메뉴 건너뛰기




Volumn 5, Issue 11, 2005, Pages 1415-1420

Current status of animal-to-human transplantation

Author keywords

Acute vascular rejection; Genetic engineering; Graft rejection; Organ transplantation; Xenotransplantation

Indexed keywords

BLOOD CLOTTING; GENETIC ENGINEERING; GRAFT REJECTION; HUMAN; MULTIPLE ORGAN FAILURE; NONHUMAN; ORGAN TRANSPLANTATION; PROTEIN EXPRESSION; RECIPIENT; REVIEW; RISK FACTOR; THROMBOSIS; XENOGRAFT; XENOTRANSPLANTATION;

EID: 27644512273     PISSN: 14712598     EISSN: None     Source Type: Journal    
DOI: 10.1517/14712598.5.11.1415     Document Type: Review
Times cited : (5)

References (55)
  • 1
    • 0001736914 scopus 로고
    • De reins au pli du coude par soutures arterielles et veineuses
    • JABOULAY M: De reins au pli du coude par soutures arterielles et veineuses. Lyon Med. (1906) 107:575-577.
    • (1906) Lyon Med. , vol.107 , pp. 575-577
    • Jaboulay, M.1
  • 2
    • 0001684806 scopus 로고
    • Tissue and organ transplantation
    • ULLMAN E: Tissue and organ transplantation. Ann. Surg. (1914) 60:195-219.
    • (1914) Ann. Surg. , vol.60 , pp. 195-219
    • Ullman, E.1
  • 3
    • 0035525291 scopus 로고    scopus 로고
    • Xenotransplantation and other means of organ replacement
    • CASCALHO M, PLATT JL: Xenotransplantation and other means of organ replacement. Nat. Rev. Immunol. (2001) 1:154-160.
    • (2001) Nat. Rev. Immunol. , vol.1 , pp. 154-160
    • Cascalho, M.1    Platt, J.L.2
  • 4
    • 0035034212 scopus 로고    scopus 로고
    • The immunological barrier to xenotransplantation
    • CASCALHO M, PLATT JL: The immunological barrier to xenotransplantation. Immunity (2001) 14:437-446. This paper reviews the immunological barriers to xenotransplantation.
    • (2001) Immunity , vol.14 , pp. 437-446
    • Cascalho, M.1    Platt, J.L.2
  • 6
    • 9244246781 scopus 로고    scopus 로고
    • Acute vascular rejection and accommodation: Divergent outcomes of the humoral response to organ transplantation
    • WILLIAMS JM, HOLZKNECHT ZE, PLUMMER TB, LIN SS, BRUNN GJ, PLATT JL: Acute vascular rejection and accommodation: divergent outcomes of the humoral response to organ transplantation. Transplantation (2004) 78:1471-1478.
    • (2004) Transplantation , vol.78 , pp. 1471-1478
    • Williams, J.M.1    Holzknecht, Z.E.2    Plummer, T.B.3    Lin, S.S.4    Brunn, G.J.5    Platt, J.L.6
  • 8
    • 1542405292 scopus 로고    scopus 로고
    • Cardiac xenotransplantation: Future and limitations
    • OGATA K, PLATT JL: Cardiac xenotransplantation: future and limitations. Cardiology (2004) 101:144-155.
    • (2004) Cardiology , vol.101 , pp. 144-155
    • Ogata, K.1    Platt, J.L.2
  • 10
    • 0036950758 scopus 로고    scopus 로고
    • Apoptosis and cellular activation in the pathogenesis of acute vascular rejection
    • HOLZKNECHT ZE, KUYPERS KL, PLUMMER TB et al.: Apoptosis and cellular activation in the pathogenesis of acute vascular rejection. Circ. Res. (2002) 91:1135-1141.
    • (2002) Circ. Res. , vol.91 , pp. 1135-1141
    • Holzknecht, Z.E.1    Kuypers, K.L.2    Plummer, T.B.3
  • 11
    • 0028881851 scopus 로고
    • Complement-mediated regulation of tissue factor activity in endothelium
    • SAADI S, HOLZKNECHT RA, PATTE CP, STERN DM, PLATT JL: Complement-mediated regulation of tissue factor activity in endothelium. J. Exp. Med. (1995) 182:1807-1814.
