Selective cyclo-oxygenase-2 inhibitors and their influence on the protective effect of a mild irritant in the rat stomach

British Journal of Pharmacology

Volumn 123, Issue 5, 1998, Pages 927-935

  Gretzer, Britta ^a   Ehrlich, Karlheinz ^a   Maricic, Nenad ^a   Lambrecht, Nils ^a,b   Respondek, Michael ^a   Peskar, Brigitta M ^a  

^a RUHR UNIVERSITY BOCHUM   (Germany)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Cyclo oxygenase 1; Cyclo oxygenase 2; DFU; Gastroprotection; L 745,337; Mild irritant; NS 398; Prostaglandins; Thromboxane

Indexed keywords

5,5 DIMETHYL 3 (3 FLUOROPHENYL) 4 (4 METHYLSULPHONYL)PHENYL 2(5H) FURANONE; 6 (2,4 DIFLUOROPHENYLTHIO) 5 METHANESULFONAMIDO 1 INDANONE; ALCOHOL; CYCLOOXYGENASE 2 INHIBITOR; DEXAMETHASONE; DIMERCAPROL; FURANONE DERIVATIVE; INDOMETACIN; IODOACETAMIDE; LITHIUM; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN E2; PROSTAGLANDIN F1 ALPHA; SALICYLATE SODIUM; THROMBOXANE B2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; GASTRITIS; HOMEOSTASIS; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RAT; STOMACH MUCOSA; STOMACH PROTECTION; SUBCUTANEOUS DRUG ADMINISTRATION; ULCEROGENESIS;

16,16-DIMETHYLPROSTAGLANDIN E2; ANIMALS; BLOOD PLATELETS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DEXAMETHASONE; DIMERCAPROL; EICOSANOIDS; ETHANOL; GASTRIC MUCOSA; IODOACETAMIDE; IRRITANTS; ISOENZYMES; LITHIUM; MALE; NITROBENZENES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RATS; RATS, WISTAR; SODIUM SALICYLATE; SULFONAMIDES;

EID: 0031932549     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701673     Document Type: Article

References (31)

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