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Volumn 33, Issue 6, 1998, Pages 792-803

Nitric oxide: A regulator of mucosal defense and injury

Author keywords

Inflammation; Inflammatory bowel disease; Mucosal defense; Nitric oxide; Ulcer

Indexed keywords

NITRIC OXIDE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE; PEROXYNITRITE;

EID: 0032457409     PISSN: 09441174     EISSN: None     Source Type: Journal    
DOI: 10.1007/s005350050178     Document Type: Review
Times cited : (92)

References (103)
  • 1
    • 0019195506 scopus 로고
    • The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
    • Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980;288:373-376.
    • (1980) Nature , vol.288 , pp. 373-376
    • Furchgott, R.F.1    Zawadzki, J.V.2
  • 2
    • 0028349156 scopus 로고
    • Nitric oxide synthases in mammals
    • Knowles RG, Moncada S. Nitric oxide synthases in mammals. Biochem J 1994;298:249-258.
    • (1994) Biochem J , vol.298 , pp. 249-258
    • Knowles, R.G.1    Moncada, S.2
  • 3
    • 0028902552 scopus 로고
    • Nitric oxide synthases: Properties and catalytic mechanism
    • Griffith OW, Stuehr DJ. Nitric oxide synthases: Properties and catalytic mechanism. Annu Rev Physiol 1995;57:707-736.
    • (1995) Annu Rev Physiol , vol.57 , pp. 707-736
    • Griffith, O.W.1    Stuehr, D.J.2
  • 4
    • 0029880235 scopus 로고    scopus 로고
    • A critical role for nitric oxide in intestinal barrier function and dysfunction
    • Alican I, Kubes P. A critical role for nitric oxide in intestinal barrier function and dysfunction. Am J Physiol 1996;270:G225-G237.
    • (1996) Am J Physiol , vol.270
    • Alican, I.1    Kubes, P.2
  • 5
    • 0029563505 scopus 로고
    • Nitric oxide as a mediator of gastrointestinal mucosal injury? Say it ain't so
    • Kubes P, Wallace JL. Nitric oxide as a mediator of gastrointestinal mucosal injury? Say it ain't so. Mediators Inflamm 1995;4:397-405.
    • (1995) Mediators Inflamm , vol.4 , pp. 397-405
    • Kubes, P.1    Wallace, J.L.2
  • 6
    • 0024844763 scopus 로고
    • Endothelium-derived relaxing factor (nitric oxide) has protective actions in the stomach
    • MacNaughton W, Cirino G, Wallace JL. Endothelium-derived relaxing factor (nitric oxide) has protective actions in the stomach. Life Sci 1989;45:1869-1876.
    • (1989) Life Sci , vol.45 , pp. 1869-1876
    • MacNaughton, W.1    Cirino, G.2    Wallace, J.L.3
  • 7
    • 0028894435 scopus 로고
    • Endogenous nitric oxide modulates ethanol-induced gastric mucosal injury in rats
    • Masuda E, Kawano S, Nagano K, et al. Endogenous nitric oxide modulates ethanol-induced gastric mucosal injury in rats. Gastroenterology 1995;108:58-64.
    • (1995) Gastroenterology , vol.108 , pp. 58-64
    • Masuda, E.1    Kawano, S.2    Nagano, K.3
  • 8
    • 0020644991 scopus 로고
    • Absorption of 51 chromium-labeled ethylenediaminetetraacetate in inflammatory bowel disease
    • Bjarnason I, O'Morain C, Levi AJ, Peters T. Absorption of 51 chromium-labeled ethylenediaminetetraacetate in inflammatory bowel disease. Gastroenterology 1983;85:318-322.
    • (1983) Gastroenterology , vol.85 , pp. 318-322
    • Bjarnason, I.1    O'Morain, C.2    Levi, A.J.3    Peters, T.4
  • 10
    • 0026632425 scopus 로고
    • Nitric oxide modulates epithelial permeability in the feline small intestine
    • Kubes P. Nitric oxide modulates epithelial permeability in the feline small intestine. Am J Physiol 1992;262:G1138-G1142.
    • (1992) Am J Physiol , vol.262
    • Kubes, P.1
  • 12
    • 0028083609 scopus 로고
    • Nitric oxide synthesis inhibition increases epithelial cell permeability via mast cells
    • Kanwar S, Wallace JL, Befus D, Kubes P. Nitric oxide synthesis inhibition increases epithelial cell permeability via mast cells. Am J Physiol 1994;266:G222-G229.
    • (1994) Am J Physiol , vol.266
    • Kanwar, S.1    Wallace, J.L.2    Befus, D.3    Kubes, P.4
  • 13
    • 0029874754 scopus 로고    scopus 로고
    • Cold restraint stress-induced gastric mucosal dystunction. Role of nitric oxide
    • Coskun T, Yegen B, Alican I, et al. Cold restraint stress-induced gastric mucosal dystunction. Role of nitric oxide. Dig Dis Sci 1996;41:956-963.
    • (1996) Dig Dis Sci , vol.41 , pp. 956-963
    • Coskun, T.1    Yegen, B.2    Alican, I.3
  • 14
    • 0027133613 scopus 로고
    • The induction of nitric oxide synthase and intestinal vascular permeability by endotoxin in the rat
    • Boughton-Smith N, Evans S, Laszlo F, et al. The induction of nitric oxide synthase and intestinal vascular permeability by endotoxin in the rat. Br J Pharmacol 1993;110:1189-1193.
