Polymorphism of the interleukin-1 receptor antagonist gene: A factor in susceptibility to rheumatoid arthritis in a Spanish population

Arthritis and Rheumatism

Volumn 52, Issue 10, 2005, Pages 3015-3019

  Carreira, Patricia E ^a   Gonzalez Crespo, Maria R ^a   Ciruelo, Elena ^a   Pablos, Jose L ^a   Santiago, Begoña ^a   Gomez Camara, Agustin ^a   Gomez Reino, Juan J ^b  

^a HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT;

ADULT; AGED; ARTHRITIS; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; POPULATION GENETICS; PRIORITY JOURNAL; RECEPTOR GENE; RHEUMATOID ARTHRITIS; SPAIN;

ADULT; AGED; ARTHRITIS, RHEUMATOID; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; MALE; MIDDLE AGED; PHENOTYPE; POLYMORPHISM, GENETIC; SIALOGLYCOPROTEINS; SPAIN; TANDEM REPEAT SEQUENCES;

EID: 26844563660     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.21287     Document Type: Article

References (42)

1. MacGregor AJ, Snieder H, Rigby AS, Koskenvuo M, Kaprio J, Aho K, et al. Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum 2000;43:30-7.
2. Deighton CM, Walker DJ, Griffiths ID, Roberts DF. The contribution of HLA to rheumatoid arthritis. Clin Genet 1989;36: 178-82.
3. Ollier WE, MacGregor A. Genetic epidemiology of rheumatoid disease. Br Med J 1995;51:267-85.
4. Cornelis F, Faure S, Martinez M, Prud'homme JF, Fritz P, Dib C, et al. New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study. Proc Natl Acad Sci U S A 1998;95: 10746-50.
5. Jawaheer D, Seldin MF, Amos CI, Chen WV, Shigeta R, Monteiro J, et al. A genome-wide screen in multiplex rheumatoid arthritis families suggests genetic overlap with other autoimmune diseases. Am J Hum Genet 2001;68:927-36.
6. MacKay K, Eyre S, Myerscough A, Millicic A, Barton A, Laval S, et al. Whole-genome linkage analysis of rheumatoid arthritis susceptibility loci in 252 affected sibling pairs in the United Kingdom. Arthritis Rheum 2002;46:632-9.
7. Arend WP, Dayer JM. Inhibition of the production and effects of interleukin-1 and tumor necrosis factor a in rheumatoid arthritis [review]. Arthritis Rheum 1995;38:151-60.
8. Wood NC, Dickens E, Symons JA, Duff GW. In situ hybridization of interleukin-1 in CD14-positive cells in rheumatoid arthritis. Clin Immunol Immunopathol 1992;62:295-300.
9. Symons JA, McDowell TL, di Giovine FS, Wood NC, Capper SJ, Duff GW. Interleukin 1 in rheumatoid arthritis: potentiation of immune response within the joint. Lymphokine Res 1989;8: 365-72.
10. Eastgate JA, Symons JA, Wood NC, Grinlinton FM, di Giovine FS, Duff GW. Correlation of plasma interleukin 1 levels with disease activity in rheumatoid arthritis. Lancet 1988;2:706-9.
11. Arend WP, Guthridge CJ. Biological roles of interleukin-1 receptor antagonist isoforms. Ann Rheum Dis 2000;59 Suppl 1:i60-4.
12. Dinarello CA. Biologic basis for interleukin-1 in disease. Blood 1996;87:2095-147.
13. Horai R, Saijo S, Tanioka H, Nakae S, Sudo K, Okahara A, et al. Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-efficient mice. J Exp Med 2000;191:313-20.
14. Bakker AC, Joosten LA, Arntz OJ, Helsen MM, Bendele AM, van de Loo FA, et al. Prevention of murine collagen-induced arthritis in the knee and ipsilateral paw by local expression of human interleukin-1 receptor antagonist protein in the knee. Arthritis Rheum 1997;40:893-900.
15. Wooley PH, Whalen JD, Chapman DL, Berger AE, Richard KA, Aspar DG, et al. The effect of an interleukin-1 receptor antagonist protein on type II collagen-induced arthritis and antigen-induced arthritis in mice. Arthritis Rheum 1993;36:1305-14.
16. Cohen S, Hurd E, Cush J, Schiff M, Weinblatt ME, Moreland LW, et al. Treatment of rheumatoid arthritis with anakinra, a recombinant human interleukin-1 receptor antagonist, in combination with methotrexate: results of a twenty-four-week, multicenter, randomized, double-blind, placebo-controlled trial. Arthritis Rheum 2002;46:614-24.
17. Niclin MJ, Weith A, Duff GW. A physical map of the region encompassing the human interleukin-1α, interleukin-1β, and interleukin-1 receptor antagonist genes. Genomics 1994;19:382-4.
18. Tarlow JK, Blakemore AI, Lennard A, Solari R, Hughes HN, Steinkasserer A, et al. Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat. Hum Genet 1993;91:403-4.
19. Cork MJ, Tarlow JK, Blakemore AI, McDonagh JG, Messenger AG, Bleehen SS, et al. Genetics of interleukin one receptor antagonists in inflammatory skin diseases [abstract]. J Invest Dermatol 1993;100:552.
