Inducible nitric oxide synthase inhibition improves intestinal microcirculatory oxygenation and CO2 balance during endotoxemia in pigs

Intensive Care Medicine

Volumn 31, Issue 7, 2005, Pages 985-992

  Siegemund, Martin ^a,b   Van Bommel, Jasper ^c   Schwarte, Lothar A ^a   Studer, Wolfgang ^b   Girard, Thierry ^b   Marsch, Stephan ^b   Radermacher, Peter ^d   Ince, Can ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

Endotoxemia, physiopathology; Microcirculation, physiopathology; Nitric oxide synthase; Oxygen consumption, drug effects; Regional blood flow, drug effects; Shock, septic

Indexed keywords

CARBON DIOXIDE; INDUCIBLE NITRIC OXIDE SYNTHASE; N [3 (AMINOMETHYL)BENZYL]ACETAMIDINE; N [3 (AMINOMETHYL)BENZYL]ACETAMIDINE HYDROCHLORIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR; PALLADIUM; PORPHYRIN; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOMESTIC PIG; ENDOTOXEMIA; ENZYME INHIBITION; HEART OUTPUT; HEMODYNAMICS; INTESTINE BLOOD FLOW; LIQUID; MEAN ARTERIAL PRESSURE; MICROCIRCULATION; NONHUMAN; OXYGEN TRANSPORT; OXYGENATION; PHOSPHORESCENCE; RESUSCITATION; SEPTIC SHOCK; TONOMETRY;

ANIMALS; BLOOD PRESSURE; ENDOTOXEMIA; ENZYME INHIBITORS; INTESTINES; MICROCIRCULATION; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OXYGEN CONSUMPTION; SWINE;

EID: 21744461894     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-005-2664-7     Document Type: Article

References (50)