    • (1993) Br J Pharmacol , vol.110 , pp. 1189-1193
    • Boughton-Smith, N.1    Evans, S.2    Laszlo, F.3
  • 15
    • 0027364361 scopus 로고
    • Nitric oxide generators and cGMP stimulate mucus secretion by gastric mucosal cells
    • Brown J, Keates A, Hanson P, Whittle B. Nitric oxide generators and cGMP stimulate mucus secretion by gastric mucosal cells. Am J Physiol 1993;265:G418-G422.
    • (1993) Am J Physiol , vol.265
    • Brown, J.1    Keates, A.2    Hanson, P.3    Whittle, B.4
  • 16
    • 0026495220 scopus 로고
    • Nitric oxide donors increase mucus gel thickness in rat stomach
    • Brown J, Hanson P, Whittle B. Nitric oxide donors increase mucus gel thickness in rat stomach. Eur J Pharmacol 1992; 223:103-104.
    • (1992) Eur J Pharmacol , vol.223 , pp. 103-104
    • Brown, J.1    Hanson, P.2    Whittle, B.3
  • 17
    • 0029983079 scopus 로고    scopus 로고
    • Exogenous nitric oxide stimulates mucin secretion from LS174T colonic adenocarcinoma cells
    • Gottke M, Chadee K. Exogenous nitric oxide stimulates mucin secretion from LS174T colonic adenocarcinoma cells. Inflamm Res 1996;45:209-212.
    • (1996) Inflamm Res , vol.45 , pp. 209-212
    • Gottke, M.1    Chadee, K.2
  • 18
    • 0028071735 scopus 로고
    • Stimulation by carbachol of mucus gel thickness in rat stomach involves nitric oxide
    • Price K, Hanson P, Whittle B. Stimulation by carbachol of mucus gel thickness in rat stomach involves nitric oxide. Eur J Pharmacol 1994;263:199-202.
    • (1994) Eur J Pharmacol , vol.263 , pp. 199-202
    • Price, K.1    Hanson, P.2    Whittle, B.3
  • 19
    • 0027259303 scopus 로고
    • Nitric oxide-donating compounds stimulate electrolyte transport in the guinea pig intestine in vitro
    • MacNaughton WK. Nitric oxide-donating compounds stimulate electrolyte transport in the guinea pig intestine in vitro. Life Sci 1993;53:585-593.
    • (1993) Life Sci , vol.53 , pp. 585-593
    • MacNaughton, W.K.1
  • 20
    • 0027359660 scopus 로고
    • Sodium nitroprusside stimulates anion secretion and inhibits sodium chloride absorption in rat colon
    • Wilson KT, Xie Y, Musch MW, Chang EB. Sodium nitroprusside stimulates anion secretion and inhibits sodium chloride absorption in rat colon. J Pharmacol Exp Ther 1993;266:224-230.
    • (1993) J Pharmacol Exp Ther , vol.266 , pp. 224-230
    • Wilson, K.T.1    Xie, Y.2    Musch, M.W.3    Chang, E.B.4
  • 21
    • 0029980999 scopus 로고    scopus 로고
    • Nitric oxide donating compounds stimulate human colonic ion transport in vitro
    • Stack WA, filipowicz B, Hawkey CJ. Nitric oxide donating compounds stimulate human colonic ion transport in vitro. Gut 1996;39:93-99.
    • (1996) Gut , vol.39 , pp. 93-99
    • Stack, W.A.1    Filipowicz, B.2    Hawkey, C.J.3
  • 24
    • 0027471669 scopus 로고
    • Inhibitors of nitric oxide synthetase prevent castor-oil-induced diarrhoea in the rat
    • Mascolo N, Izzo AA, Barbato F, Capasso F. Inhibitors of nitric oxide synthetase prevent castor-oil-induced diarrhoea in the rat. Br J Pharmacol 1993;108:861-864.
    • (1993) Br J Pharmacol , vol.108 , pp. 861-864
    • Mascolo, N.1    Izzo, A.A.2    Barbato, F.3    Capasso, F.4
  • 25
    • 0028944940 scopus 로고
    • Significance of nitric oxide in the stimulation of intestinal fluid absorption in the rat jejunum in vivo
    • Schirgi-Degen A, Beubler E. Significance of nitric oxide in the stimulation of intestinal fluid absorption in the rat jejunum in vivo. Br J Pharmacol 1995;114:13-18.
    • (1995) Br J Pharmacol , vol.114 , pp. 13-18
    • Schirgi-Degen, A.1    Beubler, E.2
  • 26
    • 0025783191 scopus 로고
    • Nitric oxide: A regulatory mediator of mast cell reactivity
    • Salvemini D, Masini E, Pistelli A, et al. Nitric oxide: A regulatory mediator of mast cell reactivity. J Cardio Pharmacol 1991;17:S258-S264.
    • (1991) J Cardio Pharmacol , vol.17
    • Salvemini, D.1    Masini, E.2    Pistelli, A.3
  • 27
    • 0027258129 scopus 로고
    • Modulation of rat mast cell reactivity by IL-1β. Divergent effects on nitric oxide and platelet-activating factor release
    • Hogaboam C, Befus D, Wallace JL. Modulation of rat mast cell reactivity by IL-1β. Divergent effects on nitric oxide and platelet-activating factor release. J Immunol 1993;151:3767-3774.
    • (1993) J Immunol , vol.151 , pp. 3767-3774
    • Hogaboam, C.1    Befus, D.2    Wallace, J.L.3
  • 28
    • 0025865285 scopus 로고
    • Rat mast cells synthesize a nitric oxide-like factor which modulates the release of histamine
    • Masini E, Salvemini D, Pistelli A, et al. Rat mast cells synthesize a nitric oxide-like factor which modulates the release of histamine. Agents Actions 1991;33:61-63.
