Inhibition of lipopolysaccharide-induced microglial activation by preexposure to neurotrophin-3

Journal of Neuroscience Research

Volumn 81, Issue 5, 2005, Pages 666-676

  Tzeng, Shun Fen ^a   Huang, Hsin Ying ^a   Lee, Tsung I ^a   Jwo, Jeng Kuan ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

iNOS; Microglia; Neuroinflammation; Neurotrophin; Nuclear factor B; Signal transduction

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; K 252A; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NEUROTROPHIN 3; NITRIC OXIDE SYNTHASE; PHOSPHATIDYLINOSITOL 3 KINASE; SYNAPTOTAGMIN; AUTACOID; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1; NITRIC OXIDE; NOS2 PROTEIN, RAT; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL FUNCTION; CONTROLLED STUDY; DNA BINDING; DRUG INHIBITION; ENZYME INDUCTION; MICROGLIA; MOUSE; NEUROPROTECTION; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT; ANIMAL; CELL CULTURE; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; GEL MOBILITY SHIFT ASSAY; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; INFLAMMATION MEDIATORS; INTERLEUKIN-1; LIPOPOLYSACCHARIDES; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASES; NEUROTROPHIN 3; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PHAGOCYTOSIS; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 27244441679     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.20586     Document Type: Article

References (54)

