메뉴 건너뛰기




Volumn 5, Issue 5, 2004, Pages 551-556

Nitroflurbiprofen (NicOx)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG DERIVATIVE; FLURBIPROFEN; FLURBIPROFEN 4 NITROXYBUTYL ESTER; NITRIC OXIDE DONOR; PROSTAGLANDIN SYNTHASE INHIBITOR;

EID: 3342984044     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (11)

References (47)
  • 1
    • 68549089505 scopus 로고    scopus 로고
    • 210830 NicOx files. NicOx SA PRESS RELEASE 1996 June 12
    • 210830 NicOx files. NicOx SA PRESS RELEASE 1996 June 12.
  • 2
    • 0028182409 scopus 로고    scopus 로고
    • 220943 Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat. Wallace JL, Reuter B, Cicala C, McNight W, Grisham MB, Cirino G GASTROENTEROLOGY 1994 107 1 173-179
    • 220943 Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat. Wallace JL, Reuter B, Cicala C, McNight W, Grisham MB, Cirino G GASTROENTEROLOGY 1994 107 1 173-179
  • 3
    • 68549089504 scopus 로고    scopus 로고
    • 224276 NO-NSAID: A new class of GI sparing nonsteroidal anti-inflammatory drugs. Cirino G, Del Soldato P, Robinson B, Wallace JL INT CONGR INFLAMM RES ASSOC 1996 8 Abs P70
    • 224276 NO-NSAID: A new class of GI sparing nonsteroidal anti-inflammatory drugs. Cirino G, Del Soldato P, Robinson B, Wallace JL INT CONGR INFLAMM RES ASSOC 1996 8 Abs P70
  • 4
    • 0029015241 scopus 로고    scopus 로고
    • 229295 Flurbinitroxybutylester: A novel anti-inflammatory drug has enhanced antithrombotic activity. Cirino G, Cicala C, Mancuso F, Baydoun AR, Wallace JL THROMB RES 1995 79 1 73-81
    • 229295 Flurbinitroxybutylester: A novel anti-inflammatory drug has enhanced antithrombotic activity. Cirino G, Cicala C, Mancuso F, Baydoun AR, Wallace JL THROMB RES 1995 79 1 73-81
  • 5
    • 68549123996 scopus 로고    scopus 로고
    • 243679 NicOx completes phase I clinical trial in UK of its anti-inflammatory HCT 1026. NicOx SA PRESS RELEASE 1997 April 25
    • 243679 NicOx completes phase I clinical trial in UK of its anti-inflammatory HCT 1026. NicOx SA PRESS RELEASE 1997 April 25
  • 6
    • 68549125857 scopus 로고    scopus 로고
    • 247995 Symposium on 'Newer, Safer NSAIDs' held in conjunction with Digestive Disease Week Washington DC, USA. IDDB MEETING REPORT 1997 May 10-14
    • 247995 Symposium on 'Newer, Safer NSAIDs' held in conjunction with Digestive Disease Week Washington DC, USA. IDDB MEETING REPORT 1997 May 10-14
  • 7
    • 8544278962 scopus 로고    scopus 로고
    • 257936 Intestinal tolerability of nitroxybutyl-flurbiprofen in rats. Somasundaram S, Rafi S, Jacob M, Sigthorsson G, Mahmud T, Sherwood R, Price AB, Macpherson A, Scott D, Wrigglesworth JM, Bjarnason I GUT 1997 40 5 608-613
    • 257936 Intestinal tolerability of nitroxybutyl-flurbiprofen in rats. Somasundaram S, Rafi S, Jacob M, Sigthorsson G, Mahmud T, Sherwood R, Price AB, Macpherson A, Scott D, Wrigglesworth JM, Bjarnason I GUT 1997 40 5 608-613
  • 8
    • 0027094145 scopus 로고    scopus 로고
    • 258550 Brain-derived neurotrophic factor rescues developing avian motoneurons from cell death. Oppenheim RW, Yin QW, Prevette D, Yan Q NATURE 1992 360 6406 755-757