    • (1991) Agents Actions , vol.33 , pp. 61-63
    • Masini, E.1    Salvemini, D.2    Pistelli, A.3
  • 29
    • 0027524594 scopus 로고
    • Nitric oxide synthesis inhibition induced leukocyte adhesion via superoxide and mast cells
    • Kubes P, Kanwar S, Niu X, Gaboury J, Nitric oxide synthesis inhibition induced leukocyte adhesion via superoxide and mast cells. FASEB J 1993;7:1293-1299.
    • (1993) FASEB J , vol.7 , pp. 1293-1299
    • Kubes, P.1    Kanwar, S.2    Niu, X.3    Gaboury, J.4
  • 30
    • 0025873421 scopus 로고
    • Platelet-activating factor-induced mucosal dysfunction: Role of oxidants and granulocytes
    • Kubes P, Arfors KE, Granger DN. Platelet-activating factor-induced mucosal dysfunction: Role of oxidants and granulocytes. Am J Physiol 1991;260:G965-G971.
    • (1991) Am J Physiol , vol.260
    • Kubes, P.1    Arfors, K.E.2    Granger, D.N.3
  • 31
    • 0025770213 scopus 로고
    • Potential role of histamine monochloramine in a rabbit model of ileitis
    • Miller MJS, Zhang X, Barkemeyer B, et al. Potential role of histamine monochloramine in a rabbit model of ileitis. Scand J Gastroenterol 1991;26:852-858.
    • (1991) Scand J Gastroenterol , vol.26 , pp. 852-858
    • Miller, M.J.S.1    Zhang, X.2    Barkemeyer, B.3
  • 32
    • 0029953816 scopus 로고    scopus 로고
    • The cellular and molecular basis of gastric mucosal defense
    • Wallace JL, Granger DN. The cellular and molecular basis of gastric mucosal defense. FASEB J 1996;10:731-740.
    • (1996) FASEB J , vol.10 , pp. 731-740
    • Wallace, J.L.1    Granger, D.N.2
  • 33
    • 0023898089 scopus 로고
    • Local effector functions of capsaicin-sensitive sensory nerve endings: Involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides
    • Holzer P. Local effector functions of capsaicin-sensitive sensory nerve endings: Involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience 1988; 24:739-768.
    • (1988) Neuroscience , vol.24 , pp. 739-768
    • Holzer, P.1
  • 34
    • 0026537015 scopus 로고
    • Participation of endothelium-derived nitric oxide but not prostacyclin in the gastric mucosal hyperaemia due to acid back-diffusion
    • Lippe IT, Holzer P. Participation of endothelium-derived nitric oxide but not prostacyclin in the gastric mucosal hyperaemia due to acid back-diffusion. Br J Pharmacol 1992;105:708-714.
    • (1992) Br J Pharmacol , vol.105 , pp. 708-714
    • Lippe, I.T.1    Holzer, P.2
  • 35
    • 0022483272 scopus 로고
    • Gastric mucosal protection against ulcerogenic factors in the rat mediated by capsaicin-sensitive afferent neutrons
    • Holzer P, Sametz W. Gastric mucosal protection against ulcerogenic factors in the rat mediated by capsaicin-sensitive afferent neutrons. Gastroenterology 1986;91:975-981.
    • (1986) Gastroenterology , vol.91 , pp. 975-981
    • Holzer, P.1    Sametz, W.2
  • 36
    • 0025370449 scopus 로고
    • Effect of endothelium-derived relaxing factor on the gastric lesion induced by HCI in rats
    • Kitagawa H, Takeda F, Kohei H. Effect of endothelium-derived relaxing factor on the gastric lesion induced by HCI in rats. J Pharmacol Exp Ther 1990;253:1133-1137.
    • (1990) J Pharmacol Exp Ther , vol.253 , pp. 1133-1137
    • Kitagawa, H.1    Takeda, F.2    Kohei, H.3
  • 37
    • 0028905016 scopus 로고
    • Impaired vasodilatory responses in the gastric microcirculation of anesthetized rats with secondary biliary cirrhosis
    • Ferraz JGP, McKnight W, Sharkey KA, Wallace JL. Impaired vasodilatory responses in the gastric microcirculation of anesthetized rats with secondary biliary cirrhosis. Gastroenterology 1995;108:1183-1191.
    • (1995) Gastroenterology , vol.108 , pp. 1183-1191
    • Ferraz, J.G.P.1    McKnight, W.2    Sharkey, K.A.3    Wallace, J.L.4
  • 38
    • 0024539821 scopus 로고
    • Endothelin has potent ulcerogenic and vasoconstrictor actions in the stomach
    • Wallace JL, Cirino G, De Nucci G, et al. Endothelin has potent ulcerogenic and vasoconstrictor actions in the stomach. Am J Physiol 1989;256:G661-G666.
    • (1989) Am J Physiol , vol.256
    • Wallace, J.L.1    Cirino, G.2    De Nucci, G.3
  • 39
  • 40
    • 0027396551 scopus 로고
    • The actions of nitric oxide donors in the prevention or induction of injury to the rat gastric mucosa
    • Lopez-Belmonte J, Whittle B, Moncada S. The actions of nitric oxide donors in the prevention or induction of injury to the rat gastric mucosa. Br J Pharmacol 1993;108:73-78.
