Differential UGT1A1 induction by chrysin in primary human hepatocytes and HepG2 cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 315, Issue 3, 2005, Pages 1256-1264

  Smith, Cornelia M ^a   Graham, Richard A ^a,b   Krol, Wojciech L ^b   Silver, Ivin S ^b   Negishi, Masahiko ^c   Wang, Hongbing ^a   Lecluyse, Edward L ^a,d  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b GLAXOSMITHKLINE   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d CellzDirect   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; CHRYSIN; GLUCURONOSYLTRANSFERASE 1A1; MESSENGER RNA;

ADULT; AGED; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; GENE INDUCTION; HUMAN; HUMAN CELL; LIVER CELL; MALE; METABOLIC CLEARANCE RATE; METABOLISM; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADOLESCENT; ADULT; AFRICAN CONTINENTAL ANCESTRY GROUP; AGED; CARCINOGENS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELLS, CULTURED; CHILD, PRESCHOOL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENZYME INDUCTION; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FLAVONOIDS; GENES, REPORTER; GLUCURONOSYLTRANSFERASE; HEPATOCYTES; HUMANS; LIVER NEOPLASMS; LUCIFERASES; MALE; METHYLCHOLANTHRENE; MIDDLE AGED; RNA, MESSENGER;

EID: 27744435377     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.090795     Document Type: Article

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