Allele loss and promoter hypermethylation of VHL, RAR-β, RASSF1A, and FHIT tumor suppressor genes on chromosome 3p in esophageal squamous cell carcinoma

Cancer Research

Volumn 63, Issue 13, 2003, Pages 3724-3728

  Kuroki, Tamotsu ^a   Trapasso, Francesco ^a   Yendamuri, Sai ^a   Matsuyama, Ayumi ^a   Alder, Hansjuerg ^a   Mori, Masaki ^b   Croce, Carlo M ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; FRAGILE HISTIDINE TRIAD PROTEIN; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; RETINOIC ACID RECEPTOR BETA; RNA; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; VON HIPPEL LINDAU PROTEIN;

ADULT; AGED; ALLELE; ARTICLE; CARCINOGENESIS; CHROMOSOME 3P; CLINICAL FEATURE; CONTROLLED STUDY; ESOPHAGUS CARCINOMA; FEMALE; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; METHYLATION; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SQUAMOUS CELL CARCINOMA; TUMOR SUPPRESSOR GENE; VON HIPPEL LINDAU DISEASE;

ACID ANHYDRIDE HYDROLASES; ALLELES; BASE SEQUENCE; CARCINOMA, SQUAMOUS CELL; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 3; DNA METHYLATION; DNA PRIMERS; DNA, NEOPLASM; ESOPHAGEAL NEOPLASMS; GENES, TUMOR SUPPRESSOR; HUMANS; LIGASES; NEOPLASM PROTEINS; PROMOTER REGIONS (GENETICS); RECEPTORS, RETINOIC ACID; RNA, NEOPLASM; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN-PROTEIN LIGASES; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 0038756374     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Esteller, M. CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future. Oncogene. 21: 5427-5440, 2002.
2. Toyama, M., Ahuja, N., Ohe-Toyota, M., Herman, J. G., Baylin, S. B., and Issa, J. P. CpG island methylator phenotype in colorectal cancer. Proc. Natl. Acad. Sci. USA, 96: 8681-8686, 1999.
3. Jin, Z., Tamura, G., Tsuchiya, T., Sakata, K., Kashiwaba, M., Osakabe, M., and Motoyama, T. Adenornatous polyposis coli (APC) gene promoter hypermethylation in primary breast cancers. Br. J. Cancer, 85: 69-73, 2001,
4. Soria, J. C., Lee, H. Y., Lee, J. I., Wang, L., Issa, J. P., Kemp. B. L., Liu, D. D., Kurie, J. M., Mao, L., and Khuri, F. R. Lack of PTEN expression in non-small cell lung cancer could be related to promoter methylation. Clin. Cancer Res., 8: 1178-1184, 2002.
5. Chan, M. W. Y., Chan, L. W., Tang, N. L. S., Tong, J. H. M., Lo, K. W., Lee, T, L., Cheung, H. Y., Wong, W. S., Chan, P. S. F., Lai, F. M. M., and To, K. F. Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients. Clin. Cancer Res., 8: 464-470, 2002.
6. Tanaka, H., Shimada, Y., Harada, H., Shinoda, M., Hatooka, S., Imamura, M., and Ishizaki, K. Methylation of the 5′ CpG island of the FHIT gene is closely associated with transcriptional inactivation in esophageal squamous cell carcinomas. Cancer Res., 58: 3429-3434, 1998.
7. Huebner, K. Tumor suppressors on 3p: a neoclassic quartet. Proc. Natl. Acad. Sci. USA, 98: 14763-14765, 2001.
8. Lerman, M. I., and Minna, J. D. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. Cancer Res., 60: 6116-6133, 2000.
9. Latif, F., Tory, K., Gnarra, J., Yao, M., Duh, F. M., Orcutt, M. L., Stackhouse, T., Kuzmin, I., Modi, W., Geil, L., Schmidt, L., Zhou, F., Li, H., Wei, M. F., Chen, F., Glenn, G. M., Choyke, P., Walther, M. M., Weng, Y., Duan, D. R., Dean, M., Glavac, D., Richards, F., Crossey, P. A., Fergason-Smith, M., Le Paslier, D., Chumakov, I., Cohen, D., Chinault, A. C., Maher, E., Linehan, W. M., Zbar, B., and Lerman, M. I. Identification of the von Hippel-Lindau disease tumor suppressor gene. Science (Wash. DC), 260: 1317-1320, 1993.
