Molecular pathways involved in the anti-apoptotic effect of 1,25-dihydroxyvitamin D3 in primary human keratinocytes

Journal of Cellular Biochemistry

Volumn 93, Issue 5, 2004, Pages 951-967

  De Haes, Petra ^a   Garmyn, Marjan ^a   Carmeliet, Geert ^a   Degreef, Hugo ^a   Vantieghem, Katleen ^a   Bouillon, Roger ^a,b   Segaert, Siegfried ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b LEGENDO   (Belgium)

Author keywords

1,25 dihydroxyvitamin D3; Akt; Anti apoptosis; Bcl 2 family; Extracellular signal regulated kinase

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CALCITRIOL; CISPLATIN; CYCLOHEXIMIDE; DACTINOMYCIN; DOXORUBICIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; AKT1 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; BAD PROTEIN, HUMAN; BAX PROTEIN, HUMAN; CARRIER PROTEIN; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; ONCOPROTEIN; PROTEIN BAD; PROTEIN BAX; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE;

APOPTOSIS; ARTICLE; DRUG ACTIVITY; DRUG INHIBITION; DRUG MECHANISM; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; CELL CULTURE; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVATION; METABOLISM; PHYSIOLOGY; PRESCHOOL CHILD; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-ASSOCIATED DEATH PROTEIN; CALCITRIOL; CARRIER PROTEINS; CELLS, CULTURED; CHILD, PRESCHOOL; CISPLATIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; ENZYME ACTIVATION; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; KERATINOCYTES; MAP KINASE KINASE 1; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; SIGNAL TRANSDUCTION;

EID: 26444510603     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.20227     Document Type: Article

References (70)