    • (1995) J. Exp. Med. , vol.182 , pp. 1807-1814
    • Saadi, S.1    Holzknecht, R.A.2    Patte, C.P.3    Stern, D.M.4    Platt, J.L.5
  • 12
    • 0034681909 scopus 로고    scopus 로고
    • Endothelial cell activation by pore forming structures: Pivotal role for IL-1α
    • SAADI S, HOLZKNECHT RA, PATTE CP, PLATT JL: Endothelial cell activation by pore forming structures: pivotal role for IL-1α. Circulation (2000) 101:1867-1873.
    • (2000) Circulation , vol.101 , pp. 1867-1873
    • Saadi, S.1    Holzknecht, R.A.2    Patte, C.P.3    Platt, J.L.4
  • 13
    • 10644296310 scopus 로고    scopus 로고
    • Cardiac xenotransplantation: Progress toward the clinic
    • MCREGOR CG, TEOTIA SS, BYRNE GW et al.: Cardiac xenotransplantation: progress toward the clinic. Transplantation (2004) 78:1569-1575.
    • (2004) Transplantation , vol.78 , pp. 1569-1575
    • Mcregor, C.G.1    Teotia, S.S.2    Byrne, G.W.3
  • 14
    • 0025225361 scopus 로고
    • Transplantation of discordant xenografts: A review of progress
    • PLATT JL, VERCELLOTTI GM, DALMASSO AP et al.: Transplantation of discordant xenografts: a review of progress. Immunol. Today (1990) 11:450-456. This paper provides the first suggestion that genetic engineering and accommodation might be applied in xenotransplantation.
    • (1990) Immunol. Today , vol.11 , pp. 450-456
    • Platt, J.L.1    Vercellotti, G.M.2    Dalmasso, A.P.3
  • 15
    • 2142750917 scopus 로고    scopus 로고
    • Accommodation: Preventing injury in transplantation and disease
    • KOCH CA, KHALPEY ZI, PLATT JL: Accommodation: preventing injury in transplantation and disease. J. Immunol. (2004) 172:5143-5148.
    • (2004) J. Immunol. , vol.172 , pp. 5143-5148
    • Koch, C.A.1    Khalpey, Z.I.2    Platt, J.L.3
  • 16
    • 0026623093 scopus 로고
    • Identification of carbohydrate structures that bind human antiporcine antibodies: Implications for discordant xenografting in humans
    • GOOD AH, COOPER DK, MALCOLM AJ et al.: Identification of carbohydrate structures that bind human antiporcine antibodies: implications for discordant xenografting in humans. Transplant. Proc. (1992) 24:559-562. This paper first mentions Galα1-3Gal as a potential target of rejection in xenotransplantation.
    • (1992) Transplant. Proc. , vol.24 , pp. 559-562
    • Good, A.H.1    Cooper, D.K.2    Malcolm, A.J.3
  • 17
    • 0030716263 scopus 로고    scopus 로고
    • The role of natural anti-Galα1-3Gal antibodies in hyperacute rejection of pig-to-baboon cardiac xenotransplants
    • LIN SS, KOOYMAN DL, DANIELS LJ et al.: The role of natural anti-Galα1-3Gal antibodies in hyperacute rejection of pig-to-baboon cardiac xenotransplants. Transpl. Immunol. (1997) 5:212-218.
    • (1997) Transpl. Immunol. , vol.5 , pp. 212-218
    • Lin, S.S.1    Kooyman, D.L.2    Daniels, L.J.3
  • 18
    • 0034722881 scopus 로고    scopus 로고
    • The role of anti-Galα1-3Gal antibodies in acute vascular rejection and accommodation of xenografts
    • LIN SS, HANAWAY MJ, GONZALEZ-STAWINSKI GV et al.: The role of anti-Galα1-3Gal antibodies in acute vascular rejection and accommodation of xenografts. Transplantation (2000) 70:1667-1674.
    • (2000) Transplantation , vol.70 , pp. 1667-1674
    • Lin, S.S.1    Hanaway, M.J.2    Gonzalez-Stawinski, G.V.3
  • 19
    • 84981822652 scopus 로고
    • Tolerance across discordant xenogeneic barriers
    • SACHS DH, SABLINSKI T: Tolerance across discordant xenogeneic barriers. Xenotransplantation (1995) 2:234-239.
