An analysis of linkage disequilibrium in the interleukin-1 gene cluster, using a novel grouping method for multiallelic markers

American Journal of Human Genetics

Volumn 62, Issue 5, 1998, Pages 1180-1188

  Cox, Angela ^a   Camp, Nicola J ^a   Nicklin, Martin J H ^a   Di Giovine, Francesco S ^a   Duff, Gordon W ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1;

ALLELE; ARTICLE; AUTOIMMUNE DISEASE; GENE CLUSTER; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; HAPLOTYPE; HUMAN; INFLAMMATORY DISEASE; MAJOR CLINICAL STUDY; POPULATION GENETICS; PRIORITY JOURNAL;

EID: 0031961076     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/301817     Document Type: Article

References (20)

1. Chakravarti A, Buetow KH, Antonarakis SE, Waber PG, Boehm CD, Kazazian HH (1984) Nonuniform recombination within the human β-globin gene cluster. Am J Hum Genet 36:1239-1258
2. Clay FE, Tarlow JK, Cork MJ, Cox A, Nicklin MJH, Duff GW (1996) Novel interleukin-1 receptor antagonist exon polymorphisms and their use in allele-specific mRNA assessment. Hum Genet 97:723-726
3. Copeman JB, Cucca F, Hearne CM, Cornall RJ, Reed PW, Ronningen KS, Undlien DE, et al (1995) Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31-q33. Nat Genet 9:80-85
4. di Giovine FS, Takhsh E, Blakemore AIF, Duff GW (1992) Single base polymorphism at -511 in the human interleukin-1 beta gene (IL1B). Hum Mol Genet 1:450
5. Guasch JF, Bertina RM, Reitsma PH (1996) Five novel intragenic dimorphisms in the human interleukin-1 genes combine to high informativity. Cytokine 8:598-602
6. Hill WG (1974) Estimation of linkage disequilibrium in randomly mating populations. Heredity 33:229-239
7. Jorde LB, Watkins WS, Carlson M, Groden J, Albertsen H, Thliveris A, Leppert M (1994) Linkage disequilibrium predicts physical distance in the adenomatous polyposis coli region. Am J Hum Genet 54:884-898
8. Lander ES, Schork NJ (1994) Genetic dissection of complex traits. Science 265:2037-2048
9. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES (1996) Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet 58:1347-1363
10. McDowell TL, Symons JA, Ploski R, Forre O, Duff GW (1995) A genetic association between juvenile rheumatoid arthritis and a novel interleukin-1a polymorphism. Arthritis Rheum 38:221-228
11. Nicklin MJH, Weith A, Duff GW (1994) A physical map of the region encompassing the human interleukin-1α, interleukin-1β, and interleukin-1 receptor antagonist genes. Genomics 19:382-384
12. Nothwang HG, Strahm B, Denich D, Kubler M, Schwabe J, Gingrich JC, Jauch A, et al (1997) Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13. Genomics 41:370-378
13. Spurr NK, Bashir R, Bushby K, Cox A, Cox S, Hildebrandt F, Hill N, et al (1996) Report of the Fourth International Workshop on Chromosome 2 Mapping 1996. Cytogenet Cell Genet 73:255-273
14. Tarlow JK, Blakemore AIF, Lennard A, Solari R, Hughes HN, Steinkasserer A, Duff GW (1993) Polymorphism in the human II-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat. Hum Genet 91:403-404
15. Terwilliger JD, Ott J (1994) Linkage disequilibrium between alleles at marker loci. In: Handbook of human genetic linkage, 1st ed. Johns Hopkins University Press, Baltimore, pp 188-198
16. Thompson EA, Deeb S, Walker D, Motulsky AG (1988) The detection of linkage disequilibrium between closely linked markers: RFLPs at the AI-CIII apolipoprotein genes. Am J Hum Genet 42:113-124
17. Watkins WS, Zenger R, O'Brien E, Nyman D, Eriksson AW, Renlund M, Jorde LB (1994) Linkage disequilibrium patterns vary with chromosomal location: a case study from the von Willebrand factor region. Am J Hum Genet 55: 348-355
18. Weeks DE, Lathrop GM (1995) Polygenic disease - methods for mapping complex disease traits. Trends Genet 11: 513-519
19. Weir BS, Cockerham CC (1978) Testing hypotheses about linkage disequilibrium with multiple alleles. Genetics 88: 633-642
20. Worthington J, Ollier WER, Leach MK, Smith I, Hay EM, Thomson W, Pepper L, et al (1994) The Arthritis and Rheumatism Council's National Repository of Family Material: pedigrees from the first 100 rheumatoid arthritis families containing affected sibling pairs. Br J Rheumatol 33: 970-976