Uteroplacental insufficiency alters hepatic expression, phosphorylation, and activity of the glucocorticoid receptor in fetal IUGR rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 289, Issue 5 58-5, 2005, Pages

  Baserga, Mariana ^a   Hale, Merica A ^a   McKnight, Robert A ^a   Yu, Xing ^a   Callaway, Christopher W ^a   Lane, Robert H ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

11 hydroxysteroid dehydrogenase type 1; Cyclin A; Cyclin dependent kinase 2; Phosphoglucocorticoid receptor (serine 211)

Indexed keywords

CORTICOSTERONE; CYCLIN A; CYCLIN DEPENDENT KINASE 2; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; PROTEIN BAX; PROTEIN P53; SERINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY LIGATION; ARTICLE; CHROMATIN STRUCTURE; CONTROLLED STUDY; CORTICOSTERONE RELEASE; DOWN REGULATION; FEMALE; FETUS; GENE EXPRESSION REGULATION; INTRAUTERINE GROWTH RETARDATION; LIVER; NONHUMAN; PATHOPHYSIOLOGY; PLACENTA INSUFFICIENCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; UTERINE ARTERY;

ANIMALS; CHROMATIN; CORTICOSTERONE; CYCLIN A; FEMALE; FETAL GROWTH RETARDATION; GENE EXPRESSION REGULATION, DEVELOPMENTAL; LIVER; PHOSPHORYLATION; PLACENTAL INSUFFICIENCY; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER; SERINE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 27144522561     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00211.2005     Document Type: Article

References (55)