    • (1993) Br J Pharmacol , vol.108 , pp. 73-78
    • Lopez-Belmonte, J.1    Whittle, B.2    Moncada, S.3
  • 41
    • 0004559340 scopus 로고
    • Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor
    • DeNucci G, Thomas R, D'Orleans-Juste P, et al. Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor. Proc Natl Acad Sci USA 1988;85:9797-9800.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 9797-9800
    • DeNucci, G.1    Thomas, R.2    D'Orleans-Juste, P.3
  • 42
    • 0027146391 scopus 로고
    • Vascular responses to endothelin-1 following inhibition of nitric oxide synthesis in the conscious rat
    • Fllep J, Foldes-Filep E, Rousseau A, et al. Vascular responses to endothelin-1 following inhibition of nitric oxide synthesis in the conscious rat. Br J Pharmacol 1993;110:1213-1221.
    • (1993) Br J Pharmacol , vol.110 , pp. 1213-1221
    • Fllep, J.1    Foldes-Filep, E.2    Rousseau, A.3
  • 43
    • 0027165294 scopus 로고
    • Endogenous nitric oxide protects against platelet-activating factor-induced bowel injury in the rat
    • MacKendrick W, Caplan M, Hsueh W. Endogenous nitric oxide protects against platelet-activating factor-induced bowel injury in the rat. Pediatr Res 1993;34:222-228.
    • (1993) Pediatr Res , vol.34 , pp. 222-228
    • MacKendrick, W.1    Caplan, M.2    Hsueh, W.3
  • 44
    • 0025258432 scopus 로고
    • Role of nitric oxide in maintaining vascular integrity in endotoxin-induced acute intestinal damage in the rat
    • Hutcheson I, Whittle B, Boughton-Smith N. Role of nitric oxide in maintaining vascular integrity in endotoxin-induced acute intestinal damage in the rat. Br J Pharmacol 1990;101:815-820.
    • (1990) Br J Pharmacol , vol.101 , pp. 815-820
    • Hutcheson, I.1    Whittle, B.2    Boughton-Smith, N.3
  • 45
    • 0028344296 scopus 로고
    • Protection against gastric ischemia-reperfusion injury by nitric oxide generators
    • Andrews F, Malcontenti-Wilson C, O'Brien P. Protection against gastric ischemia-reperfusion injury by nitric oxide generators. Dig Dis Sci 1994;39:366-373.
    • (1994) Dig Dis Sci , vol.39 , pp. 366-373
    • Andrews, F.1    Malcontenti-Wilson, C.2    O'Brien, P.3
  • 46
    • 0025731835 scopus 로고
    • Nitric oxide: An endogenous modulator of leukocyte adhesion
    • Kubes P, Suzuki M, Granger DN. Nitric oxide: An endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA 1991;88:4651-4655.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 4651-4655
    • Kubes, P.1    Suzuki, M.2    Granger, D.N.3
  • 47
    • 0025167504 scopus 로고
    • Modulation of PAF-induced leukocyte adherence and increased microvascular permeability
    • Kubes P, Suzuki M, Granger DN. Modulation of PAF-induced leukocyte adherence and increased microvascular permeability. Am J Physiol 1990;259:G859-G864.
    • (1990) Am J Physiol , vol.259
    • Kubes, P.1    Suzuki, M.2    Granger, D.N.3
  • 48
    • 0027247634 scopus 로고
    • Inhibition of nitric oxide production. Mechanisms of vascular albumin leakage
    • Kurose I, Kubes P, Wolf R, et al. Inhibition of nitric oxide production. Mechanisms of vascular albumin leakage. Circ Res 1993;73:164-171.
    • (1993) Circ Res , vol.73 , pp. 164-171
    • Kurose, I.1    Kubes, P.2    Wolf, R.3
  • 49
    • 0028182409 scopus 로고
    • Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat
    • Wallace JL, Reuter B, Cicala C, et al. Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat. Gastroenterology 1994;107: 173-179.
    • (1994) Gastroenterology , vol.107 , pp. 173-179
    • Wallace, J.L.1    Reuter, B.2    Cicala, C.3
  • 50
    • 0029066970 scopus 로고
    • Reduction of gastrointestinal injury in acute endotoxic shock by flurbiprofen nitroxybutylester
    • Wallace JL, Cirino G, McKnight GW, Elliott SN. Reduction of gastrointestinal injury in acute endotoxic shock by flurbiprofen nitroxybutylester. Eur J Pharmacol 1995;280:63-68.
    • (1995) Eur J Pharmacol , vol.280 , pp. 63-68
    • Wallace, J.L.1    Cirino, G.2    McKnight, G.W.3    Elliott, S.N.4
  • 51
    • 0031408178 scopus 로고    scopus 로고
    • Reduction of shock-induced gastric damage by a nitric oxide-releasing aspirin derivative: Role of neutrophils
    • Wallace JL, McKnight W, Wilson TL, Del Soldato P, Cirino G. Reduction of shock-induced gastric damage by a nitric oxide-releasing aspirin derivative: Role of neutrophils. Am J Physiol 1997;273:G1246-G1251.
    • (1997) Am J Physiol , vol.273
    • Wallace, J.L.1    McKnight, W.2    Wilson, T.L.3    Del Soldato, P.4    Cirino, G.5
  • 53
    • 0026340016 scopus 로고
    • Cytoprotective function of nitric oxide: Inactivation of superoxide radicals produced by human leukocytes
    • Rubanyi GM, Ho EH, Cantor EH, et al. Cytoprotective function of nitric oxide: Inactivation of superoxide radicals produced by human leukocytes. Biochem Biophys Res Commun 1991;181: 1392-1397.
