Targeting integrins: Insights into structure and activity of cyclic RGD pentapeptide mimics containing azabicycloalkane amino acids

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 1, 2006, Pages 169-180

  Belvisi, Laura ^a   Bernardi, Anna ^a   Colombo, Matteo ^a,d   Manzoni, Leonardo ^b   Potenza, Donatella ^a   Scolastico, Carlo ^a   Giannini, Giuseppe ^c   Marcellini, Marcella ^c   Riccioni, Teresa ^c   Castorina, Massimo ^c   LoGiudice, Pietro ^c   Pisano, Claudio ^c  

^a UNIVERSITY OF MILAN   (Italy)

^b CNR   (Italy)

^c Sigma Tau   (Italy)

^d NiKem Research   (Italy)

Author keywords

Angiogenesis inhibitors; Conformational analysis; Integrin receptor antagonists; Peptidomimetics

Indexed keywords

ALPHA INTEGRIN; AMINO ACID DERIVATIVE; ANGIOGENESIS INHIBITOR; ARGINYLGLYCYLASPARTIC ACID; CYCLOPEPTIDE; INTEGRIN; ST 1646; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCULATION; CONFORMATION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG SCREENING; DYNAMICS; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; THROMBOCYTE AGGREGATION;

AMINO ACIDS; ANIMALS; CELL ADHESION; FIBRONECTINS; GUINEA PIGS; INTEGRINS; MAGNETIC RESONANCE SPECTROSCOPY; OLIGOPEPTIDES; PLATELET AGGREGATION INHIBITORS; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; VITRONECTIN;

ANIMALIA;

EID: 27744464081     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.08.048     Document Type: Article

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