10. de The, H., Vivanco, R. M., Tiollais, P., Stunnenberg, H., and Dejean, A. Identification of retinoic responsive element in the retinoic acid receptor gene. Nature (Lond.), 343: 177-180, 1990.
11. Dammann, R., Li, C., Yoon, J. H., Chin, P. L., Bates, S., and Pfeifer, G. P. Epigenetic inactivation of a RAS association domain family protein from the lung tumor suppressor locus 3p21.3. Nat. Genet., 25: 315-319, 2000.
12. Ohta, M., Inoue, H., Cotticelli, M. G., Kastury, K., Baffa, R., Palazzo, J., Siprashvili, Z., Mori, M., McCue, P., Druck, T., Croce, C. M., and Huebner, K. The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell, 84: 587-597, 1996.
13. Mori, M., Shiraishi, T., Tanaka, S., Yamagata, M., Mafune, K., Tanaka, Y., Ueo, H., Barnard, G. F., and Sugimachi, K. Lack of DMBT1 expression in esophageal, gastric and colon cancer. Br. J. Cancer, 79: 211-213, 1999.
14. Herman, J. G., Graff, J. R., Myohanen, S., Nelkin, B. D., and Baylin, S. B. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc. Natl. Acad. Sci. USA, 93: 9821-9826, 1996.
15. Cote, S., Sinnett, D., and Momparler, R. L. Demethylation by 5-aza-2′-deoxycytidine of specific 5-methylcytosine sites in the promoter region of the retinoic acid receptor β gene in human colon carcinoma cells. Anticancer Drugs, 9: 743-750, 1998.
16. Burbee, D. G., Forgacs, E., Zochbauer-Muller, S., Shivakumar, L., Fong, K., Gao, B., Randle, D., Kondo, M., Virmani, A., Bader, S., Sekido, Y., Latif, F., Milchgrub, S., Toyooka, S., Gazdar, A. F., Lerman, M. I., Zabarovsky, E., White, M., and Minna, J. D. Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression. J. Natl. Cancer Inst. (Bethesda), 93: 691-699, 2001.
17. Zochbauer-Muller, S., Fong, K. M., Maitra, A., Lam, S., Geradts, J., Ashfaq, R., Virmani, A. K., Milchgrub, S., Gazdar, A. F., and Minna, J. D. 5′ CpG island methylation of the FHIT gene is correlated with loss of gene expression in lung and breast cancer. Cancer Res., 61: 3581-3585, 2001.
18. Ishii, H., Baffa, R., Numata, S., Murakumo, Y., Rattan, S., Inoue, H., Mori, M., Fidanza, V., Alder, H., and Croce, C. M. The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors. Proc. Natl. Acad. Sci. USA, 96: 3928-3933, 1999.
19. Xu, X-C., Liu, X., Tahara, E., Lippman, S. M., and Lotan, R. Expression and up-regulation of retinoic acid receptor-β is associated with retinoid sensitivity and colony formation in esophageal cancer cell lines. Cancer Res., 59: 2477-2483, 1999.
20. Kuroki, T., Trapasso, F., Yendamuri, S., Matsuyama, A., Alder, H., Mori, M., Croce, C. M. Promoter hypermethylation of RASSF1A in esophageal squamous cell carcinoma. Clin. Cancer Res., 9: 1411-1445, 2003.
21. Zou, T-T., Lei, J., Shi, Y-Q., Yin, J., Wang, S., Souza, R. F., Kong, D., Shimada, Y., Smolinski, K. N., Greenwald, B. D., Abraham, J. M., Harpaz, N., and Meltzer, S. FHIT gene alterations in esophageal cancer and ulcerative colitis (UC). Oncogene, 15: 101-105, 1997.
22. Zochbauer-Muller, S., Fong, K. M., Virmani, A. K., Geradts, J. Gazdar, A. F., and Minna, J. D. Aberrant methylation of multiple genes in non-small cell lung cancers. Cancer Res., 61: 249-255. 2001.
23. Mori, M., Mimori, K., Shiraishi, T., Alder, H., Inoue, H., Tanaka, Y., Sugimachi, K., Huebner, K., and Croce, C. M. Altered expression of Fhit in carcinoma and precarcinomatous lesions of the esophagus. Cancer Res., 60: 1177-1182, 2000.
24. Laird, P. W., Jackson-Grusby, L., Fazeli, A., Dickinson, S. L., Jung, W. E., Li, E., Weinberg, R. A., and Jaenisch, R. Suppression of intestinal neoplasia by DNA hypomethylation. Cell, 81: 197-205, 1995.
25. Knudson, A. G. Hereditary cancer, oncogenes, and antioncogenes. Cancer Res., 45: 1437-1443, 1985.