Connexin-specific cell-to-cell transfer of short interfering RNA by gap junctions

Journal of Physiology

Volumn 568, Issue 2, 2005, Pages 459-468

  Valiunas, V ^a   Polosina, Y Y ^a   Miller, Holly ^a,c   Potapova, I A ^a   Valiuniene, L ^a   Doronin, S ^a   Mathias, R T ^a   Robinson, R B ^b   Rosen, M R ^a,b   Cohen, I S ^a   Brink, Peter R ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c FLORIDA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONNEXIN 26; CONNEXIN 32; CONNEXIN 43; DNA DIRECTED DNA POLYMERASE BETA; GAP JUNCTION PROTEIN; MESSENGER RNA; OLIGONUCLEOTIDE; SHORT HAIRPIN RNA; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; CELL JUNCTION; CELL LINE; CELL MEMBRANE PERMEABILITY; CELL MOTION; CELL SPECIFICITY; CELL TRANSFER; CELL TRANSPORT; COCULTURE; CONTROLLED STUDY; EMBRYO; FLUORESCENCE ANALYSIS; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INHIBITION KINETICS; MAMMAL CELL; MOUSE; NONHUMAN; NUCLEOTIDE METABOLISM; OLIGONUCLEOTIDE PROBE; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN TARGETING; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA HYBRIDIZATION; WILD TYPE; GAP JUNCTION;

EID: 27644502287     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2005.090985     Document Type: Article

References (53)

