Amitriptyline and clomipramine activate Gi-protein signaling pathway in the induction of analgesia

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 365, Issue 1, 2002, Pages 1-7

  Ghelardini, C ^a   Galeotti, N ^a   Bartolini, A ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Amitriptyline; Analgesia; Antisense oligonucleotides; Clomipramine; Gi proteins; Hot plate test; Mice

Indexed keywords

AMITRIPTYLINE; ANTISENSE OLIGONUCLEOTIDE; CLOMIPRAMINE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPROTEIN; MESSENGER RNA;

ALPHA CHAIN; ANALGESIA; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; HOT PLATE TEST; HYPERALGESIA; LOCOMOTION; MALE; MOTOR COORDINATION; MOUSE; NONHUMAN; PAIN THRESHOLD; PROTEIN INDUCTION; SIGNAL TRANSDUCTION;

AMITRIPTYLINE; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; CLOMIPRAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; MALE; MICE; OLIGONUCLEOTIDES, ANTISENSE; PAIN MEASUREMENT; SIGNAL TRANSDUCTION;

EID: 0036137625     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-001-0496-8     Document Type: Article

References (38)

1. Amitriptyline produces analgesia in the formalin pain test
2. Effects of noradrenergic and serotonergic antidepressants on chronic low back pain intensity
3. Endogenous pain control mechanisms: Review and hypothesis
4. Interaction of tricyclic antidepressants with opiate receptors
5. G proteins in signal transduction
6. Amitriptyline potentiates morphine analgesia by a direct action on the central nervous system
7. Effect of intrathecal or intracerebroventricular pretreatment with pertussis toxin on antinociception induced by β-endorphin or morphine administered intracerebroventricularly in mice
8. Spinal and trigeminal mechanism of nociception
9. Involvement of the serotoninergic system in the analgesic effect of tricyclic antidepressants
10. Effect of pertussis toxin on morphine, diphenhydramine, baclofen, clomipramine and physostigmine antinociception
11. Blockade of clomipramine and amitriptyline analgesia by an antisense oligonucleotide to mKv1.1, a mouse Shaker-like potassium channel
12. 2 transducer proteins
13. oα subunits restore the efficacy of opioids, clonidine and neurotensin giving rise to antinociception in G-protein knock-down mice
14. 2A-adrenoceptors
15. Pharmacological effects produced by intracerebral injection of drugs in the conscious mouse
16. GTP-binding proteins mediate transmitter inhibition of voltage-dependent calcium channels
17. Molecular mechanisms and regulation of opioid receptor signaling
18. Antidepressants and pain: A review of the pharmacological data supporting the use of certain tricyclics in chronic pain
19. New players in the 5-HT receptor field: Genes and knockout
20. Antidepressants and chronic pain
21. Quantification of the analgesic activity of narcotic antagonists by a modified hot-plate procedure
22. Pertussis toxin inhibits the antinociceptive action of morphine in the rat
23. G-protein antisense oligodeoxynucleotides and μ-opioid supraspinal antinociception
24. 2-adrenoceptor antinociception in mice
25. Utilization patterns of tricyclic antidepressants in a multidisciplinary pain clinic: A survey
26. A role for serotonin and β-endorphin in the analgesia induced by some tricyclic antidepressant drugs
27. 2-mediated supraspinal analgesia in mice
28. i3 transducer proteins
29. Delta opioid subtypes activates inositol-signaling pathways in the production of antinociception
30. In vivo injection of oligodeoxynucleotides to Gα subunits and supraspinal evoked by mu and delta opioid agonists
31. The treatment of intractable pain in terminal cancer
32. Analgesic activity of tricyclic antidepressants
33. Differential blockade of opioid analgesia by antisense oligodeoxynucleotides directed against various G protein α subunits
34. The analgesic effect of tricyclic antidepressants
35. A comparison of the antinociceptive responses to GABA-receptor agonists THIP and baclofen
36. The treatment of neuropathic pain: Antidepressants and opioids
37. Intrathecal pertussis toxin produces hyperalgesia and allodynia in mice
38. Treatment of post-herpetic neuralgia