Design, synthesis, and preliminary pharmacological evaluation of a set of small molecules that directly activate Gi proteins

Journal of Medicinal Chemistry

Volumn 48, Issue 20, 2005, Pages 6491-6503

  Manetti, Dina ^a   Mannelli, Lorenzo Di Cesare ^a   Dei, Silvia ^a   Galeotti, Nicoletta ^a   Ghelardini, Carla ^a   Romanelli, Maria Novella ^a   Scapecchi, Serena ^a   Teodori, Elisabetta ^a   Pacini, Alessandra ^a   Bartolini, Alessandro ^a   Gualtieri, Fulvio ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 PENTADECYLPIPERAZIN 1 YLAMINE; ADENYLATE CYCLASE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CYCLIC AMP; DITERPENE; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; PENTADECYLPIPERAZIN 1 YLAMINE; PERTUSSIS TOXIN; PIPERAZINE DERIVATIVE; PIPERIDINE DERIVATIVE; SODIUM CHANNEL; UNCLASSIFIED DRUG;

ARTICLE; CELL COMMUNICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LYMPHOCYTE; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION;

ADENYLATE CYCLASE; ANALGESICS; DRUG DESIGN; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; HYDROGEN-ION CONCENTRATION; LYMPHOCYTES; PIPERIDINES; PROTEIN BINDING; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 26444531051     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050498l     Document Type: Article

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