    • (1991) Biochem Biophys Res Commun , vol.181 , pp. 1392-1397
    • Rubanyi, G.M.1    Ho, E.H.2    Cantor, E.H.3
  • 54
    • 0027435577 scopus 로고
    • Nitric oxide prevents leukocyte adherence: Role of superoxide
    • Gaboury J, Woodman R, Granger DN, et al. Nitric oxide prevents leukocyte adherence: Role of superoxide. Am J Physiol 1993;265:H862-H867.
    • (1993) Am J Physiol , vol.265
    • Gaboury, J.1    Woodman, R.2    Granger, D.N.3
  • 55
    • 0022640082 scopus 로고
    • Role of oxygen radicals in ischemia-induced lesions in the cat stomach
    • Perry MA, Wadhwa S, Parks DA, et al. Role of oxygen radicals in ischemia-induced lesions in the cat stomach. Gastroenterology 1986;90:362-367.
    • (1986) Gastroenterology , vol.90 , pp. 362-367
    • Perry, M.A.1    Wadhwa, S.2    Parks, D.A.3
  • 56
    • 0025216880 scopus 로고
    • Role of oxidants in ischemia/reperfusion-induced granulocyte infiltration
    • Zimmerman BJ, Grisham MB, Granger DN. Role of oxidants in ischemia/reperfusion-induced granulocyte infiltration. Am J Physiol 1990;258:G185-G190.
    • (1990) Am J Physiol , vol.258
    • Zimmerman, B.J.1    Grisham, M.B.2    Granger, D.N.3
  • 57
    • 0026630603 scopus 로고
    • Nitric oxide, and endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase
    • Clancy R, Leszczynska-Piziak J, Abramson S. Nitric oxide, and endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase. J Clin Invest 1992;90:1116-1121.
    • (1992) J Clin Invest , vol.90 , pp. 1116-1121
    • Clancy, R.1    Leszczynska-Piziak, J.2    Abramson, S.3
  • 58
    • 0027169720 scopus 로고
    • Inhibition of nitric oxide synthase delays healing of chronic gastric ulcers
    • Konturek SJ, Brzowzowski T, Majka J, et al. Inhibition of nitric oxide synthase delays healing of chronic gastric ulcers. Eur J Pharmacol 1993;239:215-217.
    • (1993) Eur J Pharmacol , vol.239 , pp. 215-217
    • Konturek, S.J.1    Brzowzowski, T.2    Majka, J.3
  • 59
    • 0029100370 scopus 로고
    • A nitric-oxide releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats
    • Elliott SN, McKnight W, Cirino G, Wallace JL. A nitric-oxide releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats. Gastroenterology 1995;109:524-530.
    • (1995) Gastroenterology , vol.109 , pp. 524-530
    • Elliott, S.N.1    McKnight, W.2    Cirino, G.3    Wallace, J.L.4
  • 60
    • 0028817870 scopus 로고
    • Topical nitroglycerin therapy for anal fissures and ulcers
    • Gorfine SR. Topical nitroglycerin therapy for anal fissures and ulcers. N Engl J Med 1995;333:1156-1157.
    • (1995) N Engl J Med , vol.333 , pp. 1156-1157
    • Gorfine, S.R.1
  • 61
    • 0028271453 scopus 로고
    • Time-dependent enhancement or inhibition of endotoxin-induced vascular injury in rat intestine by nitric oxide synthase inhibitors
    • Laszlo F, Whittle B, Moncada S. Time-dependent enhancement or inhibition of endotoxin-induced vascular injury in rat intestine by nitric oxide synthase inhibitors. Br J Pharmacol 1994;111: 1309-1315.
    • (1994) Br J Pharmacol , vol.111 , pp. 1309-1315
    • Laszlo, F.1    Whittle, B.2    Moncada, S.3
  • 62
    • 0029974212 scopus 로고    scopus 로고
    • Failure of L-NAME to cause inhibition of nitric oxide synthesis: Role of inducible nitric oxide synthase
    • Miller MJS, Thompson J, Liu X, et al. Failure of L-NAME to cause inhibition of nitric oxide synthesis: Role of inducible nitric oxide synthase. Inflamm Res 1996;45:272-276.
    • (1996) Inflamm Res , vol.45 , pp. 272-276
    • Miller, M.J.S.1    Thompson, J.2    Liu, X.3
  • 63
    • 8944241770 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: Effect of antibiotics and antioxidants
    • Mannick EE, Bravo LE, Zarama G, et al. Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: Effect of antibiotics and antioxidants. Cancer Res 1996;56:3238-3243.
    • (1996) Cancer Res , vol.56 , pp. 3238-3243
    • Mannick, E.E.1    Bravo, L.E.2    Zarama, G.3
  • 64
    • 0028003696 scopus 로고
    • Enhanced gastric nitric oxide synthase activity in duodenal ulcer patients
    • Rachmilewitz D, Karmeli F, Eliakim R, et al. Enhanced gastric nitric oxide synthase activity in duodenal ulcer patients. Gut 1994;35:1394-1397.
    • (1994) Gut , vol.35 , pp. 1394-1397
    • Rachmilewitz, D.1    Karmeli, F.2    Eliakim, R.3
  • 65
    • 0029071036 scopus 로고
    • Spontaneous intestinal inflammation and nitric oxide metabolism in HLA-B27 transgenic rats
    • Aiko S, Grisham MB. Spontaneous intestinal inflammation and nitric oxide metabolism in HLA-B27 transgenic rats. Gastroenterology 1995;109:142-150.
