Curcumin suppresses interleukin 1β-mediated microsomal prostaglandin E synthase 1 by altering early growth response gene 1 and other signaling pathways

Journal of Pharmacology and Experimental Therapeutics

Volumn 315, Issue 2, 2005, Pages 788-795

  Moon, Yuseok ^a,c   Glasgow, Wayne C ^b   Eling, Thomas E ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b MERCER UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Pusan National University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ARACHIDONIC ACID; CYCLOOXYGENASE 2; CYTOKINE; EARLY GROWTH RESPONSE FACTOR 1; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2; PROSTAGLANDIN F2 ALPHA; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; SYNTHETASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; INFLAMMATION; LUNG ALVEOLUS EPITHELIUM; METABOLITE; MICROSOME; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; RNA ANALYSIS; SIGNAL TRANSDUCTION;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTICARCINOGENIC AGENTS; ARACHIDONIC ACID; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL SURVIVAL; CURCUMIN; CYCLOOXYGENASE 2; EARLY GROWTH RESPONSE PROTEIN 1; HUMANS; INTERLEUKIN-1; INTRAMOLECULAR OXIDOREDUCTASES; LUCIFERASES; MICROSOMES, LIVER; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; NF-KAPPA B; PLASMIDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 27144503124     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.105.084434     Document Type: Article

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