20. Carter MJ, di Giovine FS, Jones S, Mee J, Camp NJ, Lobo AJ, et al. Association of the interleukin 1 receptor antagonist gene with ulcerative colitis in Northern European Caucasians. Gut 2001;48: 461-7.
21. Mandrup-Poulsen T, Pociot F, Molvig J, Shapiro L, Nilsson P, Emdal T, et al. Monokine antagonism is reduced in patients with IDDM. Diabetes 1994;43:1242-7.
22. Blakemore AI, Tarlow JK, Cork MJ, Gordon C, Emery P, Duff GW. Interleukin-1 receptor antagonist gene polymorphism as a disease severity factor in systemic lupus erythematosus. Arthritis Rheum 1994;37:1380-5.
23. Vencovsky J, Jarosova K, Ruzickova S, Nemcova D, Niederlova J, Ozen S, et al. Higher frequency of allele 2 of the interleukin-1 receptor antagonist gene in patients with juvenile idiopathic arthritis. Arthritis Rheum 2001;44:2387-91.
24. Perrier S, Coussediere C, Dubost JJ, Albuisson E, Sauvezie B. IL-1 receptor antagonist (IL-1RA) gene polymorphism in Sjogren's syndrome and rheumatoid arthritis. Clin Immunol Immunopathol 1998;87:309-13.
25. Meulenbelt I, Seymour AB, Nieuwland M, Huizinga TW, van Duijn CM, Slagboom PE. Association of the interleukin-1 gene cluster with radiographic signs of osteoarthritis of the hip. Arthritis Rheum 2004;50:1179-86.
26. Cantagrel A, Navaux F, Loubet-Lescoulie P, Nourhashemi F, Enault G, Abbal M, et al. Interleukin-1β, interleukin-1 receptor antagonist, interleukin-4, and interleukin-10 gene polymorphisms: relationship to occurrence and severity of rheumatoid arthritis. Arthritis Rheum 1999;42:1093-100.
27. Barrera P, Faure S, Prud'homme JF, Balsa A, Migliorini P, Chimenti D, et al. European genetic study on rheumatoid arthritis: is there a linkage of the interleukin-1 (IL-1), IL-10 or IL-4 genes to RA? Clin Exp Rheumatol 2001;19:709-14.
28. Cox A, Camp NJ, Cannings C, di Giovine FS, Dale M, Worthington J, et al. Combined sib-TDT and TDT provide evidence for linkage of the interleukin-1 gene cluster to erosive rheumatoid arthritis. Hum Mol Genet 1999;8:1707-13.
29. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
30. Gomez-Reino JJ, Pablos JL, Carreira PE, Santiago B, Serrano L, Vicario JL, et al. Association of rheumatoid arthritis with a functional chemokine receptor, CCR5. Arthritis Rheum 1999;42: 989-92.
31. Vamvakopoulos JE, Taylor CJ, Morris-Stiff GJ, Green C, Metcalfe S. The interleukin-1 receptor antagonist gene: a single copy variant of the intron 2 variable number tandem repeat (VNTR) polymorphism. Eur J Immunogenet 2002;29:337-40.
32. Colhoun HM, Mckeigue PM, Smith GD. Problems reporting genetic associations with complex outcomes. Lancet 2003;361: 865-72.
33. Cardon LR, Palmer LJ. Population stratification and spurious allelic association. Lancet 2003;361:598-604.
34. Tountas NA, Casini-Raggi V, Yang H, di Giovine FS, Vecchi M, Kam L, et al. Functional and ethnic association of allele 2 of the interleukin-1 receptor antagonist gene in ulcerative colitis. Gastroenterology 1999;117:806-13.
35. Craggs A, West S, Curtis A, Welfare M, Hudson M, Donaldson P, et al. Absence of a genetic association between IL-1RN and IL-1β gene polymorphisms in ulcerative colitis and Crohn disease in multiple populations from Northeast England. Scand J Gastroenterol 2001;11:1173-8.
36. Lee YH, Kim HJ, Rho YH, Choi SJ, Ji JD, Song GG. Interleukin-1 receptor antagonist gene polymorphism and rheumatoid arthritis. Rheumatol Int 2004;24:131-6.
37. Cox A, Camp NJ, Nicklin MJ, di Giovine FS. An analysis of linkage disequilibrium in the interleukin-1 gene cluster, using a novel grouping method for multiallelic markers. Am J Hum Genet 1998;62:1180-8.
38. Danis VA, Millington M, Hyland VJ, Grennan D. Cytokine production by normal human monocytes: inter-subject variation and relationship to an IL-1 receptor antagonist (IL-1RA) gene polymorphism. Clin Exp Immunol 1995;99:303-10.
39. Carter MJ, Jones S, Camp NJ, Cox A, Mee J, Warren B, et al. Functional correlates of the interleukin-1 receptor antagonist gene polymorphism in the colonic mucosa in ulcerative colitis. Genes Immun 2004;5:8-15.
40. Redlitz KH, Yamshchikov VF, Cominelli F. Differential contribution of IL-1Ra isoforms to allele-specific IL-1Ra mRNA accumulation. J Interferon Cytokine Res 2004;24:253-60.
41. Malyak M, Smith MF Jr, Abel AA, Hance KR, Arend WP. The differential production of three forms of IL-1 receptor antagonist by human neutrophils and monocytes. J Immunol 1998;161: 2004-10.
42. Santtila S, Savinainen K, Hurme M. Presence of the IL-1Ra allele 2 (IL1RN*2) is associated with enhanced IL-1β production in vitro. Scand J Immunol 1998;47:195-8.