1. American Physiological Society. Guiding principles for research involving animals and human beings. Am J Physiol Regul Integr Comp Physiol 283: R281-R283, 2002.
2. Barker DJ. The developmental origins of adult disease. J Am Coll Nutr 23, Suppl 6; 588S-595S, 2004.
3. Barker DJ, Hales CN, Fall CH, Osmond C, Phipps K, and Clark PM. Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia 36: 62-67, 1993.
4. Baserga M, Bertolotto C, Maclennan NK, Hsu JL, Pham T, Laksana GS, and Lane RH. Uteroplacental insufficiency decreases small intestine growth and alters apoptotic homeostasis in term intrauterine growth retarded rats. Early Hum Dev 79: 93-105, 2004.
5. Blum A and Maser E. Enzymology and molecular biology of glucocorticoid metabolism in humans. Prog Nucleic Acid Res Mol Biol 75: 173-216, 2003.
6. Bodwell JE, Webster JC, Jewell CM, Cidlowski JA, Hu JM, and Munck A. Glucocorticoid receptor phosphorylation: overview, function and cell cycle-dependence. J Steroid Biochem Mol Biol 65: 91-99, 1998.
7. Cleasby ME, Livingstone DE, Nyirenda MJ, Seckl JR, and Walker BR. Is programming of glucocorticoid receptor expression by prenatal dexamethasone in the rat secondary to metabolic derangement in adulthood? Eur J Endocrinol 148: 129-138, 2003.
8. Deroo BJ and Archer TK. Glucocorticoid receptor-mediated chromatin remodeling in vivo. Oncogene 20: 3039-3046, 2001.
9. Economides DL and Nicolaides KH. Blood glucose and oxygen tension levels in small-for-gestational-age fetuses. Am J Obstet Gynecol 160: 385-389, 1989.
10. Economides DL, Nicolaides KH, and Campbell S. Metabolic and endocrine findings in appropriate and small for gestational age fetuses. J Perinat Med 19: 97-105, 1991.
11. Economides DL, Nicolaides KH, Gahl WA, Bernardini I, Bottoms S, and Evans M. Cordocentesis in the diagnosis of intrauterine starvation. Am J Obstet Gynecol 161: 1004-1008, 1989.
12. Economides DL, Nicolaides KH, Linton EA, Perry LA, and Chard T. Plasma cortisol and adrenocorticotropin in appropriate and small for gestational age fetuses. Fetal Ther 3: 158-164, 1988.
13. Fu Q, McKnight RA, Yu X, Wang L, Callaway CW, and Lane RH. Uteroplacental insufficiency induces site-specific changes in histone H3 covalent modifications and affects DNA-histone H3 positioning in day 0 IUGR rat liver. Physiol Genomics 20: 108-116, 2004.
14. Ganguli G, Back J, Sengupta S, and Wasylyk B. The p53 tumour suppressor inhibits glucocorticoid-induced proliferation of erythroid progenitors. EMBO Rep 3: 569-574, 2002.
15. Higuchi R, Fockler C, Dollinger G, and Watson R. Kinetic PCR analysis: real-time monitoring of DNA amplification reactions. Biotechnology 11: 1026-1030, 1993.
16. Holt RI. Fetal programming of the growth hormone-insulin-like growth factor axis. Trends Endocrinol Metab 13: 392-397, 2002.
17. Ismaili N and Garabedian MJ. Modulation of glucocorticoid receptor function via phosphorylation. Ann NY Acad Sci 1024: 86-101, 2004.
18. Jamieson PM, Chapman KE, and Seckl JR. Tissue- and temporal-specific regulation of 11β-hydroxysteroid dehydrogenase type 1 by glucocorticoids in vivo. J Steroid Biochem Mol Biol 68: 245-250, 1999.
19. Kalinyak JE, Griffin CA, Hamilton RW, Bradshaw JG, Perlman AJ, and Hoffman AR. Developmental and hormonal regulation of glucocorticoid receptor messenger RNA in the rat. J Clin Invest 84: 1843-1848, 1989.
20. Kellendonk C, Tronche F, Reichardt HM, and Schutz G. Mutagenesis of the glucocorticoid receptor in mice. J Steroid Biochem Mol Biol 69: 253-259, 1999.
21. Kloesz JL, Serdikoff CM, Maclennan NK, Adibi SA, and Lane RH. Uteroplacental insufficiency alters liver and skeletal muscle branched-chain amino acid metabolism in intrauterine growth-restricted fetal rats. Pediatr Res 50: 604-610, 2001.
22. Ko LJ and Prives C. p53: puzzle and paradigm. Genes Dev 10: 1054-1072, 1996.
23. Kotelevtsev Y, Holmes MC, Burchell A, Houston PM, Schmoll D, Jamieson P, Best R, Brown R, Edwards CR, Seckl JR, and Mullins JJ. 11β-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress. Proc Natl Acad Sci USA 94: 14924-14929, 1997.
24. Krstic MD, Rogatsky I, Yamamoto KR, and Garabedian MJ. Mitogen-activated and cyclin-dependent protein kinases selectively and differentially modulate transcriptional enhancement by the glucocorticoid receptor. Mol Cell Biol 17: 3947-3954, 1997.
25. Lane RH, Flozak AS, Ogata ES, Bell GI, and Simmons RA. Altered hepatic gene expression of enzymes involved in energy metabolism in the growth-retarded fetal rat. Pediatr Res 39: 390-394, 1996.
26. Lane RH, Kelley DE, Gruetzmacher EM, and Devaskar SU. Uteroplacental insufficiency alters hepatic fatty acid-metabolizing enzymes in juvenile and adult rats. Am J Physiol Regul Integr Comp Physiol 280: R183-R190, 2001.
27. Lane RH, MacLennan NK, Hsu JL, Janke SM, and Pham TD. Increased hepatic peroxisome proliferator-activated receptor-γ coactivator-1 gene expression in a rat model of intrauterine growth retardation and subsequent insulin resistance. Endocrinology 143: 2486-2490, 2002.
28. Levitt NS, Lambert EV, Woods D, Hales CN, Andrew R, and Seckl JR. Impaired glucose tolerance and elevated blood pressure in low birth weight, nonobese, young South African adults: early programming of cortisol axis. J Clin Endocrinol Metab 85: 4611-4618, 2000.
