Gsα-selective G protein antagonists

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 1, 1998, Pages 346-351

  Hohenegger, M ^a   Waldhoer, M ^a   Beindl, W ^a   Boing B ^b   Kreimeyer, A ^b   Nickel, P ^b   Nanoff, C ^a   Freissmuth, M ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; ISOPRENALINE; NF 449; NF 503; PROTEIN INHIBITOR; SARALASIN; SURAMIN; UNCLASSIFIED DRUG; 4,4' (CARBONYLBIS(IMINO 3,1 PHENYLENE(2,5 BENZIMIDAZOLYLENE)CARBONYLIMINO))BISBENZENESULFONATE; 4,4'-(CARBONYLBIS(IMINO-3,1-PHENYLENE(2,5-BENZIMIDAZOLYLENE)CARBONYLIMINO))BISBENZENESULFONATE; 4,4,',4'',4''' (CARBONYLBIS(IMINO 5,1,3 BENZENETRIYLBIS(CARBONYLIMINO)))TETRAKIS(BENZENE 1,3 DISULFONATE); 4,4,',4'',4'''-(CARBONYLBIS(IMINO-5,1,3-BENZENETRIYLBIS(CARBONYLIMINO)))TETRAKIS(BENZENE-1,3-DISULFONATE); ADENOSINE RECEPTOR; ADENYLATE CYCLASE; ANGIOTENSIN RECEPTOR; BENZENESULFONIC ACID DERIVATIVE; BENZIMIDAZOLE DERIVATIVE; BETA ADRENERGIC RECEPTOR; CYANOIODOPINDOLOL; DRUG DERIVATIVE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); ONCOPROTEIN; PINDOLOL; RECOMBINANT PROTEIN; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN;

ADRENERGIC RECEPTOR BLOCKING; ANIMAL CELL; ANIMAL TISSUE; CONFERENCE PAPER; DRUG MECHANISM; ENZYME INHIBITION; ESCHERICHIA COLI; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; RAT; STRUCTURE ACTIVITY RELATION; ANIMAL; ARTICLE; DRUG ANTAGONISM; METABOLISM;

ADENYLATE CYCLASE; ANIMALS; BENZENESULFONATES; BENZIMIDAZOLES; ESCHERICHIA COLI; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); IODOCYANOPINDOLOL; ISOPROTERENOL; ONCOGENE PROTEINS; PINDOLOL; RATS; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, ANGIOTENSIN; RECEPTORS, PURINERGIC P1; RECOMBINANT PROTEINS; SARALASIN;

EID: 0031595019     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.1.346     Document Type: Article

References (34)