1. Dellinger RP (2003) Cardiovascular management of septic shock. Crit Care Med 31:946-955
2. Price S, Anning PB, Mitchell JA, Evans TW (1999) Myocardial dysfunction in sepsis: mechanisms and therapeutic implications. Eur Heart J 20:715-724
3. Ince C, Sinaasappel M (1999) Microcirculatory oxygenation and shunting in sepsis and shock. Crit Care Med 27:1369-1377
4. Siegemund M, van Bommel J, Ince C (1999) Assessment of tissue oxygenation. Intensive Care Med 25:1044-1060
5. Fink MP (2002) Bench-to-bedside review: cytopathic hypoxia. Crit Care 6:491-499
6. Brown GC (2001) Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxidase. Biochim Biophys Acta 1504:46-57
7. Lopez A, Lorente JA, Steingrub J, Bakker J, McLuckie A, Willatts S, Brockway M, Anzueto A, Holzapfel L, Breen D, Silverman MS, Takala J, Donaldson J, Arneson C, Grove G, Grossman S, Grover R (2004) Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock. Crit Care Med 32:21-30
8. Liaudet L, Rosselet A, Schaller MD, Markert M, Perret C, Feihl F (1998) Nonselective versus selective inhibition of inducible nitric oxide synthase in experimental endotoxic shock. J Infect Dis 177:127-132
9. Laszlo F, Whittle BJ (1997) Actions of isoform-selective and non-selective nitric oxide synthase inhibitors on endotoxin-induced vascular leakage in rat colon. Eur J Pharmacol 334:99-102
10. Strunk V, Hahnenkamp K, Schneuing M, Fischer LG, Rich GF (2001) Selective iNOS inhibition prevents hypotension in septic rats while preserving endothelium-dependent vasodilation. Anesth Analg 92:681-687
11. Pittner A, Nalos M, Asfar P, Yang Y, Ince C, Georgieff M, Bruckner UB, Radermacher P, Froba G (2003) Mechanisms of inducible nitric oxide synthase (iNOS) inhibition-related improvement of gut mucosal acidosis during hyperdynamic porcine endotoxemia. Intensive Care Med 29:312-316
12. Stehr A, Ploner F, Tugtekin I, Matejovic M, Theisen M, Zulke C, Georgieff M, Radermacher P, Jauch KW (2003) Effect of combining nicotinamide as a PARS-inhibitor with selective iNOS blockade during porcine endotoxemia. Intensive Care Med 29:995-1002
13. 2-exchange and energy metabolism during hyperdynamic porcine endotoxemia. Shock 16:203-210
14. Cohen RI, Shapir Y, Davis A, Loona R, Scharf SM (2000) Comparison between selective and nonselective nitric oxide synthase inhibition and phenylephrine in normal and endotoxic swine. Crit Care Med 28:3257-3267
15. Borutaite V, Matthias A, Harris H, Moncada S, Brown GC (2001) Reversible inhibition of cellular respiration by nitric oxide in vascular inflammation. Am J Physiol Heart Circ Physiol 281:H2256-H2260
16. 2 extraction in sepsis. Am J Physiol 282:H156-H164
17. Lam C, Tyml K, Martin C, Sibbald W (1994) Microvascular perfusion is impaired in a rat model of normotensive sepsis. J Clin Invest 94:2077-2083
18. Lush CW, Kvietys PR (2000) Microvascular dysfunction in sepsis. Microcirculation 7:83-101
19. 2 gap is associated with impaired villus microcirculation in endotoxic pigs. Intensive Care Med 27:757-766
20. Revelly JP, Ayuse T, Brienza N, Fessler HE, Robotham JL (1996) Endotoxic shock alters distribution of blood flow within the intestinal wall. Crit Care Med 24:1345-1351
21. Revelly J-P, Liaudet L, Frascarolo P, Joseph J-M, Martinet O, Markert M (2000) Effects of norepinephrine on the distribution of intestinal blood flow and tissue adenosine triphosphate content in endotoxic shock. Crit Care Med 28:2500-2506
22. Neviere RR, Pitt-Hyde ML, Piper RD, Sibbald WJ, Potter RF (1999) Microvascular perfusion deficits are not a prerequisite for mucosal injury in septic rats. Am J Physiol 276:G933-G940
23. van der Meer JT, Wang H, Fink MP (1995) Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock. Crit Care Med 23:1217-1226
24. Morin M, J, Unno N, Hodin RA, Fink MP (1998) Differential experession of inducible nitric oxide synthase messenger RNA along the longitudinal and crypt-villus axes of the intestine in endotoxemic rats. Crit Care Med 26:1258-1264
25. Avontuur JAM, Bruining HA, Ince C (1997) Nitric oxide causes dysfunction of coronary autoregulation in endotoxemic rats. Cardiovasc Res 35:368-376
26. Garvey EP, Oplinger JA, Furfine ES, Kiff RJ, Laszlo F, Whittle BJ, Knowles RG (1997) 1400 W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem 272:4959-4963