29. Lindsay RS, Lindsay RM, Waddell BJ, and Seckl JR. Prenatal glucocorticoid exposure leads to offspring hyperglycaemia in the rat: studies with the 11β-hydroxysteroid dehydrogenase inhibitor carbenoxolone. Diabetologia 39: 1299-1305, 1996.
30. MacLennan NK, James SJ, Melnyk S, Piroozi A, Jernigan S, Hsu JL, Janke SM, Pham TD, and Lane RH. Uteroplacental insufficiency alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR rats. Physiol Genomics 18: 43-50, 2004.
31. Menon RK, Shaufl A, Yu JH, Stephan DA, and Friday RP. Identification and characterization of a novel transcript of the murine growth hormone receptor gene exhibiting development- and tissue-specific expression. Mol Cell Endocrinol 172: 135-146, 2001.
32. Mitchell MJ, Woods DR, Tucker PK, Opp JS, and Bishop CE. Homology of a candidate spermatogenic gene from the mouse Y chromosome to the ubiquitin-activating enzyme E1. Nature 354: 483-486, 1991.
33. Nishimura K, Makino S, Tanaka Y, Kaneda T, and Hashimoto K. Altered expression of p53 mRNA in the brain and pituitary during repeated immobilization stress: negative correlation with glucocorticoid receptor mRNA levels. J Neuroendocrinol 16: 84-91, 2004.
34. Nyirenda MJ, Lindsay RS, Kenyon CJ, Burchell A, and Seckl JR. Glucocorticoid exposure in late gestation permanently programs rat hepatic phosphoenolpyruvate carboxykinase and glucocorticoid receptor expression and causes glucose intolerance in adult offspring. J Clin Invest 101: 2174-2181, 1998.
35. Ogata ES, Bussey ME, and Finley S. Altered gas exchange, limited glucose and branched chain amino acids, and hypoinsulinism retard fetal growth in the rat. Metabolism 35: 970-977, 1986.
36. Ogata ES, Bussey ME, LaBarbera A, and Finley S. Altered growth, hypoglycemia, hypoalaninemia, and ketonemia in the young rat: postnatal consequences of intrauterine growth retardation. Pediatr Res 19: 32-37, 1985.
37. Ogata ES, Swanson SL, Collins JW Jr, and Finley SL. Intrauterine growth retardation: altered hepatic energy and redox states in the fetal rat. Pediatr Res 27: 56-63, 1990.
38. Pham TD, MacLennan NK, Chiu CT, Laksana GS, Hsu JL, and Lane RH. Uteroplacental insufficiency increases apoptosis and alters p53 gene methylation in the full-term IUGR rat kidney. Am J Physiol Regul Integr Comp Physiol 285: R962-R970, 2003.
39. Phillips DI, Barker DJ, Fall CH, Seckl JR, Whorwood CB, Wood PJ, and Walker BR. Elevated plasma cortisol concentrations: a link between low birth weight and the insulin resistance syndrome? J Clin Endocrinol Metab 83: 757-760, 1998.
40. Phipps K, Barker DJ, Hales CN, Fall CH, Osmond C, and Clark PM. Fetal growth and impaired glucose tolerance in men and women. Diabetologia 36: 225-228, 1993.
41. Reichardt HM, Umland T, Bauer A, Kretz O, and Schutz G. Mice with an increased glucocorticoid receptor gene dosage show enhanced resistance to stress and endotoxic shock. Mol Cell Biol 20: 9009-9017, 2000.
42. Schmidt TJ and Meyer AS. Autoregulation of corticosteroid receptors. How, when, where, and why? Receptor 4: 229-257, 1994.
43. Schuler M and Green DR. Mechanisms of p53-dependent apoptosis. Biochem Soc Trans 29: 684-688, 2001.
44. Seckl JR, Cleasby M, and Nyirenda MJ. Glucocorticoids, 11β-hydroxysteroid dehydrogenase, and fetal programming. Kidney Int 57: 1412-1417, 2000.
45. Seckl JR and Walker BR. Minireview: 11β-hydroxysteroid dehydrogenase type 1-a tissue-specific amplifier of glucocorticoid action. Endocrinology 142: 1371-1376, 2001.
46. Sengupta S and Wasylyk B. Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2. Genes Dev 15: 2367-2380, 2001.
47. Sengupta S and Wasylyk B. Physiological and pathological consequences of the interactions of the p53 tumor suppressor with the glucocorticoid, androgen, and estrogen receptors. Ann NY Acad Sci 1024: 54-71, 2004.
48. Simmons RA, Templeton LJ, and Gertz SJ. Intrauterine growth retardation leads to the development of type 2 diabetes in the rat. Diabetes 50: 2279-2286, 2001.
49. Sloboda DM, Newnham JP, and Challis JR. Repeated maternal glucocorticoid administration and the developing liver in fetal sheep. J Endocrinol 175: 535-543, 2002.
50. Stewart PM and Krozowski ZS. 11β-Hydroxysteroid dehydrogenase. Vitam Horm 57: 249-324, 1999.
51. Tronche F, Kellendonk C, Reichardt HM, and Schutz G. Genetic dissection of glucocorticoid receptor function in mice. Curr Opin Genet Dev 8: 532-538, 1998.
52. Trotter KW and Archer TK. Reconstitution of glucocorticoid receptor-dependent transcription in vivo. Mol Cell Biol 24: 3347-3358, 2004.
53. Tsirka AE, Gruetzmacher EM, Kelley DE, Ritov VH, Devaskar SU, and Lane RH. Myocardial gene expression of glucose transporter 1 and glucose transporter 4 in response to uteroplacental insufficiency in the rat. J Endocrinol 169: 373-380, 2001.
54. Wang Z, Frederick J, and Garabedian MJ. Deciphering the phosphorylation "code" of the glucocorticoid receptor in vivo. J Biol Chem 277: 26573-26580, 2002.
55. Witlin AG and Sibai BM. Hypertension in pregnancy: current concepts of preeclampsia. Annu Rev Med 48: 115-127, 1997.