1. Simon, M. I., Strathman, M. P. & Gautam, N. (1991) Science 252, 802-808.
2. Offermanns, S. & Schultz, G. (1994) Naunyn Schmiedeberg's Arch. Pharmacol 350, 329-338.
3. Gudermann, T., Kalkbrenner, F. & Schultz, G. (1996) Annu. Rev. Pharmacol Toxicol. 36, 429-459.
4. Laugwitz, K. L., Allgeier, A., Offermanns, S., Spicher, K., van Sande, J., Dumont, J. E. & Schultz, G. (1996) Proc. Natl. Acad. Sci. USA 93, 116-120.
5. Clapham, D. E. (1995) Nature 371, 109-110.
6. Freissmuth M., Boehm, S., Beindl, W., Nickel, P., Ijzerman, A. P., Hohenegger, M. & Nanoff, C. (1996) Mol. Pharmacol. 49, 602-611.
7. Butler, S., Kelly, E. C. H., McKenzie, F., Guild, S., Wakelam, M. O. & Milligan, G. (1988) Biochem. J. 251, 201-205.
8. Huang, R.-R. C., Dehaven, R. N., Cheung, A. H., Diehl, R. E., Dixon, R. A. F. & Strader, C. D. (1990) Mol. Pharmacol. 37, 304-310.
9. Beindl, W., Mitterauer, T., Hohenegger, M., Ijzerman, A. P., Nanoff, C. & Freissmuth, M. (1996) Mol. Pharmacol 50, 415-423.
10. Kreimeyer, A., Müller, G., Kassack. M., Gagliardi, A. & Nickel, P. (1997) Arch. Pharm. Pharm. Med. Chem. 330, in press.
11. Nickel, P., Haack, H. J., Widjaja, H., Ardanuy, U., Gurgel, Ch., Düwel, D., Loewe, H. & Raether, W. (1986) Drug Res. 36, 1153-1157.
12. Kassack, M. & Nickel, P. (1996) J. Chromatogr. B 686, 275-284.
13. Freissmuth, M., Schütz, W. & Linder, M. E. (1991) J. Biol. Chem. 266, 17778-17783.
14. Freissmuth, M. & Gilman, A. G. (1989) J. Biol. Chem. 264, 21907-21914.
15. Mumby, S. M. & Linder, M. E. (1994) Methods Enzymol. 237, 254-268.
16. Freissmuth, M., Hausleithner, V., Nees, S., Böck, M. & Schütz, W. (1986) Naunyn Schmiedeberg's Arch. Pharmacol. 334, 56-62.
17. Freissmuth, M., Kraupp, O., Hausleithner, V., Tuisl, E. & Schütz, W. (1986) J. Cardiovasc. Pharmacol. 8, 60-66.
18. Jockers, R., Linder, M. E., Hohenegger, M., Nanoff, C., Bertin, B., Strosberg, A. D., Marullo, S. & Freissmuth, M. (1994) J. Biol. Chem. 269, 32077-32084.
19. Freund, S., Ungerer, M. & Lohse, M. J. (1994) Naunyn Schmiedeberg's Arch. Pharmacol. 350, 49-56.
20. Freissmuth, M., Selzer, E., Marullo, S., Schütz, W. & Strosberg, A. D. (1991) Proc. Natl. Acad. Sci. USA 88, 8548-8552.
21. Graziano, M. P., Freissmuth, M. & Gilman, A. G. (1989) J. Biol. Chem. 264, 409-418.
22. Birnbaumer, L., Abramowitz, J. & Brown, A. M. (1990) Biochim. Biophys. Acta 1031, 163-224.
23. Hepler, J. & Gilman, A. G. (1992) Trends Biochem. Sci. 17, 383-387.
24. Jakobs, K. H., Aktories, K. & Schultz, G. (1983) Nature 303, 177-178.
25. Dohlmann, H. G., Thorner, J. R., Caron, M. G. & Lefkowitz, R. G. (1991) Annu. Rev. Biochem. 60, 653-688.
26. Schütz, W. & Freissmuth, M. (1992) Trends Pharmacol. Sci. 13, 376-380.
27. Lefkowitz, R. J., Cotecchia, S., Sanama, P. & Costa, T. (1993) Trends Pharmacol. Sci. 14, 303-307.
28. Graber, S. G., Figler, R. A. & Garrison, J. C. (1992) J. Biol. Chem. 267, 1271-1278.
29. Shibata, T., Suzuki, C., Ohnishi, J., Murakami, K. & Miyazaki, H. (1996) Biochem. Biophys. Res. Commun. 218, 383-389.
30. Nanoff, C., Freissmuth, M., Tuisl, E. & Schütz, W. (1990) Br. J. Pharmacol. 100, 63-68.
31. Edwards, R. M., Stack, E. J., Weidley, E. F., Aiyar, N., Keenan, R. M., Hill, D. Z. & Weinstock, J. (1992) J. Pharmacol. Exp. Ther. 260, 933-938.
32. Masters, S. B., Sullivan, K. A., Miller, R. T., Beidermann, B., Copey, N. G., Ranachandran, J. & Bourne, H. R. (1988) Science 241, 448-451.
33. Osawa, S., Dhanasekaran, N., Woon, C. W. & Johnson, G. L. (1990) Cell 63, 697-706.
34. Sprang, R. (1997) Annu. Rev. Biochem. 66, 639-678.