1. Adams JM. 2003. Ways of dying: Multiple pathways to apoptosis. Genes Dev 17:2481-2495.
2. 3 target gene in squamous cell and breast carcinoma. Biochem Biophys Res Commun 281:1051-1056.
3. Bektas M, Orfanos CE, Geilen CC. 2000. Different vitamin D analogues induce sphingomyelin hydrolysis and apoptosis in the human keratinocyte cell line HaCaT. Cell Mol Biol (Noisy-le-grand) 46:111-119.
4. 3, transforming growth factor β, calcium, and ultraviolet B radiation induce apoptosis in cultured human keratinocytes. J Invest Dermatol 109:276-282.
5. 3 and vitamin D analogs on tumor-derived endothelial cells. Endocrinology 143:2508-2514.
6. Bikle DD, Tu C-L, Xie Z, Oda Y. 2003. Vitamin D regulated keratinocyte differentiation: Role of coactivators. J Cell Biochem 88:290-295.
7. 3 ex vivo. Arch Dermatol Res 288:453-457.
8. Bonni A, Brunet A, West AE, Datta SR, Takasu MA, Greenberg ME. 1999. Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms. Science 286:1358-1362.
9. Bouillon R. 2000. Vitamin D: From photosynthesis, metabolism, and action to clinical applications. In: DeGroot LJ, Jameson JL, editors. Endocrinology. Philadelphia: Saunders. pp 1009-1028.
10. Caelles C, Gonzales-Sancho JM, Munoz A. 1997. Nuclear hormone receptor antagonism with AP-1 by inhibition of the JNK pathway. Genes Dev 11:3351-3364.
11. Chang F, Steelman LS, Lee JT, Shelton JG, Navolanic PM, Blalock WL, Franklin RA, McCubrey JA. 2003. Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: Potential targeting for therapeutic intervention. Leukemia 17:1263-1293.
12. Cory S, Adams JM. 2002. The Bcl2 family: Regulators of the cellular life-or-death switch. Nat Rev Cancer 2:647-656.
13. Cross TG, Scheel-Toellner D, Henriquez NV, Deacon E, Salmon M, Lord JM. 2000. Serine/threonine protein kinases and apoptosis. Exp Cell Res 256:34-41.
14. Danielsen AJ, Maihle NJ. 2002. The EGF/ErbB receptor family and apoptosis. Growth Factors 20:1-15.
15. 3 inhibits ultraviolet B-induced apoptosis, Jun kinase activation, and interleukin-6 production in primary human keratinocytes. J Cell Biochem 89:663-673.
16. 3 protect human keratinocytes against the effects of UVB. Arch Dermatol Res 295:527-534.
17. 3 and its analogue EB1089 in colorectal adenoma and carcinoma cells: Possible implications for prevention and therapy. Cancer Res 60:2304-2312.
18. Dunkern TR, Wedemeyer I, Baumgartner M, Fritz G, Kaina B. 2003. Resistance of p53 knockout cells to doxorubicin is related to reduced formation of DNA strand breaks rather than impaired apoptotic signaling. DNA Repair (Amst) 2:49-60.
19. 3. Mol Cell Endocrinol 63:189-198.
20. Fukazawa H, Uehara Y. 2000. U0126 reverses Ki-ras-mediated transformation by blocking both mitogen-activated protein kinase and p70 S6 kinase pathways. Cancer Res 60:2104-2107.
21. Galbiati F, Polastri L, Thorens B, Dupraz P, Fiorina P, Cavallaro U, Christofori G, Davalli AM. 2003. Molecular pathways involved in the antineoplastic effects of calcitriol on insulinoma cells. Endocrinology 144:1832-1841.
22. 3 increases the growth-promoting activity of autocrine epidermal growth factor receptor ligands in keratinocytes. Endocrinology 140: 713-721.
23. 3 in normal human keratinocytes. J Invest Dermatol 106:1212-1217.
24. Goetzl EJ, Kong Y, Mei B. 1999. Lysophosphatidic acid and sphingosine 1-phosphate protection of T cells from apoptosis in association with suppression of Bax. J Immunol 162:2049-2056.
25. Gonzalez EA, Disthabanchong S, Kowalewski R, Martin KJ. 2002. Mechanisms of the regulation of EGF receptor gene expression by calcitriol and parathyroid hormone in UMR 106-01 cells. Kidney Int 61:1627-1634.
26. 3 in prostate cancer. Mol Cancer Ther 1:667-677.
27. (Waf1/Cip1) in vitro and in vivo. Cancer Res 59:2644-2649.
28. 3-induced myeloid cell differentiation is regulated by a vitamin D receptor-phosphatidylinositol 3-kinase signaling complex. J Exp Med 190:1583-1594.
29. Ishida-Yamamoto A, Tanaka H, Nakane H, Takahashi H, Hashimoto Y, Iizuka H. 1999. Programmed cell death in normal epidermis and loricrin keratoderma. Multiple functions of profilaggrin in keratinization. J Invest Dermatol Symp Proc 4:145-149.
30. 3 stimulates activator protein 1 DNA-binding activity by a phosphatidylinositol 3-kinase/Ras/MEK/ extracellular signal regulated kinase 1/2 and c-Jun N-terminal kinase 1-dependent increase in c-Fos, Fra1, and c-Jun expression in human keratinocytes. J Invest Dermatol 120:561-570.
31. 3 in cultured cells and in mice. Proc Natl Acad Sci USA 84:8810-8813.
32. Kensler TW, Dolan PM, Gange SJ, Lee JK, Wang Q, Posner GH. 2000. Conceptually new deltanoids (vitamin D analogs) inhibit multistage skin tumorigenesis. Carcinogenesis 21:1341-1345.
33. Ketley NJ, Allen PD, Kelsey SM, Newland AC. 2000. Mechanisms of resistance to apoptosis in human AML blasts: The role of differentiation-induced perturbations of cell-cycle checkpoints. Leukemia 14:620-628.
34. Kousteni S, Bellido T, Plotkin LI, O'Brien CA, Bodenner DL, Han L, Han K, DiGregorio GB, Katzenellenbogen JA, Katzenellenbogen BS, Roberson PK, Weinstein RS, Jilka RL, Manolagas SC. 2001. Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: Dissociation from transcriptional activity. Cell 104:719-730.