    • 258550 Brain-derived neurotrophic factor rescues developing avian motoneurons from cell death. Oppenheim RW, Yin QW, Prevette D, Yan Q NATURE 1992 360 6406 755-757
  • 9
    • 0028335192 scopus 로고    scopus 로고
    • 261735 Antiproliferative effect of nonsteroidal antiinflammatory drugs against human colon cancer cells. Hixson LJ, Alberts DS, Krutzsch M, Einsphar J, Brendel K, Gross PH, Paranka NS, Baier M, Emerson S, Pamukcu R CANCER EPIDEMIOL BIOMARKERS PREV 1994 3 5 433-438
    • 261735 Antiproliferative effect of nonsteroidal antiinflammatory drugs against human colon cancer cells. Hixson LJ, Alberts DS, Krutzsch M, Einsphar J, Brendel K, Gross PH, Paranka NS, Baier M, Emerson S, Pamukcu R CANCER EPIDEMIOL BIOMARKERS PREV 1994 3 5 433-438
  • 10
    • 0031897299 scopus 로고    scopus 로고
    • 288552 Nitroflurbiprofen, a new nonsteroidal anti-inflammatory, ameliorates structural injury in the remnant kidney. Fujihara CK, Malheiros DMAC, Donato JL, Poli A, De Nucci G, Zatz R AM J PHYSIOL -RENAL PHYSIOL 1998 274 3 Pt 2 F573-F579
    • 288552 Nitroflurbiprofen, a new nonsteroidal anti-inflammatory, ameliorates structural injury in the remnant kidney. Fujihara CK, Malheiros DMAC, Donato JL, Poli A, De Nucci G, Zatz R AM J PHYSIOL -RENAL PHYSIOL 1998 274 3 Pt 2 F573-F579
  • 11
    • 0026460941 scopus 로고    scopus 로고
    • 290035 Role of nitric oxide in gastrointestinal and hepatic function and disease. Stark ME, Szurszewski JH GASTROENTEROLOGY 1992 103 6 1928-1949
    • 290035 Role of nitric oxide in gastrointestinal and hepatic function and disease. Stark ME, Szurszewski JH GASTROENTEROLOGY 1992 103 6 1928-1949
  • 12
    • 0029442233 scopus 로고    scopus 로고
    • 290036 Nitric oxide donors: Biochemical, pharmacology and therapeutics. Bauer JA, Booth BP, Fung HL ADV PHARMACOL 1995 34 361-381
    • 290036 Nitric oxide donors: Biochemical, pharmacology and therapeutics. Bauer JA, Booth BP, Fung HL ADV PHARMACOL 1995 34 361-381
  • 13
    • 68549140742 scopus 로고    scopus 로고
    • 295025 Nitric oxide donating flurbiprofen (HCT 1026) causes less endoscopic damage in healthy volunteers than flurbiprofen. Donnelly MT, Stack WA, Courtauld EM, Garlick N, Del Soldato P, Hawkey CJ GASTROENTEROLOGY 1998 114 4 Pt 2 A107
    • 295025 Nitric oxide donating flurbiprofen (HCT 1026) causes less endoscopic damage in healthy volunteers than flurbiprofen. Donnelly MT, Stack WA, Courtauld EM, Garlick N, Del Soldato P, Hawkey CJ GASTROENTEROLOGY 1998 114 4 Pt 2 A107
  • 14
    • 68549117608 scopus 로고    scopus 로고
    • 333029 Prevention of chronic neuro-inflammation by NO-releasing flurbiprofen in a new animal model of Alzheimer's disease. Hauss-Wegrzyniak B, Wenk GL MEDIATORS INFLAMM 1999 8 Suppl 1 P-11-15
    • 333029 Prevention of chronic neuro-inflammation by NO-releasing flurbiprofen in a new animal model of Alzheimer's disease. Hauss-Wegrzyniak B, Wenk GL MEDIATORS INFLAMM 1999 8 Suppl 1 P-11-15
  • 15
    • 68549096783 scopus 로고    scopus 로고
    • 334019 NicOx initiates phase IIa trial with HCT-1026 for urinary incontinence. NicOx SA PRESS RELEASE 1999 July 26
    • 334019 NicOx initiates phase IIa trial with HCT-1026 for urinary incontinence. NicOx SA PRESS RELEASE 1999 July 26
  • 16