1. Alisky JM & Davidson BL (2004). Towards therapy using RNA interference. Am J Pharmacogenomics 4, 45-51.
2. Barr L, Dewey M & Berger W (1965). Propagation of action potentials and the structure of the nexus in cardiac muscle. J General Physiol 48, 797-823.
3. Bennett MVL (1977). Electrical transmission: a functional analysis and comparison to chemcial transmission. In The Nervous System, vol. 1, Cellular Biology of Neurons, part 1, ed. Brookhart J, Moutcastle V, Kandel E & Geiger S, pp. 357-416. Am Physiol Soc, Bethesda, Maryland.
4. Berendsen HJC, van der Spoel D & van Drunen R (1995). GROMACS: a message-passing parallel molecular dynamics implementation. Comp Phys Comm 91, 43-56.
5. Berkhout B (2004). RNA interference as an antiviral approach: targeting HIV-1. Curr Opin Mol Ther 6, 141-145.
6. Bevans CG & Harris AL (1999). Direct high affinity modulation of connexin channel activity by cyclic nucleotides. J Biol Chem 274, 3372-3720.
7. Biade S, Sobol RW, Wilson SH & Matsumoto Y (1998). Impairment of proliferating cell nuclear antigen-dependent apurinic/apyrimidinic site repair on linear DNA. J Biol Chem 273, 898-902.
8. Brink PR, Cronin K, Banach K, Peterson E, Westphale E, Seul KH, Ramanan SV & Beyer EC (1997). Evidence for heteromeric gap junction channels formed from rat Connexin43 and human connexin37. Am J Physiol 273, C1386-C1396.
9. Bruzzone R, Barbe MT, Jakob NJ & Monyer H (2005). Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes. J Neurochem 92, 1033-1043.
10. Caplen NJ & Mousses S (2003). Short interfering RNA (siRNA)-mediated RNA interference (RNAi) in human cells. Ann N Y Acad Sci 1002, 56-62.
11. Carystinos GD, Kandouz M, Alaoue-Jamali MA & Batist G (2003). Unexpected induction of the human connexin 43 promoter by the ras signaling pathway is mediated by a novel putative promoter sequnce. Mol Pharmocol 63, 821-831.
12. Elbashir SM, Lendeckel W & Tuschl T (2001). RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev 15, 188-200.
13. Elfgang C, Eckert R, Lichtenberg-Rate H, Butterweck A, Taub O, Klein RA, Hulser DF & Willecke K (1995). Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells. J Cell Biol 129, 805-817.
14. Feinberg EH & Hunter CP (2003). Transport of dsRNA into cells by the transmembrane protein SID-1. Science 301, 1545-1547.
15. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE & Mello CC (1998). Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391, 806-811.
16. Gemel J, Valiunas V, Brink PR & Beyer EC (2004). Connexin43 and connexin26 form gap junctions, but not heteromeric channels in co-expressing cells. J Cell Sci 117, 2469-2480.
17. Goldberg G, Lampe PE & Nichols BJ (1999). Selective transfer of endogenous metabolites through gap junctions composed of different connexins. Nature Cell Biol 7, 457-459.
18. Goldberg G, Valiunas V & Brink PR (2004). Selectivity permeability of gap junction channels. Biochem Biophys Acta 662, 96-101.
19. Gu H, Marth JD, Orban PC, Mossmann H & Rajewsky K (1994). Deletion of a DNA polymerase β gene segment in T cells using type-specific gene targeting. Science 265, 103-106.
20. Hampton T (2004). With RNA interference, silence is golden. JAMA 291, 2803-2804.
21. Hand GM, Muller DJ, Nicholson BJ, Engels A & Sosinsky GE (2002). Isolation and characterization of gap junctions from tissue cultured cells. J Mol Biol 315, 587-600.
22. Kittler R & Buchholz F (2003). RNA interference: gene silencing in the fast lane. Seminars Cancer Biol 13, 259-265.
23. Kolodny GM (1971). Evidence for transfer of macromolecular RNA between mammalian cells in culture. Exp Cell Res 65, 313-324.
24. Lieberman J, Song E, Lee S & Shankar P (2003). Interfering with disease: opportunities and roadblocks to harnassing RNA interference. Trends Mol Med 9, 397-403.
25. Lindahl E, Hess B & van der Spoel D (2001). GROMACS 3.0: a package for molecular simulation and trajectory analysis. J Mol Mod 7, 306-317.
26. Lipardi C, Wei Q & Paterson BM (2001). RNAi as random degradative PCR: siRNA primers convert mRNA into dsRNAs that are degraded to generate new siRNAs. Cell 107, 297-307.
27. Loewenstein WR (1981). Junctional intercellular communication: the cell to cell membrane channel. Physiol Rev 61, 829-913.
28. Miller H & Grollman AP (2003). DNA repair investigations using siRNA. DNA Repair 2, 759-763.
29. Mudziak RM, Barofsky E, Barofsky DF, Weller DL, Huang SB & Weller DD (1996). Resistance of morpholino phosphorodiamidate oligomers to enzymatic degradation. Antisense Nuc Acid Drug Dev 6, 267-272.