35. Kulms D, Zeise E, Poppelmann B, Schwarz T. 2002. DNA damage, death receptor activation, and reactive oxygen species contribute to ultraviolet radiation-induced apoptosis in an essential and independent way. Oncogene 21: 5844-5851.
36. 3 stimulates the production of insulin-like growth factor-binding proteins-2, -3, and -4 in human bone marrow stromal cells. Eur J Endocrinol 144:549-557.
37. 3 in an in vitro human skin equivalent model. J Invest Dermatol 117:1179-1185.
38. Maes C, Carmeliet P, Moermans K, Stockmans I, Smets N, Collen D, Bouillon R, Carmeliet G. 2002. Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Mech Dev 111:61-73.
39. 3 protects human keratinocytes from apoptosis by the formation of sphingosine-1-phosphate. J Invest Dermatol 117:1241-1249.
40. 3-induced apoptosis of murine squamous cell carcinoma cells. Selective induction of caspase-dependent MEK cleavage and up-regulation of MEKK-1. J Biol Chem 276:26365-26373.
41. 3. Recent results. Cancer Res 164:427-432.
42. 3. Arch Dermatol Res 292:455-462.
43. Narvaez CJ, Welsh J. 2001. Role of mitochondria and caspases in vitamin D-mediated apoptosis of MCF-7 breast cancer cells. J Biol Chem 276:9101-9107.
44. Norman AW, Mizwicki MT, Norman DP. 2004. Steroid-hormone rapid actions, membrane receptors, and a conformational ensemble model. Nat Rev Drug Discov 3:27-41.
45. 3 on tumor promotion in mouse skin. Nutr Cancer 16:171-181.
46. Polakowska RR, Piacentini M, Bartlett R, Goldsmith LA, Haake AR. 1994. Apoptosis in human skin development: Morphogenesis, periderm, and stem cells. Dev Dyn 199: 176-188.
47. Pugazhenthi S, Nesterova A, Sable C, Heidenreich KA, Boxer LM, Heasley LE, Reusch JE. 2000. Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein. J Biol Chem 275: 10761-10766.
48. Ravid A, Rubinstein E, Gamady A, Rotem C, Liberman UA, Koren R. 2002. Vitamin D inhibits the activation of stress-activated protein kinases by physiological and environmental stresses in keratinocytes. J Endocrinol 173:525-532.
49. 3 protects RINm5F and human islet cells against cytokine-induced apoptosis: Implication of the antiapoptotic protein A20. Endocrinology 143:4809-4819.
50. 3 in cultured human epidermal keratinocytes. J Invest Dermatol 109:46-54.
51. 2(d(pGpG))]. Science 230:412-417.
52. 3 is accompanied by an increase in insulin-like growth factor binding protein-3. J Endocrinol 170:609-618.
53. Studzinski GP, Moore DC. 1995. Sunlight-Can it prevent as well as cause cancer? Cancer Res 55:4014-4022.
54. Sutton AL, MacDonald PN. 2003. Vitamin D: More than a "bone-a-fide" hormone. Mol Endocrinol 17:777-791.
55. Swinnen JV, Heemers H, Deboel L, Foufelle F, Heyns W, Verhoeven G. 2000. Stimulation of tumor-associated fatty acid synthase expression by growth factor activation of the sterol regulatory element-binding protein pathway. Oncogene 19:5173-5181.
56. 3 analogues in the treatment of psoriasis. Skin Pharmacol Appl Skin Physiol 11:2-10.
57. 3 inhibit the growth of human breast cancer cells in vitro and in vivo. Cancer Res 15:2673-2679.
58. Vincent AM, Feldman EL. 2002. Control of cell survival by IGF signaling pathways. Growth Horm IGF Res 12:193-197.
59. Vivanco I, Sawyers CL. 2002. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2:489-501.
60. 3-induced apoptosis of retinoblastoma cells is associated with reciprocal changes of Bcl-2 and bax. Exp Eye Res 77:1-9.
61. 3 is associated with increased mitochondrial MCL-1 and RAF-1 proteins and reduced release of cytochrome c. Exp Cell Res 235:210-217.
62. 3 up-regulates Bcl-2 expression and protects normal human thyrocytes from programmed cell death. Endocrinology 140:1649-1656.
63. Wang WH, Li LF, Zhang BX, Lu XY. 2004. Metallothionein-null mice exhibit reduced tolerance to ultraviolet B injury in vivo. Clin Exp Dermatol 29:57-61.
64. Weil M, Raff MC, Braga VM. 1999. Caspase activation in the terminal differentiation of human epidermal keratinocytes. Curr Biol 9:361-364.
65. Wong G, Gupta R, Dixon KM, Deo SS, Choong SM, Halliday GM, Bishop JE, Ishizuka S, Norman AW, Posner GH, Mason RS. 2004. 1,25-dihydroxyvitamin D and three low-calcemic analogs decrease UV-induced DMA damage via the rapid response pathway. J Steroid Biochem Mol Biol 90:567-570.
66. 3 inhibits phorbol ester-dependent chemical carcinogenesis in mouse skin. Biochem Biophys Res Commun 116:605-611.
67. 3 on the formation of skin tumors in mice treated chronically with 7,12-dimethylbenz[a]anthracene. Biochem Biophys Res Commun 130: 924-931.
68. Wu J, Spiegel S, Sturgill TW. 1995. Sphingosine 1-phosphate rapidly activates the mitogen-activated protein kinase pathway by a G protein-dependent mechanism. J Biol Chem 270:11484-11488.
69. Xie SP, Pirianov G, Colston KW. 1999. Vitamin D analogues suppress IGF-I signalling and promote apoptosis in breast cancer cells. Eur J Cancer 35:1717-1723.
70. 3 receptor ablation sensitizes skin to chemically induced tumorigenesis. Carcinogenesis 23:2103-2109.