Functional analysis of the phospholipase C gene CaPLC1 and two unusual phospholipase C genes, CaPLC2 and CaPLC3, of Candida albicans

Microbiology

Volumn 151, Issue 10, 2005, Pages 3381-3394

  Kunze, Donika ^a   Melzer, Inga ^b   Bennett, Désirée ^c   Sanglard, Dominique ^d   MacCallum, Donna ^e   Nörskau, Jan ^b   Coleman, David C ^c   Odds, Frank C ^e   Schäfer, Wilhelm ^b   Hube, Bernhard ^a  

^a ROBERT KOCH INSTITUTE   (Germany)

^b UNIVERSITY OF HAMBURG   (Germany)

^c TRINITY COLLEGE DUBLIN   (Ireland)

^d LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^e UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; PHOSPHOLIPASE C; PHOSPHOLIPASE C1; PHOSPHOLIPASE C2; PHOSPHOLIPASE C3; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; CELL FUNCTION; CONTROLLED STUDY; ENZYME RELEASE; EXPERIMENTAL INFECTION; FUNGAL GENE; FUNGAL VIRULENCE; FUNGUS GROWTH; FUNGUS HYPHAE; GENE FUNCTION; GENETIC SCREENING; GENETIC TRANSCRIPTION; HETEROZYGOSITY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSMOTIC STRESS; PHENOTYPIC VARIATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN MOTIF; REGULATORY MECHANISM; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; TEMPERATURE MEASUREMENT; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CANDIDA ALBICANS; CANDIDIASIS; DROSOPHILA PROTEINS; FUNGAL PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, FUNGAL; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; PHOSPHOLIPASE C; PROTEIN-SERINE-THREONINE KINASES; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION, GENETIC;

BACTERIA (MICROORGANISMS); CANDIDA ALBICANS; FUNGI;

EID: 27144469035     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/mic.0.28353-0     Document Type: Article

References (56)