    • (1995) Gastroenterology , vol.109 , pp. 142-150
    • Aiko, S.1    Grisham, M.B.2
  • 66
    • 0028941787 scopus 로고
    • Potential role of nitric oxide in a model of chronic colitis in rhesus macaques
    • Ribbons K, Zhang X, Thompson J, et al. Potential role of nitric oxide in a model of chronic colitis in rhesus macaques. Gastroenterology 1995;108:705-711.
    • (1995) Gastroenterology , vol.108 , pp. 705-711
    • Ribbons, K.1    Zhang, X.2    Thompson, J.3
  • 67
    • 0028928065 scopus 로고
    • The selective beneficial effects of nitric oxide inhibition in experimental colitis
    • Hogaboam C, Jacobson K, Collins S, Blennerhassett M. The selective beneficial effects of nitric oxide inhibition in experimental colitis. Am J Physiol 1995;268:G673-G684.
    • (1995) Am J Physiol , vol.268
    • Hogaboam, C.1    Jacobson, K.2    Collins, S.3    Blennerhassett, M.4
  • 68
    • 0028111497 scopus 로고
    • Nitric oxide synthase inhibition can initiate or prevent gut inflammation: Role of enzyme source
    • Miller MJS, Clark D. Nitric oxide synthase inhibition can initiate or prevent gut inflammation: Role of enzyme source. Agents Actions 1994;41:C231-C232.
    • (1994) Agents Actions , vol.41
    • Miller, M.J.S.1    Clark, D.2
  • 69
    • 0029115715 scopus 로고
    • Experimental colitis is ameliorated by inhibition of nitric oxide synthase activity
    • Rachmilewitz D, Karmeli F, Okon E, Bursztyn M. Experimental colitis is ameliorated by inhibition of nitric oxide synthase activity. Gut 1995;37:247-255.
    • (1995) Gut , vol.37 , pp. 247-255
    • Rachmilewitz, D.1    Karmeli, F.2    Okon, E.3    Bursztyn, M.4
  • 71
    • 0042399698 scopus 로고    scopus 로고
    • α MSH modulates experimental inflammatory bowel disease
    • Rajora N, Boccoli G, Catania A, Lipton J. α MSH modulates experimental inflammatory bowel disease. Peptides 1997;18:381-385.
    • (1997) Peptides , vol.18 , pp. 381-385
    • Rajora, N.1    Boccoli, G.2    Catania, A.3    Lipton, J.4
  • 72
    • 0028072869 scopus 로고
    • Effects of nitric oxide synthase inhibition on the pathophysiology observed in a model of chronic granulomatous colitis
    • Grisham MB, Specian R, Zimmerman TE. Effects of nitric oxide synthase inhibition on the pathophysiology observed in a model of chronic granulomatous colitis. J Pharm Exp Ther 1994;271: 1114-1121.
    • (1994) J Pharm Exp Ther , vol.271 , pp. 1114-1121
    • Grisham, M.B.1    Specian, R.2    Zimmerman, T.E.3
  • 73
    • 0342378148 scopus 로고    scopus 로고
    • Actions of isoform-selective and non-selective nitric oxide synthase inhibitors on endotoxin-induced vascular leakage in rat colon
    • Laszlo F, Whittle B. Actions of isoform-selective and non-selective nitric oxide synthase inhibitors on endotoxin-induced vascular leakage in rat colon. Eur J Pharmacol 1997;34:99-102.
    • (1997) Eur J Pharmacol , vol.34 , pp. 99-102
    • Laszlo, F.1    Whittle, B.2
  • 74
    • 0030783158 scopus 로고    scopus 로고
    • Inhibition of inducible nitric oxide synthase ameliorates endotoxin-induced gut mucosal barrier dysfunction in rats
    • Unno N, Wang H, Menconi M, et al. Inhibition of inducible nitric oxide synthase ameliorates endotoxin-induced gut mucosal barrier dysfunction in rats. Gastroenterology 1997;113: 1246-1257.
    • (1997) Gastroenterology , vol.113 , pp. 1246-1257
    • Unno, N.1    Wang, H.2    Menconi, M.3
  • 75
    • 0028577721 scopus 로고
    • Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase
    • Szabo C, Southan G, Thiemermann C. Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase. Proc Natl Acad Sci USA 1994;91:12 472-12 476.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12472-12476
    • Szabo, C.1    Southan, G.2    Thiemermann, C.3
  • 76
    • 0028879567 scopus 로고
    • Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis
    • Miller MJS, Thompson J, Zhang X, et al. Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis. Gastroenterology 1995;109:1475-1483.
    • (1995) Gastroenterology , vol.109 , pp. 1475-1483
    • Miller, M.J.S.1    Thompson, J.2    Zhang, X.3
  • 77
    • 0027402115 scopus 로고
    • Selective inhibition of the inducible nitric oxide sythase by aminoguanidine
    • Misko T, Moore W, Kasten T, et al. Selective inhibition of the inducible nitric oxide sythase by aminoguanidine. Eur J Pharmacol 1993;233:119-125.
    • (1993) Eur J Pharmacol , vol.233 , pp. 119-125
    • Misko, T.1    Moore, W.2    Kasten, T.3
  • 78
    • 0027161939 scopus 로고
    • Nitric oxide synthase induction and intestinal epithelial cell viability in rats
    • Tepperman B, Brown J, Whittle B. Nitric oxide synthase induction and intestinal epithelial cell viability in rats. Am J Physiol 1993;265:G214-G218.
    • (1993) Am J Physiol , vol.265
    • Tepperman, B.1    Brown, J.2    Whittle, B.3
  • 79
    • 0023001209 scopus 로고
    • Detectable colonic nitrite levels in inflammatory bowel disease - Mucosal or bacterial malfunction?