30. Musil LS & Goodenough DA (1991). Biochemical analysis of connexin43 intracellular transport phosphoprylation, and assembly into gap junctional plaques. J Cell Biol 115, 1357-1374.
31. Neijssen J, Herberts C, Drijfhout JW, Reits E, Janssen L & Neefjes J (2005). Cross-presentation by intercellular peptide transfer through gap junctions. Nature 434, 83-88.
32. Neyton J & Trautmann A (1985). Single channel currents of an intercellular junction. Nature 317, 331-335.
33. Pitts JD (1998). The discovery of metabolic co-operation. Bioessays 20, 1047-1051.
34. Polosina YY, Rosenquist TA, Grollman AP & Miller H (2004). 'Knock down' of DNA polymerase β by RNA interference: recapitulation of null phenotype. DNA Repair 3, 1469-1474.
35. Potapova I, Plotnikov A, Lu Z, Danilo P, Valiunas V, Qu J, Doronin S, Zuckerman J, Shlapakova I, Gao J, Pan Z, Herron A, Robinson RB, Brink PR, Rosen M & Cohen IS (2004). Human mesenchymal stem cells as a gene delivery system to fabricate a biological pacemaker. Circ Res 94, 952-959.
36. Schuettelkopf AW & van Aalten DMF (2004). PRODRG - a tool for high-throughput crystallography of protein-ligand complexes. Acta Crystallogr, Biol Crystallogr 60, 1355-1363.
37. Shankar P, Manjunath W & Liebermann J (2005). The prospect of silencing disease using RNA interference. JAMA 293, 1367-1373.
38. Simpson I, Rose B & Loewenstein WR (1977). Size limit of molecules permeating the junctional membrane channels. Science 195, 294-296.
39. Sobol RW, Horton JK, Kuhn R, Gu H, Singhal RK, Prasad R, Rajewsky K & Wilson SH (1996). Requirement of mammalian DNA polymerase-β in base-excision repair. Nature 379, 183-186.
40. Studney N, Marini FC, Dembinski JL, Zompetta C, Cabreira-Hansen M, Nebiyou Bekele B, Champlin RE & Andreeff M (2004). Mesenchymal stem cells: potential precursors for tumor stoma and targeted-delivery vehicles for anticancer agents. J Nat Cancer Inst 96, 1593-1603.
41. Summerton J & Weller D (1997). Morpholino antisense oligmers: design, preparation and properties. Antisense Nucl Acid Drug Dev 7, 187-195.
42. Tran Van Nhieu G, Clair C, Bruzzone R, Mesnil M, Samsonetti P & Combettes L (2003). Connexin-dependent inter-cellular communication increases invasion and dissemination of Shigella in epithelial cells. Nature Cell Biol 5, 720-727.
43. Tsien RW & Weingart R (1976). Inotropic effect of cyclic AMP in calf ventricular muscle studied by a cut end method. J Physiol 260, 117-142.
44. Valiunas V, Beyer EC & Brink PR (2002). Gap junction channels show a quantitative difference in selectivity. Circ Res 91, 104-111.
45. Valiunas V, Doronin S, Valiuniene L, Potapova I, Zuckerman J, Walcott B, Robinson RB, Rosen MR, Brink PR & Cohen IS (2004). Human mesenchymal stem cells make cardiac connexins and form functional gap junctions. J Physiol 555, 617-626.
46. van der Spoel D, Lindahl E, Hess B, van Buuren AR, Apol E, Meulenhoff PJ, Tielman DP, Sijbers ALTM, Feenstra KA, van Drunen R & Berendsen HJC (2004). Gromacs User Manual, version 3.2. www.gromacs.org.
47. Veenstra RD, Wang HZ, Beblo DA, Chilton MG, Harris AL, Beyer EC & Brink PR (1995). Selectivity of connexin-specific gap junctions does not correlate with channel conductance. Circ Res 77, 1156-1165.
48. Veenstra RD, Wang HZ, Beyer EC, Ramanan SV & Brink PR (1994). Connexin37 forms high conductance gap junction channels with subconductance state activity and selective dye and ionic permeabilities. Biophys J 66, 1915-1928.
49. Walcott B, Moore LC, Birzgalis A, Claros N, Valiunas V, Ott T, Willecke K & Brink PR (2002). The role of gap junctions in fluid secretion of lacrimal glands. Am J Physiol 282, C501-C507.
50. White TW, Wang H, Mui R, Litteral J & Brink PR (2004). Cloning and functional expression of invertebrate connexin from Halocynthia pyroformis. FEBS 577, 42-48.
51. Xu Y, Linde A, Larsson O, Thormeyer D, Elmen J, Wahlestedt C & Liang Z (2004). Functional comparison of single- and double-stranded siRNAs in mammalian cells. Biochem Biophys Res Comm 316, 680-687.
52. Yoo B, Kragler F, Varkonyi-Gasic E, Haywood V, Archer-Evans S, Lee YM, Lough TJ & Lucasa WJ (2004). A systemic small RNA signaling system in plants. Plant Cell 16, 1979-2000.
53. Zhang G, Song YK, Vollmer R, Stolz DB, Gasiorowski JZ, Dean DA & Liu D (2004). Hydroporation as a mechanism of hydrodynamic delivery. Gene Therapy 11, 675-682.