27. Siegemund M, van Bommel J, Schwarte LA, Emons M, Ince C (2001) Selective blockade of iNOS by 1400 W restores the gut oxygenation in a pig model of low-dose endotoxemia (abstract 48). Intensive Care Med 27:S147
28. 2 difference is a better marker of ischemia than intramural pH (pHi) or arterial pH-pHi difference. J Crit Care 11:51-56
29. Sinaasappel M, Ince C (1996) Calibration of Pd-porphyrin phosphorescence for oxygen concentration measurements in vivo. J Appl Physiol 81:2297-2303
30. Vanderkooi JM, Maniara G, Green TJ, Wilson DF (1987) An optical method for measurement of dioxygen concentration based upon quenching of phosphorescence. J Biol Chem 262:5476-5482
31. Shonat RD, Johnson PC (1997) Oxygen tension gradients and heterogeneity in venous microcirculation: a phosphorescence quenching study. Am J Physiol 272:H2233-H2240
32. Sinaasappel M, van Iterson M, Ince C (1999) Microvascular oxygen pressure in the pig intestine during haemorrhagic shock and resuscitation. J Physiol (Lond) 514:245-253
33. 2 measurements in the rat intestinal microcirculation. Am J Physiol 276:G1515-G1520
34. Flesch M, Kilter H, Cremers B, Laufs U, Sudkamp M, Ortmann M, Muller FU, Bohm M (1999) Effects of endotoxin on human myocardial contractility involvement of nitric oxide and peroxynitrite. J Am Coll Cardiol 33:1062-1070
35. Cohen RI, Hassell AM, Ye X, Marzouk K, Liu SF (2003) Lipopolysaccharide down-regulates inducible nitric oxide synthase expression in swine heart in vivo. Biochem Biophys Res Commun 307:451-458
36. Avontuur JA, Bruining HA, Ince C (1995) Inhibition of nitric oxide synthesis causes myocardial ischemia in endotoxemic rats. Circ Res 76:418-425
37. G-monomethyl-L-arginine in porcine septic shock. Am J Respir Crit Care Med 159:1758-1765
38. Sielenkämper AW, Meyer J, Kloppenburg H, Eicker K, Van Aken H (2001) The effects of sepsis on gut mucosal blood flow in rats. Eur J Anaesthesiol 18:673-678
39. Crouser ED, Julian MW, Weinstein DM, Fahy RJ, Bauer JA (2000) Endotoxin-induced ileal mucosal injury and nitric oxide dysregulation are temporally dissociated. Am J Respir Crit Care Med 161:1705-1712
40. Unno N, Wang H, Menconi MJ, Tytgat SH, Larkin V, Smith M, Morin MJ, Chavez A, Hodin RA, Fink MP (1997) Inhibition of inducible nitric oxide synthase ameliorates endotoxin-induced gut mucosal barrier dysfunction in rats. Gastroenterology 113:1246-1257
41. Kalff JC, Schraut WH, Billiar TR, Simmons RL, Bauer AJ (2000) Role of inducible nitric oxide synthase in post-operative intestinal smooth muscle dysfunction in rodents. Gastroenterology 118:316-327
42. Matejovic M, Krouzecky A, Martinkova V, Rokyta R Jr, Kralova H, Treska V, Radermacher P, Novak I (2004) Selective inducible nitric oxide synthase inhibition during long-term hyperdynamic porcine bacteremia. Shock 21:458-465
43. Brown GC (1999) Nitric oxide and mitochondrial respiration. Biochim Biophys Acta 1411:351-369
44. Javeshghani D, Magder S (2001) Presence of nitrotyrosine with minimal inducible nitric oxide synthase induction in lipopolysaccharide-treated pigs. Shock 16:304-311
45. King CJ, Tytgat S, Delude RL, Fink MP (1999) Ileal mucosal oxygen consumption is decreased in endotoxemic rats but is restored toward normal by treatment with aminoguanidine. Crit Care Med 27:2518-2524
46. Cohen RI, Hassell AM, Marzouk K, Marini C, Liu SF, Scharf SM (2001) Renal effects of nitric oxide in endotoxemia. Am J Respir Crit Care Med 164:1890-1895
47. Albertini M, Lafortuna CL, Clement MG, Mazzola S, Radice S, Hussain SN (2002) Effect of NO synthase inhibition on cardiovascular and pulmonary dysfunction in a porcine short-term model of endotoxic shock. Prostaglandins Leukot Essent Fatty Acids 67:365-372
48. Snygg J, Casselbrant A, Pettersson A, Holm M, Fandriks L, Aneman A (2000) Tonometric assessment of jejunal mucosal nitric oxide formation in anaesthetized pigs. Acta Physiol Scand 169:39-45
49. Mehta S, Javeshghani D, Datta P, Levy RD, Magder S (1999) Porcine endotoxemic shock is associated with increased expired nitric oxide. Crit Care Med 27:385-393
50. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345:1368-1377