1. Andaluz, E., Coque, J. J., Cueva, R. & Larriba, G. (2001). Sequencing of a 4.3 kbp region of chromosome 2 of Candida albicans reveals the presence of homologues of SHE9 from Saccharomyces cerevisiae and of bacterial phosphatidylinositol-phospholipase C. Yeast 18, 711-721.
2. Ansari, K., Martin, S., Farkasovsky, M., Ehbrecht, I. M. & Kuntzel, H. (1999). Phospholipase C binds to the receptor-like GPR1 protein and controls pseudohyphal differentiation in Saccharomyces cerevisiae. J Biol Chem 274, 30052-30058.
3. Bennett, D. E., McCreary, C. E. & Coleman, D. C. (1998). Genetic characterization of a phospholipase C gene from Candida albicans: presence of homologous sequences in Candida species other than Candida albicans. Microbiology 144, 55-72.
4. Berridge, M. J. (1993). Inositol trisphosphate and calcium signalling. Nature 361, 315-325.
5. Buffo, J., Herman, M. A. & Soil, D. R. (1984). A characterization of pH-regulated dimorphism in Candida albicans. Mycopathologia 85, 21-30.
6. Calderone, R. A. & Fonzi, W. A. (2001). Virulence factors of Candida albicans. Trends Microbiol 9, 327-335.
7. Care, R. S., Trevethick, J., Binley, K. M. & Sudbery, P. E. (1999). The MET3 promoter: a new tool for Candida albicans molecular genetics. Mol Microbiol 34, 792-798.
8. +-ATPase. Biochim Biophys Acta 1405, 147-154.
9. Davis, D. A., Bruno, V. M., Loza, L., Filler, S. G. & Mitchell, A. P. (2002). Candida albicans Mds3p, a conserved regulator of pH responses and virulence identified through insertional mutagenesis. Genetics 162, 1573-1581.
10. De Backer, M. D., Maes, D., Vandoninck, S., Logghe, M., Contreras, R. & Luyten, W. H. (1999). Transformation of Candida albicans by electroporation. Yeast 15, 1609-1618.
11. d'Enfert, C., Goyard, S., Rodriguez-Arnaveilhe, S. & 25 other authors (2005). CandidaDB: a genome database for Candida albicans pathogenomics. Nucleic Acids Res 33, D353-D357.
12. Dingwall, C. & Laskey, R. A. (1991). Nuclear targeting sequences - a consensus? Trends Biochem Sci 16, 478-481.
13. Enloe, B., Diamond, A. & Mitchell, A. P. (2000). A single-transformation gene function test in diploid Candida albicans. J Bacteriol 182, 5730-5736.
14. Felk, A., Kretschmar, M., Albrecht, A. & 7 other authors (2002). Candida albicans hyphal formation and the expression of the Efg1-regulated proteinases Sap4 to Sap6 are required for the invasion of parenchymal organs. Infect Immun 70, 3689-3700.
15. Flick, J. S. & Thorner, J. (1993). Genetic and biochemical characterization of a phosphatidylinositol-specific phospholipase C in Saccharomyces cerevisiae. Mol Cell Biol 13, 5861-5876.
16. Fonzi, W. A. & Irwin, M. Y. (1993). Isogenic strain construction and gene mapping in Candida albicans. Genetics 134, 717-728.
17. Fradin, C. & Hube, B. (2003). Tissue infection and site-specific gene expression in Candida albicans. Adv Appl Microbiol 53, 271-290.
18. Fradin, C., De Groot, P., MacCallum, D., Schaller, M., Klis, F., Odds, F. C. & Hube, B. (2005). Granulocytes govern the transcriptional response, morphology and proliferation of Candida albicans in human blood. Mol Microbiol 56, 397-415.
19. Fu, Y., Ibrahim, A. S., Fonzi, W., Zhou, X., Ramos, C. F. & Ghannoum, M. A. (1997). Cloning and characterization of a gene (LIP1) which encodes a lipase from the pathogenic yeast Candida albicans. Microbiology 143, 331-340.
20. Ghannoum, M. A. (2000). Potential role of phospholipases in virulence and fungal pathogenesis. Clin Microbiol Rev 13, 122-143.
21. Griffith, O. H. & Ryan, M. (1999). Bacterial phosphatidylinositol-specific phospholipase C: structure, function, and interaction with lipids. Biochim Biophys Acta 1441, 237-254.
22. Hube, B. (2004). From commensal to pathogen: stage- and tissue-specific gene expression of Candida albicans. Curr Opin Microbiol 7, 336-341.
23. Hube, B., Monod, M., Schofield, D. A., Brown, A. J. & Gow, N. A. (1994). Expression of seven members of the gene family encoding secretory aspartyl proteinases in Candida albicans. Mol Microbiol 14, 87-99.
24. Hube, B., Stehr, F., Bossenz, M., Mazur, A., Kretschmar, M. & Schafer, W. (2000). Secreted lipases of Candida albicans: cloning, characterisation and expression analysis of a new gene family with at least ten members. Arch Microbiol 174, 362-374.
25. Hube, B., Hess, D., Baker, C. A., Schaller, M., Schafer, W. & Dolan, J. W. (2001). The role and relevance of phospholipase D1 during growth and dimorphism of Candida albicans. Microbiology 147, 879-889.
26. Jun, Y., Fratti, R. A. & Wickner, W. (2004). Diacylglycerol and its formation by phospholipase C regulate Rab- and SNARE-dependent yeast vacuole fusion. J Biol Chem 279, 53186-53195.
27. Knechtle, P., Goyard, S., Brachat, S., Ibrahim-Granet, O. & d'Enfert, C. (2005). Phosphatidylinositol-dependent phospholipases C Plc2 and Plc3 of Candida albicans are dispensable for morphogenesis and host-pathogen interaction. Res Microbiol 156, 822-829.