    • 68549140740 scopus 로고    scopus 로고
    • 344641 NicOx Corporate Profile. NicOx SA COMPANY BROCHURE 1999 October 25
    • 344641 NicOx Corporate Profile. NicOx SA COMPANY BROCHURE 1999 October 25
  • 17
    • 68549138241 scopus 로고    scopus 로고
    • 351194 NicOx initiates phase IIa trial with HCT-1026 in Paget's disease. NicOx SA PRESS RELEASE 1999 December 20
    • 351194 NicOx initiates phase IIa trial with HCT-1026 in Paget's disease. NicOx SA PRESS RELEASE 1999 December 20
  • 18
    • 68549104842 scopus 로고    scopus 로고
    • 359768 NicOx initiates human clinical trials in dermatology with HCT-1026. NicOx SA PRESS RELEASE 2000 March 15
    • 359768 NicOx initiates human clinical trials in dermatology with HCT-1026. NicOx SA PRESS RELEASE 2000 March 15
  • 19
    • 68549123294 scopus 로고    scopus 로고
    • 363794 NicOx granted CTX for HCT-1026 by UK Medicines Control Agency in urinary incontinence. NicOx SA PRESS RELEASE 2000 April 20
    • 363794 NicOx granted CTX for HCT-1026 by UK Medicines Control Agency in urinary incontinence. NicOx SA PRESS RELEASE 2000 April 20
  • 20
    • 68549114139 scopus 로고    scopus 로고
    • 373045 NicOx announces positive preliminary phase I/II results in contact urticaria, commences second dermatology study. NicOx SA PRESS RELEASE 2000 July 03
    • 373045 NicOx announces positive preliminary phase I/II results in contact urticaria - commences second dermatology study. NicOx SA PRESS RELEASE 2000 July 03
  • 21
    • 68549138845 scopus 로고    scopus 로고
    • 391626 HCT 1026 shows positive clinical results in the treatment of skin inflammation. NicOx SA PRESS RELEASE 2000 November 28
    • 391626 HCT 1026 shows positive clinical results in the treatment of skin inflammation. NicOx SA PRESS RELEASE 2000 November 28
  • 22
    • 68549104841 scopus 로고    scopus 로고
    • 396119 NicOx: Harnessing the power of nitric oxide, Technology Update: NicOx SA, London UK. Brown H COMPANY PRESENTATION 2001 January 16
    • 396119 NicOx: Harnessing the power of nitric oxide - Technology Update: NicOx SA, London UK. Brown H COMPANY PRESENTATION 2001 January 16
  • 23
    • 0034042495 scopus 로고    scopus 로고
    • 399698 Opposite effects of flurbiprofen and the nitroxybutyl ester of flurbiprofen on apoptosis in cultured guinea-pig gastric mucous cells. Johal K, Hanson PJ BR J PHARMACOL 2000 130 4 811-818
    • 399698 Opposite effects of flurbiprofen and the nitroxybutyl ester of flurbiprofen on apoptosis in cultured guinea-pig gastric mucous cells. Johal K, Hanson PJ BR J PHARMACOL 2000 130 4 811-818
  • 24
    • 68549113516 scopus 로고    scopus 로고
    • 399993 Annual Report 1999: NicOx. NicOx SA ANNUAL REPORT 1999 December 31
    • 399993 Annual Report 1999: NicOx. NicOx SA ANNUAL REPORT 1999 December 31
  • 25
    • 68549138844 scopus 로고    scopus 로고
    • 406181 NicOx's HCT-1026 shows positive clinical dermatology results in prolonged contact urticaria. NicOx SA PRESS RELEASE 2001 April 18
    • 406181 NicOx's HCT-1026 shows positive clinical dermatology results in prolonged contact urticaria. NicOx SA PRESS RELEASE 2001 April 18
  • 26
    • 68549123995 scopus 로고    scopus 로고
