Presence of the IL-1RA allele 2 (IL1RN*2) is associated with enhanced IL-1β production in vitro

Scandinavian Journal of Immunology

Volumn 47, Issue 3, 1998, Pages 195-198

  Santtila, S ^a   Savinainen, K ^a   Hurme, M ^a  

^a UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA;

ALLELE; ARTICLE; CYTOKINE PRODUCTION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; HUMAN CELL; MONONUCLEAR CELL; NORMAL HUMAN; PRIORITY JOURNAL; RECEPTOR GENE; REGULATOR GENE; TANDEM REPEAT;

ALLELES; BLOOD DONORS; CELLS, CULTURED; GENOTYPE; HUMANS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1; LEUKOCYTES, MONONUCLEAR; SIALOGLYCOPROTEINS;

EID: 0031955425     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1998.00300.x     Document Type: Article

References (12)

1. Dinarello CA. Biologic basis for interleukin-1 in disease. Blood 1996;87:2095-147.
2. Tarlow JL, Blakemore AIF, Lennard A et al. Polymorphism in human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat. Hum Genet 1993;91:403-4.
3. Mansfield JC, Holden H, Tarlow JK et al. Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist. Gastroenterology 1994;106:637-42.
4. Crusius JBA, Pena AS, van Oosten BW et al. Interleukin-1-receptor antagonist gene polymorphism and multiple sclerosis. Lancet 1995;346:979-80.
5. Blakemore AIF, Cox A, Gonzales A-M et al. Interleukin-1 receptor antagonist allele (IL1RN*2) associated with nephropathy in diabetes mellitus. Hum Gen 1996;97:369-374.
6. Tarlow JK, Clay FE, Cork MJ et al. Severity of alopecia areata is associated with a polymorphism in the interleukin-1 receptor antagonist gene. J Invest Dermatol 1994;103:387-390.
7. Danis VA, Millington M, Hyland VJ, Grenman D. Cytokine production by normal human monocytes: inter-subject variation and relationship to an IL-1 receptor antagonist (IL-1Ra) gene polymorphism. Clin Exp Immunol 1995;99:303-10.
8. di Giovine FS, Takhsh E, Blakemore AIF, Duff GW. Single base polymorphisms at -511 in the human interleukin-1β gene. Hum Mol Gen 1992;1:450.
9. Pociot F, Molvig J, Wogensen L, Worsaae H, Nerup J. A Taql polymorphism in the human interleukin-10 (IL-1β) gene correlates with IL-1β secretion in vitro. Eur J Clin Invest 1992;22:396-402.
10. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucl Acids Res 1988;16:1215.
11. Fenton MJ. Transcriptional and post-transcriptional regulation of interleukin 1 gene. Int J Immunopharmacol 1992;14:401-11.
12. Bioque G, Crusius JBA, Koutroubakis I et al. Allelic polymorphism in IL-1β and IL-1 receptor antagonist (IL-1Ra) genes in inflammatory bowel diseases. Clin Exp Immunol 1995;102:379-83.