28. Leuker, C. E., Sonneborn, A., Delbruck, S. & Ernst, J. F. (1997). Sequence and promoter regulation of the PCK1 gene encoding phosphoenolpyruvate carboxykinase of the fungal pathogen Candida albicans. Gene 192, 235-240.
29. Lin, H., Choi, J. H. & Vancura, A. (1998). Phosphoinositide-specific phospholipase C interacts with phosphatidylinositol kinase homolog TOR2. Biochem Biophys Res Commun 252, 285-289.
30. Lin, H., Choi, J. H., Hasek, J., DeLillo, N., Lou, W. & Vancura, A. (2000). Phospholipase C is involved in kinetochore function in Saccharomyces cerevisiae. Mol Cell Biol 20, 3597-3607.
31. Lin, H., Nguyen, P. & Vancura, A. (2002). Phospholipase C interacts with Sgd1p and is required for expression of GPD1 and osmoresistance in Saccharomyces cerevisiae. Mol Genet Genomics 267, 313-320.
32. Liu, H., Köhler, J. & Fink, G. R. (1994). Suppression of hyphal formation in Candida albicans by mutation of a STE12 homolog. Science 266, 1723-1725.
33. Naglik, J., Albrecht, A., Bader, O. & Hube, B. (2004). Candida albicans proteinases and host/pathogen interactions. Cell Microbiol 6, 915-926.
34. Nishizuka, Y. (1992). Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 258, 607-614.
35. Ochocka, A. M. & Pawelczyk, T. (2003). Isozymes delta of phosphoinositide-specific phospholipase C and their role in signal transduction in the cell. Acta Biochim Pol 50, 1097-1110.
36. Odom, A. R., Stahlberg, A., Wente, S. R. & York, J. D. (2000). A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control. Science 287, 2026-2029.
37. Payne, W. E. & Fitzgerald-Hayes, M. (1993). A mutation in PLC1, a candidate phosphoinositide-specific phospholipase C gene from Saccharomyces cerevisiae, causes aberrant mitotic chromosome segregation. Mol Cell Biol 13, 4351-4364.
38. Pugh, D. & Cawson, R. A. (1977). The cytochemical localization of phospholipase in Candida albicans infecting the chick chorio-allantoic membrane. Sabouraudia 15, 29-35.
39. Rhee, S. G. (2001). Regulation of phosphoinositide-specific phospholipase C. Annu Rev Biochem 70, 281-312.
40. Roemer, T., Jiang, B., Davison, J. & 15 other authors (2003). Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery. Mol Microbiol 50, 167-181.
41. Sanchez-Martinez, C. & Perez-Martin, J. (2002). Gpa2, a G-protein alpha subunit required for hyphal development in Candida albicans. Eukaryot Cell 1, 865-874.
42. Sanglard, D., Ischer, F., Monod, M. & Bille, J. (1996). Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors. Antimicrob Agents Chemother 40, 2300-2305.
43. Sanglard, D., Ischer, F., Marchetti, O., Entenza, J. & Bille, J. (2003). Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence. Mol Microbiol 48, 959-976.
44. Schaller, M., Korting, H. C., Schafer, W., Bastert, J., Chen, W. & Hube, B. (1999). Secreted aspartic proteinase (Sap) activity contributes to tissue damage in a model of human oral candidosis. Mol Microbiol 34, 169-180.
45. Shepherd, M. G., Yin, C. Y., Ram, S. P. & Sullivan, P. A. (1980). Germ tube induction in Candida albicans. Can J Microbiol 26, 21-26.
46. Sigle, H. C., Thewes, S., Niewerth, M., Korting, H. C., Schafer-Korting, M. & Hube, B. (2005). Oxygen accessibility and iron levels are critical factors for the antifungal action of ciclopirox against Candida albicans. J Antimicrob Chemother 55, 663-673.
47. Stoldt, V. R., Sonneborn, A., Leuker, C. E. & Ernst, J. F. (1997). Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi. EMBO J 16, 1982-1991.
48. Sudbery, P., Gow, N. & Berman, J. (2004). The distinct morphogenic states of Candida albicans. Trends Microbiol 12, 317-324.
49. Tisi, R., Baldassa, S., Belotti, F. & Martegani, E. (2002). Phospholipase C is required for glucose-induced calcium influx in budding yeast. FEBS Lett 520, 133-138.
50. Uhl, M. A., Biery, M., Craig, N. & Johnson, A. D. (2003). Haploinsufficiency-based large-scale forward genetic analysis of filamentous growth in the diploid human fungal pathogen C. albicans. EMBO J 22, 2668-2678.
51. Whiteway, M. & Oberholzer, U. (2004). Candida morphogenesis and host-pathogen interactions. Curr Opin Microbiol 7, 350-357.
52. Wilson, R. B., Davis, D. & Mitchell, A. P. (1999). Rapid hypothesis testing with Candida albicans through gene disruption with short homology regions. J Bacteriol 181, 1868-1874.
53. Yesland, K. & Fonzi, W. A. (2000). Allele-specific gene targeting in Candida albicans results from heterology between alleles. Microbiology 146, 2097-2104.
54. Yoko-o, T., Matsui, Y., Yagisawa, H., Nojima, H., Uno, I. & Toh-e, A. (1993). The putative phosphoinositide-specific phospholipase C gene, PLC1, of the yeast Saccharomyces cerevisiae is important for cell growth. Proc Natl Acad Sci U S A 90, 1804-1808.
55. York, J. D., Odom, A. R., Murphy, R., Ives, E. B. & Wente, S. R. (1999). A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export. Science 285, 96-100.
56. York, J. D., Guo, S., Odom, A. R., Spiegelberg, B. D. & Stolz, L. E. (2001). An expanded view of inositol signaling. Adv Enzyme Regul 41, 57-71.