    • 409357 NO-NSAIDs alter cell kinetics in human colon cancer cell lines more efficiently than traditional NSAIDs. Williams JL, Hasan I, Borgo S, Castillo E, Traganos F, Rigas B GASTROENTEROLOGY 2001 120 5 Suppl 1 Abs 879
    • 409357 NO-NSAIDs alter cell kinetics in human colon cancer cell lines more efficiently than traditional NSAIDs. Williams JL, Hasan I, Borgo S, Castillo E, Traganos F, Rigas B GASTROENTEROLOGY 2001 120 5 Suppl 1 Abs 879
  • 27
    • 68549087711 scopus 로고    scopus 로고
    • 445294 NicOx announces positive phase IIa clinical results for HCT 1026 in overactive bladder. NicOx SA PRESS RELEASE 2002 April 02
    • 445294 NicOx announces positive phase IIa clinical results for HCT 1026 in overactive bladder. NicOx SA PRESS RELEASE 2002 April 02
  • 28
    • 0032999306 scopus 로고    scopus 로고
    • 449904 Nitric oxide-releasing NSAIDs inhibit interleukin-1β converting enzyme-like cysteine proteases and protect endothelial cells from apoptosis induced by TNFα. Fiorucci S, Santucci L, Federici B, Antonelli E, Distrutti E, Morelli O, Renzo GD, Coata G, Cirino G, Soldato PD, Morelli A ALIMENT PHARMACOL THER 1999 13 3 421-435
    • 449904 Nitric oxide-releasing NSAIDs inhibit interleukin-1β converting enzyme-like cysteine proteases and protect endothelial cells from apoptosis induced by TNFα. Fiorucci S, Santucci L, Federici B, Antonelli E, Distrutti E, Morelli O, Renzo GD, Coata G, Cirino G, Soldato PD, Morelli A ALIMENT PHARMACOL THER 1999 13 3 421-435
  • 29
    • 68549104843 scopus 로고    scopus 로고
    • 480468 NicOx reports year-end 2002 financial results. NicOx SA PRESS RELEASE 2003 March 03
    • 480468 NicOx reports year-end 2002 financial results. NicOx SA PRESS RELEASE 2003 March 03
  • 30
    • 68549119462 scopus 로고    scopus 로고
    • 489398 NicOx announces successful phase I clinical results with HCT 1026 in development for Alzheimer's disease. NicOx SA PRESS RELEASE 2003 May 13
    • 489398 NicOx announces successful phase I clinical results with HCT 1026 in development for Alzheimer's disease. NicOx SA PRESS RELEASE 2003 May 13
  • 31
    • 68549100446 scopus 로고    scopus 로고
    • 490909 Neurodegenerative Disorders, SMi's Third Annual Conference, London, UK. Davies J IDDB MEETING REPORT 2003 May 21-22
    • 490909 Neurodegenerative Disorders - SMi's Third Annual Conference, London, UK. Davies J IDDB MEETING REPORT 2003 May 21-22
  • 32
    • 0035352883 scopus 로고    scopus 로고
    • 494638 Nitric oxide-releasing nonsteroidal anti-inflammatory drugs: Novel gastrointestinal-sparing drugs. Bandarage UK, Janero DR MINI REV MED CHEM 2001 1 1 57-70
    • 494638 Nitric oxide-releasing nonsteroidal anti-inflammatory drugs: Novel gastrointestinal-sparing drugs. Bandarage UK, Janero DR MINI REV MED CHEM 2001 1 1 57-70
  • 33
    • 0037119059 scopus 로고    scopus 로고
    • 507246 Metabolic profile of NO-flurbiprofen (HCT1026) in rat brain and plasma: A LC-MS study. Aldini G, Carini M, Orioli M, Facino RM, Wenk GL LIFE SCI 2002 71 13 1487-1500
    • 507246 Metabolic profile of NO-flurbiprofen (HCT1026) in rat brain and plasma: A LC-MS study. Aldini G, Carini M, Orioli M, Facino RM, Wenk GL LIFE SCI 2002 71 13 1487-1500
  • 34