    • (1995) Xenotransplantation , vol.2 , pp. 234-239
    • Sachs, D.H.1    Sablinski, T.2
  • 20
    • 0033561172 scopus 로고    scopus 로고
    • Long-term discordant xenogeneic (porcine-to-primate) bone marrow engraftment in a monkey treated with porcine-specific growth factors
    • SABLINSKI T, EMERY DW, MONROY R et al.: Long-term discordant xenogeneic (porcine-to-primate) bone marrow engraftment in a monkey treated with porcine-specific growth factors. Transplantation (1999) 67:972-977.
    • (1999) Transplantation , vol.67 , pp. 972-977
    • Sablinski, T.1    Emery, D.W.2    Monroy, R.3
  • 21
    • 0032544673 scopus 로고    scopus 로고
    • Inhibition of xenoreactive natural antibody production by retroviral gene therapy
    • BRACY JL, SACHS DH, IACOMINI J: Inhibition of xenoreactive natural antibody production by retroviral gene therapy. Science (1998) 281:1845-1847.
    • (1998) Science , vol.281 , pp. 1845-1847
    • Bracy, J.L.1    Sachs, D.H.2    Iacomini, J.3
  • 22
    • 0029033071 scopus 로고
    • Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury
    • MCCURRY KR, KOOYMAN DL, ALVARADO CG et al.: Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury. Nat. Med. (1995) 1:423-427. This paper reports the first transplants using genetically engineered pigs as a source of organs.
    • (1995) Nat. Med. , vol.1 , pp. 423-427
    • McCurry, K.R.1    Kooyman, D.L.2    Alvarado, C.G.3
  • 24
    • 0034661964 scopus 로고    scopus 로고
    • Long-term survival of nonhuman primates receiving life-supporting transgenic porcine kidney xenografts
    • COZZI E, BHATTI F, SCHMOECKEL M et al.: Long-term survival of nonhuman primates receiving life-supporting transgenic porcine kidney xenografts. Transplantation (2000) 70:15-21.
    • (2000) Transplantation , vol.70 , pp. 15-21
    • Cozzi, E.1    Bhatti, F.2    Schmoeckel, M.3
  • 25
    • 0037039771 scopus 로고    scopus 로고
    • Production of α-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning
    • LAI L, KOLBER-SIMONDS D, PARK KW et al.: Production of α-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science (2002) 295:1089-1092.
    • (2002) Science , vol.295 , pp. 1089-1092
    • Lai, L.1    Kolber-Simonds, D.2    Park, K.W.3
  • 26
    • 0347367029 scopus 로고    scopus 로고
    • Production of alpha 1,3-galactosyltransferase-deficient pigs
    • PHELPS CJ, KOIKE C, VAUGHT TD et al.: Production of alpha 1,3-galactosyltransferase-deficient pigs. Science (2003) 299:411-414.
    • (2003) Science , vol.299 , pp. 411-414
    • Phelps, C.J.1    Koike, C.2    Vaught, T.D.3
  • 27
    • 0037385339 scopus 로고    scopus 로고
    • Xeno: Still stuck without alphaGal
    • MIYATA Y, PLATT J: Xeno: still stuck without alphaGal. Nat. Biotechnol. (2003) 21:359-360.
    • (2003) Nat. Biotechnol. , vol.21 , pp. 359-360
    • Miyata, Y.1    Platt, J.2
  • 28
    • 13444282227 scopus 로고    scopus 로고
    • Heart transplantation in baboons using alpha 1,3-galactosyltransferase gene-knockout pigs as donors: Initial experience
    • KUWAKI K, TSENG YL, DOR FJ et al.: Heart transplantation in baboons using alpha 1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nat. Med. (2005) 11:29-31. This paper reports the first use of Galα1-3Gal-deficient pigs as a source of cardiac xenografts.
    • (2005) Nat. Med. , vol.11 , pp. 29-31
    • Kuwaki, K.1    Tseng, Y.L.2    Dor, F.J.3
  • 29
    • 13444269248 scopus 로고    scopus 로고
    • Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3-galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue
    • YAMADA K, YAZAWA K, SHIMIZU A et al.: Marked prolongation of porcine renal xenograft survival in baboons through the use of alpha1,3- galactosyltransferase gene-knockout donors and the cotransplantation of vascularized thymic tissue. Nat. Med. (2005) 11:32-34. This paper reports the first use of Galα1-3Gal-deficient pigs as a source of renal xenografts.