1. Akama KT, Albanese C, Pestell RG, Van Eldik LJ. 1998. Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism. Proc Natl Acad Sci U S A 95:5795-5800.
2. Aloisi F. 1999. The role of microglia and astrocytes in CNS immune surveillance and immunopathology. Adv Exp Med Biol 468:123-133.
3. Aloisi F. 2001. Immune function of microglia. Glia 36:165-179.
4. Banati RB, Gehrmann J, Schubert P, Kreutzberg GW. 1993. Cytotoxicity of microglia. Glia 7:111-118.
5. Barren KD. 1995. The microglial cell. A historical review. J Neurol Sci 134(Suppl):57-68.
6. Batchelor PE, Liberatore GT, Wong JY, Porritt MJ, Frerichs F, Donnan GA, Howells DW. 1999. Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor.J Neurosci 19:1708-1716.
7. Bezzi P, Domercq M, Brambilla L, Galli R, Schols D, De Clercq E, Vescovi A, Bagetta G, Kollias G, Meldolesi J, Volterra A. 2001. CXCR4-activated astrocyte glutamate release via TNFalpha: amplification by microglia triggers neurotoxicity. Nat Neurosci 4:702-710.
8. Blinzinger K, Kreutzberg G. 1968. Displacement of synaptic terminals from regenerating motoneurons by microglial cells. Z Zellforsch Mikrosk Anat 85:145-157.
9. Chao CC, Hu S, Molitor TW, Shaskan EG, Peterson PK. 1992. Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J Immunol 149:2736-2741.
10. Chao CC, Hu S, Peterson PK. 1995. Glia, cytokines, and neurotoxicity. Crit Rev Neurobiol 9:189-205.
11. Chao MV. 2003. Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat Rev Neurosci 4:299-309.
12. Cuadros MA, Navascues J. 1998. The origin and differentiation of microglial cells during development. Prog Neurobiol 56:173-189.
13. Dai X, Lercher LD, Clinton PM, Du Y, Livingston DL, Vieira C, Yang L, Shen MM, Dreyfus CF. 2003. The trophic role of oligodendrocytes in the basal forebrain. J Neurosci 23:5846-5853.
14. Dehmer T, Lindenau J, Haid S, Dichgans J, Schulz JB. 2000. Deficiency of inducible nitric oxide synthase protects against MPTP toxicity in vivo. J Neurochem 74:2213-2216.
15. Dickson DW, Lee SC, Mattiace LA, Yen SH, Brosnan C. 1993. Microglia and cytokines in neurological disease, with special reference to AIDS and Alzheimer's disease. Glia 7:75-83.
16. Elkabes S, DiCicco-Bloom EM, Black IB. 1996. Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function. J Neurosci 16:2508-2521.
17. Elkabes S, Peng L, Black IB. 1998. Lipopolysaccharide differentially regulates microglial trk receptor and neurotrophin expression. J Neurosci Res 54: 117-122.
18. Gebicke-Haerter PJ. 2001. Microglia in neurodegeneration: molecular aspects. Microsc Res Techniq 54:47-58.
19. Ghosh S, May MJ, Kopp EB. 1998. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16:225-260.
20. Giulian D, Corpuz M. 1993. Microglial secretion products and their impact on the nervous system. Adv Neurol 59:315-320.
21. Hanisch UK. 2002. Microglia as a source and target of cytokines. Glia 40:140-155.
22. Heese K, Hock C, Otten U. 1998. Inflammatory signals induce neurotrophin expression in human microglial cells. J Neurochem 70:699-707.
23. Huang EJ, Reichardt LF. 2001. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24:677-736.
24. Kahn MA, Kumar S, Liebl D, Chang R, Parada LF, De Vellis J. 1999. Mice lacking NT-3, and its receptor TrkC, exhibit profound deficiencies in CNS glial cells. Glia 26:153-165.
25. Kreutzberg GW. 1996. Microglia: a sensor for pathological events in the CNS. Trends Neurosci 19:312-318.
26. Lewin GR, Barde YA. 1996. Physiology of the neurotrophins. Annu Rev Neurosci 19:289-317.
27. Lu B, Figurov A. 1997. Role of neurotrophins in synapse development and plasticity. Rev Neurosci 8:1-12.
28. Liu B, Hong JS. 2003. Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J Pharmacol Exp Ther 304:1-7.
29. Liu B, Wang K, Gao HM, Mandavilli B, Wang JY, Hong JS. 2001. Molecular consequences of activated microglia in the brain: overactivation induces apoptosis. J Neurochem 77:182-189.
30. Liu B, Gao HM, Wang JY, Jeohn GH, Cooper CL, Hong JS. 2002. Role of nitric oxide in inflammation-mediated neurodegeneration. Ann N Y Acad Sci 962:318-331.
31. Maisonpierre PC, Belluscio L, Friedman B, Alderson RF, Wiegand SJ, Furth ME, Lindsay RM, Yancopoulos GD. 1990. NT-3, BDNF, and NGF in the developing rat nervous system: parallel as well as reciprocal patterns of expression. Neuron 5:501-509.
32. Martin MU, Wesche H. 2002. Summary and comparison of the signaling mechanisms of the Toll/interleukin-1 receptor family. Biochim Biophys Acta 1592:265-280.
33. McCarthy KD, de Vellis J. 1980. Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J Cell Biol 85:890-902.
34. Merrill JE, Ignarro LJ, Sherman MP, Melinek J, Lane TE. 1993. Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide. J Immunol 151:2132-2141.
35. Nakajima K, Kohsaka S. 2001. Microglia: activation and their significance in the central nervous system. J Biochem (Tokyo) 130:169-175.
36. Nakajima K, Kikuchi Y, Ikoma E, Honda S, Ishikawa M, Liu Y, Kohsaka S. 1998. Neurotrophins regulate the function of cultured microglia. Glia 24:272-289.
37. Nakajima K, Honda S, Tohyama Y, Imai Y, Kohsaka S, Kurihara T. 2001. Neurotrophin secretion from cultured microglia. J Neurosci Res 65:322-331.
38. Neumann H, Boucraut J, Hahnel C, Misgeld T, Wekerle H. 1996. Neuronal control of MHC class II inducibility in rat astrocytes and microglia. Eur J Neurosci 8:2582-2590.
39. Neumann H, Misgeld T, Matsumuro K, Wekerle H. 1998. Neurotrophins inhibit major histocompatibility class II inducibility of microglia: involvement of the p75 neurotrophin receptor. Proc Natl Acad Sci U S A 95:5779-5784.
40. O'Neill LA, Kaltschmidt C. 1997. NF-kappa B: a crucial transcription factor for glial and neuronal cell function. Trends Neurosci 20:252-258.
41. Poo MM. 2001. Neurotrophins as synaptic modulators. Nat Rev Neurosci 2:24-32.
42. Rudge JS, Alderson RF, Pasnikowski E, McClain J, Ip NY, Lindsay RM. 1992. Expression of ciliary neurotrophic factor and the neurotrophins nerve growth factor, brain-derived neurotrophic factor and neurotrophin 3 in cultured rat hippocampal astrocytes. Eur J Neurosci 4:459-471.
43. Streit WJ. 2002. Microglia as neuroprotective, immunocompetent cells of the CNS. Glia 40:133-139.
44. Streit WJ, Graeber MB, Kreutzberg GW. 1989. Peripheral nerve lesion produces increased levels of major histocompatibility complex antigens in the central nervous system. J Neuroimmunol 21:117-123.
45. Thoenen H. 1995. Neurotrophins and neuronal plasticity. Science 270: 593-598.
46. Tzeng SF, Huang HY. 2003. Downregulation of inducible nitric oxide synthetase by neurotrophin-3 in microglia. J Cell Biochem 90:227-233.
47. Tzeng SF, Lee JL, Kuo JS, Yang CS, Murugan P, Ai Tai L, Chu Hwang K. 2002. Effects of malonate C60 derivatives on activated microglia. Brain Res 940:61-68.
48. Vass K, Lassmann H. 1990. Intrathecal application of interferon gamma. Progressive appearance of MHC antigens within the rat nervous system. Am J Pathol 137:789-800.
49. Weinstein DL, Walker DG, Akiyama H, McGeer PL. 1990. Herpes simplex virus type I infection of the CNS induces major histocompatibility complex antigen expression on rat microglia. J Neurosci Res 26:55-65.
50. Xie Z, Wei M, Morgan TE, Fabrizio P, Han D, Finch CE, Longo VD. 2002. Peroxynitrite mediates neurotoxicity of amyloid beta-peptide1-42- and lipopolysaccharide-activated microglia. J Neurosci 22:3484-3492.
51. Zhang G, Ghosh S. 2001. Toll-like receptor-mediated NF-kappaB activation: a phylogenetically conserved paradigm in innate immunity. J Clin Invest 107:13-19.
52. Zhang J, Geula C, Lu C, Koziel H, Hatcher LM, Roisen FJ. 2003. Neurotrophins regulate proliferation and survival of two microglial cell lines in vitro. Exp Neurol 183:469-481.
53. Zielasek J, Hartung HP. 1996. Molecular mechanisms of microglial activation. Adv Neuroimmunol 6:191-122.
54. Zielasek J, Tausch M, Toyka KV, Hartung HP. 1992. Production of nitrite by neonatal rat microglial cells/brain macrophages. Cell Immunol 141:111-120.