Suppression of transcription factor Egr-1 by curcumin

Thrombosis Research

Volumn 97, Issue 4, 2000, Pages 179-189

  Pendurthi, Usha R ^a   Rao, L Vijaya Mohan ^a  

^a UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

Author keywords

Curcumin; Egr 1; Tissue factor

Indexed keywords

COMPLEMENTARY DNA; CURCUMIN; MESSENGER RNA; NATURAL PRODUCT; PHORBOL 13 ACETATE 12 MYRISTATE; THROMBOPLASTIN; TRANSCRIPTION FACTOR; UROKINASE;

ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; FIBROBLAST CULTURE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IMMEDIATE EARLY GENE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; THROMBOSIS; TRANSCRIPTION REGULATION;

BINDING SITES; BLOOD; CELLS, CULTURED; CURCUMIN; DNA-BINDING PROTEINS; DRUG INTERACTIONS; EARLY GROWTH RESPONSE PROTEIN 1; ENDOTHELIUM, VASCULAR; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; IMMEDIATE-EARLY PROTEINS; RECEPTORS, CELL SURFACE; RNA, MESSENGER; TETRADECANOYLPHORBOL ACETATE; THROMBOPLASTIN; TRANSCRIPTION FACTORS;

EID: 0033963647     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0049-3848(99)00148-6     Document Type: Article

References (47)