    • (2005) Nat. Med. , vol.11 , pp. 32-34
    • Yamada, K.1    Yazawa, K.2    Shimizu, A.3
  • 30
    • 24644482765 scopus 로고    scopus 로고
    • Cardiac xenotransplantation: Recent preclinical progress with 3-month median survival
    • MCGREGOR CG, DAVIES WR, OI K et al.: Cardiac xenotransplantation: recent preclinical progress with 3-month median survival. J. Thorac. Cardiovasc. Surg. (2005) 130:e844 e841. This paper reports the outstanding outcome of xenografts that express Galα1-3Gal and no evidence of spontaneous, uncontrollable coagulation independent of rejection.
    • (2005) J. Thorac. Cardiovasc. Surg. , vol.130
    • McGregor, C.G.1    Davies, W.R.2    Oi, K.3
  • 31
    • 27644443066 scopus 로고    scopus 로고
    • Induced anti-non-Gal antibodies lead to acute humoral xenograft rejection in baboons using alpha1,3-galactosyltransferase gene-knockout pigs as kidney donors
    • In Press
    • CHEN G, QIAN H, STARZL T et al.: Induced anti-non-Gal antibodies lead to acute humoral xenograft rejection in baboons using alpha1,3- galactosyltransferase gene-knockout pigs as kidney donors. Nat. Med. (2005) (In Press). This paper cautions that eliminating Galα1-3Gal, the main target in pigs of the human antibody response, may not impirove the outcome of xenografts.
    • (2005) Nat. Med.
    • Chen, G.1    Qian, H.2    Starzl, T.3
  • 32
    • 0032523166 scopus 로고    scopus 로고
    • The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants
    • LIN SS, WEIDNER BC, BYRNE GW et al.: The role of antibodies in acute vascular rejection of pig-to-baboon cardiac transplants. J. Clin. Invest. (1998) 101:1745-1756.
    • (1998) J. Clin. Invest. , vol.101 , pp. 1745-1756
    • Lin, S.S.1    Weidner, B.C.2    Byrne, G.W.3
  • 33
    • 0034669536 scopus 로고    scopus 로고
    • Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates
    • BUHLER L, BASKER M, ALWAYN IP et al.: Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates. Transplantation (2000) 70:1323-1331.
    • (2000) Transplantation , vol.70 , pp. 1323-1331
    • Buhler, L.1    Basker, M.2    Alwayn, I.P.3
  • 34
    • 18544404547 scopus 로고    scopus 로고
    • Renal xenografts from triple-transgenic pigs are not hyperacutely rejected but cause coagulopathy in non-immunosuppressed baboons
    • COWAN PJ, AMINIAN A, BARLOW H et al.: Renal xenografts from triple-transgenic pigs are not hyperacutely rejected but cause coagulopathy in non-immunosuppressed baboons. Transplantation (2000) 69:2504-2515.
    • (2000) Transplantation , vol.69 , pp. 2504-2515
    • Cowan, P.J.1    Aminian, A.2    Barlow, H.3
  • 35
    • 10744228498 scopus 로고    scopus 로고
    • Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human anti-human CD154 mAb-based regimen
    • KUWAKI K, KNOSALLA C, DOR FJ et al.: Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human anti-human CD154 mAb-based regimen. Am. J. Transplant. (2004) 4:363-372.
    • (2004) Am. J. Transplant. , vol.4 , pp. 363-372
    • Kuwaki, K.1    Knosalla, C.2    Dor, F.J.3
  • 36
    • 0029997623 scopus 로고    scopus 로고
    • Porcine von Willebrand factor binding to human platelet GPIb induces transmembrane calcium influx
    • MAZZUCATO M, DE MARCO L, PRADELLA P, MASOTTI A, PARETI FI: Porcine von Willebrand factor binding to human platelet GPIb induces transmembrane calcium influx. Thromb. Haemost. (1996) 75:655-660.