    • Roediger W, Lawson M, Nance S, Radcliffe B. Detectable colonic nitrite levels in inflammatory bowel disease - mucosal or bacterial malfunction? Digestion 1986;35:199-204.
    • (1986) Digestion , vol.35 , pp. 199-204
    • Roediger, W.1    Lawson, M.2    Nance, S.3    Radcliffe, B.4
  • 80
    • 0028081788 scopus 로고
    • Greatly increased luminal nitric oxide in ulcerative colitis
    • Lundberg J, Hellstrom P, Lundberg JM, Alving K. Greatly increased luminal nitric oxide in ulcerative colitis. Lancet 1994;344:1673-1674.
    • (1994) Lancet , vol.344 , pp. 1673-1674
    • Lundberg, J.1    Hellstrom, P.2    Lundberg, J.M.3    Alving, K.4
  • 81
    • 0027397892 scopus 로고
    • Increased nitric oxide synthesis in ulcerative colitis
    • Middleton S, Shorthouse M, Hunter J. Increased nitric oxide synthesis in ulcerative colitis. Lancet 1993;341:465-466.
    • (1993) Lancet , vol.341 , pp. 465-466
    • Middleton, S.1    Shorthouse, M.2    Hunter, J.3
  • 82
    • 0028998288 scopus 로고
    • Enhanced colonic nitric oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn's disease
    • Rachmilewitz D, Stamler J, Bachwich D, et al. Enhanced colonic nitric oxide generation and nitric oxide synthase activity in ulcerative colitis and Crohn's disease. Gut 1995;36:718-723.
    • (1995) Gut , vol.36 , pp. 718-723
    • Rachmilewitz, D.1    Stamler, J.2    Bachwich, D.3
  • 83
    • 0028885004 scopus 로고
    • Induction of nitric oxide synthase in colonic smooth muscle from patients with toxic megacolon
    • Mourelle M, Casellas F, Guarner F, et al. Induction of nitric oxide synthase in colonic smooth muscle from patients with toxic megacolon. Gastroenterology 1995;109:1497-1502.
    • (1995) Gastroenterology , vol.109 , pp. 1497-1502
    • Mourelle, M.1    Casellas, F.2    Guarner, F.3
  • 84
    • 0028784785 scopus 로고
    • Inducible nitric oxide synthase activity and expression in a human colonic epithelial cell line, HT-29
    • Kolios G, Brown Z, Robson R, et al. Inducible nitric oxide synthase activity and expression in a human colonic epithelial cell line, HT-29. Br J Pharmacol 1995;116:2866-2872.
    • (1995) Br J Pharmacol , vol.116 , pp. 2866-2872
    • Kolios, G.1    Brown, Z.2    Robson, R.3
  • 85
    • 0027255461 scopus 로고
    • Differential changes in nitric oxide synthase activity in ulcerative colitis and Crohn's disease
    • Boughton-Smith N, Evans S, Hawkey C, et al. Differential changes in nitric oxide synthase activity in ulcerative colitis and Crohn's disease. Lancet 1993;342:338-340.
    • (1993) Lancet , vol.342 , pp. 338-340
    • Boughton-Smith, N.1    Evans, S.2    Hawkey, C.3
  • 86
    • 0031049081 scopus 로고    scopus 로고
    • Interleukin-8 and inducible nitric oxide synthase mRNA levels in inflammatory bowel disease at first presentation
    • McLaughlan J, Seth R, Vautier G, et al. Interleukin-8 and inducible nitric oxide synthase mRNA levels in inflammatory bowel disease at first presentation. J Pathol 1997;181:87-92.
    • (1997) J Pathol , vol.181 , pp. 87-92
    • McLaughlan, J.1    Seth, R.2    Vautier, G.3
  • 87
    • 0026586461 scopus 로고
    • The role of nitric oxide in endothelial cell damage and its inhibition by glucocorticoids
    • Palmer RMJ, Bridge L, Foxwell NA, Moncada S. The role of nitric oxide in endothelial cell damage and its inhibition by glucocorticoids. Br J Pharmacol 1992;105:11-12.
    • (1992) Br J Pharmacol , vol.105 , pp. 11-12
    • Palmer, R.M.J.1    Bridge, L.2    Foxwell, N.A.3    Moncada, S.4
  • 88
    • 0029805172 scopus 로고    scopus 로고
    • Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and the ugly
    • Beckman J, Koppenol W. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and the ugly. Am J Physiol 1996;271:C1424-C1437.
    • (1996) Am J Physiol , vol.271
    • Beckman, J.1    Koppenol, W.2
  • 89
    • 0028905417 scopus 로고
    • Inhibition by sodium nitroprusside of the expression of inducible nitric oxide synthase in rat neutrophils
    • Mariotto S, Cuzzolin L, Adami A, et al. Inhibition by sodium nitroprusside of the expression of inducible nitric oxide synthase in rat neutrophils. Br J Pharmacol 1995;114:1105-1106.
    • (1995) Br J Pharmacol , vol.114 , pp. 1105-1106
    • Mariotto, S.1    Cuzzolin, L.2    Adami, A.3
  • 90
    • 0028863627 scopus 로고
    • Molecular mechanisms and therapeutic strategies related to nitric oxide
    • Moncada S, Higgs EA. Molecular mechanisms and therapeutic strategies related to nitric oxide. FASEB J 1995;9:1319-1330.