1. Sukhatme V.P. Early transcriptional events in cell growth. The Egr-1 family J Am Soc Nephrol. 1:1990;859-866.
2. Gashler A., Sukhatme V.P. Early growth response protein 1 (Egr-1). Prototype of a zinc-finger family of transcription factors Prog Nucleic Acid Res. 50:1995;191-224.
3. McMahon S.B., Monroe J. The role of early growth response gene-1 (egr-1) in regulation of the immune response. J Leukoc Biol. 60:1996;159-166.
4. Liu C., Adamson E., Mercola D. Transcription factor Egr-1 suppresses the growth and transformation of human HT-1080 fibrosarcoma cells by induction of transforming growth factor β1. Proc Natl Acad Sci USA. 93:1996;11831-11836.
5. Khachigian L.M., Lindner V., Williams A.J., Collins T. Egr-1-induced endothelial gene expression. A common theme in vascular injury Science. 271:1996;1427-1431.
6. Christy B.A., Lau L.F., Nathans D. A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences. Proc Natl Acad Sci USA. 85:1988;7857-7861.
7. Cao X., Guy G.R., Sukhatme V.P., Tan Y.H. Regulation of the Egr-1 gene by tumor necrosis factor and interferons in primary human fibroblasts. J Biol Chem. 267:1992;1345-1349.
8. Rupprecht H.D., Sukhatme V.P., Lacy J., Sterzei R.B., Coleman D.L. PDGF-induced Egr-1 expression in rat mesangial cells is mediated through upstream serum response elements. Am J Physiol. 365:1993;F351-F360.
9. 6GG sequences to mediate activation of the early growth response 1 transcription factor gene by ionizing radiation. Proc Natl Acad Sci USA. 90:1993;2419-2422.
10. Chaudhary L.R., Cheng S., Avioli L.V. Induction of early growth response-1 gene by interleukin and tumor necrosis factor-α in normal human bone marrow stromal and osteoblastic cells. Regulation by a protein kinase C inhibitor Mol Cell Biochem. 156:1996;69-77.
11. Mackman N. Regulation of the tissue factor gene. FASEB J. 9:1995;883-889.
12. Verde P., Boast S., Franze A., Robbiati F., Blasi F. An upstream enhancer and a negative element in the 5′ flanking region of the human urokinase plasminogen activator gene. Nucleic Acids Res. 16:1988;10699-10716.
13. Parry GC, Mackman N. Transcriptional regulation of the human urokinase-type plasminogen activator receptor gene. Circulation 1996;94(Suppl.):I-644 (Abstract).
14. Kim S.J., Glick A., Sporn M.B., Roberts A.B. Characterization of the promoter region of the human transforming growth factor-β1 gene. J Biol Chem. 264:1989;402-408.
15. Dey B.R., Sukhatme V.P., Roberts A.B., Sporn M.B., Rauscher F.J. III, Kim S.J. Repression of the transforming growth factor-β1 gene by the Wilms' tumor suppressor WT1 gene product. Mol Endocrinol. 8:1994;595-602.
16. Khachigian L.M., Williams A.J., Collins T. Interplay of Sp1 and Egr-1 in the proximal platelet-derived growth factor A-chain promoter in cultured vascular endothelial cells. J Biol Chem. 270:1995;27679-27686.
17. Drake T.A., Morrissey J.H., Edgington T.S. Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis Am J Pathol. 134:1989;1087-1097.
18. Fleck R.A., Rao L.V.M., Rapaport S.I., Varki N. Localization of human tissue factor antigen by immunostaining with monospecific, polyclonal anti-human tissue factor antibody. Thromb Res. 59:1990;421-437.
19. Østerud B. Cellular interactions in tissue factor expression by blood monocytes. Blood Coag Fibrin. 6:1995;S20-S25.
20. Drake T.A., Cheng J., Chang A., Taylor F.B. Jr. Expression of tissue factor, thrombomodulin, and E-selectin in baboons with lethal Escherichia coli sepsis. Am J Pathol. 142:1993;1458-1470.
21. Contrino J., Hair G., Kreutzer D.L., Rickles F.R. In situ detection of tissue factor in vascular endothelial cells. Correlation with the malignant phenotype of human breast disease Nature Medicine. 2:1996;209-215.
22. Zhang Y., Deng Y., Wendt T., Liliensiek B., Bierhaus A., Greten J., He W., Chen B., Hach-Wunderle V., Waldherr R., Ziegler R., Mannel D., Stern D.M., Nawroth P.P. Intravenous somatic gene transfer with antisense tissue factor restores blood flow by reducing tumor necrosis factor-induced expression and fibrin deposition in mouse Meth-A sarcomas. J Clin Invest. 97:1996;2213-2214.
23. Østerud B. Tissue factor. A complex biological role Thromb Haemost. 78:1997;755-758.
24. Semeraro N., Colucci M. Tissue factor in health and disease. Thromb Haemost. 78:1997;759-764.
25. Taubman M.B., Fallon J.T., Schecter A.D., Giesen P., Mendlowitz M., Fyfe B.S., Marmur J.D., Nemerson Y. Tissue factor in the pathogenesis of atherosclerosis. Thromb Haemost. 78:1997;200-204.
26. Mackman N. Regulation of the tissue factor gene. Thromb Haemost. 78:1997;747-754.
27. Parry G.C.N., Mackman N. Transcriptional regulation of tissue factor expression in human endothelial cells. Arterioscler Thromb Vasc Biol. 15:1995;612-621.
28. Yan S.F., Zou Y.S., Gao Y., Zhai C., Mackman N., Lee S.L., Milbrandt J., Pinsky D., Kisiel W., Stern D. Tissue factor transcription driven by Egr-1 is a critical mechanism of murine pulmonary fibrin deposition in hypoxia. Proc Natl Acad Sci USA. 95:1998;8298-8303.
29. Govindarajan V.S. Turmeric - Chemistry, technology, and quality. Crit Rev Food Sci Nutr. 12:1980;199-301.
30. Satoskar R.R., Shah S.J., Shenoy S.G. Evaluation of anti-inflammatory properties of curcumin (diferuloyl methane) in patients with postoperative inflammation. Int J Clin Pharmacol Ther Toxicol. 24:1986;651-654.
31. Huang M.T., Smart R.C., Wong C.Q., Conney A.H. Inhibitory effects of curcumin, chlorogenic acid, caffeic acid and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol 13-acetate. Cancer Res. 48:1988;5941-5946.
32. Sharma O.P. Antioxidant activity of curcumin and related compounds. Biochem Pharmacol. 25:1976;1811-1812.
33. Ammon H.P.T., Safayhi H., Mack T., Sabieraj J. Mechanism of antiinflammatory actions of curcumine and boswellic acids. J Ethnopharmacology. 38:1993;113-119.
34. Rao C.V., Rivenson A., Simi B., Reddy B.S. Chemoprevention of colon carcinogenesis by dietary curcumin a naturally occurring plant phenolic compound. Cancer Research. 55:1995;259-266.
35. Huang T.S., Lee S.C., Lin J.K. Suppression of c-Jun/AP-1 activation by an inhibitor of tumor promotion in mouse fibroblast cells. Proc Natl Acad Sci USA. 88:1991;5292-5296.
36. Singh S., Aggarwal B.B. Activation of transcription factor NF-kB is suppressed by curcumin. J Biol Chem. 270:1995;24995-25000.
37. Pendurthi U.R., Williams J.T., Rao L.V.M. Inhibition of tissue factor gene activation in cultured endothelial cells by curcumin. Suppression of activation of transcription factors Egr-1, AP-1 and NF-kB Arterioscler Thromb Vasc Biol. 17:1997;3406-3417.
38. Bierhaus A., Zhang Y., Quenhenberger P., Luther T., Haase M., Muller M., Mackman N., Ziegler R., Nawroth P. The dietary pigment curcumin reduces endothelial tissue factor gene expression by inhibiting binding of AP-1 to the DNA and activation of NF-kB. Thromb Haemost. 77:1997;772-782.
39. Callander N.S., Rao L.V.M., Nordfang O., Sandset P.M., Warn-Cramer B., Rapaport S.I. Mechanisms of binding of recombinant extrinsic pathway inhibitor (rEPI) to cultured cell surfaces. Evidence that rEPI can bind to and inhibit factor VIIa-tissue factor complexes in the absence of factor Xa. J Biol Chem. 267:1992;876-882.
40. Mosmann T. Rapid colorimetric assay for cellular growth and survival. Application to proliferation and cytotoxic assays J Immunol Methods. 65:1983;55-63.
41. Tsai-Moris C.-H., Cao X., Sukhatme V.P. 5′ flanking sequence and genomic structure of Egr-1, a murine mitogen inducible zinc finger encoding gene. Nucleic Acids Res. 16:1988;8835-8846.
42. Reddy S., Aggarwal B.B. Curcumin is a non-competitive and selective inhibitor of phosphorylase kinase. FEBS Lett. 341:1994;19-22.
43. Hunter T., Karin M. The regulation of transcription by phosphorylation. Cell. 70:1992;375-387.
44. Angel P., Karin M. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta. 1072:1991;129-157.
45. Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. J Biol Chem. 270:1995;16483-16486.
46. Thanos D., Maniatis T. Nf-kB. A lesson in family values Cell. 80:1995;529-532.
47. Collins T. Biology of disease. Endothelial nuclear factor-kappa B and the initiation of atherosclerotic lesion Lab Invest. 68:1993;499-508.