    • (1996) Thromb. Haemost. , vol.75 , pp. 655-660
    • Mazzucato, M.1    De Marco, L.2    Pradella, P.3    Masotti, A.4    Pareti, F.I.5
  • 37
    • 0029839492 scopus 로고    scopus 로고
    • Molecular barriers to xenotransplantation
    • LAWSON JH, PLATT JL: Molecular barriers to xenotransplantation. Transplantation (1996) 62:303-310.
    • (1996) Transplantation , vol.62 , pp. 303-310
    • Lawson, J.H.1    Platt, J.L.2
  • 38
    • 0030910713 scopus 로고    scopus 로고
    • The evaluation of thrombomodulin activity in porcine to human xenotransplantation
    • LAWSON JH, DANIELS L, PLATT JL: The evaluation of thrombomodulin activity in porcine to human xenotransplantation. Transplant. Proc. (1997) 29:884-885.
    • (1997) Transplant. Proc. , vol.29 , pp. 884-885
    • Lawson, J.H.1    Daniels, L.2    Platt, J.L.3
  • 39
    • 10044240662 scopus 로고    scopus 로고
    • Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium
    • CHEN D, WEBER M, MCVEY JH et al.: Complete inhibition of acute humoral rejection using regulated expression of membrane-tethered anticoagulants on xenograft endothelium. Am. J. Transplant. (2004) 4:1958-1963.
    • (2004) Am. J. Transplant. , vol.4 , pp. 1958-1963
    • Chen, D.1    Weber, M.2    McVey, J.H.3
  • 40
    • 85047692190 scopus 로고    scopus 로고
    • Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation
    • DWYER KM, ROBSON SC, NANDURKAR HH et al.: Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation. J. Clin. Invest. (2004) 113:1440-1446.
    • (2004) J. Clin. Invest. , vol.113 , pp. 1440-1446
    • Dwyer, K.M.1    Robson, S.C.2    Nandurkar, H.H.3
  • 41
    • 22144472241 scopus 로고    scopus 로고
    • Targeted deletion of Fgl-2/fibroleukin in the donor modulates immunologic response and acute vascular rejection in cardiac xenografts
    • MENDICINO M, LIU M, GHANEKAR A et al.: Targeted deletion of Fgl-2/fibroleukin in the donor modulates immunologic response and acute vascular rejection in cardiac xenografts. Circulation (2005) 112:248-256.
    • (2005) Circulation , vol.112 , pp. 248-256
    • Mendicino, M.1    Liu, M.2    Ghanekar, A.3
  • 42
    • 0036664209 scopus 로고    scopus 로고
    • Protective effects of recombinant human antithrombin III in pig-to-primate renal xenotransplantation
    • COWAN PJ, AMINIAN A, BARLOW H et al.: Protective effects of recombinant human antithrombin III in pig-to-primate renal xenotransplantation. Am. J. Transplant. (2002) 2:520-525.
    • (2002) Am. J. Transplant. , vol.2 , pp. 520-525
    • Cowan, P.J.1    Aminian, A.2    Barlow, H.3
  • 43
    • 20244380021 scopus 로고    scopus 로고
    • Warfarin or low-molecular-weight heparin therapy does not prolong pig-to-primate cardiac xenograft function
    • BYRNE GW, SCHIRMER JM, FASS DN et al.: Warfarin or low-molecular-weight heparin therapy does not prolong pig-to-primate cardiac xenograft function. Am. J. Transplant. (2005) 5:1011-1020.
    • (2005) Am. J. Transplant. , vol.5 , pp. 1011-1020
    • Byrne, G.W.1    Schirmer, J.M.2    Fass, D.N.3
  • 44
    • 0031054438 scopus 로고    scopus 로고
    • Infection of human cells by an endogenous retrovirus of pigs
    • PATIENCE C, TAKEUCHI Y, WEISS RA: Infection of human cells by an endogenous retrovirus of pigs. Nat. Med. (1997) 3:282-286.
    • (1997) Nat. Med. , vol.3 , pp. 282-286
    • Patience, C.1    Takeuchi, Y.2    Weiss, R.A.3
  • 45
    • 0032578268 scopus 로고    scopus 로고
    • No evidence of pig DNA or retroviral infection in patients with short-term extracorporeal connection to pig kidneys
    • PATIENCE C, PATTON GS, TAKEUCHI Y et al.: No evidence of pig DNA or retroviral infection in patients with short-term extracorporeal connection to pig kidneys. Lancet (1998) 352:699-701.
