Donitriptan decreases jugular venous oxygen saturation in rats in the absence of cranial vasoconstriction: An overlooked mechanism of antimigraine action?

Journal of Pharmacology and Experimental Therapeutics

Volumn 315, Issue 2, 2005, Pages 849-857

  Létienne, Robert ^a   Blanchet, Jean Christophe ^a   Sole, Estelle ^a   John, Gareth W ^a   Le Grand, Bruno ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMIGRAINE AGENT; CARBON DIOXIDE; DONITRIPTAN; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; SEROTONIN 1B ANTAGONIST; SEROTONIN 1D ANTAGONIST; SUMATRIPTAN; VASOCONSTRICTOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; ARTICLE; BLOOD FLOW; BRAIN OXYGEN CONSUMPTION; CAROTID ARTERY; CONTROLLED STUDY; HEART RATE; JUGULAR VEIN; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RAT; VASOCONSTRICTION; VEIN ANASTOMOSIS; VENOUS BLOOD; VENOUS OXYGEN TENSION; VENOUS PRESSURE;

ANIMALS; BLOOD GAS ANALYSIS; CEREBROVASCULAR CIRCULATION; HEMODYNAMIC PROCESSES; JUGULAR VEINS; MALE; MIGRAINE DISORDERS; NITRILES; OXADIAZOLES; OXYGEN; PIPERAZINES; RATS; RATS, SPRAGUE-DAWLEY; REGIONAL BLOOD FLOW; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SUMATRIPTAN; TRYPTAMINES; VASOCONSTRICTION;

EID: 27144503434     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.090159     Document Type: Article

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