    • 0036841077 scopus 로고    scopus 로고
    • 507247 NO-flurbiprofen maintains duodenal blood flow, enhances mucus secretion contributing to lower mucosal injury. Holm L, Phillipson M, Perry MA AM J PHYSIOL, GASTROINTEST LIVER PHYSIOL 2002 283 5 G1090-G1097
    • 507247 NO-flurbiprofen maintains duodenal blood flow, enhances mucus secretion contributing to lower mucosal injury. Holm L, Phillipson M, Perry MA AM J PHYSIOL - GASTROINTEST LIVER PHYSIOL 2002 283 5 G1090-G1097
  • 35
    • 0037174811 scopus 로고    scopus 로고
    • 507248 A nitric oxide-donating flurbiprofen derivative reduces neuroinflammation without interacting with galantamine in the rat. Wenk GL, Rosi S, McGann K, Hauss-Wegrzyniak B EUR J PHARMACOL 2002 453 2-3 319-324
    • 507248 A nitric oxide-donating flurbiprofen derivative reduces neuroinflammation without interacting with galantamine in the rat. Wenk GL, Rosi S, McGann K, Hauss-Wegrzyniak B EUR J PHARMACOL 2002 453 2-3 319-324
  • 36
    • 0036159486 scopus 로고    scopus 로고
    • 507249 Beneficial effects of NO-releasing derivative of flurbiprofen (HCT-1026) in rat model of vascular injury and restenosis. Maffia P, Ianaro A, Sorrentino R, Lippolis L, Maiello FM, del Soldato P, Ialenti A, Cirino G ARTERIOSCLEROSIS 2002 22 2 263-267
    • 507249 Beneficial effects of NO-releasing derivative of flurbiprofen (HCT-1026) in rat model of vascular injury and restenosis. Maffia P, Ianaro A, Sorrentino R, Lippolis L, Maiello FM, del Soldato P, Ialenti A, Cirino G ARTERIOSCLEROSIS 2002 22 2 263-267
  • 37
    • 0035462290 scopus 로고    scopus 로고
    • 507253 Inhibition of bone resorption in vitro and prevention of ovariectomy-induced bone loss in vivo by flurbiprofen nitroxybutylester HCT1026, Armour KJ, van' t RJ, Armour KE, Torbergsen AC, Del Soldato P, Ralston SH ARTHRITIS RHEUM 2001 44 9 2185-2192
    • 507253 Inhibition of bone resorption in vitro and prevention of ovariectomy-induced bone loss in vivo by flurbiprofen nitroxybutylester (HCT1026). Armour KJ, van' t RJ, Armour KE, Torbergsen AC, Del Soldato P, Ralston SH ARTHRITIS RHEUM 2001 44 9 2185-2192
  • 38
    • 0035889551 scopus 로고    scopus 로고
    • 507254 Differential effects of the nonsteroidal antiinflammatory drug flurbiprofen and its nitric oxide-releasing derivative, nitroflurbiprofen, on prostaglandin E2, interleukin-1β, and nitric oxide synthesis by activated microglia. Ajmone-Cat MA, Nicolini A, Minghetti L J NEUROSCI RES 2001 66 4 715-722
    • 2, interleukin-1β, and nitric oxide synthesis by activated microglia. Ajmone-Cat MA, Nicolini A, Minghetti L J NEUROSCI RES 2001 66 4 715-722
  • 39
    • 68549084155 scopus 로고    scopus 로고
    • 507649 Biopartnering, NicOx SA. ANN BIOPARTENERING EUROPE MEET 2001 11 October 12-14
    • 507649 Biopartnering - NicOx SA. ANN BIOPARTENERING EUROPE MEET 2001 11 October 12-14
  • 40
    • 68549117607 scopus 로고    scopus 로고
    • 509463 Anti-Inflammatory Therapeutics, SMi Conference, London, UK. Lunec A IDDB MEETING REPORT 2003 October 15-16
    • 509463 Anti-Inflammatory Therapeutics - SMi Conference, London, UK. Lunec A IDDB MEETING REPORT 2003 October 15-16
  • 41
    • 68549123297 scopus 로고    scopus 로고
