(1S,2S,3R,6R)-6-aminocyclohex-4-ene-1,2,3-triol (=(-)-conduramine B-1) is a selective inhibitor of α-mannosidases. Its inhibitory activity is enhanced by N-benzylation

Helvetica Chimica Acta

Volumn 88, Issue 10, 2005, Pages 2788-2811

  Łysek, Robert ^a   Schütz, Catherine ^a   Vogel, Pierre ^a  

^a EPFL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

SPECTROSCOPIC ANALYSIS; STRUCTURE (COMPOSITION); SUGARS;

ALMOUNDS; INHIBITORS; JACK BEANS;

AROMATIC COMPOUNDS;

1 [4 [4 [[(4,5,6 TRIHYDROXYCYCLOHEX 2 EN 1 YL)AMINO]METHYL]PHENOXY]PHENYL] ETHANONE; 4 [(NAPHTHALEN 1 YLMETHYL)AMINO]CYCLOHEX 4 ENE 1,2,3 TRIOL; 6 (BENZYLAMINO)CYCLOHEX 4 ENE 1,2,3 TRIOL; 6 (HEXYLAMINO)CYCLOHEX 4 ENE 1,2,3 TRIOL; 6 (OCTYLAMINO)CYCLOHEX 4 ENE 1,2,3 TRIOL; 6 (PROPYLAMINO)CYCLOHEX 4 ENE 1,2,3 TRIOL; 6 [(1H IMIDAZOL 5 YLMETHYL)AMINO]CYCLOHEX 4 ENE 1,2,3 TRIOL; 6 [(1H INDOL 3 YLMETHYL)AMINO]CYCLOHEX 4 ENE 1,2,3 TRIOL; 6 [(2 BROMO 5 HYDROXY 4 METHOXYBENZYL)AMINO]CYCLOHEX 4 ENE 1,2,3 TRIOL; 6 [(2 HYDROXYBENZYL)AMINO]CYCLOHEX 4 ENE 1,2,3 TRIOL; 6 [(2 PHENYLETHYL)AMINO]CYCLOHEX 4 ENE 1,2,3 TRIOL; 6 [(2,6 DIFLUOROBENZYL)AMINO]CYCLOHEX 4 ENE 1,2,3 TRIOL; 6 [(3 METHOXYBENZYL)AMINO]CYCLOHEX 4 ENE 1,2,3 TRIOL; 6 [(4 CHLOROBENZYL)AMINO]CYCLOHEX 4 ENE 1,2,3 TRIOL; 6 [(4 HYDROXYBENZYL)AMINO]CYCLOHEX 4 ENE 1,2,3 TRIOL; 6 [(4 METHOXYBENZYL)AMINO]CYCLOHEX 4 ENE 1,2,3 TRIOL; 6 [(4 PHENOXYBENZYL)AMINO]CYCLOHEX 4 ENE 1,2,3 TRIOL; 6 [[(1,1' BIPHENYL) 4 YLMETHYL]AMINO]CYCLOHEX 4 ENE 1,2,3 TRIOL; 6 [[(5 METHYL 2 THIENYL)METHYL]AMINO]CYCLOHEX 4 ENE 1,2,3 TRIOL; 6 [[4 (4 BROMOPHENOXY)BENZYL]AMINO]CYCLOHEX 4 ENE 1,2,3 TRIOL; 6 [[4 (4 METHOXYPHENOXY)BENZYL]AMINO]CYCLOHEX 4 ENE 1,2,3 TRIOL; 6 [[4 (4 PHENOXYPHENOXY)BENZYL]AMINO]CYCLOHEX 4 ENE 1,2,3 TRIOL; 6 [[4 [(2 METHYLQUINOLIN 8 YL)OXY]BENZYL]AMINO]CYCLOHEX 4 ENE 1,2,3 TRIOL; 6 [[4 [4 (1 HYDROXYETHYL)PHENOXY]BENZYL]AMINO]CYCLOHEX 4 ENE 1,2,3 TRIOL; 6 [[4 [4 (1H IMIDAZOL 1 YL)PHENOXY]BENZYL]AMINO]CYCLOHEX 4 ENE 1,2,3 TRIOL; ALPHA MANNOSIDASE; CONDURAMINE B 1; CYCLOHEXENE DERIVATIVE; MANNOSIDASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALMOND; ARTICLE; BEAN; BENZYLATION; COMPETITIVE INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; PRIORITY JOURNAL;

EID: 27644473102     PISSN: 0018019X     EISSN: None     Source Type: Journal    
DOI: 10.1002/hlca.200590220     Document Type: Article

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