5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6] naphthyridin-6-ones and related compounds as TOP1-targeting agents: Influence of structure on the ternary cleavable complex formation

Bioorganic and Medicinal Chemistry Letters

Volumn 13, Issue 20, 2003, Pages 3395-3399

  Kerrigan, John E ^a,b   Pilch, Daniel S ^a,b   Ruchelman, Alexander L ^c   Zhou, Nai ^a   Liu, Angela ^a   Liu, Leroy ^a,b   LaVoie, Edmond J ^b,c  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^b RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DNA TOPOISOMERASE; KETONE DERIVATIVE; NAPHTHYRIDINE DERIVATIVE;

ARTICLE; COMPLEX FORMATION; CORRELATION ANALYSIS; CRYSTAL STRUCTURE; DNA BINDING; DNA CLEAVAGE; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVITY; ENZYME INHIBITION; X RAY DIFFRACTION;

EID: 0141740219     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(03)00797-2     Document Type: Article

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