    • 509781 Nitric Oxide (NO) Based Anti-Inflammatory agents; New Effective Anti-Inflammatory Drugs Based on Contribution by NO. Ongini E SMI CONF, ANTIINFLAMM THER 2003 October 15-16
    • 509781 Nitric Oxide (NO) Based Anti-Inflammatory agents; New Effective Anti-Inflammatory Drugs Based on Contribution by NO. Ongini E SMI CONF - ANTIINFLAMM THER 2003 October 15-16
  • 42
    • 68549115980 scopus 로고    scopus 로고
    • 512827 Cerebrospinal fluid concentration of flurbiprofen after multiple administrations of HCT 1026, a NO-donating derivative of flurbiprofen, in humans. Tocchetti P, Sardina M, Santus G, Casamenti F, Del Soldato P ABSTR SOC NEUROSCI 2003 33 Abs 525.12
    • 512827 Cerebrospinal fluid concentration of flurbiprofen after multiple administrations of HCT 1026, a NO-donating derivative of flurbiprofen, in humans. Tocchetti P, Sardina M, Santus G, Casamenti F, Del Soldato P ABSTR SOC NEUROSCI 2003 33 Abs 525.12
  • 43
    • 0036792055 scopus 로고    scopus 로고
    • 513790 Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: Shifting the angiogenic balance. Ma L, del Soldato P, Wallace JL PROC NATL ACAD SCI USA 2002 99 20 13243-13247
    • 513790 Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: Shifting the angiogenic balance. Ma L, del Soldato P, Wallace JL PROC NATL ACAD SCI USA 2002 99 20 13243-13247
  • 44
    • 0033063534 scopus 로고    scopus 로고
    • 515842 Nitric Oxide. V. therapeutic potential of nitric oxide donors and inhibitors. Muscara MN, Wallace JL AM J PHYSIOL 1999 276 6 Pt 1 G1313-G1316
    • 515842 Nitric Oxide. V. therapeutic potential of nitric oxide donors and inhibitors. Muscara MN, Wallace JL AM J PHYSIOL 1999 276 6 Pt 1 G1313-G1316
  • 45
    • 0035909511 scopus 로고    scopus 로고
    • 517677 Inhibition of human brain tumor cell growth by the anti-inflammatory drug, flurbiprofen. King JG, Khalili K ONCOGENE 2001 20 47 6864-6870
    • 517677 Inhibition of human brain tumor cell growth by the anti-inflammatory drug, flurbiprofen. King JG, Khalili K ONCOGENE 2001 20 47 6864-6870
  • 46
    • 0034655083 scopus 로고    scopus 로고
    • 517680 E-7869 (R-flurbiprofen) inhibits progression of prostate cancer in the TRAMP mouse. Wechter WJ, Leipold DD, Murray ED, Quiggle D, McCracken JD, Barrios RS, Greenberg NM CANCER RES 2000 60 8 2203-2208
    • 517680 E-7869 (R-flurbiprofen) inhibits progression of prostate cancer in the TRAMP mouse. Wechter WJ, Leipold DD, Murray ED, Quiggle D, McCracken JD, Barrios RS, Greenberg NM CANCER RES 2000 60 8 2203-2208
  • 47
    • 68549117606 scopus 로고    scopus 로고
    • 517685 Asprin and other nonsteroidal antiinflammatory drugs and the risk of cancer development. Thun MJ, Hennekens CH CANCER: PRINCIPLES PRACTICE ONCOL Devita VT, Hellman S, Rosenberg SA Eds, Lippincott Williams and Wilkins, Philadelphia, PA, USA 2001 5 602-606
    • 517685 Asprin and other nonsteroidal antiinflammatory drugs and the risk of cancer development. Thun MJ, Hennekens CH CANCER: PRINCIPLES PRACTICE ONCOL Devita VT, Hellman S, Rosenberg SA (Eds), Lippincott Williams and Wilkins, Philadelphia, PA, USA 2001 5 602-606


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.