    • (1995) FASEB J , vol.9 , pp. 1319-1330
    • Moncada, S.1    Higgs, E.A.2
  • 91
    • 0029561225 scopus 로고
    • Nitric oxide as a mediator of inflammation? You had better believe it
    • Miller MJS, Grisham MB. Nitric oxide as a mediator of inflammation? You had better believe it. Mediators Inflamm 1995;4: 387-396.
    • (1995) Mediators Inflamm , vol.4 , pp. 387-396
    • Miller, M.J.S.1    Grisham, M.B.2
  • 92
    • 0027138788 scopus 로고
    • Peroxynitrite-induced rat colitis. A new model of colonic inflammation
    • Rachmilewitz D, Stamler J, Karmeli F, et al. Peroxynitrite-induced rat colitis. A new model of colonic inflammation. Gastroenterology 1993;105:1681-1688.
    • (1993) Gastroenterology , vol.105 , pp. 1681-1688
    • Rachmilewitz, D.1    Stamler, J.2    Karmeli, F.3
  • 94
    • 0027488067 scopus 로고
    • Inhibition of viral replication by interferon-gamma induced nitric oxide synthase
    • Karupiah G, Xie Q, Buller R, et al. Inhibition of viral replication by interferon-gamma induced nitric oxide synthase. Science 1993;261:1445-1448.
    • (1993) Science , vol.261 , pp. 1445-1448
    • Karupiah, G.1    Xie, Q.2    Buller, R.3
  • 95
    • 0028999596 scopus 로고
    • Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase
    • MacMicking J, Nathan C, Hom G, et al. Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase. Cell 1995;81:641-650.
    • (1995) Cell , vol.81 , pp. 641-650
    • MacMicking, J.1    Nathan, C.2    Hom, G.3
  • 96
    • 0026585423 scopus 로고
    • The rectal mucosa-associated microflora in patients with ulcerative colitis
    • Hartley M, Hudson M, Swarbrick E, et al. The rectal mucosa-associated microflora in patients with ulcerative colitis. J Med Microbiol 1992;36:96-103.
    • (1992) J Med Microbiol , vol.36 , pp. 96-103
    • Hartley, M.1    Hudson, M.2    Swarbrick, E.3
  • 97
    • 0028642343 scopus 로고
    • Nitric oxide synthase induction and cytoprotection of rat gastric mucosa from injury by ethanol
    • Tepperman B, Soper B, Nitric oxide synthase induction and cytoprotection of rat gastric mucosa from injury by ethanol. Can J Physiol Pharmacol 1994;72:1308-1312.
    • (1994) Can J Physiol Pharmacol , vol.72 , pp. 1308-1312
    • Tepperman, B.1    Soper, B.2
  • 98
    • 0031041841 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase plays a critical role in resolving intestinal inflammation
    • McCafferty D, Mudgett J, Swain M, Kubes P. Inducible nitric oxide synthase plays a critical role in resolving intestinal inflammation. Gastroenterology 1997;112:1022-1027.
    • (1997) Gastroenterology , vol.112 , pp. 1022-1027
    • McCafferty, D.1    Mudgett, J.2    Swain, M.3    Kubes, P.4
  • 99
    • 0029011129 scopus 로고
    • Induction and stabilization of IKB-alpha by nitric oxide mediates inhibition of NF-κB
    • Peng H, Libby P, Liao J. Induction and stabilization of IKB-alpha by nitric oxide mediates inhibition of NF-κB. J Biol Chem 1995;270:14214-14219.
    • (1995) J Biol Chem , vol.270 , pp. 14214-14219
    • Peng, H.1    Libby, P.2    Liao, J.3
  • 100
    • 0030774574 scopus 로고    scopus 로고
    • Endogenous but not exogenous nitric oxide decreases TNF-α-induced leukocyte rolling
    • Kubes P, Shihota E, Hickey M. Endogenous but not exogenous nitric oxide decreases TNF-α-induced leukocyte rolling. Am J Physiol 1997;273:G628-G635.
    • (1997) Am J Physiol , vol.273
    • Kubes, P.1    Shihota, E.2    Hickey, M.3
  • 101
    • 0031027504 scopus 로고    scopus 로고
    • Peroxynitrite inhibits leukocyte-endothelial cell interactions and protects against ishcemia-reperfusion injury in rats
    • Lefer DJ, Scalia R, Campbell B, et al. Peroxynitrite inhibits leukocyte-endothelial cell interactions and protects against ishcemia-reperfusion injury in rats. J Clin Invest 1997;99:684-691.
    • (1997) J Clin Invest , vol.99 , pp. 684-691
    • Lefer, D.J.1    Scalia, R.2    Campbell, B.3
  • 102
    • 0030048479 scopus 로고    scopus 로고
    • Modulation of superoxide-dependent oxidation and hydroxylation reactions by nitric oxide
    • Miles A, Bohle D, Glassbrennor P, et al. Modulation of superoxide-dependent oxidation and hydroxylation reactions by nitric oxide. J Biol Chem 1996;271:40-47.
    • (1996) J Biol Chem , vol.271 , pp. 40-47
    • Miles, A.1    Bohle, D.2    Glassbrennor, P.3
  • 103
    • 0028795665 scopus 로고
    • Excess nitric oxide does not cause cellular, vascular, or mucosal dysfunction in the cat small intestine
    • Kubes P, Reinhardt P, Payne D, Woodman R. Excess nitric oxide does not cause cellular, vascular, or mucosal dysfunction in the cat small intestine. Am J Physiol 1995;269:G34-G41.
    • (1995) Am J Physiol , vol.269
    • Kubes, P.1    Reinhardt, P.2    Payne, D.3    Woodman, R.4


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