Hydrophilic bile salt ursodeoxycholic acid protects myocardium against reperfusion injury in a PI3K/Akt dependent pathway

Journal of Molecular and Cellular Cardiology

Volumn 39, Issue 5, 2005, Pages 766-776

  Rajesh, Katare Gopalrao ^a,b   Suzuki, Ryoko ^a   Maeda, Hironori ^a   Yamamoto, Murio ^a   Yutong, Xing ^a   Sasaguri, Shiro ^a  

^a Department of Cardiovascular Surgery and Regeneration Technology ^*  (Japan)

^b KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

Akt; Apoptosis; Mitochondrial permeability transition pore; Reperfusion injury; UDCA

Indexed keywords

ATRACTYLOSIDE; CYTOCHROME C; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAD; PROTEIN BCL 2; PROTEIN KINASE B; URSODEOXYCHOLIC ACID; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; CORONARY ARTERY OBSTRUCTION; CYTOSOL; DOWN REGULATION; DRUG MECHANISM; ENZYME INHIBITION; ENZYME RELEASE; HEART CELL CULTURE; HEART INJURY; HEART MITOCHONDRION; HEART MUSCLE REPERFUSION; HEART PROTECTION; HYDROPHILICITY; LEFT CORONARY ARTERY; MALE; MITOCHONDRIAL MEMBRANE; MITOCHONDRION SWELLING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REPERFUSION INJURY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOSINE TRIPHOSPHATE; ANDROSTADIENES; ANIMALS; APOPTOSIS; ATRACTYLOSIDE; BCL-ASSOCIATED DEATH PROTEIN; CELL HYPOXIA; CELL SURVIVAL; CELLS, CULTURED; CYTOCHROMES C; MALE; MITOCHONDRIAL SWELLING; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; MYOCYTES, CARDIAC; OXYGEN; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; URSODEOXYCHOLIC ACID;

RATTUS NORVEGICUS;

EID: 26844537040     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2005.07.014     Document Type: Article

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