., MIURA, K., WU, D.J., Lois, A., TAKABAYASHI, K. and CARSON, D.A., Deletions of the cyclin-dependent kinase-4-inhibitor gene in multiple human cancers. Nature (Land.), 368, 753-756 (1994).
15. OTTERSON, G.A., KHLEIF, S.N., CHEN, W., COXON, A.B. and KAYE, F.J., CDKN2-gene silencing in lung cancer by DNA hypermethylation and kinetics of p16(INK4)-protein induction by 5-aza 2′deoxycytidine. Oncogene. 11, 1211-1216 (1995).
16. QUELLE, D.E., ZINDY, F., ASHMUN, R.A. and SHERR, C.J., Alternative reading frames of the INK4a tumor-suppressor gene encode two unrelated proteins capable of inducing cell-cycle arrest. Cell, 83, 993-1000 (1995).
17. SERRANO, M., HANNON, G.J. and BEACH, D., A new regulatory motif in cell-cycle control causine specific inhibition of cyclin D/CDK4. Nature (Lond.), 366, 704-707 (1993).
18. SERRANO, M., LEE, H.W., CHIN, L., CORDON-CARDO, C., BEACH, D. and DEPINHO, R.A., Role of the INK4a locus in tumor suppression and cell mortality. Cell, 85, 27-37 (1996).
19. SHIMADA, Y., IMAMURA, M., WAGATA, T. and TOBE, T., Characterization of 21 newly established esophageal-cancer cell lines. Cancer, 69, 277-284 (1992).
20. STONE, S., DAYANANTH, R., JIANG, R., WEAVER-FELDHAUS, J.M., TAVTIGIAN, S.V., CANNON-ALBRIGHT, L. and KAMB, A., Genomic structure, expression and mutational analysis of p15 (MTS2) gene. Oncogene, 11, 987-991 (1995a).
21. STONE, S., JIANG, P., DAYANANTH, P., TAVTIGIAN, S.V., KATCHER, H., PARRY, D., PETERS, G. and KAMB, A., Complex structure and regulation of the p16 (MTS1) locus. Cancer Res., 55, 2988-2994 (1995b).
22. SUZUKI, S., ZHOU, K., YIN, J., LEI, J., JIAN, H.Y., SUZUKI, Y., CHAN, T., HANNON, G.J., MERGNER, W.J., ABRAHAM, J.M. and MELZER, S.J., Intragenic mutations of CDKN2B and CDKN2A in primary human esophageal cancers. Hum. mol. Genet., 10, 1883-1887 (1995).
23. TARMIN, L., YIN, J., ZHOU, X., SUZUKI, H., JIANG, H.Y., RHYU, M.G., ABRAHAM, J.M., KRASNA, M.J., COTTRELL, J. and MELTZER, S.J., Frequent loss of heterozygosity on chromosome 9 in adenocarcinoma and squamouscell carcinoma of the esophagus. Cancer Res., 54, 6094-6096 (1994).
24. WASHIMI, O., NAGATAKE, M., OSADA, H., UEDA, R., KOSHIKAWA, T., SEKI., T., TAKAHASHI, T. and TAKAHASHI, T., In vivo occurrence of p16 (MTS1) and p15 (MTS2) alterations preferentially in non-small-cell lung cancers. Cancer Res., 55, 514-517 (1995).
25. ZHOU, X., SUZUKI, H., SHIMADA, Y., IMAMURA, M., YIN, J., JIAN, H.Y., TARMIN, L., ABRAHAM, J.M. and MELTZER, S.J., Genomic DNA and messenger RNA expression alterations of the CDKN2B and CDKN2 genes in esophageal squamous-carcinoma cell lines. Genes Chromosomes Cancer, 13, 285-290 (1995).
26. ZHOU, X., TARMIN, L., YIN, J., JIANG, H.Y., SUZUKI, H., RHYU, M.G., ABRAHAM, J.M. and MELTZER, S.J., The MTS1 gene is frequently mutated in primary human esophageal tumors. Oncogene, 9, 3737-3741 (1994).