    • (1998) Lancet , vol.352 , pp. 699-701
    • Patience, C.1    Patton, G.S.2    Takeuchi, Y.3
  • 46
    • 0033588002 scopus 로고    scopus 로고
    • Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue
    • PARADIS K, LANGFORD G, LONG Z et al.: Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue. Science (1999) 285:1236-1241.
    • (1999) Science , vol.285 , pp. 1236-1241
    • Paradis, K.1    Langford, G.2    Long, Z.3
  • 47
    • 2442643047 scopus 로고    scopus 로고
    • Spontaneous fusion of cells between species yields transdifferentiation and retroviral in vivo
    • OGLE BM, BUTTERS KB, PLUMMER TB et al.: Spontaneous fusion of cells between species yields transdifferentiation and retroviral in vivo. FASEB J. (2004) 18:548-550. This paper provides the first evidence of transfer of the endogenous retrovirus of pigs from swine to human cells in vivo.
    • (2004) FASEB J. , vol.18 , pp. 548-550
    • Ogle, B.M.1    Butters, K.B.2    Plummer, T.B.3
  • 49
    • 0026654128 scopus 로고
    • Mechanism of complement activation in the hyperacute rejection of porcine organs transplanted into primate recipients
    • DALMASSO AP, VERCELLOTTI GM, FISCHEL RJ, BOLMAN RM, BACH FH, PLATT JL: Mechanism of complement activation in the hyperacute rejection of porcine organs transplanted into primate recipients. Am. J. Pathol. (1992) 140:1157-1166.
    • (1992) Am. J. Pathol. , vol.140 , pp. 1157-1166
    • Dalmasso, A.P.1    Vercellotti, G.M.2    Fischel, R.J.3    Bolman, R.M.4    Bach, F.H.5    Platt, J.L.6
  • 50
    • 0028889431 scopus 로고
    • Human anti-porcine xenogeneic T cell response. Evidence for allelic specificity of mixed leukocyte reaction and for both direct and indirect pathways of recognition
    • YAMADA K, SACHS DH, DERSIMONIAN H: Human anti-porcine xenogeneic T cell response. Evidence for allelic specificity of mixed leukocyte reaction and for both direct and indirect pathways of recognition. J. Immunol. (1995) 155:5249-5256.
    • (1995) J. Immunol. , vol.155 , pp. 5249-5256
    • Yamada, K.1    Sachs, D.H.2    Dersimonian, H.3
  • 51
    • 0030051044 scopus 로고    scopus 로고
    • Detection of primary direct and indirect human anti-porcine T cell responses using a porcine dendritic cell population
    • DORLING A, LOMBARDI G, BINNS R, LECHLER RI: Detection of primary direct and indirect human anti-porcine T cell responses using a porcine dendritic cell population. Eur. J. Immunol. (1996) 26:1378-1387.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 1378-1387
    • Dorling, A.1    Lombardi, G.2    Binns, R.3    Lechler, R.I.4
  • 52
  • 53
    • 0030745335 scopus 로고    scopus 로고
    • Activation of naive xenogeneic but not allogeneic endothelial cells by human naive neutrophils: A potential occult barrier to xenotransplantation
    • AL-MOHANNA F, COLLISON K, PARHAR R et al.: Activation of naive xenogeneic but not allogeneic endothelial cells by human naive neutrophils: a potential occult barrier to xenotransplantation. Am. J. Pathol. (1997) 151:111-120.
    • (1997) Am. J. Pathol. , vol.151 , pp. 111-120
    • Al-Mohanna, F.1    Collison, K.2    Parhar, R.3
  • 55
    • 0035881991 scopus 로고    scopus 로고
    • Platelet-mediated activation of endothelial cells: Implications for the pathogenesis of transplant rejection
    • BUSTOS M, SAADI S, PLATT JL: Platelet-mediated activation of endothelial cells: implications for the pathogenesis of transplant rejection. Transplantation (2001) 72:509-515.
    • (2001) Transplantation , vol.72 , pp. 509-515
    • Bustos, M.1    Saadi, S.2    Platt, J.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.